2024

1.Programmable droplet microfluidics for complex multistep bioassays (Review)

  Enqi Huang, Yu Wang, Dongyang Cai, Dayu Liu 

  Interdisciplinary MEDICINE. 2024；2(1): e20230026; https://doi.org/10.1002/INMD.20230026

2.Selective expansion of renal cancer stem cells using microfluidic single-cell culture arrays for anticancer drug testing.

Wang X, He T, Chen Z, Chen J, Luo Y, Lin D, Li X, Liu D.

Lab Chip. 2024 Feb 7. doi: 10.1039/d3lc00922j. 

2023

1.Droplet Encoding-Pairing Enabled Multiplexed Digital Loop-Mediated Isothermal Amplification for Simultaneous Quantitative Detection of Multiple Pathogens

Cai D, Wang Y, Zou J, Li Z, Huang E, Ouyang X, Que Z, Luo Y, Chen Z, Jiang Y, Zhang G, Wu H, Liu D.

Advanced Science. 2023; 10(7):e2205863. 

2.Cascade filtration and droplet digital detection integrated microfluidic assay enables isolating culture-free phenotypic identification of carbapenem-resistant organisms.

Wang Y, Cai D, Ouyang X, He H, Liu Y, Zou J, Chen Z, Wu B, Wu H, Liu D. 

Biosens Bioelectron. 2023; 220:114863. doi:10.1016/j.bios.2022.114863 

2022

1.Gel-Free Single-Cell Culture Arrays on a Microfluidic Chip for Highly Efficient Expansion and Recovery of Colon Cancer Stem Cells.

Liu Y, Chen X, Chen J, Luo Y, Chen Z, Lin D, Zhang J, Liu D.

ACS Biomater Sci Eng. 2022;8(8):3623-3632. doi: 10.1021/acsbiomaterials.2c00378.

 

2. Active droplet-array microfluidics-based chemiluminescence immunoassay for point-of-care detection of procalcitonin.

Huang E, Huang D, Wang Y, Cai D, Luo Y, Zhong Z, Liu D.

Biosens Bioelectron. 2022; 195:113684. doi: 10.1016/j.bios.2021.113684.

3.Integrated Microfluidic Droplet Digital Isothermal Amplification Enabled Rapid Detection of Urinary Tract Infection Bacteria.

ZOU Jing-Jing ,  LI Zhu-Jun ,  LIU Yun-Fan ,  OUYANG Xiu-Yun ,  WANG Yu ,  CAI Dong-Yang ,  HE Xiao-Wei ,  LIU Da-Yu . 

 Chinese J Anal Chem, 2022;50(8): 1158-1167,1187. doi: 10.19756/j.issn.0253-3820.221085

 

2021

1.Microgel Single-Cell Culture Arrays on a Microfluidic Chip for Selective Expansion and Recovery of Colorectal Cancer Stem Cells.

Lin D, Chen X, Liu Y, Lin Z, Luo  Y, Fu M, Yang N, Liu D, Cao J.

Anal Chem. 2021;93(37):12628-12638. doi: 10.1021/acs.analchem.1c02335.  

 

2. A pocket-sized device automates multiplexed point-of-care RNA testing for rapid screening of infectious pathogens.

Shu B, Lin L, Wu B, Huang E, Wang Y, Li Z, He H, Lei X, Xu B, Liu D.

Biosens Bioelectron. 2021; 181:113145. doi: 10.1016/j.bios.2021.113145.

 

3. A fully automated microfluidic PCR-array system for rapid detection of multiple respiratory tract infection pathogens.

Huang E, Wang Y, Yang N, Shu B, Zhang G, Liu D.

Anal Bioanal Chem. 2021; 413(7):1787-1798. doi: 10.1007/s00216-021-03171-4.  

 

4.Paper-supported co-culture system for dynamic investigations of the lung-tropic migration of breast cancer cells.

Lin D, Chen X, Lin Z, Lin J, Liu Y, Liu D.

Biomed Mater. 2021; 16(2):025028. doi: 10.1088/1748-605X/abc28c.

5.Multifunctional microfluidic chip for cancer diagnosis and treatment.

Guo QR, Zhang LL, Liu JF, Li Z, Li JJ, Zhou WM, Wang H, Li JQ, Liu DY, Yu XY, Zhang JY.

Nanotheranostics. 2021; 5(1):73-89. doi: 10.7150/ntno.49614. eCollection 2021.

 

2020

1. Screening Therapeutic Agents Specific to Breast Cancer Stem Cells Using a Microfluidic Single-Cell Clone-Forming Inhibition Assay.

Lin D, Li P, Feng J, Lin Z, Chen X, Yang N, Wang L, Liu D.

Small. 2020; 16(9):e1901001. doi: 10.1002/smll.201901001.

2.Magnet-actuated droplet microfluidic immunosensor coupled with gel imager for detection of microcystin-LR in aquatic products.

Guan T, Liu D, Li X, Shu B, Li M, Liu Y, Xu Z, Shen Y, Sun Y, Lei H, Shen X.

Talanta. 2020; 219:121329. doi: 10.1016/j.talanta.2020.121329.

 

3.Open Surface Droplet Microfluidic Magnetosensor for Microcystin-LR Monitoring in Reservoir.

