104.
Yifan Chen, and Xiaobing Wang, Bicyclic Sultams: From Organic Chemistry to Pharmaceutical Science, Asian Journal of Organic Chemistry, 2024, DOI: 10.1002/ajoc.202400535
103.
Yonglei Zhang, Long Zheng, Liangliang Ma, Fucheng Yin, Zhongwen Luo, Shang Li, Yuhan Jiang, Lingyi Kong*, Xiaobing Wang*.
Discovery of Dual CDK6/BRD4 Inhibitor Inducing Apoptosis and Increasing the Sensitivity of Ferroptosis in Triple-Negative Breast Cancer, Journal of Medicinal Chemistry, 2024, 67, 23, 21186-21207, DOI: 10.1021/acs.jmedchem.4c01976.
102.
Shang Li, Xinxin Li, Liangliang Ma, Zhongwen Luo, Fucheng Yin, Yonglei Zhang, Yifan Chen, Siyuan Wan, Han Zhou, Xiaobing Wang,* Lingyi Kong*, Polypharmacological Drug Design Guided by Integrating Phenotypic and Restricted Fragment Docking Strategies, Journal of Medicinal Chemistry, 2024, 67, 23, 21049-21069, DOI: 10.1021/acs.jmedchem.4c01731.
此文选为JMC的Front Cover
This cover depicts a promising approach in drug discovery for the treatment of Alzheimer’s disease. Via phenotypic discovery of triple-target combinations with synergistic effects on microglia, an in silico restricted fragment docking strategy was developed to achieve “three birds with one stone”. The optimal ligand showed in vitro and in vivo efficacy by precisely modulating targets of interest.
101.
Yifan Chen, Fucheng Yin, Zhongwen Luo, Shang Li, Yonglei Zhang, Xinxin Li, Siyuan Wan, Lingyi Kong, Xiaobing Wang, Copper(II)/Rhodium(III)-Catalyzed Three-Component Sequential Annulation-Olefination of 2-Arylquinoxalines, European Journal of Organic Chemistry, 2024, 27, 44, e202400717. DOI: 10.1002/ejoc.202400717
100.
Shang Li, Liangliang Ma, Xinxin Li, Yuhan Jiang, Zhongwen Luo, Fucheng Yin, Yonglei Zhang, Yifan Chen, Siyuan Wan, Han Zhou, Lingyi Kong*, Xiaobing Wang*, Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis, Journal of Medicinal Chemistry, 2024, 67, 17, 15353–15372, DOI: 10.1021/acs.jmedchem.4c00949
99.
Yonglei Zhang, Fucheng Yin, Zhongwen Luo, Shang Li, Xinxin Li, Siyuan Wan, Yifan Chen, Lingyi Kong, Xiaobing Wang, Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1, European Journal of Medicinal Chemistry, 2024, 271, 116433. DOI: 10.1016/j.ejmech.2024.116433
98.
Fucheng Yin, Lailiang Qu, Yifan Chen, Zhongwen Luo, Lingyi Kong, Xiaobing Wang, Stereoselective Synthesis of β, γ-Fused Bicyclic γ-Ureasultams via an Intramolecular Mannich and aza-Michael Addition Cascade, Chemistry-A European Journal, 2024, 30, e202400438; DOI: 10.1002/chem.202400438
https://doi.org/10.1002/chem.202400438
97.
Fucheng Yin, Yifan Chen, Zhongwen Luo, Shang Li, Yonglei Zhang, Siyuan Wan, Xinxin Li, Lingyi Kong*, and Xiaobing Wang*, Regioselective Olefination and Arylation of Arene-Tethered Diols Using the Easily Foldable Directing Groups
Organic Letters, 2024, 26, 7, 1463-1467. DOI: 10.1021/acs.orglett.4c00096
https://doi.org/10.1021/acs.orglett.4c00096
96.
Xinxin Li, Cheng Wang, Shang Li, Fucheng Yin, Heng Luo, Yonglei Zhang, Zhongwen Luo, Yifan Chen, Siyuan Wan, Lingyi Kong*, Xiaobing Wang*, Dual Target PARP1/EZH2 Inhibitors Inducing Excessive Autophagy and Producing Synthetic Lethality for Triple-Negative Breast Cancer Therapy, European Journal of Medicinal Chemistry, 2024, 265, 116054.
DOI: 10.1016/j.ejmech.2023.116054
95.
Siyuan Wan, Xinye Chen, Fucheng Yin, Shang Li, Yonglei Zhang, Heng Luo, Zhongwen Luo, Ningjie Cui, Yifan Chen, Xinxin Li, Lingyi Kong, Xiaobing Wang, Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer, European Journal of Medicinal Chemistry, 2023, 261, 115843.
