科研项目

纵向课题

1. 国家自然科学基金面上项目： 新生隐球菌新型硫酸盐转运蛋白Sua1的鉴定及其转录调控机制研究 2023.01-2026.12

2. 国家自然科学基金面上项目：新生隐球菌N-乙酰葡萄糖胺分解代谢及调控研究 2020.01-2023.12 

3. 国家自然科学基金面上项目：拟核结合蛋白Lsr2调控玫瑰孢链霉菌隐性基因簇激活的分子机理 2017.01-2020.12 

4. 国家自然科学基金青年基金： 达托霉素生物合成调控基因的鉴定和功能研究 2012.01-2014.12

5. 重庆市自然科学基金面上项目：基于Prp8内含肽的全细胞筛选模型与抗菌化合物筛选 2020.05-2023.05 

6. 重庆市自然科学基金面上项目：达托霉素生物合成调控基因的筛选及其在高产菌株构建中的应用研究 2013.05-2016.05 

7. 真菌学国家重点实验室开放课题：靶向新型隐球菌的新型纳米药物研究

横向课题

1. 两性霉素B代谢途径改造项目

2. 化合物xxx的抗真菌药效学评价研究

学术论文

1. Yinglan Yu#, Xuefeng Tang#, Liya Zhou, Fanshu Xu, Ying Zhang, Linggao Zeng, Jun Li, Guojian Liao*, Lei Luo*. Cascade-targeting polymeric particles eliminate intracellular C. neoformans in fungal infection therapy. J Control Release. 2024 (Top期刊，中科院1区，IF=10.5) 

2. Ying Tao, Dandan Zheng, Wei Zou, Ting Guo, Guojian Liao*, Wei Zhou*. Targeting the cysteine biosynthesis pathway: Mechanism, structure, and drug discovery. European Journal of Medicinal Chemistry. 2024  (Top期刊，中科院1区，IF=6.7) 

3. Yang Meng, Yue Ni, Zhuoran Li, Tianhang Jiang, Tianshu Sun, Yanjian Li, Xindi Gao, Hailong Li, Chenhao Suo, Chao Li, Sheng Yang, Tian Lan, Guojian Liao, Tongbao Liu, Ping Wang, Chen Ding*.Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans. Elife. 2024(Top期刊，中科院1区，IF=7.7) 

4. Weixin Ke^#, Yuyan Xie ^#, Yingying Chen^#, Hao Ding, Leixin Ye, Haoning Qiu, Hao Li, Lanyue Zhang, Lei Chen, Xiuyun Tian, Zhenghao Shen, Zili Song, Xin Fan, Jian-Fa Zong, Zhengyan Guo, Xiaoyu Ma, Meng Xiao, Guojian Liao, Cui Hua Liu, Wen-Bing Yin, Zhiyang Dong, Feng Yang, Yuan-Ying Jiang, David S Perlin, Yihua Chen, Yu V Fu*, Linqi Wang*. Fungicide-tolerant persister formation during cryptococcal pulmonary infection. Cell Host Microbe. 2024(Top期刊，中科院1区，IF=30.3) 

5. Lei Chen ^#, Xiuyun Tian ^#, Lanyue Zhang ^#, Wenzhao Wang, Pengjie Hu, Zhongyi Ma, Yeqi Li, Shibin Li, Zhenghao Shen, Xin Fan, Leixin Ye, Weixin Ke, Yao Wu, Guanghou Shui, Meng Xiao, Guang-Jun He, Ying Yang, Wenxia Fang, Fan Bai, Guojian Liao, Min Chen, Xiaorong Lin, Chong Li, Linqi Wang*.Brain glucose induces tolerance of Cryptococcus neoformans to amphotericin B during meningitis. Nat Microbiol. 2024(Top期刊，中科院1区，IF=28.3) 

6. Guojuan Yi^#, Hanlu Zou^#, Tao Long, Tolbert Osire, Lin Wang, Xiaoyun Wei, Mengfei Long*, Zhiming Rao, Guojian Liao*.Novel cytochrome P450s for various hydroxylation of steroids from filamentous fungi. Bioresource Technology. 2024 (Top期刊，中科院1区，IF=11.4) 

7. Lanyu Zhang^#, Saisai Wang^#, Nan Hong ^#, Muyuan Li , Yiting Liu , Tao Zhou , Yan Peng , Changhua Hu, Xiaoxu Li, Zhen Zhang, Mengzhu Guo, Massimo Cogliati, Megan Hitchcock, Jianping Xu, Min Chen*, Guojian Liao*.Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans species complex from China, including the diploid VNIII isolates from HIV-infected patients in Chongqing region. Medical Mycology. 2023 (Top期刊，中科院1区，IF=2.9)

8. Zhu P^#, Li Y^#, Guo T, Liu S, Tancer RJ, Hu C, Zhao C*, Xue C*, Liao G*.New antifungal strategies: Drug combination and co-delivery.Advanced Drug Delivery Reviews. 2023 Top期刊，中科院1区，IF=17.8）

9. Zhao Y*, Ye L, Zhao F, Zhang L, Lu Z, Chu T, Wang S, Liu Z, Sun Y, Chen M, Liao G, Ding C, Xu Y, Liao W, Wang L*. Cryptococcus neoformans, a global threat to human health. Infect Dis Poverty. 2023 （Top期刊，中科院1区，IF=10.5）

