56. Guosong Shen, Faqian He, Xiaoyu Yang*, Divergent asymmetric reactions of α-alkenyl ketones with β,γ-alkynyl-α-imino esters enabled by chiral phosphoric acids, Green Synth. Catal. 2024, DOI:10.1016/j.gresc.2024.10.003

55. Zidan Ye, Wansen Xie, Wei Liu, Changyu Zhou, Xiaoyu Yang*, Catalytic Enantioselective Synthesis of Axially Chiral Diaryl Ethers Via Asymmetric Povarov Reaction Enabled Desymmetrization, Adv. Sci. 2024, 2403125.

54. Shaoze Yu,  Mengyao Yuan,  Wansen Xie,  Zidan Ye,  Tianren Qin,  Na Yu,  Xiaoyu Yang*, Catalytic Enantioselective Synthesis of Inherently Chiral Calix[4]arenes via Sequential Povarov Reaction and Aromatizations, Angew. Chem. Int. Ed. 2024, 63, e202410628. （Hot Paper）

53. Wansen Xie, Jinmiao Zhou, Wei Liu, Tianren Qin, Xiaoyu Yang*, Divergent asymmetric synthesis of heterohelicenes via sequential organocatalyzed Povarov reaction and aromatization, Cell Rep. Phy. Sci. 2024, 5, 101993.

52. Jinmiao Zhou, Mengyao Tang, Xiaoyu Yang*, Catalytic Asymmetric Synthesis of Inherently Chiral Saddle-Shaped Dibenzo[b,f][1,5]diazocines, Chin. J. Chem. 2024, 42, 1953-1959. (Invited as Emerging Investigators in 2024, selected as Breaking Report)

51. Zidan Ye, Wansen Xie, Donglei Wang, Hua Liu, and Xiaoyu Yang*, Atroposelective Synthesis of Diarylamines via Organocatalyzed Electrophilic Amination, ACS Catal. 2024, 14, 4958-4967.

50. Mengyao Tang, Mengyao Yuan, Shibin Hong, Qianwen Jiang, Huanchao Gu, and Xiaoyu Yang*, Kinetic Resolution of Sulfoximines via Asymmetric Organocatalyzed Formation of Benzothiadiazine-1-oxides, Org. Lett. 2024, 26, 1914–1919.

49. Dekun Zhang#, Jinmiao Zhou#, Tianren Qin, Xiaoyu Yang*,  Asymmetric synthesis of saddle-shaped eight-membered azaheterocycles via (dynamic) kinetic resolution, Chem. Catal. 2024, 4, 100827.

48. Qianwen Jiang, Dekun Zhang, Mengyao Tang, Hua Liu, Xiaoyu Yang*, (Parallel) kinetic resolution of 3,3-disubstituted indolines via organocatalyzed reactions with azodicarboxylates, Sci. China Chem. 2024, 67, 973-980.

47. Mengyao Tang, Xiaoyu Yang,* One-step synthesis of indole atropisomers with vicinal diaxes via Co-catalyzed C–H activation, Chem. Catal. 2023, 3, 100754. (Invited preview)

46. Guosong Shen , Faqian He, Wansen Xie, Huanchao Gu, and Xiaoyu Yang*, Diastereodivergent Asymmetric [4 + 2] Cycloaddition of In Situ Generated ortho-Quinone Methides and Allenyl Ketones Enabled by Chiral Phosphoric Acid Catalysis, ACS Catal. 2023, 13, 12472–12480.

45. Mengyao Tang and Xiaoyu Yang*, Catalytic Enantioselective Synthesis of Inherently ChiralMolecules: Recent Advances, Eur. J. Org. Chem. 2023, e202300738. (invited review)

44. Shaoze Yu, Hanyang Bao, Dekun Zhang and Xiaoyu Yang*, Kinetic resolution of substituted amido[2.2]paracyclophanes via asymmetric electrophilic amination, Nat. Commun. 2023, 14, 5239.

43. Zidan Ye, Wei Liu, Huanchao Gu, and Xiaoyu Yang*, Enantioselective Dearomatization of Substituted Phenols via Organocatalyzed Electrophilic Amination, Org. Lett. 2023, 25, 5838–5843.