DOI: 10.1016/j.ejmech.2023.115843
94. Xinye Chen, Cheng Wang, Dehua Lu, Heng Luo, Shang Li, Fucheng Yin, Zhongwen Luo, Ningjie Cui, Lingyi Kong, Xiaobing Wang. Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.Bioorganic & Medicinal Chemistry, 2023, 91, 117386.
DOI: 10.1016/j.bmc.2023.117386
93. Cheng Wang, Heng Luo, Xinye Chen, Yonglei Zhang, Dehua Lu, Xingchen Liu, Fucheng Yin, Shang Li, Lingyi Kong, Xiaobing Wang. Discovery of dual PARP and CDK6 inhibitors for triple-negative breast cancer with wild-type BRCA.Bioorganic Chemistry, 2023, 139, 106683.
DOI: 10.1016/j.bioorg.2023.106683
92. LI Shang, WANG Xiaobing. Design and synthesis of antiviral pseudo-natural products via effective one-step acylmethylation macrocyclization.Chinese Journal of Natural Medicine, 2023, 21(8): 561-562.
DOI: 10.1016/S1875-5364(23)60440-6
91. Zhongwen Luo, Shang Li, Yonglei Zhang, Fucheng Yin, Heng Luo, Xinye Chen, Ningjie Cui, Siyuan Wan, Xinxin Li, Lingyi Kong, Xiaobing Wang. Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3β inhibitory and neuroprotective activities against Alzheimer's disease. European Journal of Medicinal Chemistry, 2023, 256, 115415. IF 7.084
DOI: 10.1016/j.ejmech.2023.115415
90. Ningjie Cui; Shang Li; Yonglei Zhang; Fucheng Yin; Xinye Chen; Zhongwen Luo; Siyuan Wan; Xinxin Li; Lingyi Kong; Xiaobing Wang. Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors. European Journal of Medicinal Chemistry, 2023, 250, 115190. IF 7.084
DOI: 10.1016/j.ejmech.2023.115190
89. LIU Xingchen, WANG Xiaobing. Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents.Chin J Nat Med, 2022, 20(11): 814-829.
doi: 10.1016/S1875-5364(22)60238-3.
88. Dehua Lu, Cheng Wang, Lailiang Qu, Fucheng Yin, Shang Li, Heng Luo, Yonglei Zhang, Xingchen Liu, Xinye Chen, Zhongwen Luo, Ningjie Cui, Lingyi Kong*, Xiaobing Wang*.Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting Synergistic a Effect for the Treatment of Hematological Malignancies. J Med Chem, 2022，65，19, 12838-12859. IF: 8.037
DOI: 10.1021/acs.jmedchem.2c00673
具有协同作用的HDAC和EZH2双靶点抑制剂的设计- X-MOL资讯
87. Fucheng Yin, Yifan Chen, Zhongwen Luo, Shang Li, Lingyi Kong, and Xiaobing Wang, Aryl Halides as Halogenation Reagents in the Bromination and Iodination of Arene-Tethered Diols, Org. Lett. 2022, 24, 36, 6510–6514. DOI: 10.1021/acs.orglett.2c02358 IF 6.072
86. Cheng Wang, Xinye Chen, Xingchen Liu, Dehua Lu, Shang Li, Lailiang Qu, Fucheng Yin, Heng Luo, Yonglei Zhang, Zhongwen Luo, Ningjie Cui, Lingyi Kong*, Xiaobing Wang*，Discovery of Precision Targeting EZH2 Degraders for Triple-Negative Breast Cancer, European Journal of Medicinal Chemistry, Available online 20 May 2022, 114462. DOI: 10.1016/j.ejmech.2022.114462 IF 7.084
85. Fucheng Yin, Wan Peng, Cheng Wang, Lailiang Qu, Xinye Chen, Lingyi Kong, Xiaobing Wang, Rhodium(III)- Catalyzed Cleavage of C-C Bond and C-H Bond Cascaded by Michael Addition for the Conversion of α-Hydroxy Ketones to Phthalides and Isocoumarins, Asian Journal of Organic Chemistry, 2022, e202200024. https://doi.org/10.1002/ajoc.202200024 IF 3.319
84.Shang Li, Lailiang Qu, Xiaobing Wang*, Lingyi Kong*, Novel insights into RIPK1 as a promising target for future Alzheimer’s disease treatment, Pharmacology & Therapeutics, 2022, 231, 107979, DOI: 10.1016/j.pharmthera.2021.107979. IF: 13.400.
