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成果及论文
  • 1. Tong Zhao, Qing Meng, Zhuosen Sun, Yanyu Chen, Wei Ai, Zean Zhao, Dongwei Kang, Yue Dong, Ruipeng Liang, Ting Wu, Jianxin Pang, Xinyong Liu*, Peng Zhan*. Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability. J Med Chem. 2020. doi: 10.1021/acs.jmedchem.0c00223.      
  • 2. Lin Sun, Alexej Dick, Megan E Meuser, Tianguang Huang, Waleed A Zalloum, Chin-Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin*, Kuo-Hsiung Lee*, Xinyong Liu*, Peng Zhan*. Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. J Med Chem. 2020, 63(9): 4790-4810.        
  • 3. Dongwei Kang, Da Feng, Yanying Sun, Zengjun Fang, Fenju Wei, Erik De Clercq, Christophe Pannecouque*, Xinyong Liu*, Peng Zhan*. Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. J Med Chem. 2020, 63(9): 4837-4848.        
  • 4. Dongwei Kang, F. Xavier Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, Erik De Clercq, Christophe Pannecouque, Eddy Arnold*, Xinyong Liu*, Peng Zhan*. Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. J Med Chem. 2020, 63(3): 1298-1312.
  • 5. Dongwei Kang, Tong Zhao, Zhao Wang, Da Feng, Heng Zhang, Boshi Huang, Gaochan Wu, Fenju Wei, Zhongxia Zhou, Lanlan Jing, Xiaofang Zuo, Ye Tian, Vasanthanathan Poongavanam , Jacob Kongsted , Erik De Clercq , Christophe Pannecouque*, Peng Zhan*, Xinyong Liu*. Discovery of piperidine-substituted thiazolo[5,4-d] pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors. Communication Chemistry. 2019;2:74.
  • 6. Gaochan Wu, Tong Zhao, Dongwei Kang, Jian Zhang, Yuning Song, Vigneshwaran Namasivayam, Jacob Kongsted, Christophe Pannecouque, Erik De Clercq, Vasanthanathan Poongavanam, Xinyong Liu*, Peng Zhan*. Overview of Recent Strategic Advances in Medicinal Chemistry. J Med Chem, 2019, Nov 14;62(21):9375-414.
  • 7. Dongwei Kang, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, Francisco Javier Luque, Yang Yang, Gaochan Wu, Da Feng, Fenju Wei, Jian Zhang, Erik De Clercq, Christophe Pannecouque, Chin Ho Chen, Kuo-Hsiung Lee, N. Arul Murugan, Thomas A. Steitz, Peng Zhan*, Xinyong Liu*. Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties, J Med Chem, 2019, 62(3): 1484-1501.  
  • 8. Boshi Huang, Wenmin Chen, Tong Zhao, Zhenyu Li, Xiangyi Jiang, Tiziana Ginex, David Vílchez, Francisco Javier Luque, Dongwei Kang, Ping Gao, Jian Zhang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque*, Peng Zhan*, Xinyong Liu*, Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles, J Med Chem, 2019, 62(4): 2083-98.  
  • 9. Xiangyi Jiang, Ji Yu, Zhongxia Zhou, Jacob Kongsted, Yuning Song, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Vasanthanathan Poongavanam, Xinyong Liu*, Peng Zhan*. Molecular design opportunities presented by solvent-exposed regions of target proteins. Medicinal Research Reviews. 2019 Nov;39(6):2194-238  
  • 10. Yang Yang, Dongwei Kang, Laura A Nguyen, Zachary B Smithline, Christophe Pannecouque, Peng Zhan*, Xinyong Liu*, Thomas A Steitz*. Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors, Elife, 2018, 7: e36340.  
  • 11. Zhang, Jian; Poongavanam, Vasanthanathan; Kang, Dongwei; Bertagnin, Chiara; Lu, Huamei; Kong, Xiujie; Ju, Han; Lu, Xueyi; Gao, Ping; Tian, Ye; Jia, Haiyong; Desta, Samuel; Ding, Xiao; Sun, Lin; Fang, Zengjun; Huang, Boshi; Liang, Xuewu; Jia, Ruifang; Ma, Xiuli; Xu, Wenfang; Murugan, Natarajan Arul; Loregian, Arianna; Huang, Bing*; Zhan, Peng*; Liu*, Xinyong*, Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant, J Med Chem, 2018, 61(14):6379-97.  
  • 12. Zhang, Jian; Murugan, Natarajan Arul; Tian, Ye; Bertagnin, Chiara; Fang, Zengjun; Kang, Dongwei; Kong, Xiujie; Jia, Haiyong; Sun, Zhuosen; Jia, Ruifang; Gao, Ping; Poongayanam, Vasanthanathan; Loregian, Arianna; Xu, Wenfang; Ma, Xiuli; Ding, Xiao; Huang, Bing*; Zhan, Peng*; Liu, Xinyong*, Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant, J Med Chem, 2018, 61(22):9976-99.  
  • 13. Dongwei Kang, Zengjun Fang, Boshi Huang, Xueyi Lu, Heng Zhang, Haoran Xu, Zhipeng Huo, Zhongxia Zhou, Zhao Yu, Qing Meng, Gaochan Wu, Xiao Ding, Ye Tian, Dirk Daelemans, Eric De Clercq, Christophe Pannecouque*, Peng Zhan*, Xinyong Liu*. Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants. J Med Chem. 2017;60(10):4424-43.  
  • 14. Kang, Dongwei; Fang, Zengjun; Li, Zhenyu; Huang, Boshi; Zhang, Heng; Lu, Xueyi; Xu, Haoran; Zhou, Zhongxia; Ding, Xiao; Daelemans, Dirk; De Clercq, Erik;Pannecouque, Christophe*; Zhan, Peng*; Liu, Xinyong*. Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles. J Med Chem. 2016, 59(17):7991-8007.  