42. Wei Liu,# Tianren Qin,# Wansen Xie, Jinmiao Zhou, Zidan Ye and Xiaoyu Yang*, Enantioselective Synthesis of Azahelicenes through Organocatalyzed Multicomponent Reactions, Angew. Chem. Int. Ed. 2023, 62, e202303430.

41. Qianwen Jiang, Wansen Xie and Xiaoyu Yang*, Asymmetric Synthesis of Highly Sterically Congested α-Tertiary Amines via Organocatalyzed Kinetic Resolution, Chem. Commun. 2023, 59, 4762-4765. (Invited as 2023 Pioneering Investigators)

40. Hanyang Bao, Yunrong Chen, Xiaoyu Yang*, Catalytic Asymmetric Synthesis of Axially Chiral Diaryl Ethers through Enantioselective Desymmetrization, Angew. Chem. Int. Ed. 2023, 62, e202300481.

39. Dekun Zhang,# Ying-Bo Shao,# Wansen Xie, Yunrong Chen, Wei Liu, Hanyang Bao, Faqian He, Xiao-Song Xue*, and Xiaoyu Yang* Remote Enantioselective Desymmetrization of 9,9-Disubstituted 9,10-Dihydroacridines through Asymmetric Aromatic Aminations, ACS Catal. 2022, 12, 14609–14618

38. Wei Liu, Tianren Qin, Wansen Xie, Xiaoyu Yang* Catalytic Enantioselective Synthesis of Helicenes, Chem. Eur. J. 2022, 28, e202202369 (Invited Review)

37. Shaoze Yu, Guosong Shen, Faqian He and Xiaoyu Yang* Asymmetric Synthesis of Planar-chiral Macrocycles via Organocatalyzed Enantioselective Macrocyclization, Chem. Commun. 2022, 58, 7293-7296.

36. Jinglei Xie#, Zheng Guo#, Wei Liu, Dekun Zhang, Yu-Peng He*, Xiaoyu Yang* Kinetic Resolution of 1,2-Diamines via Organocatalyzed Asymmetric Electrophilic Aminations of Anilines, Chin. J. Chem. 2022, 40, 1674-1680.

35. Yunrong Chen, Wei Liu, Xiaoyu Yang*, Recent Advances in Kinetic Resolution of Tertiary Alcohols, Chin. J. Org. Chem., 2022, 42, 679-697. (Invited Review, Cover Paper) 

  

34. Donglei Wang,# Ying-Bo Shao,# Yunrong Chen, Xiao-Song Xue*, Xiaoyu Yang*, Enantioselective Synthesis of Planar-Chiral Macrocycles through Asymmetric Electrophilic Aromatic Amination. Angew. Chem. Int. Ed. 2022,  61,  e2022010.

33. Wei Liu , Donglei Wang , Dekun Zhang , Xiaoyu Yang* Catalytic Kinetic Resolution and Desymmetrization of Amines, Synlett 2022, 33, 1788-1812 (Invited account)

32. Qianwen Jiang, Tianren Qin and Xiaoyu Yang*, Asymmetric Synthesis of Hydroquinazolines Bearing C4-Tetrasubstituted Stereocenters via Kinetic Resolution of α-Tertiary Amines, Org. Lett. 2022, 24, 625–630.

31. Faqian He, Guosong Shen and Xiaoyu Yang*, Asymmetric Aminations and Kinetic Resolution of Acyclic α-Branched Ynones, Chin. J. Chem. 2022, 40, 15.

30. Jiawen Wang,# Faqian He# and Xiaoyu Yang*, Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides, Nat. Commun. 2021, 12, 6700. (Highlighted by Synfacts 2022,  10.1055/s-0041-1737523)

29. Yunrong Chen*, Xueqian Ye, Faqian He and Xiaoyu Yang*, Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition–enantioselective protonation enabled by cooperative catalysis, Org. Chem. Front. 2021, 8, 5804-5809.

28. Zheng Guo, Jinglei Xie, Tao Hu,  Yunrong Chen,* Houchao Tao*  and  Xiaoyu Yang*, Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines, Chem. Commun. 2021, 57, 9394-9397.