83. Dehua Lu, Lailiang Qu, Cheng Wang, Heng Luo, Shang Li, Fucheng Yin, Xingchen Liu, Xinye Chen, Zhongwen Luo, Ningjie Cui, Wan Peng, Limei Ji, Lingyi Kong*, and Xiaobing Wang*. Harmine-Based Dual Inhibitors Targeting Histone Deacetylase (HDAC) and DNA as a Promising Strategy for Cancer Therapy. Bioorganic Chemistry (IF: 5.275), 2022, 120, 105604. DOI: 10.1016/j.bioorg.2022.105604
82. Xingchen Liu,Cheng Wang,Shang Li,Lailiang Qu,Fucheng Yin,Dehua Lu, Heng Luo, Xinye Chen, Zhongwen Luo, Ningjie Cui, Xiaobing Wang*, and Lingyi Kong*
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer Journal of Medicinal Chemistry, 2021, 64: 17304-17325. DOI: 10.1021/acs.jmedchem.1c01380. IF：8.039
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01380
81. Lailiang Qu, Shang Li, Limei Ji, Si Luo, Ming Ding, Fucheng Yin, Cheng Wang, Heng Luo, Dehua Lu, Xingchen Liu, Wan Peng, Lingyi Kong*, Xiaobing Wang*, Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease, European Journal of Medicinal Chemistry, 2021, 226: 113889.
DOI：10.1016/j.ejmech.2021.113889 IF 7.084
80. Cheng Wang, Lailiang Qu, Shang Li, Fucheng Yin, Limei Ji, Wan Peng, Heng Luo, Dehua Lu, Xingchen Liu, Xinye Chen, Lingyi Kong*, and Xiaobing Wang*, Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA, Journal of Medicinal Chemistry, 2021, 64: 12630-12650. DOI: 10.1021/acs.jmedchem.1c00567. IF：8.039
the woman and the maze
CAS No. : 2687273-52-3
一种 PARP（IC50 6.87 nM）和 EZH2（IC50 36.51 nM）的双特异性抑制剂，用于治疗野生型BRCA三阴性乳腺癌。
Synthetic lethality是比较先进的一种治疗癌症的策略和方法，BRCA与PARP为一对Synthetic lethality Pair，本研究中通过引入EZH2抑制剂片段，使PARP抑制剂对BRCA野生型细胞敏感，从而间接达到Synthetic lethality效应，这也是该研究的一个关键的创新。
https://www.x-mol.com/news/695445
https://mp.weixin.qq.com/s/QgOipmi4LzZTCfCskQNHvg
79. Lailiang Qu, Limei Ji, Cheng Wang, Heng Luo, Shang Li, Wan Peng, Fucheng Yin, Dehua Lu, Xingchen Liu, Lingyi Kong, Xiaobing Wang. Synthesis and Evaluation of Multi-Target-Directed Ligands with BACE-1 Inhibitory and Nrf2 Agonist Activities as Potential Agents against Alzheimer's Disease, European Journal of Medicinal Chemistry, 2021, 113441. IF 7.084 DOI：10.1016/j.ejmech.2021.113441
78. Wan Peng, Qiaohong Liu, Fucheng Yin, Cunjian Shi, Limei Ji, Lailiang Qu, Cheng Wang, Heng Luo, Lingyi Kong*， Xiaobing Wang *. Rhodium(III) catalyzed olefination and deuteration of tetrahydrocarbazole , RSC Advances, 2021, 11(14), 8356-8361. IF: 3.361, DOI: 10.1039/D1RA00236H
77. Huali Yang , Xiaobing Wang, Cheng Wang, Fucheng Yin, Lailiang Qu, Cunjian Shi, JinhuaZhao, Shang Li, Limei Ji, WanPeng, Heng Luo, Maosheng Cheng, Lingyi Kong. Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer, European Journal of Medicinal Chemistry, 2021, 210, 113080. IF 7.084 DOI: 10.1016/j.ejmech.2020.113080
76. Limei Ji, Lailiang Qu, Cheng Wang, Wan Peng, Shang Li, Huali Yang, Heng Luo, Fucheng Yin, Dehua Lu, Xingchen Liu, Lingyi Kong, Xiaobing Wang. Identification and optimization of Piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2. European Journal of Medicinal Chemistry, 2021, 210,112965. IF 7.084
75. Cheng Wang, Shang Li, Jinhua Zhao, Huali Yang, Fucheng Yin, Ming Ding, Jianguang Luo, Xiaobing Wang*, Lingyi Kong*. Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment. Journal of Medicinal Chemistry, 2020, 63, 11195-11214, DOI: 10.1021/acs.jmedchem.0c01128 。IF：7.446
该文章被选为Journal of Medicinal Chemistry的2020年63卷19期的封面文章。
结构修饰与构效关系
蛋白质质谱
共价键结合
74. Jinhua Zhao, Fucheng Yin, Limei Ji, Cheng Wang, Cunjian Shi, Xingchen Liu, Huali Yang, Xiaobing Wang*, Lingyi Kong*. Development of a Tau-Targeted Drug Delivery System Using a Multifunctional Nanoscale Metal–Organic Framework for Alzheimer’s Disease Therapy. ACS Applied Materials & Interfaces, 2020, 12, 44447-44458. DOI： 10.1021/acsami.0c11064 IF 9.229.
