163. S. Ye, B. Yang, M. Wu, Z. Chen, J. Shen, D. Shabat*, D. Yang*, Recurring Real-Time Monitoring of Inflammations in Living Mice with a Chemiluminescent Probe for Hypochlorous Acid. CCS Chem. 2021, 3, 2181-2188. 162. F. Yang, B. Pang, K. K. Lai, N. N. Cheung, J. Dai, W. Zhang, J. Zhang, K. H. Chan, H. Chen, K. H. Sze, H. Zhang, Q. Hao, D. Yang, K. Y. Yuen*, R. Y. Kao*. Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle. J. Virol. 2021, 95, e01432. 161. C.-W. Ma, K. K.-H. Ng, B. H.-C. Yam, P.-L. Ho, R. Y.-T. Kao, D. Yang*. Rapid Broad Spectrum Detection of Carbapenemases with a Dual Fluorogenic-Colorimetric Probe. J. Am. Chem. Soc. 2021, 18, 6886–6894. 160. H. Chen, B. Guan, S. Chen, D. Yang, J. Shen*. Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia. Free Radic. Biol. Med. 2021, 165, 171-183. 159. P. Jiang, L. Ren, L. Zhi, Z. Yu, F. Lv, F. Xu, W. Peng, X. Bai, K. Cheng, L. Quan, X. Zhang, X. Wang, Y. Zhang, D. Yang, X. Hu*, R.-P. Xiao*. Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53. Mol. Cell. 2021, 81, 629-637. 158. S. Ye, J. J. Hu, Q. A. Zhao, D. Yang*. Fluorescent probes for in vitro and in vivo quantification of hydrogen peroxide. Chem. Sci. 2020, 11, 11989–11997 (Highlighted as Front Cover). 157. S.-Y. Dai, D. Yang*. A Visible and Near-Infrared Light Activatable Diazo-Coumarin Probe for Fluorogenic Protein Labeling in Living Cells. J. Am. Chem. Soc. 2020, 142, 17156–17166 (Highlighted as Supplementary Cover). 156. S. Ye, N. Hananya, O. Green, H.-S. Chen, A. Q. Zhao, J.-G. Shen, D. Shabat*, D. Yang*. A Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals. Angew. Chem. Int. Ed. 2020, 59, 14326–14330. |
155. F.-F. Shen, S.-Y. Dai, N.-K. Wong, S. Deng, A. S.-T. Wong, D. Yang*. Mediating K+/H+ Transport on Organelle Membranes to Selectively Eradicate Cancer Stem Cells by a Small Molecule. J. Am. Chem. Soc. 2020, 142, 10769–10779 (Highlighted as Supplementary Cover). |
154. X.-Y. Bai, B.-W. Yang, H.-S. Chen, J.-G. Shen, D. Yang*. HKOCl-4: A Rhodol-based Yellow Fluorescent Probe for Detection of Hypochlorous Acid in Living Cells and Tissues. Org. Chem. Front. 2020, 7, 993–996. |
153. X. Zhou, X. Ding, J.-G. Shen, D. Yang, L.G. Hudson, K.J. Liu*. Peroxynitrite contributes to arsenic-induced PARP-1 inhibition through ROS/RNS generation. Toxicol. Appl. Pharmacol. 2019, 378, 114602. |
152. B. Tsoi, S.-L. Wang, C. Gao, Y.-H. Luo, W.-T. Li, D. Yang, D.-P. Yang, J.-G. Shen*. Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury, Toxicol. Appl. Pharmacol. 2019, 377, 114613. |
151. W. Li, J. Feng, C. Gao, M. Wu, Q. Du, B. Tsoi, Q. Wang, D. Yang, J. Shen*. Nitration of Drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis, Free Radic. Biol. Med. 2019, 143, 70-83. |
150. X.-Y. Bai, K. K.-H. Ng, J. J. Hu, S. Ye, D. Yang*. Small Molecule-based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems. Annu. Rev. Biochem. 2019, 88, 605–633. |
149. S. P. T. Yiu, K. F. Hui, C. K. Choi, R. Y. T. Kao, C. W. Ma, D. Yang, A. K. S. Chiang*. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers. Cancers 2018, 10, 505. |
