课题和项目：
主持项目：
1.温州市重大科技创新攻关项目（项目编号：ZY2023006）
神经精神疾病诊治新技术研究——基于整合生物学的精神分裂症精准诊疗标志物筛选与机制研究
项目负责人：谭涛
2024年1月-2026年12月
项目经费：40万元
2.瓯江实验室科研启动项目 (项目编号：OJQD2022002)
孤独症高风险基因致病机制及无创干预研究
项目负责人：谭涛
2022年4月-2027年3月
项目经费：XXX万元
近五年主持或参加的科研项目/课题：
1. NIH, R01, R01-MH126443, Synaptic and Genetic Mechanisms of Sex-Specific Effects of Stress, 2021-01 至 2026-12, 600万元, 在研, 参与
2. NIH, U01, U01AA025932-01, Synaptic Plasticity and Alcohol Use Disorder, 2017-01 至 2022-12, 600万元, 结题, 参与
3. NIH, R01, MH108842, Physiological and Pathophysiological Basis of Stress, 2015-01 至2020-12, 600万元, 结题, 参与
4. NIH, R01, R01-DA037618, Functions of Dopamine D4 Receptors in Prefrontal Cortex, 2014-01至 2019-12, 600万元, 结题, 参与
曾主持或参加的科研项目/课题：
1. 国家自然科学基金青年科学基金项目、 81400874、 rTMS 调节 AD 认知功能的突触可塑性机制研究、2015/01-2017/12、 22 万元、 结题、主持；
2. 中国博士后科学基金第56批面上资助“西部地区博士后人才资助计划” 二等资助、 2014M562505XB、rTMS 调节 AD 认知功能的突触可塑性机制研究、 2014/01-2016/12、 5 万元、 结题、主持；
3. 2014 年“重庆市博士后科研项目特别资助”项目 二等资助、 xm2014051、 低频 rTMS 调节 AD 认知功能的突触可塑性机制研究、 2014/01-2016/1、 10 万元、 结题、主持；
4. 天津医科大学“211 工程”博士创新基金、 2010 GSI09、 rTMS 修复 Aβ 模型大鼠记忆损伤的机制研究、2010/01-2013/12、 8 万元、结题、主持；
5. 重庆医科大学附属儿童医院杰出青年计划 B 类人才、 2015-2020、 75-100 万、主持；
代表论著
2023论文
1. Chen H, He T, Li M, Wang C, Guo C, Wang W, Yu B, Huang J, Cui L, Guo P, Yuan Y, Tan T*. Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons. Front Psychiatry. 2023 Jan 12;13:1070478. doi: 10.3389/fpsyt.2022.1070478. PMID: 36713928; PMCID: PMC9877455. (IF:5.4)
2. Lin P, Yang J, Wu S, Ye T, Zhuang W, Wang W, Tan T*. Current trends of high-risk gene Cul3 in neurodevelopmental disorders. Front Psychiatry. 2023 Jul 28;14:1215110. doi: 10.3389/fpsyt.2023.1215110. PMID: 37575562; PMCID: PMC10416632. (IF:5.4)
3. Zhuang W, Ye T, Wang W, Song W, Tan T*. CTNNB1 in neurodevelopmental disorders. Front Psychiatry. 2023 Mar 16;14:1143328. doi: 10.3389/fpsyt.2023.1143328. PMID: 37009120; PMCID: PMC10061110. (IF:5.4)
4. Wang X, Mei D, Gou L, Zhao S, Gao C, Guo J, Luo S, Guo B, Yang Z, Wang Q, Tan T*, Zhang Y*. Functional Evaluation of a Novel GRIN2B Missense Variant Associated with Epilepsy and Intellectual Disability. Neuroscience. 2023 Aug 21;526:107-120. doi: 10.1016/j.neuroscience.2023.06.018. Epub 2023 Jun 28. PMID: 37385334. (IF:3.7)
5. Zhao K, Zhou X, Chen M, Gou L, Mei D, Gao C, Zhao S, Luo S, Wang X*, Tan T*, Zhang Y*. Neuroprotective Effects of CXCR2 Antagonist SB332235 on Traumatic Brain Injury Through Suppressing NLRP3 Inflammasome. Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04021-8. Epub ahead of print. PMID: 37702890. (IF:4.4)