该文章被选为ACS Applied Materials & Interfaces的2020年12卷40期的封面文章，我们开发的NMOF递药系统可以像“导弹”一样定点释放MB，抑制磷酸化Tau的聚集，保护神经元，最终改善AD的症状。
72. Cun-Jian Shi, Wan Peng, Jin-Hua Zhao, Hua-Li Yang, Lai-Liang Qu, Cheng Wang, Ling-Yi Kong*, Xiao-Bing Wang*, Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors, European Journal of Medicinal Chemistry, 2020, 187, 111961. (IF: 5.383) DOI: 10.1016/j.ejmech.2019.111961
71.Hua-Li Yang, Si-Qiang Fang, Yan-Wei Tang, Cheng Wang, Heng Luo, Lai-Liang Qu, Jin-Hua Zhao, Cun-Jian Shi, Fu-Cheng Yin, Xiao-Bing Wang *, Ling-Yi Kong*, A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer’s disease. European Journal of Medicinal Chemistry (IF: 4.833), 2019, 179, 736-743. DOI:10.1016/j.ejmech.2019.07.005
70. Siqiang Fang, Xiaobing Wang*, Fucheng Yin, Pei Cai, Huali Yang and Lingyi Kong*, Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group. Org. Lett.(IF: 6.492), 2019, 21 (6), 1841–1844. DOI: 10.1021/acs.orglett.9b00433
69. Yan-Wei Tang, Cun-Jian Shi, Hua-Li Yang, Pei Cai, Qiao-Hong Liu, Xue-Lian Yang, Ling-Yi Kong*, Xiao-Bing Wang*, Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer’s disease. European Journal of Medicinal Chemistry (IF: 4.816), 2019, 163, 307-319. DOI:10.1016/j.ejmech.2018.11.040
68. Pei Cai, Si-Qiang Fang, Hua-Li Yang, Xue-Lian Yang, Qiao-Hong Liu, Ling-Yi Kong*, Xiao-Bing Wang*. Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer’s disease agents with cholinergic, antioxidant, and neuroprotective properties.European Journal of Medicinal Chemistry (IF: 4.816), 2018, 157, 161-176. DOI: 10.1016/j.ejmech.2018.08.005
67. Xuelian Yang, Pei Cai, Qiaohong Liu, Jiajia Wu, Yong Yin, Xiaobing Wang*, Lingyi Kong*. Novel 8-hydroxyquinoline derivatives targeting β-amyloid aggregation, metal chelation and oxidative stress against Alzheimer’s disease. Bioorganic & Medicinal Chemistry(IF:2.9), 2018, 26, 3191-3201. DOI: 10.1016/j.bmc.2018.04.043
66. Qing-Feng Wu, Xiao-Bing Wang, Peng-Xiang Shen and Jin-Quan Yu*. Enantioselective C-H Arylation and Vinylation of Cyclobutyl Carboxylic Amides ACS Catalysis (IF: 11.384), 2018, 8, 2577-2581. DOI: 10.1021/acscatal.8b00069 (Q.-F.W. and X.-B.W. contributed equally to this work.)
65. Hua-Li Yang, Pei Cai, Qiao-Hong Liu, Xue-Lian Yang, Si-Qiang Fang, Yan-Wei Tang, Cheng Wang, Xiao-Bing Wang*, Ling-Yi Kong*. Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer’s disease. Bioorganic & Medicinal Chemistry (IF: 2.930), 2017, 25, 5917-5928. DOI: 10.1016/j.bmc.2017.08.048
64. Pei Cai, Si-Qiang Fang, Xue-Lian Yang, Jia-Jia Wu, Qiao-Hong Liu, Hao Hong, Xiao-Bing Wang*, Ling-Yi Kong*. Rational Design and Multibiological Profiling of Novel Donepezil–Trolox Hybrids against Alzheimer’s Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties. ACS Chemical Neuroscience (IF: 4.211), 2017, 8, 2496-2511. DOI: 10.1021/acschemneuro.7b00257
63. Qing-Feng Wu, Peng-Xiang Shen, Jian He, Xiao-Bing Wang, Forrest Zhang, Qian Shao, Ru-Yi Zhu, Claudio Mapelli, Jennifer X. Qiao, Michael A. Poss, Jin-Quan Yu. Formation of alpha-chiral centers by asymmetric beta-C(sp3)-H arylation, alkenylation, and alkynylation.Science (IF: 41.058), 2017, 355, 499-503. DOI: 10.1126/science.aal5175
62. Hua-Li Yang, Pei Cai, Qiao-Hong Liu, Xue-Lian Yang, Fan Li, Jin Wang, Jia-Jia Wu, Xiao-Bing Wang, Ling-Yi Kong*. Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid- β aggregation for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry(IF: 4.816), 2017, 138, 715-728.
