u 科研成果：
ü 基金：
1、国家自然科学基金面上项目，21977024，具有自供氧、近红外光趋化功能的上转换-蓝藻复合载体用于乏氧肿瘤的光动力学治疗、2020年1月-2023年12月、66万、在研、主持人
2、国家自然科学基金青年科学基金项目，21601046，靶向肿瘤乏氧区的智能载药体系的构建及其抗肿瘤作用研究、2017年01月至2019年12月、19万、已结题、主持人。
3、粤莞联合基金重点项目，2021B1515120065，基于工程化细胞囊泡硼药递送系统的癌症协同BNCT-免疫治疗研究，2021年10月至2024年09月，200万，在研，主持人。
4、河北省自然科学基金项目，B2015201097、多功能上转换纳米药物载体连接的间充质干细胞：新型“细胞补丁”用于肿瘤趋向的治疗、2015年01月至2017年12月、4万、已结题、主持人。
ü 近五年论文（第一，共一及通讯）
(1) Zhenhua Li#, Zhenzhen Wang#, Phuong-Uyen C. Dinh#, Dashuai Zhu, Kristen D. Popowski, Halle Lutz, Shiqi Hu, Mark Lewis, Anthony Cook, Hanne Anderson Elyard, Jack Greenhouse, Laurent Pessaint, Jason Lobo, and Ke Cheng*. Cell-Mimicking Nanodecoys Neutralize SARS-CoV-2 and Mitigate Lung Injury in a Nonhuman Primate Model of COVID-19. Nature Nanotechnology. 2021, 16, 942–951. (IF=39.213)
(2) Zhenhua Li#, Shiqi Hu#, Ke Huang, Teng Su, Jhon Cores and Ke Cheng*. Targeted Anti-IL-1β Platelet Microparticles for Cardiac Detoxing and Repair. Science Advances, 2020, 6, eaay0589. (IF=14.136)
(3) Zhenzhen Wang, Kristen D. Popowski, Dashuai Zhu, Blanca López de Juan Abad, Xianyun Wang, Mengrui Liu, Halle Lutz, Nicole De Naeyer, Todd C. DeMarco, Thomas N. Denny, Phuong-Uyen C. Dinh, Zhenhua Li*, Ke Cheng*; An Inhalable Virus-Like Particle Vaccine against SARS-CoV-2 Based on RBD Conjugated Exosomes, Nature Biomedical Engineering, 2022. Accept (IF=25.671)
(4) Zhenhua Li, Shiqi Hu and Ke Cheng*. Chemical Engineering of Cell Therapy for Heart Diseases. Accounts of Chemical Research, 2019, 52, 1687−1696. (IF= 22.384）
(5) Pengli Zheng#, Miao Fan#, Huifang Liu, Yinghua Zhang, Xinyue Dai, Hang Li, Xiaohan Zhou, Shiqi Hu, Xinjian Yang, Yi Jin, Na Yu, Shutao Guo, Jinchao Zhang*, Xing-Jie Liang, Ke Cheng*, and Zhenhua Li*. Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy. ACS Nano 2021, 15, 1100−1110. (IF=15.881)
(6) Zhenhua Li#, Dashuai Zhu#, Qi Hui#, Jianing Bi, Bingjie Yu, Zhen Huang, Shiqi Hu, Zhenzhen Wang, Thomas Caranasos, Joseph Rossi, Xiaokun Li, Ke Cheng,* Xiaojie Wang*. Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair. Advanced Functional Materials. 2021, 31, 2004377. (IF=18.808)
(7) Zhenhua Li#, Deliang Shen#, Shiqi Hu, Teng Su, Ke Huang, Feiran Liu, Lei Hou* and Ke Cheng*. Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair. ACS Nano 2018, 12, 12193-12200. (IF=15.881)
(8) Miao Fan, Huifang Liu, Hongyu Yan, Ruijun Che, Yi Jin, Xinjian Yang, Xiaohan Zhou, Hua Yang, Kun Ge, Xing-Jie Liang, Jinchao Zhang*, Zhenhua Li*. A CAR T-inspiring platform based on antibody-engineered exosomes from antigen-feeding dendritic cells for precise solid tumor therapy, Biomaterials, 2022, 282, 121424. (IF=12.479)
(9) Dashuai Zhu#, Zhenhua Li#, Ke Huang, Thomas Caranasos, Joe Rossi, Ke Cheng.* Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair. Nature Communications, 2021, 12, 1412. (IF= 14.919)
(10) Shiqi Hu#, Zhenhua Li#, Deliang Shen, Dashuai Zhu, Ke Huang, Teng Su, Phuong Uyen Dinh, Jhon Cores, and Ke Cheng*. Exosome-Eluting Stents to Promote Vascular Healing and Treat Ischemic Injury. Nature Biomedical Engineering, 2021. 5, 1174–1188. (IF=25.671)
(11) Deliang Shen#, Zhenhua Li#，*, Shiqi Hu, Ke Huang, Teng Su, Hongxia Liang, Feiran Liu, and Ke Cheng*. Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells. Nano Letters, 2019, 19, 1883−1891. (IF=11.238)
(12) Shutao Gao, Yan Jin, Kun Ge, Zhenhua Li*, Huifang Liu, Xinyue Dai, Yinghua Zhang, Shizhu Chen, Xingjie Liang* and Jinchao Zhang*. Self-Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy. Advanced Science, 2019, 6, 1902137. (IF=16.806)
(13) Shutao Gao, Pengli Zheng, Zhenhua Li*, Xiaochen Feng, Weixiao Yan, Shizhu Chen, Weisheng Guo, Dandan Liu, Xinjian Yang, Shuxiang Wang, Xing-Jie Liang*, Jinchao Zhang*. Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor. Biomaterials, 2018, 178, 83-94. (IF=10.317)
