Shen M#, Kang Y#. (2023) Cancer fitness genes: emerging therapeutic targets for metastasis. Trends in Cancer 9 (1), 69-82. (#Corresponding author, cover story)
Chen H., Zhan M., Liu J., Liu Z., Shen M., Yang F., Kang Y., Yin F., Li Z. (2022) Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction. J. Med. Chem. 65 (18), 12188-12199.
2022
Li J., Chen D., Shen M#. (2022) Tumor Microenvironment Shapes Colorectal Cancer Progression, Metastasis, and Treatment Responses. Frontiers in Medicine. https://doi.org/10.3389/fmed.2022.869010
Shen M., Wei Y., Kim H., Wan L., Jiang Y., Hang X., Raba M., Remiszewski S., Rowicki M., Zhang L., Lu X., Yuan M., Smith H., Zheng A., Lin H., Bertino J., Jin J., Xing Y., Shao Z., Kang Y. (2022) Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis. Nature Cancer. https://doi.org/10.1038/s43018-021-00279-5
Shen M., Smith H., Wei Y., Jiang Y., Zhao S., Wang N., Rowicki M., Tang Y., Hang X., Wan L., Shao Z., Kang Y. (2022) Pharmacological disruption of the MTDH–SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nature Cancer. https://doi.org/10.1038/s43018-021-00280-y
Pérez-Núñez I, Rozalén C, Palomeque JÁ, Sangrador I, Dalmau M, Comerma L, Hernández-Prat A, Casadevall D, Menendez S, Liu DD, Shen M., Berenguer J, Ruiz IR, Peña R, Montañés JC, Albà MM, Bonnin S, Ponomarenko J, Gomis RR, Cejalvo JM, Servitja S, Marzese DM, Morey L, Voorwerk L, Arribas J, Bermejo B, Kok M, Pusztai L, Kang Y, Albanell J, Celià-Terrassa T. (2022) LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer. Nature Cancer. doi: 10.1038/s43018-022-00339-4.
2021
Shen M., Xie S., Rowicki M., Michel S., Wei Y., Hang X., Wan L., Lu X., Yuan M., Jin JF., Jaschinski F., Zhou T., Klar R., Kang Y. (2021) Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Research DOI: 10.1158/0008-5472.CAN-20-1876.
Shen M., Kang Y. (2020) Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities. Genes & Development 34 (23-24), 1577-1598.
Li W., Shen M., Jiang YZ., Zhang R., Zheng H., Wei Y., Shao ZM., Kang Y. (2020) Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2. Genes & Development 34 (19-20), 1310-1315.
Fan H., Wang X., Li W., Shen M., Wei Y., Zheng H., Kang Y. (2020) ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. Genes & Development 34 (19-20), 1359-1372
Shen M., Jiang YZ., Wei Y., Ell B., Sheng X., Esposito M., Kang J., Hang X., Zheng H., Rowicki M., Zhang L., Shih WJ., Celia-Terrassa T., Liu Y., Shao ZM., Crestea I., Kang Y. (2019) Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Cancer Cell. 35(1): 64-80.
Shen M., Kang Y. (2019) Role Reversal: A Pro-metastatic Function of E-Cadherin. Developmental Cell 51 (4), 417-419
Fan H., Wang X., Li W., Shen M., Wei Y., Zheng H., Kang Y. (2019) ASB13 inhibits breast cancer progression and metastasis through SNAI2 degradation and transcriptional regulation of YAP. Cancer Research 79 (13 Supplement), 162-162
Shen M., Kang, Y. (2018) pSTAT3+ Reactive Astrocytes Promote Brain Metastasis. Trends Mol Med. pii: S1471-4914(18)30141-2.
Shen M., Kang, Y. (2018) The Complex Interplay between the Tumor Microenvironment and Cancer Therapy. Frontiers of Medicine. 12: 426-439.
Feng S*., Song Y*., Shen M*., Xie S*., Li W., Yang Y., Zhou J., Wang F., Ou G., Yan X., Liang X., Lu Y., Zhou T. (2017) Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migration. Cell Discovery doi:10.1038/celldisc.2017.32. (*co-first author)
Zheng H., Bae Y., Kasimir-Bauer S., Tang R., Chen J., Ren G., Yuan M., Esposito M., Li W., Wei Y., Shen M., Zhang L., Tupitsyn N., Pantel K., King C., Sun J., Moriguchi J., Jun H., Coxon A., Lee B., Kang Y. (2017) Therapeutic Antibody Targeting Tumor-and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. Cancer cell 32(6), 731-747. e6.
Zheng H, Shen M, Cha Y-L, Li W, Wei Y, Blanco M., Ren G, Zhou T, Storz P., Wang H-Y, and Kang Y. (2014) PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. Cancer Cell 26:358-73.
Wan L., Lu X., Yuan S., Wei Y., Guo F., Shen M., Yuan M., Chakrabarti R., Hua Y., Smith H., Blanco M., Chekmareva M., Wu H., Broson R., Haffty B., Xing Y., Kang Y. (2014) MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors. Cancer Cell 26: 92-105
Guo F., Wan L., Zheng A., Stanevich V., Wei Y., Satyshur KA., Shen M., Lee W., Kang Y., Xing Y. (2014) Structural Insights into the Tumor-Promoting Function of the MTDH-SND1 Complex. Cell Reports 8:1704-1713
Deng Y., Xu Y., Huang Z., Jin J., Zhang C., Zhang X., Shen M., Yin Y., Yan X., Wang L., Wang X., Kang Y., Si J., Zhou T. (2014) MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Letters 342:27-35
Shen M., Cai Y., Yan X., Yang Y., Zhou T. (2013) Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes. Cell Research 23:1284-1295
Cai Y., Yang Y., Shen M., Zhou T. (2009) Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody. Cell Research 19:1305-1308