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成果及论文

【28】Yuan, C., Fan, W., Zhou, T., Sun, D., Liu, H., He, Z., & Wang, Y. (2023). Ligand-free high loading capacity ursolic acid self-carried nanovesicles enable hepatocyte targeting via absorbing apolipoproteins. International journal of pharmaceutics638, 122931. Advance online publication. https://doi.org/10.1016/j.ijpharm.2023.122931 

【27】Yu, Y. Y., Yuan, M., Qin, W. J., Bai, H. H., Liu, H. Z., & Che, J. J. (2023). A Novel Strategy for Liposomal Drug Separation in Plasma by TiO2 Microspheres and Application in Pharmacokinetics. International journal of nanomedicine18, 1321–1334. https://doi.org/10.2147/IJN.S396746 

【26】Gao, Y., Zhang, Y., Xia, H., Ren, Y., Zhang, H., Huang, S., Li, M., Wang, Y., Li, H., & Liu, H. (2023). Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy. Drug delivery30(1), 2183814. https://doi.org/10.1080/10717544.2023.2183814 

【25】Wang, Y., Yu, J., Li, D., Zhao, L., Sun, B., Wang, J., Wang, Z., Zhou, S., Wang, M., Yang, Y., Liu, H., Zhang, H., Lv, Q., Jiang, Q., He, Z., & Wang, Y. (2022). Paclitaxel derivative-based liposomal nanoplatform for potentiated chemo-immunotherapy. Journal of controlled release : official journal of the Controlled Release Society341, 812–827. https://doi.org/10.1016/j.jconrel.2021.12.023 

【24】Li, J., Cai, W., Yu, J., Zhou, S., Li, X., He, Z., Ouyang, D., Liu, H., & Wang, Y. (2022). Autophagy inhibition recovers deficient ICD-based cancer immunotherapy. Biomaterials287, 121651. Advance online publication. https://doi.org/10.1016/j.biomaterials.2022.121651 

【23】Zhou, S., Li, J., Yu, J., Wang, Y., Wang, Z., He, Z., Ouyang, D., Liu, H., & Wang, Y. (2022). Tumor microenvironment adrenergic nerves blockade liposomes for cancer therapy. Journal of controlled release : official journal of the Controlled Release Society351, 656–666. https://doi.org/10.1016/j.jconrel.2022.09.049 

【22】Li, N., Zhan, A., Jiang, Y., & Liu, H. (2022). A novel matrix metalloproteinases-cleavable hydrogel loading deferoxamine accelerates diabetic wound healing. International journal of biological macromolecules222(Pt A), 1551–1559. https://doi.org/10.1016/j.ijbiomac.2022.09.185 

【21】Wang, Z., Liu, Y., Li, S., Meng, F., Yu, J., Zhou, S., Dong, S., Ye, J., Li, L., Zhang, C., Qiu, S., Lin, G., Liu, H., Li, S. D., He, Z., & Wang, Y. (2022). Bioinspired Nanocomplexes Comprising Phenolic Acid Derivative and Human Serum Albumin for Cancer Therapy. Nano letters22(24), 10040–10048. https://doi.org/10.1021/acs.nanolett.2c03763 

【20】Xu, L., Guan, R., Yu, B., Li, Y., Liu, H., & Jiang, Y. (2022). Fluorene methoxycarbonyl-PEG-deferoxamine conjugates "hitchhike" with albumin in situ for iron overload therapy. International journal of pharmaceutics625, 122136. https://doi.org/10.1016/j.ijpharm.2022.122136 

【19】Yang, Y., Song, W., Wang, N., Ren, Y., & Liu, H. (2022). Tip-concentrated microneedle patch delivering everolimus for therapy of multiple sclerosis. Biomaterials advances135, 212729. https://doi.org/10.1016/j.bioadv.2022.212729 

【18】Liu, Y., Li, C., Xia, H., Bi, J., Guan, R., Du, X., Zhang, H., He, Z., Wang, Y., & Liu, H. (2022). An injectable superior depot of Telratolimod inhibits post-surgical tumor recurrence and distant metastases. Acta biomaterialia141, 132–139. https://doi.org/10.1016/j.actbio.2022.01.013 

【17】Li, C., Liu, Y., Li, D., Wang, Q., Zhou, S., Zhang, H., Wang, Y., He, Z., Liu, H., & Sun, J. (2022). Promising alternatives of CD47 monoclonal antibody: an injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRPα signal. Theranostics12(10), 4581–4598. https://doi.org/10.7150/thno.72310 

【16】Wang, Y., Yu, J., Li, D., Zhao, L., Sun, B., Wang, J., Wang, Z., Zhou, S., Wang, M., Yang, Y., Liu, H., Zhang, H., Lv, Q., Jiang, Q., He, Z., & Wang, Y. (2022). Paclitaxel derivative-based liposomal nanoplatform for potentiated chemo-immunotherapy. Journal of controlled release : official journal of the Controlled Release Society341, 812–827. https://doi.org/10.1016/j.jconrel.2021.12.023 

【15】Zhang, Y., Du, X., Wang, H., He, Z., & Liu, H. (2021). Sacubitril-valsartan cocrystal revisited: role of polymer excipients in the formulation. Expert opinion on drug delivery18(4), 515–526. https://doi.org/10.1080/17425247.2021.1860940 