148. M.-D. Li, N.-K. Wong, J. Xiao, R.-X. Zhu, L.-L. Wu, S. Y. Dai, F. Chen, G.-H. Huang, X.-Y. Bai, M. R. Geraskina, A. H. Winter, X.-B. Chen*, Y.-X. Liu, W.-H. Fang, D. Yang*, D. L. Phillips*. Dynamics of oxygen-independent photocleavage of blebbistatin as a one-photon blue or two-photon near infrared light-gated hydroxyl radical photocage. J. Am. Chem. Soc. 2018, 140, 15957–15968. |
147. S. Ye, J. J. Hu, D. Yang*. Tandem Payne/Dakin Reaction: A New Strategy for Hydrogen Peroxide Detection and Molecular Imaging. Angew. Chem. Int. Ed. 2018, 57, 10173 –10177. (Very Important Paper) |
146. W.-T. Li, H. Wu, C. Gao, D. Yang, D.-P. Yang, J.-G. Shen*. Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-derived Nitrative Damage. Front. Physiol. 2018, doi: 10.3389/fphys.2018.00864. |
145. X. Chen, B. Zhou, T. Yan, H. Wu, J. Feng, H. Chen, C. Gao, T. Peng, D. Yang, J.-G. Shen*. Peroxynitrite Enhances Self-renewal, Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells through Activating HIF-1a and Wnt/ß-catenin Signaling Pathway. Free Radic. Biol. Med. 2018, 117, 158-167. doi: 10.1016/j.freeradbiomed.2018.02.011. Epub 2018 Feb 7. |
144. H.-S. Chen, B.-H. Guan, X. Chen, X.-M. Chen, C.-M. Li, J.-H. Qiu, D. Yang, K.-J. Liu, S.-H. Qi, J.-G. Shen*. Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO--MMP-9 Pathway. Transl. Stroke Res. 2018, 9, 515-529. Doi: 10.1007/s12975-017-0598-3. |
143. H. Tse, Q.-S. Gu, K.-H. Sze, I. K. Chu, R. Y.-T. Kao, K.-C. Lee, C.-W. Lam, D. Yang, S. S.-C. Tai, Y.-H. Ke, E. Chan, W.-M. Chan, J. Dai, S.-P. Leung, S.-Y. Leung, K.-Y. Yuen*. A Tricyclic Pyrrolobenzodiazepine Produced by Klebsiella oxytoca is Associated with Cytotoxicity in Antibiotic Associated Hemorrhagic Colitis. J. Biol. Chem. 2017, 292, 19503–19520. |
142. X.-Y. Bai, Y.-Y. Huang, M.-Y. Lu, D. Yang*. HKOH-1: A Highly Sensitive and Selective Fluorescent Probe for Detecting Endogenous Hydroxyl Radical in Living Cells. Angew. Chem. Int. Ed. 2017, 56, 12873 –12877. |
141. W. Du, Q.-S. Gu, Y. Li, Z.-Y. Lin, D. Yang*. Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides. Org. Lett. 2017, 19, 316−319. |
140. L. Ye, K.-Y. Lo, Q.-S. Gu, D. Yang*. Pd-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes: Access to Diverse N-Heterocycles. Org. Lett. 2017, 19, 308−311. |
139. Q.-S. Gu, D. Yang*. Enantioselective Synthesis of (+)-Mitomycin K via Palladium-Catalyzed Oxidative Tandem Cyclization. Angew. Chem. Int. Ed. 2017, 56, 5886-5889. |
138. J. J. Hu, S. Ye, D. Yang*. Fluorescent Probes for HOCl Imaging. Isr. J. Chem. 2017, 57, 251 –258. |
137. P.-Y. Liu, S.-T. Li, F.-F. Shen, W.-H. Ko*, X.-Q. Yao*,D. Yang*. A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells. Chem. Commun. 2016, 52, 7380-7383. |
136. L. Gao, X.-M. Chen, T. Peng, D. Yang, Q. Wang, Z.-P. Lv, J.-G. Shen*. Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death. Free Rad. Biol. Med. 2016, 95, 209–215. |
135. T. Peng, X.-M. Chen, L. Gao, T. Zhang, W. Wang, J.-G. Shen, D. Yang*. A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues. Chem. Sci. 2016, 7, 5407–5413. |