61. Jia-Jia Wu, Ting Ma, Zhi-Min Wang, Wen-Jun Xu, Xue-Lian Yang, Jian-Guang Luo, Ling-yi Kong*, Xiao-Bing Wang*. Polycyclic xanthones via pH-switched biotransformation of alpha-mangostin catalysed by horseradish peroxidase exhibited cytotoxicity against hepatoblastoma cells in vitro. Journal of Functional Foods (IF: 3.144), 2017, 28, 205-214.
60. Xiao-Bing Wang, Chang-Shui Yang, Jian-Guang Luo, Chao Zhang, Jun Luo, Ming-Hua Yang, Ling-Yi Kong*. Experimental and theoretical calculation studies on the structure elucidation and absolute configuration of calyxins from Alpinia katsumadai. Fitoterapia(IF: 2.698), 2017, 119, 121-129.
59. Jin Wang, Pei Cai, Xue-Lian Yang, Fan Li, Jia-Jia Wu, Ling-Yi Kong*, Xiao-Bing Wang*. Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer’s disease. European Journal of Medicinal Chemistry (IF: 4.519), 2017, 139, 68-83.
58. Qiao-Hong Liu, Jia-Jia Wu, Fan Li, Pei Cai, Xue-Lian Yang, Ling-Yi Kong*, Xiao-Bing Wang*. Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer’s disease. MedChemComm (IF: 2.608), 2017, 8, 1459-1467.
57. Fan Li, Jia-Jia Wu, Jin Wang, Xue-Lian Yang, Pei Cai, Qiao-Hong Liu, Ling-Yi Kong*, Xiao-Bing Wang*. Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer’s disease. Bioorganic & Medicinal Chemistry (IF: 2.930), 2017, 25, 3815-3826.
56. Wei Xu, Xiao-Bing Wang, Zhi-Min Wang, Jia-Jia Wu, Fan Li, Jin Wang, Ling-Yi Kong*. Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer’s disease. MedChemComm (IF: 2.458), 2016, 7, 990-998.
55. Sai-Sai Xie, Jin-Shuai Lan, Xiao-Bing Wang, Zhi-Min Wang, Neng Jiang, Fan Li, Jia-Jia Wu, Jin Wang, Ling-Yi Kong*. Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry (IF:2.930), 2016, 24, 1528-1539.
54. Zhi-Min Wang, Pei Cai, Qiao-Hong Liu, Ding-Qiao Xu, Xue-Lian Yang, Jia-Jia Wu, Ling-Yi Kong*, Xiao-Bing Wang*. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry (IF:4.519), 2016, 123, 282-297.
53. Zhimin Wang, Jiajia Wu, Xuelian Yang, Pei Cai, Qiao-Hong Liu, Kelvin D. G. Wang, Lingyi Kong*, Xiaobing Wang*. Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson’s disease. Bioorganic & Medicinal Chemistry, 2016, 24, 5929-5940.
52. Jin Wang, Zhi-Min Wang, Xue-Mei Li, Fan Li, Jia-Jia Wu, Ling-Yi Kong*, Xiao-Bing Wang*. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin. Bioorganic & Medicinal Chemistry, 2016, 24, 4324-4338.
51. Fan Li, Zhi-Min Wang, Jia-Jia Wu, Jin Wang, Sai-Sai Xie, Jin-Shuai Lan, Wei Xu, Ling-Yi Kong*, Xiao-Bing Wang*. Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry (IF: 4.293), 2016, 31, 41-53.
50. Weisi Xiong, Xiaobing Wang, Lingyi Kong*. Design and application of a biphasic system that enhances productivity of Daucus carota-catalyzed asymmetric reduction. Biotechnology Letters 2015, 37 (8), 1703-1709.
49. Sai-Sai Xie, Xiaobing Wang, Neng Jiang, Wenying Yu, Kelvin D.G. Wang, Jin-Shuai Lan, Zhong-Rui Li, Ling-Yi Kong*. Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer’s disease. European Journal of Medicinal Chemistry 2015, 95, 153-165.