6. Wang W, Xie X, Zhuang X, Huang Y, Tan T, Gangal H, Huang Z, Purvines W, Wang X, Stefanov A, Chen R, Rodriggs L, Chaiprasert A, Yu E, Vierkant V, Hook M, Huang Y, Darcq E, Wang J*. Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect. Cell Rep. 2023 Feb 28;42(2):112089. doi: 10.1016/j.celrep.2023.112089. Epub 2023 Feb 15. PMID: 36796365; PMCID: PMC10404641. (IF:8.8)
往期成果
Google Scholar Citations: 1164; h-index: 20; i10-index: 26
1. Huanxin Chen; Ting He; Meiyi Li; Chunlian Wang; Chen Guo; Wei Wang; Baocong Yu; JintaoHuang; Lijun Cui; Ping Guo; Yonggui Yuan; Tao Tan ; Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons, Frontiers in Psychiatry, 2023, 13(1070478): 1-11 (期刊论文) IF=5.6
2. Tao Tan; Wei Wang; Tiaotiao Liu; Ping Zhong; Megan Conrow-Graham; Xin Tian; Zhen Yan; Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress., Cell reports, 2021, 34(12): 108874 (期刊论文) IF=9.4
3. Maximiliano Rapanelli; Tao Tan; Wei Wang; Xue Wang; Zi-Jun Wang; Ping Zhong; Luciana Frick; Luye Qin; Kaijie Ma; Jun Qu; Zhen Yan ; Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3, Molecular Psychiatry, 2021, 2021(26): 1491-1504 (期刊论文) IF=15.99
4. Tao Tan; Wei Wang; Jamal Williams; Kaijie Ma; Qing Cao; Zhen Yan ; Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission, Schizophrenia Bulletin, 2019, 45(5): 1012-1023 (期刊论文) IF=9.3
5. Tao Tan; Wei Wang; Haitao Xu; Zhilin Huang; Yu Tian Wang; Zhifang Dong ; Low-Frequency rTMS Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation Through Regulating the Synaptic GABA Transmission, Frontiers in Cellular Neuroscience, 2018, 12: 46 (期刊论文) IF=4.555
已发表的其余论著：
1. Tan, Tao; Zhang, Yun; Luo, Wenhong; Lv, Jihui; Han, Chanshuai; Hamlin, Jason N. R.; Luo, Hongjun; Li, Hui; Wan, You; Yang, Xu; Song, Weihong; Tong, Zhiqian ; Formaldehyde induces diabetes-associated cognitive impairments, FASEB JOURNAL, 2018, 7(32): 3669-3679 (期刊论文) IF=5.5
2. Tao Tan; Jiacun Xie; Tiaotiao Liu; Xiaojia Chen; Xiaobo Zheng; Zhiqian Tong; Xin Tian; Low-frequency (1Hz) repetitive transcranial magnetic stimulation (rTMS) reverses Aβ1–42- mediated memory deficits in rats, Experimental Gerontology, 2013, 48(8): 786-794 (期刊论文) IF=3.911
3. Tao Tan; Jiacun Xie; Zhiqian Tong; Tiaotiao Liu; Xiaojia Chen; Xin Tian ; Repetitive transcranial magnetic stimulation increases excitability of hippocampal CA1 pyramidal neurons, Brain Research, 2013, 1520: 23-35 (期刊论文) IF= 2.879
4. Li Ai; Tao Tan; Yonghe Tang; Jun Yang; Dehua Cui; Rui Wang; Aibo Wang; Xuechao Fei; Yalan Di; Xiaoming Wang; Yan Yu; Shengjie Zhao; Weishan Wang; Shangying Bai; Xu Yang; Rongqiao He; Weiying Lin; Hongbin Han; Xiang Cai; Zhiqian Tong ; Endogenous formaldehyde is a memory-related molecule in mice and humans, Communications Biology, 2019, 2(1): 446 (期刊论文) IF=6.3 (Co-first)