134. J. J. Hu, N.-K. Wong, M.-Y. Lu, X.-M. Chen, S. Ye, A. Q. Zhao, P. Gao, R. Y.-T. Kao, J.-G. Shen, D. Yang*. HKOCl-3: A fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and 96-well microplate assay. Chem. Sci. 2016, 7, 2094 – 2099. |
133. J. J. Hu, N.-K. Wong, S. Ye, X.-M. Chen, M.-Y. Lu, A. Q. Zhao, Y.-H. Guo, A. C.-H. Ma, A. Y.-H. Leung, J.-G. Shen, D. Yang∗. Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo. J. Am. Chem. Soc. 2015, 137, 6837–6843. |
132. Y. Hao, K. An, D.-W. Zhang, D. Yang. A Short Helix Formed by Cyclic b2,3-Aminoxy Peptides in Protic Solvents. Chem. Asian J. 2015, 10, 2126-2129. |
131. P. Di Tomo, S. Di Silvestre, V.G.P. Cordone, A. Giardinelli, B. Faricelli, C. Pipino, P. Lanuti, T. Peng, G. Formoso, D. Yang, A. Arduini, F. Chiarelli, A. Pandolfi, N. Di Pietro*. Centella Asiatica and Lipoic Acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women. Nutr. Metab. Cardiovasc. Dis. 2015, 25, 659‒666. |
130. Q. Zhao, Y. Ding, Z.-S. Deng, O.-Y. Lee, P. Gao, P. Chen, R. J. Rose, H. Zhao, Z.-H. Zhang, X.-P. Tao, A. J. R. Heck, R.Y.C. Kao, D. Yang*. Identification of Natural Products Triptolide, Celastrol and Withaferin A as Binding Ligands of Peroxiredoxin I. Chem. Sci. 2015, 6, 4124‒4130. |
129. Z.-L. Li, D. Yang. Construction of 9,10-syn-trans-Decalin Skeleton via Semipinacol Rearrangement: Asymmetric Synthesis of (+)-syn-Copalol and a Candelalide Analog. Tetrahedron Lett. Wasserman Special Issue. 2015, 56, 3667–3669. |
128. W. Du, Q.-S. Gu, Z.-L. Li, D. Yang*. Palladium(II)-Catalyzed Intramolecular Tandem Aminoalkylation via Divergent C(sp3)–H Functionalization. J. Am. Chem. Soc. 2015, 137, 1130–1135. |
127. S. S.-W. Wong, R. Y.-T. Kao*, K.-Y. Yuen, Y. Wang, D. Yang, L. P. Samaranayake, C. J. Seneviratne*. In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections. PLoS One, 2014, 9, e85836. |
126. H.-Y. Zha, B. Shen, K.-H. Yau, S.-T. Li, X.-Q. Yao*, D. Yang*. A Small Synthetic Molecule Forms Selective Potassium Channels to Regulate Cell Membrane Potential and Blood Vessel Tone. Org. Biol. Chem. 2014, 12, 8174–8179. |
125. T. Peng, N.-K. Wong, X.-M. Chen, Y.-K. Chan, D. H.-H. Ho, Z.-N. Sun, J. J. Hu, J.-G. Shen, H. El-Nezami, D. Yang*. Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues. J. Am. Chem. Soc. 2014, 136, 11728–11734. |
124. W. R. Zhang, K. T. Li, X. T. Zhu, D. Wu, W. Shang, X. F. Yuan, Z. L. Huang, M. Zheng, X. H. Wang, D. Yang, J. Liu, H. P. Cheng. Subsarcolemmal Mitochondrial Flashes Induced by Hypochlorous Acid Stimulation in Cardiac Myocytes. Free Radical Res. 2014, 48, 1085–1094. |
123. J. J. Hu, N.-K. Wong, Q.-S. Gu, X.-Y. Bai, S. Ye, D. Yang. HKOCl-2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells. Org. Lett., 2014, 16, 3544–3547. |
122. Z.-Y. Wang, W.-T. Wong, D. Yang*. Asymmetric Organocatalytic Synthesis of Dihydrodibenzofuran Species Based on a Dienamine Process. Org. Lett., 2013, 15, 4980–4983. |
121. M. Xu, X. Chen, Y. Gu, T. Peng, D. Yang, R. Chang, K.F. So, K.J. Liu, J.-G. Shen. Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury. J Ethnopharmacol. 2013, 150, 116-124. |
