代表性论文:
(1). Tingting Liu#, Qing Wang #, Yuxin Zhou, Baixin Ye, Tingting Liu, Linyang Yan, Jinbao Fan, Yingjun Zhou, Zanxian Xia*, Xu Deng*; Discovery of a meisoindigo-derived PROTAC as the ATM degrader: revolutionizing colorectal cancer therapy via synthetic lethality with ATR inhibitors. Journal of Medicinal Chemistry, 2024, 67 (9), 7620-7634
(2)Qingtian Gao#, Sixu Liu#, Yuzheng Zhou, Jinbao Fan, Shufen Ke, Yuqing Zhou, Kaiqiang Fan, Yuxuan Wang, Yingjun Zhou, Zanxian Xia*, Xu Deng*, Discovery of Meisoindigo derivatives as noncovalent and orally available Mpro inhibitors: their therapeutic implications in the treatment of COVID-19. European Journal of Medicinal Chemistry, 2024. 273, 116498.
(3)Moude Liu#, Qin Tang#, Qing Wang, Weixi Xie, Jinbao Fan, Siyuan Tang, Wei Liu, Yingjun Zhou*, Xu Deng*; Rapid access to icetexane diterpenes: their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-B axis in macrophages. European Journal of Medicinal Chemistry, 2023, 260, 115769.
(4). Yan Wu#, Moude Liu#, Qing Wang, Huan Tian, Jinbao Fan, Yingjun Zhou, Yajing Wang*, Xu Deng*; Divergent Synthesis of Bis(indolyl) methanes via FeIII catalyzed Regioselective Dehydrogenative Coupling Reactions: A Biomimetic Approach to 6,6’-bis-(debromo)-gelliusine F. Organic & Biomolecular Chemistry, 2023, 21, 639-643 (IF = 3.876).
(5). Shuting Yang#, Jinbao Fan#, Tingting Liu#, Shuai Ning, Jiahao Xu, Yingjun Zhou*, Xu Deng*; Development of strigolactones as novel autophagy/mitophagy inhibitors against colorectal cancer cells by blocking the autophagosome-lysosome fusion. Journal of Medicinal Chemistry, 2022, 65, 9706-9713.
(6). Qing Wang, Senlin Wang, Jinbao Fan, Guangyao Zeng, Yingjun Zhou*, Xu Deng*; Acid-promoted intra- and intermolecular [2+2] cycloaddition of indoles with aryl alkynes to access cyclobutene-based indolines. Chem. Comm., 2022, 58, 9270-9273 (IF = 6.06).
(7). Xu Deng#, Suling Huang#, Jian Ren, Zhenghong Pan, Yu Shen, Haofeng Zhou, Zhili Zuo*, Ying Leng*, Qinshi Zhao*; Development and structure-activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors. Nat. Prod. Bioprospect., 2022, 12. 36
(8). Wei Cao#, Tingting Liu#, Shuting Yang, Moude Liu, Zhenghong Pan, Yingjun Zhou*, Xu Deng*; Efficient synthesis of icetexane diterpenes and apoptosis inducing effect by upregulating Bip-ATF4-CHOP axis in colorectal cells. Journal of Natural Products, 2021, 84, 2012-2019.
(9)Xu Deng#, Li-Yang Shi#, Jia-ling Lan#, Yu-Qing Guan, Xiao-yong Zhang, Hui Lv*, Lung-Wa Chung*, Xu-mu Zhang*; Enantioselective rhodium-catalyzed cycloisomerization of 1,6-allenynes to access 5/6-fused bicycle[4.3.0]nonadienes, Nature Communications, 2019, 10, 949-959 (#equal contribution).
(10). Xu Deng, Shao-Fei Ni, Zheng-Yu Han, Yu-Qing Guan, Hui Lv, Li Dang*, Xu-Mu Zhang*, Enantioselective rhodium-catalyzed cycloisomerization of (E)-1,6-enynes. Angewandte Chemie International Edition, 2016, 55, 6295-6299.
(11)Wei Cao, Jin-Bao Fan, Ling-Yang Yan, Guang-Yao Zeng, Jin-Jin Ma, Ya-Jing Wang, Ying-Jun Zhou*, Xu Deng*, Divergent reactivity in CuII-catalyzed oxidative coupling between indole/tryptamine derivatives and β-arylacrylic acids, Organic Letters, 2019, 21, 9506-9511.