(14) Fei Duan#, Xiaochen Feng#, Xinjian Yang, Huifang Liu, Guoqiang Zhou, Shuxiang Wang, Zhenhua Li*, Xing-Jie Liang* and Jinchao Zhang*. Metal–Carbenicillin Frameworks Based Nanoantibiotics with Enhanced Penetration and Highly Efficient Killing Multidrug-Resistant Bacteria. Biomaterials, 2017, 144, 155-165. (IF=12.479)
(15) Fei Duan, Xiaochen Feng, Xinjian Yang, Wentong Sun, Yi Jin, Huifang Liu, Kun Ge, Xing-Jie Liang, Zhenhua Li* and Jinchao Zhang*. A Simple and Powerful Co-Delivery System Based on pH-Responsive Metal-Organic Frameworks for Enhanced Cancer Immunotherapy. Biomaterials, 2017, 122, 23-33. (IF=12.479)
(16) Kai Dong#, Zhenhua Li#, Hanjun Sun, Enguo Ju, Jinsong Ren, Xiaogang Qu. Pathogen-mimicking nanocomplexes: self-stimulating oxidative stress in tumor microenvironment for chemo-immunotherapy. Materials Today, 2017, 20, 346-353. (IF=26.416)
(17) Hongxia Liang#, Ke Huang#, Teng Su#, Zhenhua Li#, Shiqi Hu, Phuong-Uyen Dinh, Emily A. Wrona, Chen Shao, Li Qiao, Adam C. Vandergriff, M. Taylor Hensley, Jhon Cores, Tyler Allen, Hongyu Zhang, Qinglei Zeng, Jiyuan Xing, Donald O. Freytes, Deliang Shen, Zujiang Yu, and Ke Cheng*. Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ACS Nano, 2018, 12 (7), 6536–6544. (IF=15.881)
(18) Cui Ren, Huifang Liu,* Fangfang Lv, Wencong Zhao, Shutao Gao, Xinjian Yang, Yi Jin, Yanli Tan, Jinchao Zhang,* Xing-Jie Liang, Zhenhua Li*. Prodrug-Based Nanoreactors with Tumor-Specific in situ Activation for Multisynergistic Cancer Therapy. ACS Applied Materials & Interfaces 2020, 12, 31, 34667–34677. (IF= 9.229)
(19) Yinghua Zhang#, Huifang Liu#, Xinyue Dai, Hang Li, Xiaohan Zhou, Shizhu Chen, Jinchao Zhang*, Xing-Jie Liang, Zhenhua Li*. Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors. Nano Research 2021, 14, 667–673. (IF=8.040)
(20) Erman Zhao, Huifang Liu*, Yaru Jia, Tingshan Xiao, Jiaxin Li, Guoqiang Zhou, June Wang, Xiaohan Zhou, Xing-Jie Liang, Jinchao Zhang*, Zhenhua Li*. Engineering a Photosynthetic Bacteria-incorporated Hydrogel for Infected Wound Healing. Acta Biomaterialia 2022, 140, 302-313. (IF=8.947)
(21) Fangfang Lv, Huifang Liu*, Gaoqian Zhao, Erman Zhao, Hongyu Yan, Ruijun Che, Xinjian Yang, Xiaohan Zhou, Jinchao Zhang, Xing-Jie Liang*, Zhenhua Li*. Therapeutic exosomal vaccine for enhanced cancer immunotherapy by mediating tumor microenvironment. iScience 2022, 25, 103639. (IF=5.08)
(22) Wencong Zhao, Zhenhua Li*, Hua Yang, Cui Ren, Fangfang Lv, Shutao Gao, Huanyun Ma, Yi Jin, Kun Ge, Dandan Liu, Jinchao Zhang,* and Huifang Liu*. Mesoporous Platinum Nanotherapeutics for Combined Chemophotothermal Cancer Treatment. ACS Applied Bio Materials 2019, 2, 3269−3278.
(23) Zhenhua Li#，*, Xiaochen Feng#, Shutao Gao, Yan Jin, Wencong Zhao, Huifang Liu, Xinjian Yang, Shiqi Hu, Ke Cheng*, and Jinchao Zhang*. Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection. ACS Applied Bio Materials 2019, 2, 613–618.
(24) Xiaohan Zhou, Pengli Zheng, Yan Jin, Wencong Zhao, Zhenhua Li*. A biocompatible strategy for the construction of cell patch using upconversion nanoparticles-conjugated mesenchymal stem cells. Materials Letters, 2018, 221, 131–134. (IF=3.204)
(25) Huihui Ren,# Shizhu Chen,# Yanan Jin, Cuimiao Zhang, Xinjian Yang, Kun Ge, Xing-Jie Liang, Zhenhua Li* and Jinchao Zhang*. A Traceable and Bone-targeted Nanoassembly Based on Defect-related Luminescent Mesoporous Silica for Enhanced Osteogenic Differentiation. Journal of Materials Chemistry B, 2017, 5, 1585-1593. (IF=5.344)
(26) Ke Huang#, Zhenhua Li#, Teng Su, Deliang Shen, Shiqi Hu, Ke Cheng*. Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells. Advanced Therapeutics 2019, 2, 1900009.
(27) Zhenhua Li#, Shiqi Hu# and Ke Cheng*. Platelets and their biomimetics for regenerative medicine and cancer therapies. Journal of Materials Chemistry B 2018, 6 (45), 7354-7365. (IF=5.344)