Guan T, He J, Liu D, Liang Z, Shu B, Chen Y, Liu Y, Shen X, Li X, Sun Y, Lei H.

Anal Chem. 2020; 92(4):3409-3416. doi: 10.1021/acs.analchem.9b05516.

 

4. Paper-supported Co-culture System for Investigation of Exosomes Mediated Interactions between Breast Cancer Cells and Lung Fibroblasts.

LIN Zhun, CHEN Xiao, LIN Dong-Guo, LIU Da-Yu.

Chinese J Anal Chem, 2020; 48(6): 695-702. doi:10.19756/j.issn.0253-3820.201007

 

5. Droplet Digital Microfluidic Assay for Rapid Bacterium Quantitation.

HE Hao-Yan, HUANG En-Qi, LI Zhu-Jun, SHU Bo-Wen, XU Bang-Lao, LIU Da-Yu.

Chinese J Anal Chem, 2020; 48(7): 855-862. doi:10.19756/j.issn.0253-3820.201022

 

2018

1.Active droplet-array (ADA) microfluidics enables multiplexed complex bioassays for point of care testing.

Shu B , Li Z , Yang X , Xiao F , Lin D , Lei X , Xu B , Liu D .

Chem Commun (Camb). 2018; 54(18):2232-2235. doi: 10.1039/c7cc09377b.

 

2017

1.Orthogonal Screening of Anticancer Drugs Using an Open-Access Microfluidic Tissue Array System.

Lin D, Li P, Lin J, Shu B, Wang W, Zhang Q, Yang N, Liu D, Xu B.

Anal Chem. 2017; 89(22):11976-11984. doi: 10.1021/acs.analchem.7b02021.

 

2.Ultrasensitive detection of serum hepatitis B virus by coupling ultrafiltration DNA extraction with real-time PCR.

Wu B, Xiao F, Li P, Du Y, Lin J, Ming K, Chen B, Lei X, Xu B, Liu D.

PLoS One. 2017; 12(2):e0170290. doi: 10.1371/journal.pone.0170290. eCollection 2017.

 

2016

1.Simultaneous Identification and Antimicrobial Susceptibility Testing of Multiple Uropathogens on a Microfluidic Chip with Paper-Supported Cell Culture Arrays.

Xu B, Du Y, Lin J, Qi M, Shu B, Wen X, Liang G, Chen B, Liu D.

Anal Chem. 2016 Dec 6;88(23):11593-11600. doi: 10.1021/acs.analchem.6b03052.

 

Before 2015

1.Ultra-small droplet generation via volatile component evaporation.

Zhang Q, Liu X, Liu D, Gai H.

Lab Chip. 2014 Apr 21;14(8):1395-400. doi: 10.1039/c3lc51183a.

 

2.Detection of Mycobacterium tuberculosis using a capillary-array microsystem with integrated DNA extraction, loop-mediated isothermal amplification, and fluorescence detection.

Liu D, Liang G, Zhang Q, Chen B.

Anal Chem. 2013 May 7;85(9):4698-704. doi: 10.1021/ac400412m.

 

3.A high throughput multiplex PCR assay for simultaneous detection of seven aminoglycoside-resistance genes in Enterobacteriaceae.

Hu X, Xu B, Yang Y, Liu D, Yang M, Wang J, Shen H, Zhou X, Ma X.

BMC Microbiol. 2013 Mar 14;13:58. doi: 10.1186/1471-2180-13-58.

 

4.Highly efficient capillary polymerase chain reaction using an oscillation droplet microreactor.

Liu D, Liang G, Lei X, Chen B, Wang W, Zhou X.

Anal Chim Acta. 2012 Mar 9;718:58-63. doi: 10.1016/j.aca.2011.12.066.

 

5. Rapid screening of phenylketonuria using a CD microfluidic device.

Chen B, Zhou X, Li C, Wang Q, Liu D, Lin B.

J Chromatogr A. 2011 Apr 8;1218(14):1907-12. doi: 10.1016/j.chroma.2011.02.001.

 

6. On-chip coupling of free-solution transient ITP and CGE for highly efficient separation of dsDNA with variable sample loading amounts.

Liu D, Chen B, Wang L, Zhou X.

Electrophoresis. 2009 Dec;30(24):4300-5. doi: 10.1002/elps.200900333.

 

7.Fabrication of a microfluidic chip containing dam, weirs and gradient generator for studying cellular response to chemical modulation, Ruan J，Wang L，Xu M，Cui D，Zhou X，Liu D

Materials Science and Engineering: C 2009, 29(3),674–679

8.A simple and sensitive transient ITP method for on-chip analysis of PCR samples.

Wang L, Liu D, Chen H, Zhou X.

Electrophoresis. 2008 Dec;29(24):4976-83. doi: 10.1002/elps.200800258.

 

9.Simplified transient isotachophoresis/capillary gel electrophoresis method for highly sensitive analysis of polymerase chain reaction samples on a microchip with laser-induced fluorescence detection.

Liu D, Ou Z, Xu M, Wang L.

J Chromatogr A. 2008 Dec 19;1214(1-2):165-70. doi: 10.1016/j.chroma.2008.10.066.