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成果及论文

2024年

  1. Teng Huang#, Xiaofei Wen#,*, Yuxuan Liang, Xiao Liu, Jun Zhao, and Xin Long*. Irreversible Electroporation-Induced Inflammation Facilitates Neutrophil-Mediated Drug Delivery to Enhance Pancreatic Cancer Therapy. Molecular Pharmaceutics, Article ASAP, DOI: 10.1021/acs.molpharmaceut.4c00006

2023年

  1. Xin Long, Anna Dai, Teng Huang, Wenhao Niu, Luoxia Liu, Hui Xu, Tao Yin, Tian’an Jiang, Shuguo Sun, Ping Lei, Chun Li*, Xiaohua Zhu*, and Jun Zhao*. Simultaneous Delivery of Dual Inhibitors of DNA Damage Repair Sensitizes Pancreatic Cancer Response to Irreversible Electroporation. ACS Nano, Article ASAP. DOI: 10.1021/acsnano.3c05009

2022年

  1. Peng, H.;  Shen, J.;  Long, X.;  Zhou, X.;  Zhang, J.;  Xu, X.;  Huang, T.;  Xu, H.;  Sun, S.;  Li, C.;  Lei, P.*;  Wu, H.*; Zhao, J.*, Local Release of TGF-beta Inhibitor Modulates Tumor-Associated Neutrophils and Enhances Pancreatic Cancer Response to Combined Irreversible Electroporation and Immunotherapy. Advanced Science (Weinh), 2022, e2105240

2021年

  1. Lincha, V. R.; Zhao, J.; Wen, X.; Xiong, C.; D, S. L. Chow; and Li, C.*, A polymeric micellar drug delivery system developed through a Design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. International Journal Pharmaceutics, 2021: p. 120523
  2. Bao, G.; Tang, M.; Zhao, J.*; and Zhu, X.*, Nanobody: a promising toolkit for molecular imaging and disease therapy. EJNMMI Res, 2021. 11(1): p. 6. DOI: 10.1186/s13550-021-00750-5

2020年

  1. Wu, Z. L.; Zhao, J.; and Xu, R.*, Recent advances in oral nano-antibiotics for bacterial infection therapy. Interntional Journal of Nanomedicine, 2020. 15: p. 9587-9610(影响因子5.115

  2. Zhao, J.; Wen, X.; Li, T.; Shi, S.; Xiong, C.; Wang, Y. A.; and Li, C.*, Concurrent Injection of Unlabeled Antibodies Allows Positron Emission Tomography Imaging of Programmed Cell Death Ligand 1 Expression in an Orthotopic Pancreatic Tumor Model. ACS Omega, 2020, 5(15): p. 8474-8482. 

  3. He, J.; Qiao, Y.; Zhang H.; Zhao, J.; Li, W.; Xie, T.; Zhong, D.; Wei, Q.; Hua, S.; Yu, Y.; Yao, K.; Santos, H.; Zhou M*. Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging. Biomaterials 2020, 234, 119763.

2019年及以前

  1. Zhong, D.; Zhao, J.; Li, Y; Qiao, Y.; Wei, Q.; He, J.; Xie, T.; Li, W., Zhou, M*. Laser-triggered aggregated cubic α-Fe2O3@Au nanocomposites for magnetic resonance imaging and photothermal/enhanced radiation synergistic therapy. Biomaterials 2019, 210, 119369.                                                                                      

  2. Zhao, J.; Wen, X. F.; Tian, L.; Li, T.; Xu, C.; Wen, X. X.; Melancon, M. P., Gupta, S.; Shen, B.; Peng, W.; Li, C*. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nature Communications 2019, 10:899.                    

  3. Zhao, J.; Xiao, Z.; Li, T.; Chen, H.; Yuan, Y.; Wang, A. Y.; Hsiao, C. -H.; Chow, D. S.-L.; Overwijk, W.; Li, C*. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano 2018, 12, 9881-9893.                                                                                                                

  4. Zhou, B.; Zhao, J.; Qiao, Y.; Wei, Q.; He, J.; Li, W.; Zhong, D.; Ma, F.; Li, Y.; Zhou, M*. Simultaneous multimodal imaging and photothermal therapy via renal-clearable manganese-doped copper sulfide nanodots. Applied Materials Today 2018, 13, 285-297.                                   

  5. Zhao, J.; Wang, H.; Hsiao, C.-H.; Chow, D. S.-L.; Koay, E. J.; Kang, Y.; Wen, X.; Huang, Q.; Ma, Y.; Bankson, J. A.; et al. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials 2018, 159, 215-228.                                                                                                                                 

  6. Zhao, J.; Koay, E. J.; Li, T.; Wen, X.; Li, C.*, A hindsight reflection on the clinical studies of poly (lglutamic acid)paclitaxel. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2018, 10 (3), e1497.

  7. Wang, W.; Zhao, J.; Wen, X.; Lin, C. C.-J.; Li, J.; Huang, Q.; Yu, Y.; Lin, S.-Y.; Li, C.*, MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging 2017, 2017. 

  8. Zhao, J.; Zhou, M.; Li, C.*, Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnology 2016, 7 (9). 

  9. Zhao, J.; Wu, C.; Abbruzzese, J.; Hwang, R. F.; Li, C.*, Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. Molecular Pharmaceutics 2015, 12 (6), 2093-2100.                                                                                                                                                                                               

  10. Zhao, J.; Qiao, Y.; Zhou, M.; Wallace, M.; Gupta, S.; Li, C.*; Melancon, M. P.*, Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles. ACS Macro Letters 2015, 4 (10), 1081-1084.                                                                                                                                                                                                                                        

  11. Zhao, J.; Lee, P.; J Wallace, M.; P Melancon, M.*, Gold nanoparticles in cancer therapy: efficacy, Biodistribution, and Toxicity. Current Pharmaceutical Design 2015, 21 (29), 4240-4251.

  12. You, J.; Zhao, J.; Wen, X.; Wu, C.; Huang, Q.; Guan, F.; Wu, R.; Liang, D.; Li, C.*, Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal of Controlled Release 2015, 202, 40-48.                                                                                                                                                 

  13. Zhao, J.; Wallace, M.; Melancon, M. P.*, Cancer theranostics with gold nanoshells. Nanomedicine 2014, 9 (13), 2041-2057.

  14. Zhao, J.; Vykoukal, J.; Abdelsalam, M.; Recio-Boiles, A.; Huang, Q.; Qiao, Y.; Singhana, B.; Wallace, M.; Avritscher, R.; Melancon, M. P.*, Stem cell-mediated delivery of SPIO-loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma. Nanotechnology 2014, 25 (40), 405101.

  15. Zhao, J.; Song, S.; Zhong, M.; Li, C.*, Dual-Modal Tumor Imaging via Long-Circulating Biodegradable Core-Cross-Linked Polymeric Micelles. ACS Macro Letters 2011, 1 (1), 150-153.