本课题组致力于新方法、新配体、新催化剂、新试剂的开发，以实现不饱和烃类和生命基础小分子等大宗化学品的高效官能团化。目前特别关注两个领域的策略应用，一是探究过渡金属参与实现的非经典ƞ³-取代反应。二是探索活性分子如糖、核酸的高选择性的合成和修饰。同时，通过深入的机理研究，理解和指导新反应、新课题的提出。

    Representative work:

一.  非经典的不对称 ƞ³-取代

12. Yang Liu, Ye-Wei Chen, Yuan-Xiang Yang, John F. Hartwig*, Zhi-Tao He*. Asymmetric Amination of Unstrained C(sp3)–C(sp3) Bonds. J. Am. Chem. Soc. 2024, 146, 29857–29864.

11. Ming-Qiao Tang, Zi-Jiang Yang, Ai-Jun Han, and Zhi-Tao He*. Diastereoselective and Enantioselective Hydrophosphinylations of Conjugated Enynes, Allenes and Dienes via Synergistic Pd/Co Catalysis. Angew. Chem. Int. Ed. 2024, 63, e202413428. 

10. Ye-Wei Chen#, Yehao Qiu#, Yang Liu, Guo-Qiang Lin, John F. Hartwig*, and Zhi-Tao He*. Intermolecular asymmetric functionalization of unstrained C(sp3)–C(sp3) bonds in allylic substitution reactions. Nature Synthesis, 2024, 3, 1011–1020.

9. Yu-Ze Sun,# Zi-Yang Ren,# Yuan-Xiang Yang, Yang Liu, Guo-Qiang Lin* and Zhi-Tao He*. Asymmetric Substitution by Alkynyl Copper Driven Dearomatization and Rearomatization. Angew. Chem. Int. Ed. 2023, 62, e202314517.

8. Ming-Qiao Tang#, Zi-Jiang Yang#, Zhi-Tao He*. Asymmetric Formal sp2-Hydrocarbonations of Dienes and Alkynes via Palladium Hydride Catalysis. Nature Communications, 2023, 14, 6303.

7. Xian-Xiao Chen,# Hao Luo,# Ye-Wei Chen, Yang Liu, Zhi-Tao He.* Enantioselective Palladium-Catalyzed Directed Migratory Allylation of Remote Dienes. Angew. Chem. Int. Ed. 2023, 62, e202307628.

6. Xin Wang, Han-Zhe Miao, Guo-Qiang Lin* and Zhi-Tao He*. Ligand-Dictated Regiodivergent Allylic Functionalizations via Palladium-Catalyzed Remote Substitution. Angew. Chem. Int. Ed. 2023, 62, e202301556.

5. Shao-Qian Yang, Ai-Jun Han, Yang Liu, Xin-Yuan Tang, Guo-Qiang Lin* and Zhi-Tao He*. Catalytic Asymmetric Hydroalkoxylation and Formal Hydration and Hydroaminoxylation of Conjugated Dienes. J. Am. Chem. Soc. 2023, 145, 3915-3925.

4. Yu-Chao Wang,# Zhao-Xin Xiao,# Miao Wang,# Shao-Qian Yang, Jin-Biao Liu and Zhi-Tao He*. Umpolung Asymmetric 1,5-Conjugate Addition via Palladium Hydride Catalysis. Angew. Chem. Int. Ed. 2023, 62, e202215568.

3. Jiang-Shan Ma#, Han-Yu Lu#, Ye-Wei Chen, Wei-Cheng Zhao, Yu-Ze Sun, Rui-Peng Li, Hu-Xiao Wang, Guo-Qiang Lin*, Zhi-Tao He*. Copper-Catalyzed Convergent Regio- and Enantioselective Alkynylallylic Substitution. Nature Synthesis 2023, 2, 37-48.

2. Ye-Wei Chen,# Yang Liu,# Han-Yu Lu, Guo-Qiang Lin* and Zhi-Tao He*. Palladium-Catalyzed Regio- and Enantioselective Migratory Allylic C(sp3)-H Functionalization. Nature Communications, 2021, 12, 5626.

1. Shao-Qian Yang,# Yi-Fan Wang,# Wei-Cheng Zhao, Guo-Qiang Lin* and Zhi-Tao He*. Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis. J. Am. Chem. Soc. 2021, 143, 7285–7291.

二.  活性小分子的合成和修饰。

1. Wei-Cheng Zhao,# Rui-Peng Li,# Chao Ma, Qi-Ying Liao, Miao Wang, and Zhi-Tao He*. Stereoselective gem-C,B-Glycosylation via 1,2-Boronate Migration. J. Am. Chem. Soc. 2022, 144, 2460-2467.