120. D. Xing, D. Yang*. Pd(II)-Catalyzed Intramolecular 1,2-Aminoalkylation of Conjugated 1,3-Dienes for the Synthesis of Pyrrolizidines. Org. Lett., 2013, 15, 4370–4373. |
119. D. Obal, S.J. Dai, R. Keith, N. Dimova, J. Kingery, Y.-T. Zheng, J. Zweier, M. Velayutham, S. D. Prabhu, Q.-H. Li, D. Conklin, D. Yang, A. Bhatnagar, R. Bolli, G. Rokosh. Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion. Basic Res. Cardiol. 2012, 107, 305. |
118. K.-H. Yau, J. C.-W. Mak, S. W.-S. Leung, D. Yang, P. M. Vanhoutte*. A Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat. PLoS One, 2012, 7(9), e45340. |
117. B. Ma, C. Yin, D. Yang, G. Lin*. Effect of Structural Modification on the Gastrointestinal Stability and Hepatic Metabolism of a-Aminoxy Peptides. Amino Acids, 2012, 43, 2073–2085. |
116. B. Shen, X. Li, F. Wang, X.-Q. Yao*, D. Yang*. A Synthetic Chloride Channel Restores Chloride Conductance in Human Cystic Fibrosis Epithelial Cells. PLoS ONE, 2012, 7(4), e34694. |
115. N. Ieda, H. Nakagawa*, T. Peng, D. Yang, T. Suzuki, N. Miyata*. Photo-controllable Peroxynitrite Generator Based on N-Methyl-N-nitrosoaminophenol for Cellular Application. J. Am. Chem. Soc. 2012, 134, 2563–2568. |
114. F. Chen, B. Ma, Z.-C. Yang, G. Lin*, D. Yang*. Extraordinary Metabolic Stability of Peptides Containing a-Aminoxy Acids. Amino Acids 2012, 43, 499–503. |
113. B. Ma, S. Chai, N. Li, K. K.W. To, W. L. T. Kan, D. Yang, G. Lin*. Reversal of P-Glycoprotein-Mediated Multidrug Resistance by a Synthetic a-Aminoxy Peptidomimetic. Int. J. Pharm. 2011, 424, 33–39. |
112. A. C. H. Ma, T. K. Fung, R. H. C. Lin, M. I. S. Chung, D. Yang, A. Y. H. Leung*. Methionine Aminopeptidase 2 Is Required for Hematopoietic Stem Cell Initiation and Proliferation. Blood, 2011, 118, 5448–5457. |
111. F. Gaupels, E. Spiazzi-Vandelle, D. Yang, M. Delledonne*. Detection of Peroxynitrite Accumulation in Arabidopsis thaliana During the Hypersensitive Defense Response. Nitric Oxide 2011, 25, 222–228. |
110. D. Xing, D. Yang*. Highly Efficient Gold(I)-Catalyzed Overman Rearrangement in Water. Beilstein J. Org. Chem. 2011, 7, 781–785. |
109. B. Ma, H.-Y. Zha, N. Li, D. Yang, G. Lin*. Effect of Structural Modification of α-Aminoxy Peptides on Their Intestinal Absorption and Transport Mechanism. Mol. Pharmaceutics 2011, 8, 1073–1082. |
108. K.-T. Yip, D. Yang*. Pd(II)-Catalyzed Oxidative Cascade Cyclization Reactions: Scope and Mechanistic Investigations. Chem. Asian J. 2011, 6, 2166–2175. |
107. Z.-G. Jiao, X.-W. Chang, W. Ding, G.-J. Liu, K.-S. Song, N.-Y. Zhu, D.-W. Zhang*, D. Yang*. N–O Turn and Helix Induced by b2-Aminoxy Peptides: Synthesis and Conformational Studies. Chem. Asian J. 2011, 6, 1791–1799. |
106. N. Ieda, H. Nakagawa*, T. Horinouchi, T. Peng, D. Yang, H. Tsumoto, T. Suzuki, K. Fukuhara, N. Miyata*. Peroxynitrite Generation from NO-releasing Nitrobenzene Derivative in Response to Photoirradiation. Chem. Comm. 2011, 47, 6449–6451. |
105. K.-T. Yip, D. Yang*. Pd(II)-Catalyzed Intramolecular Amidoarylation of Alkenes with Molecular Oxygen as Sole Oxidant. Org. Lett., 2011, 13, 2134–2137. |