5. Wang W.; Tan T.; Yu Y.; Huang Z.; Du Y.; Han H.; Dong Z. ; Inhibition of AMPAR endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression, Behav Brain Res, 2018, 339: 66-72 (期刊论文) IF=3.0 (Co-first)
6. Guo, Dongyong; Gan, Jianhui; Tan, Tao; Tian, Xin; Wang, Guolin; Ng, Kevin Tak-Pan ; Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats, COGNITIVE NEURODYNAMICS, 2018, 4(12): 377-383 (期刊论文) IF=1.83 (Co-first)
7. Huang Zhilin; Tan Tao; Du Yehong; Chen Long; Fu Min; Yu Yanzhi; Zhang Lu; Song Weihong; Dong Zhifang ; Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Function and Synaptic Plasticity in APP23/PS45 Mouse Model of Alzheimer’s Disease, Frontiers in Aging Neuroscience, 2017, 9: 1-9 (期刊论文) IF=4.5 (Co-first)
8. Ying Shen; Xinyu Cao; Tao Tan; Chunlei Shan; Yingjie Wang; Jibin Pan; Hao He; Ti-Fei Yuan; 10-Hz Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex Reduces Heroin Cue Craving in Long-Term Addicts, Biological Psychiatry, 2016, 80(3): e13-e14 (期刊论文) IF=13.4 (Co-first)
9. Wei Wang; Tao Tan; Man Tu; Wenting He; Zhifang Dong; Huili Han ; Acute pentobarbital treatment impairs spatial learning and memory and hippocampal long-term potentiation in rats, Physiology & Behavior, 2015, 149: 169-173 (期刊论文) IF=2.9 (Co-first)
10. Benjamin Rein; Tao Tan; Fengwei Yang; Wei Wang; Jamal Williams; Freddy Zhang; Alea Mills; Zhen Yan ; Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4, Molecular Psychiatry, 2021, 26: 1967-1979 (期刊论文) IF=15.99
11. Wang W, Xie X, Zhuang X, Huang Y, Tan T, Gangal H, Huang Z, Purvines W, Wang X, Stefanov A, Chen R, Rodriggs L, Chaiprasert A, Yu E, Vierkant V, Hook M, Huang Y, Darcq E, Wang J. Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect. Cell Rep. 2023 Feb 7:112089. IF=9.4
12. Qin, Luye, Jamal B. Williams, Tao Tan, Tiaotiao Liu, Qing Cao, Kaijie Ma, and Zhen Yan. "Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures." Nature communications 12, no. 1 (2021): 1-14. IF=14.919
13. Wang W, Cao Q, Tan T, Yang F, Williams JB, Yan Z. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging Cell. 2021 Oct;20(10):e13456. IF=9.3
14. Wang, W., Rein, B., Zhang, F., Tan, T., Zhong, P., & Qin, L., et al. (2018). Chemogenetic activation of prefrontal cortex rescues synaptic and behavioral deficits in a mouse model of 16p11.2 deletion syndrome. Journal of Neuroscience, 44(6 Suppl), 99. IF=5.99
15. Zhu, Binglin, B Zhu, L Zhao, D Luo, D Xu, T Tan, Z Dong, Y Tang, et al. (2018). Furin promotes dendritic morphogenesis and learning and memory in transgenic mice. Cellular and Molecular Life Sciences: 1-16. IF=5.79
16. Wei, J., Zhong, P., Qin, L., Tan, T., & Yan, Z*. (2018). Chemogenetic Restoration of the Prefrontal Cortex to Amygdala Pathway Ameliorates Stress-Induced Deficits. Cerebral Cortex, 1-11. IF=6.56
