Research Experiences
The prevalence and genomic features of tet(X) and tmexCD-toprJ positive bacteria in the pork production chain (pig farms, pig slaughterhouses and market meat).
Tracking the ancestral source of the tigecycline resistance gene cluster tmexCD-toprJ with large-scale bacterial genomic and metagenomic data analysis.
Investigating the global epidemiological features of mcr-1-positive Salmonella enterica combining with the mcr-positive Salmonella in Sichuan province from 2014 to 2017 and the mcr-positive Salmonella in the NCBI Pathogen database.
Bioinformatics solutions for QitanTech nanopore sequencing in complete bacterial genome construction.
Performing a comprehensive and systematic investigation of the microbial communities, antibiotic resistance profiles and the host information of ARGs in the feces of laying hens.
Bioinformatics pipelines for nanopore metagenomic sequencing data analysis.
Web server development for online flexible bioinformatics analy
1. Peng K, Liu YX, Sun X, Wang Q, Du P, Zhang Y, Wang M, Wang Z, Li R. Long-read metagenomic sequencing reveals that high-copy small plasmids shape the highly prevalent antibiotic resistance genes in animal fecal microbiome. Sci Total Environ. 2023 Oct 1;893:164585. doi: 10.1016/j.scitotenv.2023.164585.
2. Peng K, Wang Q, Yin Y, Li Y, Liu Y, Wang M, Qin S, Wang Z, Li R. Plasmids Shape the Current Prevalence of tmexCD1-toprJ1 among Klebsiella pneumoniae in Food Production Chains. mSystems. 2021 Oct 26;6(5):e0070221. doi: 10.1128/mSystems.00702-21.
3. Peng K, Li R, He T, Liu Y, Wang Z. Characterization of a porcine Proteus cibarius strain co-harbouring tet(X6) and cfr. J Antimicrob Chemother. 2020 Jun 1;75(6):1652-1654.
4. Peng K, Yin Y, Li Y, Qin S, Liu Y, Yang X, Wang Z, Li R. QitanTech nanopore long-read sequencing enables rapid resolution of complete genomes of multi-drug resistant pathogens. Front Microbiol. 2022 Mar 23;13:778659.
5. Peng K, Wang Q, Li Y, Wang M, Kurekci C, Li R, Wang Z. Molecular mechanisms and genomic basis of tigecycline-resistant Enterobacterales from swine slaughterhouses. Microbiol Res. 2022 Nov;264:127151.
6. Peng K, Liu YX, Sun X, Wang Q, Wang Z, Li R. Large-scale bacterial genomic and metagenomic analysis reveals Pseudomonas aeruginosa as potential ancestral source of tigecycline resistance gene cluster tmexCD-toprJ. Int J Antimicrob Agents. (Under review)
7. Peng K, Liu Y, Wang Q, Yang P, Wang Z, Li R. Integrative conjugative elements mediate the high prevalence of tmexCD3-toprJ1b in Proteus spp. of animal source. mSystems. (Reversion)
8. Peng K, Deng J, Zou N, Sun X, Huang W, Li R, Yang X. Emergence of the fourth mobile sulfonamide resistance gene sul4 in clinical Salmonella enterica. Front Microbiol. (Reversion)
9. Li R#, Peng K#, Li Y, Liu Y, Wang Z. Exploring tet(X)-bearing tigecycline-resistant bacteriaof swine farming environments. Sci Total Environ. 2020 Sep 1;733:139306. doi:10.1016/j.scitotenv.2020.139306. Epub 2020 May 11.
10. Li R#, Peng K#, Huang W, Sun X, Huang Y, Lei G, Lv H, Wang Z, Yang X. The genomicepidemiology of mcr-positive Salmonella enterica in clinical patients from 2014 to 2017 in Sichuan, China and global epidemiological features. J Infect. 2022 Sep5:S0163-4453(22)00525-4.
11. Li R#, Peng K#, Xiao X, Liu Y, Peng D, Wang Z. Emergence of a multidrug resistance efflux pump with carbapenem resistance gene blaVIM-2 in a Pseudomonas putida megaplasmid of migratory bird origin. J Antimicrob Chemother. 2021 May 12;76(6):1455-1458