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成果及论文

代表性论文:

(1). Tingting Liu#, Qing Wang #, Yuxin Zhou, Baixin Ye, Tingting Liu, Linyang Yan, Jinbao Fan, Yingjun Zhou, Zanxian Xia*, Xu Deng*; Discovery of a meisoindigo-derived PROTAC as the ATM degrader: revolutionizing colorectal cancer therapy via synthetic lethality with ATR inhibitors. Journal of Medicinal Chemistry, 2024, 67 (9), 7620-7634 
2Qingtian Gao#, Sixu Liu#, Yuzheng Zhou, Jinbao Fan, Shufen Ke, Yuqing Zhou, Kaiqiang Fan, Yuxuan Wang, Yingjun Zhou, Zanxian Xia*, Xu Deng*, Discovery of Meisoindigo derivatives as noncovalent and orally available Mpro inhibitors: their therapeutic implications in the treatment of COVID-19. European Journal of Medicinal Chemistry, 2024. 273, 116498.
3Moude Liu#, Qin Tang#, Qing Wang, Weixi Xie, Jinbao Fan, Siyuan Tang, Wei Liu, Yingjun Zhou*, Xu Deng*; Rapid access to icetexane diterpenes: their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-B axis in macrophages. European Journal of Medicinal Chemistry, 2023, 260, 115769.
(4). Yan Wu#, Moude Liu#, Qing Wang, Huan   Tian, Jinbao Fan, Yingjun Zhou, Yajing Wang*, Xu   Deng*; Divergent Synthesis of Bis(indolyl) methanes via FeIII catalyzed   Regioselective Dehydrogenative Coupling Reactions: A Biomimetic Approach to   6,6’-bis-(debromo)-gelliusine F. Organic & Biomolecular Chemistry,   2023, 21, 639-643 (IF = 3.876).