104. F. Chen, C.-J. Shen, D. Yang*. A Simple Protocol for the Synthesis of 2-Arylbenzoxazoles by Oxidation with o-Iodoxybenzoic Acid (IBX) and Its Application in the Synthesis of Arylbenzoxazole-containing Amino Acids. Tetrahedron Lett. 2011, 52, 2128–2131. (Invited article for a special issue dedicated to Professor Harry Wasserman) |
103. T. Peng, D. Yang*. HKGreen-3: A Rhodol-Based Fluorescent Probe for Peroxynitrite. Org. Lett., 2010, 12, 4932–4935. |
102. D. Yang*, X.-W. Chang, D.-W. Zhang*, Z.-F. Jiang, K.-S. Song, Y.-H Zhang, N.-Y. Zhu, L.-H. Weng, M.-Q. Chen. Chiral a-Aminoxy Acid/Achiral Cyclopropane a-Aminoxy Acid Unit as a Building Block for Constructing a N-O Helix. J. Org. Chem. 2010, 75, 4796–4805. |
101. J.-D. Yu, W. Ding, G.-Y. Lian, K.-S. Song, D.-W. Zhang, X. Gao, D. Yang*. Selective Approach toward Multi-functionalized Lactams by Lewis Acid-promoted PhSe Group Transfer Radical Cyclization. J. Org. Chem. 2010, 75, 3232–3239. |
100. R. Y. Kao*, D. Yang, L.-S. Lau, W. H. W. Tsui, L.-H. Hu, J. Dai, M.-P. Chan, C.-M. Chan, P. Wang, B.-J. Zheng, J. Sun, J.-D. Huang, J. Madar, G.-H. Chen, H.-L. Chen, Y. Guan, K.-Y. Yuen*. Identification of Influenza A Nucleoprotein as an Antiviral Target. Nature Biotechnology, 2010, 28, 600-605. |
99. D. Xing, D. Yang*. Gold(I)-Catalyzed Highly Regio- and Stereoselective Decarboxylative Amination of Allylic N-Tosylcarbamates via Base-Induced Aza-Claisen Rearrangement in Water. Org. Lett. 2010, 12, 1068–1071. |
98. D. Yang*, G.-J. Liu, Y. Hao, W. Li, Z.-M. Dong, D.-W. Zhang, N.-Y. Zhu. Conformational Studies on Peptides of α-Aminoxy Acids that Have Functionalized Side Chains. Chem. Asian J. 2010, 5, 1356–1363. |
97. P. Tao, D. Yang*. Construction of a Library of Rhodol Fluorophores for Developing New Fluorescent Probes. Org. Lett. 2010, 12, 496–499. |
96. Y.-H. Zhang, K.-S. Song, N.-Y. Zhu, D.Yang*. Effect of Backbone Stereochemistry on the Folding of Acyclic b2,3-Aminoxy Peptides. Chem. Eur. J. 2010, 16, 577-587. |
95. W. He, K.-T. Yip, N.-Y. Zhu, D. Yang*. Pd(II)/tBu quinolineoxazoline: An Air-stable and Modular Chiral Catalyst System for Enantioselective Oxidative Cascade Cyclization. Org. Lett. 2009, 11, 5626-5628. |
94. D. Yang*, G.-Y. Lian, H.-F. Yang, J.-D. Yu, D.-W. Zhang*, X. Gao. Synthesis of g-Butyrolactams by Photoinduced PhSe-Group-Transfer Radical Cyclization and Formal Synthesis of (±)-Isocynometrine Using Diphenyldiselenide as Promoter. J. Org. Chem. 2009, 74, 8610–8615. |
93. X.-W. Chang, D.-W. Zhang*, F. Chen, Z.-M. Dong, D. Yang*. A Concise Asymmetric Route to Chiral a-Aminoxy Acids. Synlett, 2009, 3159–3162. |
92. X. Li, B. Shen, X.-Q. Yao*, D. Yang*. A synthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels. J. Am. Chem. Soc. 2009, 131, 13676–13680. |
91. O.-Y. Lee, K.-L. Law, D. Yang*. Secondary Amine Formation from Reductive Amination of Carbonyl Compounds Promoted by Lewis Acid Using the InCl3/Et3SiH System. Org. Lett. 2009, 11, 3302–3305. |