48. Sai-Sai Xie, Jin-Shuai Lan, Xiao-Bing Wang, Neng Jiang, Ge Dong, Zhong-Rui Li, Kelvin D.G. Wang, Ping-Ping Guo, Ling-Yi Kong. Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer’s disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. European Journal of Medicinal Chemistry 2015, 93, 42-50.
47. Zhi-Min Wang, Sai-Sai Xie, Xue-Mei Li, Jia-Jia Wu, Xiao-Bing Wang*, Ling-Yi Kong*. Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer’s disease. RSC Advances 2015, 5 (86), 70395-70409.
46. Zhi-Min Wang, Xue-Mei Li, Wei Xu, Fan Li, Jin Wang, Ling-Yi Kong*, Xiao-Bing Wang*. Acetophenone derivatives: novel and potent small molecule inhibitors of monoamine oxidase B. MedChemComm 2015, 6 (12), 2146-2157.
45. Zhi-Min Wang, Xue-Mei Li, Gui-Min Xue, Wei Xu, Xiao-Bing Wang*, Ling-Yi Kong*. Synthesis and evaluation of 6-substituted 3-arylcoumarin derivatives as multifunctional acetylcholinesterase/monoamine oxidase B dual inhibitors for the treatment of Alzheimer’s disease. RSC Advances 2015, 5 (126), 104122-104137.
44. Jiang-Yan Li, Xiao-Bing Wang, Jian-Guang Luo, Ling-Yi Kong*. Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods. Journal of chromatographic science 2015, 53 (7), 1131-1139.
43. Jin-Shuai Lan, Sai-Sai Xie, Ming Huang, Ya-Jian Hu, Ling-Yi Kong*, Xiao-Bing Wang*. Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency. MedChemComm 2015, 6 (7), 1293-1302.
42. Jin-Shuai Lan, Long-Fei Pan, Sai-Sai Xie, Xiao-Bing Wang*, Ling-Yi Kong*. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. MedChemComm 2015, 6 (4), 592-600.
41. Neng Jiang, Xiao-Bing Wang, Zhong-Rui Li, Su-Yi Li, Sai-Sai Xie, Ming Huang, Ling-Yi Kong*. Design of a structural framework with potential use to develop balanced multifunctional agents against Alzheimer’s disease. RSC Advances 2015, 5 (19), 14242-14255.
40. Ming Huang, Sai-Sai Xie, Neng Jiang, Jin-Shuai Lan, Ling-Yi Kong*, Xiao-Bing Wang*. Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 2015, 25 (3), 508-513.
39. Ya-Jian Hu, Xiao-Bing Wang*, Su-Yi Li, Sai-Sai Xie, Kelvin. D. G. Wang, Ling-Yi Kong*. Facile synthesis of spiro chromanone-tetrahydrothiophenes with three contiguous stereocenters via sulfa-Michael/aldol cascade reactions. Tetrahedron Letters 2015, 56 (1), 105-108.
38. Ya-Jian Hu, Neng Jiang, Sai-Sai Xie, Su-Yi Li, Jin-Shuai Lan, Ling-Yi Kong*, Xiao-Bing Wang*. Iodine-promoted sequential Michael and oxidative dehydrogenation processes: synthesis of trisubstituted methanes containing a coumarin and a chromone ring.Tetrahedron 2015, 71 (42), 8026-8032.
37. Zi-Chen Xu, Xiao-Bing Wang, Wen-Ying Yu, Sai-Sai Xie, Su-Yi Li, Ling-Yi Kong*. Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 2014, 24 (10), 2368-2373.
36. Xiao-Bing Wang, Chang-Shui Yang, Chao Zhang, Jun Luo, Ming-Hua Yang, Jian-Guang Luo, Wen-Ying Yu, Ling-Yi Kong*. Ten new calyxins from Alpinia katsumadai: a systematically studies on the stereochemistry of calyxins. Tetrahedron 2014, 70 (45), 8714-8722.
35. Long-Fei Pan, Xiao-Bing Wang, Sai-Sai Xie, Su-Yi Li, Ling-Yi Kong*. Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer’s disease.MedChemComm 2014, 5 (5), 609-616.
34. Su-Yi Li, Xiao-Bing Wang, Ling-Yi Kong*. Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer’s disease. European Journal of Medicinal Chemistry 2014, 71, 36-45.
33. Su-Yi Li, Xiao-Bing Wang, Neng Jiang, Ling-Yi Kong*.Synthesis of (E)-1,4-Enediones from α-Halo Ketones Through a Sodium Sulfinate Mediated Reaction. European Journal of Organic Chemistry 2014 (36), 8035-8039.
32. Su-Yi Li, Neng Jiang, Sai-Sai Xie, Kelvin. D. G. Wang, Xiao-Bing Wang*, Ling-Yi Kong*. Design, synthesis and evaluation of novel tacrine rhein hybrids as multifunctional agents for the treatment of Alzheimer’s disease. Organic & Biomolecular Chemistry 2014, 12 (5), 801-814.