17. Huang, X., Chen, Y. Y., Shen, Y., Cao, X., Li, A., Liu, Tao, T, Q., ... & Arias-Carrion, O*. (2017). Methamphetamine abuse impairs motor cortical plasticity and function. Molecular Psychiatry, 22(9), 1274. IF=13.3
18. Peng, Y., W. Wang, T. Tan, W. He, Z. Dong, Y. T. Wang and H. Han (2016). "Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the offspring rats." Mol Brain 9(1): 17. IF= 4.9
19. Zhou, Limin; Bai, Yanjie; Li, Yanxi; Liu, Xueliang; Tan, Tao; Meng, Shasha; He, Wenting; Wu, Xiaobin; Dong, Zhifang. (2016). Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells. Oncology Letters, 11, 1, 365-372. IF= 2.3
20. Chen, L., W. Wang, T. Tan, H. Han and Z. Dong*. (2015). Gaba Receptors in the Central Nucleus of the Amygdala Are Involved in Pain- and Itch-Related Responses. J Pain. IF= 4.1
21. Zhifang Dong, Huili Han, Tao Tan, Yutian Wang*, etc. (2014). Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis. J Clin Invest, p. 1-14. IF= 13.77
22. Xiaoyan Wu, Yanrui Bai, Tao Tan, Zhifang Dong*, etc. (2014). Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats. Front Behav Neurosci, 8: p. 1-12. IF= 4.2
23. Liu, T., W. Bai, H. Yi, T. Tan, J. Wei, J. Wang and X. Tian (2014). "Functional connectivity in a rat model of Alzheimer's disease during a working memory task." Curr Alzheimer Res 11(10): 981-991. IF= 3.89
24. Liu Aili, Li Yize, Tan Tao, Tian Xin*, (2014). Early exposure to sevoflurane inhibits Ca2+ channels activity in hippocampal CA1 pyramidal neurons of developing rats. Brain Research, 1557: p. 1-11. IF= 2.83
25. Chen, Xiaojia; Tan, Tao; Liu, Tiaotiao; Tian, Xin. (2013). Changes of IA and IK from the pyramidal neurons at hippocampal CA1 during the early development of rats. Sheng li xue bao:[Acta physiologica Sinica], 65, 2, 193-200
26. GUO, D. Y., TAN, T., TIAN, X., & WANG, G. L. (2012). Effect of ketamine injected into cerebro ventriles on synaptic plasticity of hippocampus in adult SD rats. Journal of Tianjin Medical University, 2, 016.
27. GUO, Dong-yong; TAN, Tao; TIAN, Xin; WANG, Guo-lin. (2012). Neonatal ketamine exposure-induced cognitive dysfunction persists into adulthood in rats, Chinese Journal of Anesthesiology. 32, 4, 420-422
28. Zhang, B., Chen, X., Lin, Y., Tan, T., Yang, Z., Dayao, C., ... & Zhang, J. (2011). Impairment of synaptic plasticity in hippocampus is exacerbated by methylprednisolone in a rat model of traumatic brain injury. Brain Research, 1382, 165-172. IF= 2.83
29. Zhang, B. L., Chen, X., Tan, T., Yang, Z., Carlos, D., Jiang, R. C., & Zhang, J. N. (2011). Traumatic brain injury impairs synaptic plasticity in hippocampus in rats. Chinese Medical Journal-Beijing, 124(5), 740.
