Bioactive natural product-based drug discovery

Associate Professor Innovative natural product-based drug discovery

Dr. Xu Deng is an Associate Professor and doctoral supervisor at the School of Pharmacy, Central South University, China. He was selected as a Distinguished Young Scholar of Hunan Province, a high-level talent in the health sector of Hunan Province, and a young backbone teacher in Hunan Province. His main research interests lie in the synthesis of natural products and the development of new drugs based on active natural products. He has successively led more than 20 longitudinal projects, including the National Natural Science Foundation of China, the High-level Foreign Expert Introduction Program of the Ministry of Science and Technology, and the Key Research and Development Program of Hunan Province. He has participated in two national key research and development projects (as the sub-project leader). He has published over 50 SCI papers, among which he is the first author/corresponding author (including co-authors) in high-level journals such as Nat. Comm., Angew. Chem. Int. Ed., Cell Death Differ., and J. Med. Chem., with a total citation of over 1000 times (Google Scholar) and an H-index of 19. He has filed 20 patents (9 as the first inventor), of which 12 have been granted. He was awarded the 2020 Thieme Chemistry Journals Award and a second prize in Natural Science of Yunnan Province. Additionally, Dr. Deng has been invited to serve as a Young Editorial Board Member of Natural Products & Bioprospecting and as a reviewer for over 20 academic journals including Adv. Sci., Theranostics, and J. Med. Chem.

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Our research group focuses on  infectious diseases and cancer, using bioactive natural products as the tools.  We have developed various efficient and selective synthetic methods for natural product frameworks, constructed a diverse library of focused natural products, obtained several unique bioactive natural product candidates, and identified and confirmed the targets and mechanisms of novel structured natural products.  

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