31. Jin-Shuai Lan, Sai-Sai Xie, Su-Yi Li, Long-Fei Pan, Xiao-Bing Wang*, Ling-Yi Kong*. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry 2014, 22 (21), 6089-6104.
30. Neng Jiang, Su-Yi Li, Sai-Sai Xie, Hequan Yao, Hongbin Sun, Xiao-Bing Wang*, Ling-Yi Kong*. FeCl3 and ether mediated direct intramolecular acylation of esters and their application in efficient preparation of xanthone and chromone derivatives. RSC Advances2014, 4 (109), 63632-63641.
29. Neng Jiang, Su-Yi Li, Sai-Sai Xie, Zhong-Rui Li, Kelvin. D. G. Wang, Xiao-Bing Wang*, Ling-Yi Kong*. Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry 2014, 87, 540-551.
28. Ye He, Xiao-Bing Wang, Bo-Yi Fan, Ling-Yi Kong*. Honokiol trimers and dimers via biotransformation catalyzed by Momordica charantia peroxidase: Novel and potent α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry 2014, 22 (2), 762-771.
27. Sai-Sai Xie, Xiao-Bing Wang*, Jiang-Yan Li, Lei Yang, Ling-Yi Kong*. Design, synthesis and evaluation of novel tacrine coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer’s disease. European Journal of Medicinal Chemistry 2013, 64, 540-553.
26. Sai-Sai Xie, Xiao-Bing Wang*, Jiang-Yan Li, Ling-Yi Kong*. Design, Synthesis and Biological Evaluation of Novel 7-Mercaptocoumarin Derivatives as α(1)-Adrenoceptor Antagonists. Chemical & Pharmaceutical Bulletin 2013, 61 (1), 16-24.
25. Xiao-Bing Wang, Yao Zhang, Jun-Song Wang, Yu-Cheng Gu, Ling-Yi Kong*. Novel ring A rearranged isomers with gamma-lactone from the fruits of Aphanamixis grandifolia. Tetrahedron Letters 2013, 54 (45), 6023-6028.
24. Su-Yi Li, Xiao-Bing Wang, Sai-Sai Xie, Neng Jiang, Kelvin D. G. Wang, He-Quan Yao, Hong-Bin Sun, Ling-Yi Kong*. Multifunctional tacrine flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry 2013, 69, 632-646.
23. Ren-Shi Li, Xiao-Bing Wang, Xiao-Jun Hu, Ling-Yi Kong*. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 2013, 23 (9), 2636-2641.
22. Xiao-Jun Hu, Xiao-Bing Wang, Ling-Yi Kong*. α-Glucosidase Inhibitors via Green Pathway: Biotransformation for Bicoumarins Catalyzed by Momordica charantia Peroxidase. Journal of Agricultural and Food Chemistry 2013, 61 (7), 1501-1508.
21. Feng-Zu Bao, Xiao-Bing Wang, Ling-Yi Kong*. Pyrrolidine catalyzed novel domino reaction for the synthesis of polysubstituted 4-oxocyclohexanecarbaldehyde derivatives. Tetrahedron Letters 2013, 54 (11), 1405-1408.
20. Xiao-Bing Wang, Wei Liu, Lei Yang, Qing-Long Guo, Ling-Yi Kong*. Investigation on the substitution effects of the flavonoids as potent anticancer agents: a structure-activity relationships study. Medicinal Chemistry Research 2012, 21 (8), 1833-1849.
19. Lingbo Wang, Xiaobing Wang, Ling-Yi Kong*. Automatic authentication and distinction of Epimedium koreanum and Epimedium wushanense with HPLC fingerprint analysis assisted by pattern recognition techniques. Biochemical Systematics and Ecology 2012, 40, 138-145.
18. Chang-Shui Yang, Xiao-Bing Wang, Jun-Song Wang, Jian-Guang Luo, Jun Luo, Ling-Yi Kong*. A [2+2] Cycloaddition Dimer and a Diels-Alder Adduct from Alpinia katsumadai. Organic Letters 2011, 13 (13), 3380-3383.
17. Xiao-Bing Wang, Yao Zhang, Jun-Song Wang, He-Quan Yao, Hong-Bin Sun, Ling-Yi Kong*. Spectroscopic characterizations, X-ray studies, and electronic circular dichroism calculations of two alkaloid triterpenoids. Structural Chemistry 2011, 22 (6), 1241-1248.