【14】Zhou, S., Li, J., Yu, J., Wang, Y., Liu, H., Lin, G., He, Z., & Wang, Y. (2021). Unique flower-like Cur-metal complexes loaded liposomes for primary and metastatic breast cancer therapy. Materials science & engineering. C, Materials for biological applications121, 111835. https://doi.org/10.1016/j.msec.2020.111835 

【13】Zhou, S., Li, J., Yu, J., Wang, Y., Liu, H., Lin, G., He, Z., & Wang, Y. (2021). Unique flower-like Cur-metal complexes loaded liposomes for primary and metastatic breast cancer therapy. Materials science & engineering. C, Materials for biological applications121, 111835. https://doi.org/10.1016/j.msec.2020.111835 

【12】Kuang, X., Chi, D., Li, J., Guo, C., Yang, Y., Zhou, S., Luo, C., Liu, H., He, Z., & Wang, Y. (2021). Disulfide bond based cascade reduction-responsive Pt(IV) nanoassemblies for improved anti-tumor efficiency and biosafety. Colloids and surfaces. B, Biointerfaces203, 111766. https://doi.org/10.1016/j.colsurfb.2021.111766 

【11】Zhou, S., Li, J., Yu, J., Yang, L., Kuang, X., Wang, Z., Wang, Y., Liu, H., Lin, G., He, Z., Liu, D., & Wang, Y. (2021). A facile and universal method to achieve liposomal remote loading of non-ionizable drugs with outstanding safety profiles and therapeutic effect. Acta pharmaceutica Sinica. B11(1), 258–270. https://doi.org/10.1016/j.apsb.2020.08.001 

【10】Yang, Y., Sun, B., Zuo, S., Li, X., Zhou, S., Li, L., Luo, C., Liu, H., Cheng, M., Wang, Y., Wang, S., He, Z., & Sun, J. (2020). Trisulfide bond-mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity. Science advances6(45), eabc1725. https://doi.org/10.1126/sciadv.abc1725 

【9】Zhang, Y., Du, X., Wang, H., He, Z., & Liu, H. (2021). Sacubitril-valsartan cocrystal revisited: role of polymer excipients in the formulation. Expert opinion on drug delivery18(4), 515–526. https://doi.org/10.1080/17425247.2021.1860940 

【8】Ma, Y., Guan, R., Gao, S., Song, W., Liu, Y., Yang, Y., & Liu, H. (2020). Designing orodispersible films containing everolimus for enhanced compliance and bioavailability. Expert opinion on drug delivery17(10), 1499–1508. https://doi.org/10.1080/17425247.2020.1828342 

【7】Zhou, S., Li, J., Yu, J., Wang, Y., Liu, H., Lin, G., He, Z., & Wang, Y. (2021). Unique flower-like Cur-metal complexes loaded liposomes for primary and metastatic breast cancer therapy. Materials science & engineering. C, Materials for biological applications121, 111835. https://doi.org/10.1016/j.msec.2020.111835 

【6】Yu, B., Yang, Y., Liu, Q., Zhan, A., Yang, Y., & Liu, H. (2020). A Novel Star Like Eight-Arm Polyethylene Glycol-Deferoxamine Conjugate for Iron Overload Therapy. Pharmaceutics12(4), 329. https://doi.org/10.3390/pharmaceutics12040329 

【5】Yu, B., Zhan, A., Liu, Q., Ye, H., Huang, X., Shu, Y., Yang, Y., & Liu, H. (2020). A designed supramolecular cross-linking hydrogel for the direct, convenient, and efficient administration of hydrophobic drugs. International journal of pharmaceutics578, 119075. https://doi.org/10.1016/j.ijpharm.2020.119075 

【4】Zhang, Y., Gao, Y., Du, X., Guan, R., He, Z., & Liu, H. (2020). Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability. Pharmaceutics12(11), 1063. https://doi.org/10.3390/pharmaceutics12111063 

【3】Wang, W., Zhang, W., Jiang, Y., Wang, X., Zhang, X., Liu, H., & Zhang, T. (2020). Preparation of ursolic acid-phospholipid complex by solvent-assisted grinding method to improve dissolution and oral bioavailability. Pharmaceutical development and technology25(1), 68–75. https://doi.org/10.1080/10837450.2019.1671864 

【2】Wang, Z., Lin, X., Chi, D., Xu, Z., Lin, G., Liu, H., Sun, J., He, Z., & Wang, Y. (2020). Single-ligand dual-targeting irinotecan liposomes: Control of targeting ligand display by pH-responsive PEG-shedding strategy to enhance tumor-specific therapy and attenuate toxicity. International journal of pharmaceutics587, 119680. https://doi.org/10.1016/j.ijpharm.2020.119680 

【1】Yang, Y., Sun, B., Zuo, S., Li, X., Zhou, S., Li, L., Luo, C., Liu, H., Cheng, M., Wang, Y., Wang, S., He, Z., & Sun, J. (2020). Trisulfide bond-mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity. Science advances6(45), eabc1725. https://doi.org/10.1126/sciadv.abc1725