27. Faqian He, Jiawen Wang,   Fang Zhou,   Houchao Tao*  and  Xiaoyu Yang*, Regio- and enantioselective amination of acyclic branched α-alkynyl ketones: asymmetric construction of N-containing quaternary stereocenters,  Org. Chem. Front. 2021, 8, 5377-5382.

26. Mengyao Tang, Huanchao Gu, Shunlong He, Subramani Rajkumar, Xiaoyu Yang* Asymmetric Enamide-Imine Tautomerism in the Kinetic Resolution of Tertiary Alcohols, Angew. Chem. Int. Ed. 2021, 60, 21334 – 21339. (Hot Paper) (Hightlighted by Synfacts 2021, 17, 1144)

25. Qi Wei, Qingyun Zhang, Longjun Xiang, Shihao Zhang, Jianpeng Liu, Xiaoyu Yang, Youqi Ke*, and Zhijun Ning* Giant Spin Splitting in Chiral Perovskites Based on Local Electrical Field Engineering，J. Phys. Chem. Lett. 2021, 12,  6492–6498.

24. Yongkai Pan,# Donglei Wang,# Yunrong Chen, DeKun Zhang, Wei Liu, and Xiaoyu Yang*, Kinetic Resolution of α-Tertiary Propargylic Amines through Asymmetric Remote Aminations of Anilines, ACS Catal. 2021, 11, 8843-8848.

23.  Chaofan Zhu , Wei Liu, Fei Zhao, Yunrong Chen*, Houchao Tao*, Yu-Peng He*,  Xiaoyu Yang* Kinetic Resolution of 2,2-Disubstituted Dihydroquinolines through Chiral Phosphoric Acid-Catalyzed C6-Selective Asymmetric Halogenations Org. Lett. 2021,  23, 4104–4108.

22. Dekun Zhang, Yunrong Chen, Yongning Lai, Xiaoyu Yang* Enantioselective desymmetrization of 2-substituted and 2,2-disubstituted 1,3-propanediamines via asymmetric para-aminations of anilines, Cell Rep. Phy. Sci. 2021, 2, 100413.

21. Wei Liu, Xiaoyu Yang*, Recent Advances in (Dynamic) Kinetic Resolution and Desymmetrization Catalyzed by Chiral Phosphoric Acids, Asian J. Org. Chem. 2021, 10, 692-710.(invited review, VIP paper)

20. Yunrong Chen, Chaofan Zhu, Zheng Guo, Wei Liu, Xiaoyu Yang* Asymmetric Synthesis of Hydroquinolines with α,α-Disubstitution via Organocatalyzed Kinetic Resolution, Angew. Chem. Int. Ed., 2021, 60, 5268 –5272.

19. Jiawen Wang#, Sujuan Zheng#, Subramani Rajkumar, Jinglei Xie, Na Yu, Qian Peng* and Xiaoyu Yang* Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies, Nat. Commun. 2020, 11, 5527. ("Featured in Org. Chem. Highlights: C-C Bond Formation").

18. Yongkai Pan, Qianwen Jiang, Subramani Rajkumar, Chaofan Zhu, Jinglei Xie, Shaoze Yu, Yunrong Chen, Yu-Peng He* and Xiaoyu Yang*  Kinetic Resolution of 2-N-Acylamido Tertiary Allylic Alcohols: Asymmetric Synthesis of Oxazolines, Adv. Syn. Catal. 2021, 363, 200-207 (VIP paper)

17. Wei Liu, Qianwen Jiang, Xiaoyu Yang*, Versatile Method for Kinetic Resolution of Protecting-Group-Free BINAMs and NOBINs through Chiral Phosphoric Acid Catalyzed Triazane Formation, Angew. Chem. Int. Ed., 2020, 59, 23598 – 23602

16. Xueqian Ye,  Yongkai Pan,  Yunrong Chen,  Xiaoyu Yang*, Enantioselective Construction of Sulfur‐Containing Tetrasubstituted Stereocenters via Asymmetric Functionalizations of α‐Sulfanyl Cyclic Ketones, Adv. Syn. Catal. 2020, 362, 3374-3379.

15. Shunlong He, Huanchao Gu, Yu-Peng He*, and Xiaoyu Yang*，Asymmetric Aza-Diels–Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N–H Ketimines Catalyzed by Chiral Phosphoric Acids，Org. Lett., 2020, 22, 5633–5639.