16. Xiang Wan, Xiao-Bing Wang, Ming-Hua Yang, Jun-Song Wang, Ling-Yi Kong*. Dimerization of piceatannol by Momordica charantia peroxidase and α-glucosidase inhibitory activity of the biotransformation products. Bioorganic & Medicinal Chemistry 2011, 19 (17), 5085-5092.
15. Jing Jin, Xiao-Bing Wang, Ling-Yi Kong*. Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as alpha(1)-adrenoceptor antagonists. Bioorganic & Medicinal Chemistry Letters 2011, 21 (3), 909-911.
14. Zuo-Fu Guo, Xiao-Bing Wang, Jian-Guang Luo, Jun Luo, Jun-Song Wang, Ling-Yi Kong*. A novel aporphine alkaloid from Magnolia officinalis. Fitoterapia 2011, 82 (4), 637-641.
13. Qin-Sheng Dai, Wei Liu, Xiao-Bing Wang, Na Lu, Dan-Dan Gong, Ling-Yi Kong, Qing-Long Guo. NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Anti-Cancer Drugs 2011, 22 (1), 46-57.
12. Zhao Xu, Xiaobing Wang, Yue Dai*, Lingyi Kong*, Fengyun Wang, Huan Xu, Dan Lu, Jie Song, Zhiguo Hou. (+/-)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis. Chemico-Biological Interactions 2010, 186 (2), 239-246.
11. Xiao-Bing Wang, Chang-Shui Yang, Shu-Zhen Hua, Ling-Yi Kong*. Chemical Constituents from the Seeds of Alpinia katsumadai Hayata. Chinese Journal of Natural Medicines 2010, 8 (6), 419-421.
10. Wang, X.; Hua, S.; Kong, L., Crystal structure of sumadain A 4-bromobenzoate, C37H37BrO5. Zeitschrift Fur Kristallographie-New Crystal Structures 2010, 225 (4), 713-714.
https://doi.org/10.1524/ncrs.2010.0314
9. Hua, S. Z.; Luo, J. G.; Wang, X. B.; Wang, J. S.; Kong, L. Y., Two novel monoterpene-chalcone conjugates isolated from the seeds of Alpinia katsumadai. Bioorganic & Medicinal Chemistry Letters 2009, 19 (10), 2728-2730.
https://doi.org/10.1016/j.bmcl.2009.03.117
8. Zhou, X.; Wang, X. B.; Wang, T.; Kong, L. Y., Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorganic & Medicinal Chemistry 2008, 16 (17), 8011-8021.
https://doi.org/10.1016/j.bmc.2008.07.068
7. Hua, S. Z.; Wang, X. B.; Luo, J. G.; Wang, J. S.; Kong, L. Y., A pair of unique sesquiterpene-chalcone conjugates isolated from the seeds of Alpinia katsumadai. Tetrahedron Letters 2008, 49 (39), 5658-5661.
https://doi.org/10.1016/j.tetlet.2008.07.082
6. Zhou, X.; Wang, X.-B.; Kong, L.-Y., 4-Methyl-7- 3-(4-o-tolylpiperazin-1-yl)propoxy -2H-chromen-2-one. Acta Crystallographica Section E-Structure Reports Online 2007, 63, O266-O267.
https://doi.org/10.1107/S1600536806052779
5. Wang, X.-B.; Kong, L.-Y., 2-(2-Chlorophenyl)-7-methyl-4H-chromen-4-one. Acta Crystallographica Section E-Structure Reports Online 2007, 63, O4340-U3599.
https://doi.org/10.1107/S1600536807050155
4. Wang, X.-B.; Kong, L.-Y., Alisol F 24-acetate: (24R)-24-acetoxy-11 beta,25-dihydroxy-16 beta,23 beta-epoxyprotost-13(17)-en-3-one. Acta Crystallographica Section E-Structure Reports Online 2007, 63, O4110-U3612.
https://doi.org/10.1107/S1600536807045126
3. Wang, X.-B.; Kong, L.-Y., (2E, 2'E)-4,6-dichloro-1,3-phenylene bis(3-phenylacrylate). Acta Crystallographica Section E-Structure Reports Online 2006, 62, O4558-O4559.
https://doi.org/10.1107/S1600536806037135
2. Wang, X. B.; Shi, Y. R.; Kong, L. Y., (+)-(3′R)-angeloxyloxy-4'-oxo-3',4'-dihydro-seselin (Pd-Ib). Acta Crystallographica Section E-Structure Reports Online 2006, 62, O2505-O2507.
https://doi.org/10.1107/S1600536806018745
1. Zunting Zhang, Xiaobing Wang, Syntheses and Br…π supramolecular interactions in the crystal structure of ipriflavone bromides, Science in China Series B-Chemistry, 2005, 48: 315-325.
https://doi.org/10.1360/042004-45