(5). Shuting Yang#, Jinbao Fan#, Tingting Liu#, Shuai Ning, Jiahao Xu,   Yingjun Zhou*, Xu Deng*; Development of   strigolactones as novel autophagy/mitophagy inhibitors against colorectal   cancer cells by blocking the autophagosome-lysosome fusion. Journal of   Medicinal Chemistry2022, 65, 9706-9713.
(6). Qing Wang, Senlin   Wang, Jinbao Fan, Guangyao Zeng, Yingjun Zhou*, Xu   Deng*; Acid-promoted intra- and intermolecular [2+2] cycloaddition of indoles   with aryl alkynes to access cyclobutene-based indolines. Chem. Comm.,   2022, 58, 9270-9273 (IF = 6.06).
(7). Xu Deng#, Suling   Huang#, Jian Ren, Zhenghong Pan, Yu Shen, Haofeng Zhou, Zhili Zuo*, Ying Leng*, Qinshi Zhao*; Development and   structure-activity relationships of tanshinones as selective 11β-hydroxysteroid   dehydrogenase 1 inhibitors. Nat. Prod. Bioprospect.2022,  12. 36
(8). Wei Cao#, Tingting Liu#, Shuting Yang, Moude Liu, Zhenghong Pan,   Yingjun Zhou*, Xu Deng*; Efficient synthesis of   icetexane diterpenes and apoptosis inducing effect by upregulating   Bip-ATF4-CHOP axis in colorectal cells. Journal of Natural Products,   2021, 84, 2012-2019.
9Xu Deng#, Li-Yang Shi#, Jia-ling Lan#, Yu-Qing Guan, Xiao-yong Zhang, Hui Lv*, Lung-Wa Chung*, Xu-mu Zhang*; Enantioselective rhodium-catalyzed cycloisomerization of   1,6-allenynes to access 5/6-fused bicycle[4.3.0]nonadienes,   Nature Communications2019, 10, 949-959 (#equal contribution).
10Xu Deng,   Shao-Fei Ni, Zheng-Yu Han, Yu-Qing Guan, Hui Lv, Li Dang*, Xu-Mu Zhang*, Enantioselective rhodium-catalyzed   cycloisomerization of (E)-1,6-enynes.   Angewandte   Chemie International Edition, 2016, 55,   6295-6299.
11Wei Cao, Jin-Bao Fan,   Ling-Yang Yan, Guang-Yao Zeng, Jin-Jin Ma, Ya-Jing Wang, Ying-Jun Zhou*, Xu Deng*Divergent   reactivity in CuII-catalyzed oxidative coupling between   indole/tryptamine derivatives and β-arylacrylic acids, Organic Letters2019, 21, 9506-9511.
12Xu   Deng, Kang-Jiang Liang, Xiao-Gang Tong, Ming Ding, Da-Shan Li, Cheng-Feng   Xia*Copper-catalyzed   radical cyclization to access 3-hydroxypyrroloindoline: biomimetic synthesis   of protubonine A, Organic Letters2014, 16, 3276-3279.
13Xiaofeng Chen#, Jinbao   Fan#Guangyao   ZengJinjin   MaChenxi   WangYajing   WangYingjun   Zhou*Xu Deng*; Access to 3a-benzoylmethyl   pyrrolidino[2,3-b]indolines via CuII-catalyzed radical   annulation/C3-functionalization sequence, The Journal of Organic   Chemistry201883 (15), 8322–8330.
14Jin-jin   Ma#, Lan Chen#, Jin-bao   Fan, Wei Cao, Guang-yao   Zeng, Ya-jing   Wang, Yuan-jian   Li,  Ying-jun Zhou*, Xu Deng*; Dual-targeting rutaecarpine-NO donor hybrids as   novel anti-hypertensive agents by promoting release of CGRP, European Journal of   Medicinal Chemistry, 2019168, 146-153 .
15Xu Deng, Yu Shen, Jing Yang, Juan He, Yu   Zhao, Li -Yan Peng, Ying Leng*, Qin-Shi Zhao*Discovery and structure-activity relationships of ent-kaurene diterpenoids as potent and   selective 11β-HSD1 inhibitors: potential impact in diabetes, European Journal of   Medicinal Chemistry201365, 403-414.
16Xu Deng, Jia Su, Yu   Zhao, Li-Yan Peng, Yan Li, Zhu-Jun Yao*, Qin-Shi Zhao*, Development of novel conformation-constrained   cytotoxic derivatives of cheliensisin A by embedment of small heterocycles, European Journal of   Medicinal Chemistry201146, 4238-4244. 
(17) Shuai Ning#, Lei Zhang#, Jin-jin Ma, Lan Chen, Guangyao Zeng, Yingjun Zhou, Xiaoli Guo*Xu Deng*, Modular and scalable   synthesis of nematode pheromone ascarosides: implications in eliciting plant   defense, Organic & Biomolecular Chemistry2020, 18 (26), 4956-4961.
18Xiaohui Hua#, Maowen Huang#,   Xu Deng#, Jiheng XuYisi LuoQipeng XieJiawei XuZhongxian TianJingxia LiJunlan ZhuChao HuangQin-shi Zhao *Haishan Huang*Chuanshu Huang*The   inhibitory effect of compound ChlA-F on human bladder cancer cell invasion   can be attributed to its blockage of SOX2 protein, Cell Death &   Differentiation, 2020, 27 (2), 632-645  (#equal contribution).
19Bai-Xin Ye#Xu Deng#,   LiDong Shao, Ying Lu, Run Xiao, YiJie Liu, Yi Jin, YinYin Xie, Mei Dong, Yan   Zhao, Ming Gao, Shun Ma, LiuFei Luo, LianRu, Juan He, Yi Chen, Min Deng,   TingXi Liu, QinShi Zhao*, SaiJuan Chen*, Zhu Chen*, Vibsanin B preferentially targets   HSP90b, inhibit interstitial leukocyte   migration and ameliorates experimental autoimmue encephalomyelitis, Journal   of Immunology2015, 194,   4489-4497 (#equal contribution).
20Ling-Mei Kong#Xu Deng#, Zhi-Li Zuo, Han-Dong Sun, Qin-Shi   Zhao*, Yan Li*, Identification and validation of   P50 as the cellular target of Eriocalyxin B, Oncotarget2014, 5, 11354-11364  (#equal contribution).
 (21). Xu Deng, Kang-Jiang Liang, Xiao-Gang   Tong, Ming Ding, Da-Shan Li, Cheng-Feng Xia*, Biomimetic synthesis of chaetominine epimers via   copper-catalyzed radical cyclization, Tetrahedron2015, 71, 3699-3704.