  • 15. Peng Zhan*, Dongwei Kang, and Xinyong Liu*. Resurrecting the Condemned: Identification of N-Benzoxaborole Benzofuran GSK8175 as a Clinical Candidate with Reduced Metabolic Liability. J Med Chem. 2019, 62(7):3251-3253.  
  • 16. Shuo Zhang, Jian Zhang, Ping Gao, Lin Sun, Yuning Song, Dongwei Kang*, Xinyong Liu*, Peng Zhan*.Efficient drug discovery by rational lead hybridization based on crystallographic overlay. Drug Discov Today. 2019, 24(3):805-813.  
  • 17. Lanlan Jing, Gaochan Wu, Dongwei Kang, Zhongxia Zhou, Yuning Song, Xinyong Liu*, Peng Zhan*.Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors. Drug Discov Today. 2019, 24(2):629-635.  
  • 18. Zhongxia Zhou, Tao Liu, Jian Zhang, Peng Zhan*, Xinyong Liu*.Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics. Drug Discov Today. 2018, 23(3):503-518.  
  • 19. Wu, Gaochan; Zalloum, Waleed A.; Meuser, Megan E.; Jing, Lanlan; Kang, Dongwei; Chen, Chin-Ho; Tian, Ye; Zhang, Fangfang; Cocklin, Simon*; Lee, Kuo-Hsiung*; Liu, Xinyong*; Zhan, Peng*. Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. Eur J Med Chem. 2018 Oct 5;158:478-92.  
  • 20. Tian, Ye; Liu, Zhaoqiang; Liu, Jinghan; Huang, Boshi; Kang, Dongwei; Zhang, Heng; De Clercq, Erik; Daelemans, Dirk; Pannecouque, Christophe; Lee, Kuo-Hsiung; Chen, Chin-Ho; Zhan, Peng*; Liu, Xinyong*. Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus. Eur J Med Chem. 2018 May 10;151:339-50.  
  • 21. Sun, Lin; Gao, Ping; Dong, Guanyu; Zhang, Xujie; Cheng, Xiqiang; Ding, Xiao; Wang, Xueshun; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe*; Menendez-Arias, Luis*; Zhan, Peng*; Liu, Xinyong*. 5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase. Eur J Med Chem. 2018 Jun 18;155:714-24.  
  • 22. Ju, Han; Zhang, Jian; Sun, Zhuose;Huang, Zheng; Qi, Wenbao; Huang, Bing; Zhan, Peng*; Liu, Xinyong*. Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors. Eur J Med Chem. 2018 Feb 25;146:220-31.  
  • 23. Huo, Zhipeng; Zhang, Heng; Kang, Dongwei; Zhou, Zhongxia; Wu, Gaochan; Desta, Samuel; Zuo, Xiaofang; Wang, Zhao; Jing, Lanlan; Ding, Xiao; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng*; Liu, Xinyong*. Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site. ACS Med Chem Lett. 2018 Feb 27;9(4):334-8.  
  • 24. Kang, Dongwei; Wang, Zhao; Zhang, Heng; Wu, Gaochan; Zhao, Tong; Zhou, Zhongxia;Huo, Zhipeng; Huang, Boshi; Feng, Da; Ding, Xiao; Zhang, Jian; (Zuo, Xiaofang; Jing, Lanlan; Luo, Wei; Guma, Samuel; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng*; Liu, Xinyong*. Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery. ACS Med Chem Lett. 2018 Mar 1;9(4):370-5.  
  • 25. Zhou, Zhongxia; Liu, Tao; Kang, Dongwei; Huo, Zhipeng; Wu, Gaochan; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng*; Liu, Xinyong*. Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel". Org Biomol Chem. 2018 Feb 7;16(6):1014-28.  
  • 26. Han Ju, Jian Zhang, Boshi Huang, Dongwei Kang, Bing Huang*, Xinyong Liu*, Peng Zhan*. Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives. Journal of Medicinal Chemistry. 2017;60(9):3533-51.  
  • 27. Dongwei Kang, Xiao Ding, Gaochan Wu, Zhipeng Huo, Zhongxia Zhou, Tong Zhao, Da Feng, Zhao Wang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan*, and Xinyong Liu*. Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP. ACS Med Chem Lett. 2017;8(11):1188-93.  
  • 28. Zhan, Peng; Pannecouque, Christophe; De Clercq, Erik*; Liu, Xinyong*. Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends. Journal of Medicinal Chemistry. 2016, 59(7): 2849-78.  
  • 29. Zhan, Peng; Itoh, Yukihiro; Suzuki, Takayoshi*; Liu, Xinyong*. Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators. Journal of Medicinal Chemistry. 2015, 58, 7611-33.  
  • 30. Dongyue Li, Peng Zhan, Erik De Clercq, Xinyong Liu*. Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of six representative candidates. Journal of Medicinal Chemistry, 2012, 55 (8), pp 3595–361.  
  • 31. Wenjun Li, Peng Zhan, Erik De Clercq, Hongxiang Lou*, Xingyong Liu*. Current Drug research on PEGytion with small molecular agents. Progress in Polymer Science, 2013; 38: 421-444.  
  • 32. Haiyong Jia, Yang Song, Ji Yu, Peng Zhan, Diwakar Rai, Xiaohong Liang, Chunhong Ma, Xinyong Liu*. Design, synthesis and primary biological evaluation of the novel 2-pyridone derivatives as potent non-nucleoside HBV inhibitors. Eur J Med Chem. 2017;136:144-53.