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成果及论文

18. Seeberger, P. H., Ge, Y., Szymanski, C. M., Kolarich, D., Thaysen-Andersen, M., Packer, N. H., Fadda, E., Davis, B., Nishihara, S., Rabinovich, G. A., Kwong, P. D., Strasser, R. What comes next in glycobiology. Cell. 2024, 187(11), 2628-2632. https://doi.org/10.1016/j.cell.2024.04.028


17. Zhang H, Li X, Hui Z, Huang S, Cai M, Shi W, Lin Y, Shen J, Sui M, Lai Q, Shao Z, Dou J, Luo X, Ge Y*, Tang X*. A Semisynthesis Platform for the Efficient Production and Exploration of Didemnin-Based Drugs. Angew. Chem. Int. Ed. 2024, 63(12):e202318784. https://doi.org/10.1002/anie.202318784


16. Chen, Y.#; Wan, R.#; Zou, Z.#; Lao, L.; Shao, G.; Zheng, Y.; Tang, L.; Yuan, Y.; Ge, Y.*; He, C.*; Lin, S.*, O-GlcNAcylation determines the biological function of YTHDF proteins. Nat. Cell Biol., 2023, 25, 1676-1690. corresponding author.Highlight by Nat. Cell Biol. “O-GlcNAc regulates YTHDF1 and YTHDF3 activity”. https://www.nature.com/articles/s41556-023-01258-X


15. Liu, Y.#; Ge, Y.#; Zeng, R.#; Ngai, W. S.; Fan, X.*; Chen, P. R.*, Proximity Chemistry in Living  Systems. CCS Chem. 2023, 5 (4), 802-813. # contributed equally. https://www.chinesechemsoc.org/doi/10.31635/ccschem.023.202202593


14. Ge, Y.*; Lu, H.; Yang, B.; Woo, C. M.* Small Molecule-Activated O-GlcNAcase for Spatiotemporal  Removal of O-GlcNAc in Live Cells. ACS Chem. Biol. 2023, 18 (1), 193-201. 一作兼通讯作者.Highlighted by Nat. Chem. Biol.https://pubs.acs.org/doi/10.1021/acschembio.2c00894


13. Schwein, P. A., Ge, Y.; Yang, B.; D’Souza, A. K.; Mody, A., Shen, D.; Woo, C. M.*, Writing and Erasing  O-GlcNAc on Casein Kinase 2 Alpha Alters the Phosphoproteome. ACS Chem. Biol. 2022, 17 (5),  1111-1121.被EurekAlert!, Phys.org, ScienMag, Science Blog, BioArt 等媒体报道https://pubs.acs.org/doi/10.1021/acschembio.1c00987


12. Ge, Y.; Ramirez, D. H.; Yang, B.; D’Souza, A. K.; Aonbangkhen, C.; Wong, S.; Woo, C. M.*, Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase. Nat. Chem. Biol. 2021, 17 (5), 593-600https://www.nature.com/articles/s41589-021-00757-y


11. Ge, Y.; Woo, C. M.*, Writing and erasing O-GlcNAc from target proteins in cells. Biochem. Soc. Trans. 2021, 49 (6), 2891-2901.

https://portlandpress.com/biochemsoctrans/article/49/6/2891/230252/Writing-and-erasing-O-GlcNAc-from-target-proteins


10. Ramirez, D. H.; Ge, Y.; Woo, C. M.*, O-GlcNAc engineering on a target protein in cells with nanobody-OGT and -OGA. Curr. Protoc. 2021, 1 (5), e117.https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.117


9. Ge, Y.#; Chen, L.#; Liu, S.; Zhao, J.; Zhang, H.; Chen, P. R.*, Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions. J. Am. Chem. Soc. 2019, 141 (5), 1833-1837.# 共同一作 https://pubs.acs.org/doi/10.1021/jacs.8b10286


8. Zhao, J.; Liu, Y.; Lin, F.; Wang, W.; Yang, S.; Ge, Y.; Chen, P. R.*, Bioorthogonal engineering of bacterial effectors for spatial-temporal modulation of cell signaling. ACS Cent. Sci. 2019, 5 (1), 145- 152. https://pubs.acs.org/doi/10.1021/acscentsci.8b00751


7. Liu, L.; Liu, Y.; Zhang, G.; Ge, Y.; Fan, X.; Lin, F.; Wang, J.; Zheng, H.; Xie, X.; Zeng, X.; Chen, P. R.*,  Genetically encoded chemical decaging in living bacteria. Biochemistry 2018, 57 (4), 446-450. https://pubs.acs.org/doi/10.1021/acs.biochem.7b01017


6. He, D.#; Xie, X.#; Yang, F.; Zhang, H.; Su, H.; Ge, Y.; Song, H.; Chen, P. R.*, Quantitative and comparative profiling of protease substrates through a genetically encoded multifunctional photocrosslinker. Angew. Chem. Int. Ed. 2017, 56 (46), 14521-14525.https://onlinelibrary.wiley.com/doi/10.1002/anie.201708151


5.Zhang, G.#; Li, J.#; Xie, R.; Fan, X.; Liu, Y.; Zheng, S.; Ge, Y.; Chen, P. R.*, Bioorthogonal chemical activation of kinases in living systems. ACS Cent. Sci. 2016, 2 (5), 325-31. https://pubs.acs.org/doi/10.1021/acscentsci.6b00024


4. Ge, Y.#; Fan, X.#; Chen, P. R.*, A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chem. Sci. 2016, 7 (12), 7055-7060.# 共同一作 https://pubs.rsc.org/en/content/articlelanding/2016/SC/C6SC02615J


3. Fan, X.; Ge, Y.; Lin, F.; Yang, Y.; Zhang, G.; Ngai, W. S.; Lin, Z.; Zheng, S.; Wang, J.; Zhao, J.; Li, J.;  Chen, P. R.*, Optimized tetrazine derivatives for rapid bioorthogonal decaging in living cells. Angew. Chem. Int. Ed. 2016, 55 (45), 14046-14050.https://onlinelibrary.wiley.com/doi/10.1002/anie.201608009


2. Zhang, H.; Song, Y.; Zou, Y.; Ge, Y.; An, Y.; Ma, Y.; Zhu, Z.; Yang, C. J.*, A diazirine-based photoaffinity probe for facile and efficient aptamer-protein covalent conjugation. Chem. Commun.  (Camb.) 2014, 50 (38), 4891-4.https://pubs.rsc.org/en/content/articlelanding/2014/CC/C4CC01528B


1. Ke, G.; Wang, C.; Ge, Y.; Zheng, N.; Zhu, Z.; Yang, C. J.*, L-DNA molecular beacon: a safe, stable,  and accurate intracellular nano-thermometer for temperature sensing in living cells. J. Am. Chem.  Soc. 2012, 134 (46), 18908-11.https://pubs.acs.org/doi/10.1021/ja3082439