(12)Xu Deng, Kang-Jiang Liang, Xiao-Gang Tong, Ming Ding, Da-Shan Li, Cheng-Feng Xia*, Copper-catalyzed radical cyclization to access 3-hydroxypyrroloindoline: biomimetic synthesis of protubonine A, Organic Letters, 2014, 16, 3276-3279.
(13)Xiaofeng Chen#, Jinbao Fan#, Guangyao Zeng, Jinjin Ma, Chenxi Wang, Yajing Wang, Yingjun Zhou*, Xu Deng*; Access to 3a-benzoylmethyl pyrrolidino[2,3-b]indolines via CuII-catalyzed radical annulation/C3-functionalization sequence, The Journal of Organic Chemistry, 2018, 83 (15), 8322–8330.
(14)Jin-jin Ma#, Lan Chen#, Jin-bao Fan, Wei Cao, Guang-yao Zeng, Ya-jing Wang, Yuan-jian Li, Ying-jun Zhou*, Xu Deng*; Dual-targeting rutaecarpine-NO donor hybrids as novel anti-hypertensive agents by promoting release of CGRP, European Journal of Medicinal Chemistry, 2019, 168, 146-153 .
(15)Xu Deng, Yu Shen, Jing Yang, Juan He, Yu Zhao, Li -Yan Peng, Ying Leng*, Qin-Shi Zhao*, Discovery and structure-activity relationships of ent-kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes, European Journal of Medicinal Chemistry, 2013, 65, 403-414.
(16)Xu Deng, Jia Su, Yu Zhao, Li-Yan Peng, Yan Li, Zhu-Jun Yao*, Qin-Shi Zhao*, Development of novel conformation-constrained cytotoxic derivatives of cheliensisin A by embedment of small heterocycles, European Journal of Medicinal Chemistry, 2011, 46, 4238-4244.
(17) Shuai Ning#, Lei Zhang#, Jin-jin Ma, Lan Chen, Guangyao Zeng, Yingjun Zhou, Xiaoli Guo*, Xu Deng*, Modular and scalable synthesis of nematode pheromone ascarosides: implications in eliciting plant defense, Organic & Biomolecular Chemistry, 2020, 18 (26), 4956-4961.
(18)Xiaohui Hua#, Maowen Huang#, Xu Deng#, Jiheng Xu, Yisi Luo, Qipeng Xie, Jiawei Xu, Zhongxian Tian, Jingxia Li, Junlan Zhu, Chao Huang, Qin-shi Zhao *, Haishan Huang*,Chuanshu Huang*, The inhibitory effect of compound ChlA-F on human bladder cancer cell invasion can be attributed to its blockage of SOX2 protein, Cell Death & Differentiation, 2020, 27 (2), 632-645 (#equal contribution).
(19)Bai-Xin Ye#, Xu Deng#, LiDong Shao, Ying Lu, Run Xiao, YiJie Liu, Yi Jin, YinYin Xie, Mei Dong, Yan Zhao, Ming Gao, Shun Ma, LiuFei Luo, LianRu, Juan He, Yi Chen, Min Deng, TingXi Liu, QinShi Zhao*, SaiJuan Chen*, Zhu Chen*, Vibsanin B preferentially targets HSP90b, inhibit interstitial leukocyte migration and ameliorates experimental autoimmue encephalomyelitis, Journal of Immunology, 2015, 194, 4489-4497 (#equal contribution).
(20)Ling-Mei Kong#, Xu Deng#, Zhi-Li Zuo, Han-Dong Sun, Qin-Shi Zhao*, Yan Li*, Identification and validation of P50 as the cellular target of Eriocalyxin B, Oncotarget, 2014, 5, 11354-11364 (#equal contribution).
(21). Xu Deng, Kang-Jiang Liang, Xiao-Gang Tong, Ming Ding, Da-Shan Li, Cheng-Feng Xia*, Biomimetic synthesis of chaetominine epimers via copper-catalyzed radical cyclization, Tetrahedron, 2015, 71, 3699-3704.