代表性科研论文：
1. C. Zhu; M. Iwase; Z. Li; F. Wang; A. Quinet; A. Vindigni; J. Shao. Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L. Nature Communications, 2022, 13(1).
2. C. Zhu; S. J. Kim; A. Mooradian; F. Wang; Z. Li; S. Holohan; P. L. Collins; K. Wang; Z. Guo; J. Hoog; C. X. Ma; E. M. Oltz; J. M. Held; J. Shao. Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1. Cell Reports, 2021, 34(7).
3. C. Zhu; A. Rogers; K. Asleh; J. Won; D. Gao; S. Leung; S. Li; K. R. Vij; J. Zhu; J. M. Held; Z. You; T. O. Nielsen; J. Shao. Phospho-Ser(784)-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer. Cell Reports, 2020, 31(10).
4. F. Wang#; C. Zhu#; S. Cai; A. Boudreau; S-J. Kim; M. Bissell; J. Shao. Ser71 Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity. Frontiers in Cell and Developmental Biology, 2021, 9.(共一第二)
5. C. Zhu; R. Wang; W. Zheng; D. Chen; X. Yue; Y. Cao; W. Qin; H. Sun; Y. Wang; Z. Liu; B. Li; J. Du; X. Bu; B. Zhou. Synthesis and evaluation of anticancer activity of BOC26P, an ortho-aryl chalcone sodium phosphate as water-soluble prodrugs in vitro and in vivo. Biomedicine & Pharmacotherapy, 2017, 96: 551-562.
6. C. Zhu; Y. Zuo; B. Liang; H. Yue; X. Yue; G. Wen; R. Wang; J. Quan; J. Du; X. Bu. Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe. Chemical Communications, 2015, 51(69): 13400-13403.
7. C. Zhu; Y. Zuo; R. Wang; B. Liang; X. Yue; G. Wen; N. Shang; L. Huang; Y. Chen; J. Du; X. Bu. Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence. Journal of Medicinal Chemistry, 2014, 57(15): 6364-6382.
图 1 DNA复制过程和复制应激诱导基因组不稳定性的新调控机制
图2 VCP磷酸化修饰（pSer784）用于接受DNA损伤药物治疗的乳腺癌患者不良预后的诊断功能
广州医科大学高层次人才建设项目，200万