14. Donglei Wang, Qianwen Jiang and Xiaoyu Yang*，Atroposelective synthesis of configurationally stable nonbiaryl N-C atropisomers through direct asymmetric aminations of 1,3-benzenediamines, Chem Commun, 2020, 56, 6201-6204. (Selected as “Chem Commun HOT Articles" by editors)

13.  Subramani Rajkumar#,  Mengyao Tang# and  Xiaoyu Yang*, Chiral Phosphoric Acid‐Catalyzed Kinetic Resolution of 2‐Amido Benzyl Alcohols: Asymmetric Synthesis of 4H‐3,1‐Benzoxazines, Angew. Chem. Int. Ed., 2020, 59, 2333 –2337

12. Donglei Wang#, WeiLiu#, MengyaoTang, NaYu, XiaoyuYang*, Atroposelective Synthesis of Biaryl Diamines and Amino Alcohols via Chiral Phosphoric Acid Catalysed para-Aminations of Anilines and Phenols, iScience, 2019, 22, 195-205

11.  Xueqian Ye, Yongkai Pan and Xiaoyu Yang*, Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter, Chem. Commun. 2020, 56, 98-101.

10. Subramani Rajkumar#, Shunlong He# and Xiaoyu Yang* Kinetic Resolution of Tertiary 2-Alkoxycarboxamido-Substituted Allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification. Angew. Chem. Int. Ed. 2019, 58, 10315-10319

     

9. Wei Liu, Subramani Rajkumar, Weihu Wu, Ziyu Huang, and Xiaoyu Yang*, Asymmetric Synthesis of β-Indolyl Cyclopentanones and Cyclopentylamides with an All-Carbon Quaternary Stereocenter via Chiral Phosphoric Acid Catalyzed Friedel–Crafts Alkylation Reactions, Org. Lett. 2019, 21, 3563-3567

        

8.  Subramani Rajkumar #, Jiawen Wang #, Xiaoyu Yang*, Asymmetric Transformations of α-Hydroxy Enamides Catalyzed by Chiral Brønsted Acids,  Synlett 2019, 30, DOI: 10.1055/s-0037-1612078 (invited synpact paper)

7. Subramani Rajkumar#, Jiawen Wang#, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng,* and Xiaoyu Yang*, Regioselective and Enantioselective Synthesis of β-Indolyl Cyclopentenamides by Chiral Anion Catalysis. Angew. Chem. Int. Ed. 2018, 57, 13489 –13494

• 6.     Shixian Lin#; Xiaoyu Yang#, S. Jia, A.M. Weeks, M. Hornsby, P.S. Lee, R.V. Nichiporuk, A.T. Iavarone, J.A. Wells, F.D. Toste, C.J. Chang, Redox-based reagents for chemoselective methionine bioconjugation. Science 2017, 355, 597-602 (# 共同第一作者)
  

Selected works before joining ShanghaiTech：

5.     Xiaoyu Yang and F. Dean Toste*.  Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid. Chem. Sci. 2016, 7, 2653-2656.

4.     Xiaoyu Yang, F. Dean Toste*. Direct Asymmetric Amination of α-Branched Cyclic Ketones Catalyzed by a Chiral Phosphoric Acid. J. Am. Chem. Soc. 2015, 137, 3205-3208.

3.     Xiaoyu Yang#, Tao Wu#, Robert J. Phipps, F. Dean Toste*.Advances in Catalytic Enantioselective Fluorination, Mono, Di, and Trifluoromethylation, and Trifluoromethylthiolation Reactions. Chem. Rev. 2015, 115, 826-870.

2.     Xiaoyu Yang#, Robert J. Phipps#, F. Dean Toste*. Asymmetric Fluorination of α-Branched Ketones Enabled by a Synergistic Combination of Chiral Anion Phase-Transfer Catalysis and Enamine Catalysis using Protected Amino Acids. J. Am. Chem. Soc. 2014, 136, 5225-5228.

1.     Xiaoyu Yang, Boqiao Fu, and Biao Yu*.Total Synthesis of Landomycin A, a Potent Antitumor Angucycline Antibiotic. J. Am. Chem. Soc. 2011, 133, 12433-12435.