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成果及论文

20. 林子涵 (本科生),林婉真*,陈发杰* "天然多肽的电化学修饰" 

大学化学,2024, 2406089. doi: 10.12461/PKU.DXHX202406089 


19. Fa-Jie Chen* "Another Side of Side Chains" 

Nat. Rev. Chem. 8, 406-407 (2024) (News & Views)

View-only version: https://rdcu.be/dGxyT



18. Wang Gu, Jingrong Huang, Yichi Lu, Wanzhen Lin*, Wei Xu*, Fa-Jie Chen* "Synthesis of Glycoconjugates through Chlorooxime-Thiol Conjugation" 

J. Org. Chem., 2024, 89, 9, 6364–6370


17. Chen, Fa-Jie*;# Lin, Wanzhen;# Chen, Fen-Er* "Non-symmetric Stapling of Native Peptides" 

Nat. Rev. Chem. 8, 304-318 (2024) (#Those authors contributed equally

View-only version: https://rdcu.be/dDF8q


16. Chen, Fa-Jie*;# Pinnette, Nicole;# Gao, Jianmin*. "Strategies for the Construction of Multicyclic Phage Display Libraries" 

ChemBioChem2024, e202400072. (VIP paper, Invited Review(#Those authors contributed equally



15. Ying, Junjie; Huang, Jingrong; Liu, Chenguang; Chen, Fa-Jie*; Xu, Chunfa*; Chen, Fen-Er* "Cu-Catalyzed Arylation of S-Tosyl Peptides with Arylboronic Acids" 

Org. Chem. Front., 2024, 11, 53-59.

- Highlighted by Frontiers Journals


Ph.D. and Postdoc Publications


14. Chen, Fa-Jie;# Pinnette, Nicole;# Yang, Fan; Gao, Jianmin.* "A Cysteine-Directed Proximity-Driven Crosslinking Method for Native Peptide Bicyclization" 

Angew. Chem. Int. Ed. 2023, e202306813. (#Those authors contributed equally


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- Highlighted by X-mol


13. Chen, Fa-Jie; Gao, Jianmin.* "Fast Cysteine Bioconjugation Chemistry" 

Chem. Eur. J. 2022, e202201843. (Invited Review)


12. Zheng, Mengmeng; Chen, Fa-Jie, Li, Kaicheng; Reja, Rahi M.; Haeffner, Fredrik; Gao, Jianmin* "Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display" 

J. Am. Chem. Soc. 2022, 144, 15885-15893.


C9E2

- Highlighted by X-mol


11. Chen, Fa-Jie;# Zheng, Mengmeng,# Nobile, Vincent, Gao, Jianmin.* "Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes" 

Chem. Eur. J. 2022, e202200058. (Hot paper) (#Those authors contributed equally


1331C

- Highlighted by WileyChem


10. Chen, Fa-Jie; Mamidipalli, Phani; Sabbasani, Venkatareddy; Liu, Huaqing; Lee, Daesung* Xia, Yuanzhi*. "Three-component Coupling Reaction for the Synthesis of Fully Substituted Triazoles: Reactivity Control of Cu-Acetylide toward Alkyl Azides and Diazo Compounds" 

Org. Chem. Front., 20218, 6095.


B63D


9. Chen, Fa-Jie; Hua, Zhenguo; Chen, Jianhui; Chen, Jiajia; Lee, Daesung* and Xia, Yuanzhi*. "One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation" 

Front. Chem. 20208, 621545.

BD3B


8. Chen, Fa-Jie; Lin, Yongjia; Xu, Man; Xia, Yuanzhi*; Wink, Donald J.; Lee, Daesung*. "C–H Insertion by Alkylidene Carbenes to Form 1,2,3-Triazines and Anionic [3 + 2] Dipolar Cycloadditions To Form Tetrazoles: Crucial Roles of Stereoelectronic and Steric Effects" 

Org. Lett. 202022, 2, 718-723.


7. Hu, Rong; Chen, Fa-Jie; Zhang, Xiaofeng; Zhang, Min; Su, Weiping.* "Copper-catalyzed Dehydrogenative γ-C(sp3)-H Amination of Saturated Ketones for Synthesis of Polysubstituted Anilines" 

Nat. Comm. 201910, 3681.


B880


6. Zhao, Sheng; Chen, Fa-Jie; Liu, Bin; Shi, Bing-Feng.* "Copper-Catalyzed Direct Acyloxylation of C(sp2)-H Bonds with Benzoic Acids" 

SCIENCE CHINA Chemistry201558, 1302-1309.


606F


5. Zhao, Sheng; Liu, Yue-Jin; Yan, Sheng-Yi; Chen, Fa-Jie; Zhang, Zhuo-Zhuo; Shi, Bing-Feng.* "Copper-/Silver-Mediated Arylation of C(sp2)–H Bonds with 2-Thiophenecarboxylic Acids." 

Org. Lett. 201517, 3338-3341.


3689


4. Chen, Fa-Jie; Liao, Gang; Li, Xin; Wu, Jun*; Shi, Bing-Feng* "Copper-Mediated C–S/N–S Bond Formation via C–H Activation: Access to Benzoisothiazolones Using Elemental Sulfur" 

Org. Lett. 20146, 5644-5647.

435F


3. Li, Xin; Liu, Yan-Hua; Gu, Wen-Jia; Li, Bo; Chen, Fa-Jie; Shi, Bing-Feng.* "Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary" 

Org. Lett. 201416, 3904-3907.


E1AC


2. Zhang, Qi; Chen, Kai; Rao, Wei-Hao.; Zhang, Yuejun; Chen, Fa-Jie, Shi, Bing-Feng.* "Stereoselective Synthesis of Chiral α-Amino-β-Lactams via Pd(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)–H Bonds" 

Angew. Chem. Int. Ed. 2013, 52, 13588-13592. (Highly Cited Paper)


5203


1. Chen, Fa-Jie; Zhao, Sheng; Hu, Fang; Chen, Kai; Zhang, Qi; Zhang, Shuo-Qing; Shi, Bing-Feng.* "Pd(II)-Catalyzed Alkoxylation of Unactivated C(sp3)–H and C(sp2)–H Bonds Using a Removable Directing Group: Efficient Synthesis of Alkyl Ethers" 

Chem. Sci. 20134, 4187-4192. (Top 25 most-read Chemical Science articles in 2013) (Highly Cited Paper)


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