30. Bei, Fang; Tan, Tao; Tian, Xin. (2011). Diabetes suppresses hippocampal synaptic plasticity in rats, International Journal of Biomedical Engineering. 34, 3, 150-153
31. Bei, Fang; Tan, Tao; Tian, Xin. (2010). Study on the Use of Water Maze to Test the Change of Spatial Memory Ability in Diabetic Rats, International Journal of Biomedical Engineering. 6, 321-325
论著之外的代表性研究成果和学术奖励：
1. 谭涛(1/1); 低频rTMS增强Abeta模型大鼠学习记忆功能的研究, 天津市人民政府学位委员会，天津市教育委员会, 自然科学, 其他, 2015(谭涛) (科研奖励)
2. 谭涛(1/1); 低频rTMS增强Abeta模型大鼠学习记忆功能的研究, 天津医科大学学位评定委员会, 自然科学, 其他, 2014(谭涛) (科研奖励)
3. 2015-10-31至2015-11-01, 举办西部地区膜片钳技术研讨会暨培训班, 重庆, 重庆医科大学附属儿童医院, 谭涛、董志芳 (举办或参加学术会议)
4. Tao Tan ; Cortical and Thalamic Inputs to D2-MSNs Distinctly Mediate Alcohol Seeking and Extinction, Neuroscience 2021, online, 2021-11-8至2021-11-11 (会议报告)
5. Tao Tan ; D1-MSN ensembles in the dorsomedial striatum positively regulate alcoholseeking and relapse, Neuroscience 2021, online, 2021-11-8至2021-11-11 (会议报告)
6. Tao Tan ; Inhibitory role of D2MSN in Alcohol addiction, 44th Annual RSA Scientific Meeting / ISBRA Congress VIRTUAL, online, 2021-6-19至2021-6-23 (会议报告)
7. Tao Tan ; Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress, SfN Global Connectome virtual event 2020, online, 2021-1-11至2021-1-13 (会议报告)
8. 谭涛 ; 实用膜片钳技术：膜片钳原理及应用, 西部地区膜片钳技术研讨会暨培训班, 重庆, 2015-10-31至2015-11-1 (会议报告)
9. Tao Tan ; Research on effects and mechanisms of maternal sleep deprivation on emotional and cognitive function in offsprings, 5th International Ion Channel Symposium, Sichuan, 2015-6-26至2015-6-30 (会议报告)
10. 谭涛 ; TMS在儿科上的应用及研究进展, 儿童康复诊疗新进展暨小儿脑瘫康复护理学习班, 长沙, 2015-6-13至2015-6-14 (会议报告)
个人荣誉
曾获奖励：
1. 2021, “Trainee Professional Development Award”, 2021 SfN Global Connectome virtual event;
2. 2020, “1st place of oral presentation (postdoc/research scientist)”, Neuroscience Across Texas-Virtual Symposium;
3. 2015, “Outstanding Doctoral Thesis of Tianjin”;
4. 2015, Chair of West China Patch-clamp training and technical seminar (2015)
5. 2014, “Outstanding Doctoral Thesis of Tianjin Medical University”;
6. 2014, “Excellence Teaching Award of CHCMU”;
学术任职：
1. Editor Board Member: Since 2017,
Review Editor: Frontiers in Behavioral Neuroscience;
Editor Board Member: Journal of Neuroscience and Cognitive Studies; the Anesthesia & Critical Care;
2. Reviewer: Since 2016, Reviewer for Frontiers in Pharmacology, Frontiers in Neuroscience, Frontiers in Behavioral Neuroscience, Brain Research, Clinical Medicine Insights: Cardiology, Alzheimer's, Dementia & Cognitive Neurology, International Journal of Clinical Anesthesiology, et al.
3. Member: Since 2015, Member of Society for Neuroscience, ISBRA (International Society for Biomedical Research on Alcoholism), The Chinese Neuroscience Society
受邀报告：
1. 2021, “Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress”, online, Young Neuroscientist Zoom meeting #35
2. 2021, “Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress”, Baylor College of Medicine, Dr. Andreas Tolias (founder and director of Center for Neuroscience and Artificial Intelligence)
3. 2021, “Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress”, online, Brain news (~1000 attendance)
4. 2020, “Genetic and environmental risk factors for neuronal developmental disorders”, Texas A&M University, Dr. Jun Wang and William H. Griffith (Regents Professor, Dean);
5. 2020, “Genetic and environmental risk factors for neuronal developmental disorders and potential non-invasive treatment”, The Jackson Laboratory, Dr. Catherine Kaczorowski (Chair);
6. 2020, “Genetic and environmental risk factors for neuronal developmental disorders”, University of Pittsburgh, Dr. Susanne Ahmari (Director);
7. 2019, “Genetic and environmental risk factors of autism”, University of Pennsylvania, Dr. Frances E. Jensen (FACP, Chair);
8. 2019, “Genetic and environmental risk factors of autism”, University at Buffalo Center for Hearing and Deafness, Dr. Richard Salvi (Distinguished professor, Director);
9. 2015, “Updates of research and application of TMS in pediatrics”, Hunan Children’s Hospital;
10. 2015, “Practical patch-clamp techniques”, West China Patch-clamp training and technical seminar (2015).