10. Hu P^#, Ding H^#, Liu H^#, Yang Y, Chen L, He G, Ke W, Zhu P, Tian X, Peng Y, Shen Z, Yao X, Tao C, Yang E, Liao G, Liu X,  Wang L*.Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen. Nature Communications. 2022 (Top期刊，中科院1区，IF=17.7)

11. Ye L^#, Wang S^#, Zheng J^#, Chen L, Shen L, Kuang Y, Wang Y, Peng Y, Hu C, Wang L, Tian X*, Liao G*.Functional Characterization of the GlcNAc Catabolic Pathway in Cryptococcus deneoformans. Applied and Environemtal Microbiology,  2022 (Top期刊，中科院2区，IF=5.0)

12. Zhang, X^#., Wang, M^#., Zhu, X., Peng, Y., Fu, T., Hu, C., Cai, J*., Liao, G.*. Development of Lipo-γ-AA Peptides as Potent Antifungal Agents. Journal of Medicinal Chemistry, 2022 (Top期刊，中科院1区，IF=8.0)

13. Liu, H^#., Yao, X^#., Ke, W., Ding, H., He, G., Ma, S., Peng, Y., Xu, X., Liao, G*., Tian, X*., Wang, L*. A Velvet Transcription Factor Specifically Activates Mating through a Novel Mating-Responsive Protein in the Human Fungal Pathogen Cryptococcus deneoformans. Microbiology Spectrum, 2022 (中科院2区，IF=9.0)

14. Fu, C*., Lv, Q., Fan, J., Wu, S., Lei, M., Zhang, X., ... & Liao, G*.  Discovery of polypyridyl iridium (III) complexes as potent agents against resistant Candida albicans. European Journal of Medicinal Chemistry, 2022 (Top期刊，中科院1区，IF=7.1)

15. Tian,J.; Ye,L.; Yang,Y.; Zhang,Y.,Hu,C*.; Liao,G*.; Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074 . Sci China Life Sci. 2020（Top期刊，中科院1区，IF=10.4）

16. Li, Z^#.; Fu, B^#.; Green, C. M.; Liu, B.; Zhang, J.; Lang, Y.; Chaturvedi, S.; Belfort, M.; Liao, G*.; Li, H*., Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein. Emerg Microbes Infect 2019（中科院2区，IF=19.6） 

17. Liao, G^#.; Wang, Y^#.; Liu, T. B.; Kohli, G.; Qian, W.; Shor, E.; Subbian, S.; Xue, C*., Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism. Fungal Genet Biol 2018（中科院3区，IF=3.9）

18. Tang, Y.; Wu, S.; Lin, J.; Cheng, L.; Zhou, J.; Xie, J.; Huang, K.; Wang, X.; Yu, Y.; Chen, Z.; Liao, G.; Li, C*., Nanoparticles Targeted against Cryptococcal Pneumonia by Interactions between Chitosan and Its Peptide Ligand. Nano Lett 2018 （中科院1区，IF=12.3） 

19. Liu, L.; He, G. J.; Chen, L.; Zheng, J.; Chen, Y.; Shen, L.; Tian, X.; Li, E.; Yang, E.; Liao, G.; Wang, L*., Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans. Elife 2018（Top期刊，中科院1区，IF=8.7）

20. Huang, X^#.; Ma, T^#.; Tian, J.; Shen, L.; Zuo, H.; Hu, C*.; Liao, G*., wblA, a pleiotropic regulatory gene modulating morphogenesis and daptomycin production in Streptomyces roseosporus. J Appl Microbiol 2017（中科院3区，IF=3.8）

21.  Huang, W^#.; Liao, G^#.; Baker, G. M^#.; Wang, Y.; Lau, R.; Paderu, P.; Perlin, D. S.; Xue, C*., Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans. mBio 2016（Top期刊，中科院1区，IF=7.8）

22. Liao, G.; Xie, L.; Li, X.; Cheng, Z.; Xie, J., Unexpected extensive lysine acetylation in the trump-card antibiotic producer Streptomyces roseosporus revealed by proteome-wide profiling. J Proteomics 201（中科院2区，IF=3.9）

23.  Liao, G^#.; Wang, L^#.; Liu, Q.; Guan, F.; Huang, Y.; Hu, C*., Manipulation of kynurenine pathway for enhanced daptomycin production in Streptomyces roseosporus. Biotechnol Prog 2013（中科院3区，IF=2.7）

24. Liao, G^#.; Liu, Q^#.; Xie, J*., Transcriptional analysis of the effect of exogenous decanoic acid stress on Streptomyces roseosporus. Microb Cell Fact 2013（中科院2区，IF=6.4）

25. Wang, L.; Zhao, Y.; Liu, Q.; Huang, Y.; Hu, C*.; Liao, G*., Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection. J Appl Microbiol 2012（中科院3区，IF=3.8）

26.  Liao, G.; Shi, T.; Xie, J*., Regulation mechanisms underlying the biosynthesis of daptomycin and related lipopeptides. J Cell Biochem 2012（中科院2区，IF=4.5）