90. Z.-N. Sun, H.-L. Wang, F.-Q. Liu, Y. Chen, P. K. H. Tam, D. Yang*, BODIPY-based Fluorescent Probe for Peroxynitrite Detection and Imaging in Living Cells. Org. Lett. 2009, 11, 1887–1890. |
89. K.-T. Yip, N.-Y. Zhu, D. Yang*. Palladium-Catalyzed Highly Diastereoselective Oxidative Cascade Cyclization Reactions. Org. Lett. 2009, 11, 1911–1914. |
88. O.-Y. Lee, K.-L. Law, C.-Y. Ho, D. Yang*. Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by InCl3/Et3SiH/MeOH System J. Org. Chem. 2008, 73, 8829-8837. |
87. X. Li, Y.-D. Wu*, D. Yang*. a-Aminoxy Acids: New Possibilities from Foldamers to Anion Receptors and Channels. Acc. Chem. Res. 2008, 41, 1428-1438. |
86. D. Yang*, G.-J. Liu, Z.-G. Jiao, D.-W. Zhang*, Z. Luo, K.-S. Song, M.-Q. Chen. Disulfide Bond Creates a Small Connecting Loop in Aminoxy Peptide Backbone. Chem. Eur. J. 2008, 14, 10297-10302. |
85. Z.-N. Sun, F.-Q. Liu, Y. Chen, P. K. H. Tam, D. Yang*. A Highly Specific BODIPY-Based Fluorescent Probe for the Detection of Hypochlorous Acid. Org. Lett. 2008, 10, 2171-2174. |
84. K. F. Wong, J. K. Chan, K. L. Chan, P. Tam, D. Yang, S. T. Fan, J. M. Luk*. Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property. Clin. Exp. Pharmacol. Physiol. 2008, 35, 55-59. |
83. F. Chen, K.-S. Song, Y.-D. Wu, D. Yang*. Synthesis and Conformational Studies of g–Aminoxy Peptides. J. Am. Chem. Soc. 2008, 130, 743-755. |
82. J.-H. Pan, M. Yang, Q. Gao, N.-Y. Zhu, D. Yang*. Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds. Synthesis 2007, 2539-2544. (Invited article for Special Topic on thioureas) |
81. X. Li, B. Shen, X.-Q. Yao, D. Yang*. A Small Synthetic Molecule Forms Chloride Channels to Mediate Chloride Transport across Cell Membranes. J. Am. Chem. Soc. 2007, 129, 7264-7265. |
80. F. Chen, D. Yang*. Condensation of Amino Acids to Form Peptides in Aqueous Solution Induced by the Oxidation of Sulfur(IV): An Oxidative Model for Prebiotic Peptide Formation. Origins Life Evol. Biospheres, 2007, 37, 47-54. |
79. D. Yang*, Y.-L. Yan, B.-F. Zheng, Q. Gao, N.-Y. Zhu. Copper(I)-Catalyzed Chlorine Atom Transfer Radical Cyclization Reactions of Unsaturated a-Chloro b-Keto Esters. Org. Lett. 2006, 8, 5757-5760. |
78. M. Yang, K.-T. Yip, J.-H. Pan, Y.-C. Chen, N.-Y. Zhu, D. Yang*. A Sterically Bulky Cyclic Thiourea as an Efficient Ligand for Palladium-Catalyzed Aerobic Oxidation of Alcohols. Synlett 2006, 3057-3060. (Invited article for a special issue dedicated to Professor Richard Heck) |
77. X. Li, D. Yang*. Peptides of Aminoxy Acids as Foldamers. Chem. Commun. 2006, 3367 -3379. (Invited Feature Article) |
76. D. Yang*, H.-L. Wang, Z.-N. Sun, N.-W. Chung, J.-G. Shen. A Highly Selective Fluorescent Probe for the Detection and Imaging of Peroxynitrite in Living Cells. J. Am. Chem. Soc. 2006, 128, 6004-6005. |
75. K.-T. Yip, M. Yang, K.-L. Law, N.-Y. Zhu, D. Yang*. Pd(II)-Catalyzed Enantioselective Oxidative Tandem Cyclization Reactions. Synthesis of Indolines through C-N and C-C Bond Formation. J. Am. Chem. Soc. 2006, 128, 3130-3131. |
74. X.-G. Guan, D. L. Phillips*, D. Yang*. A Density Functional Theory Study of the 5-Exo Cyclization Reactions of a-Substituted 6,6-Diphenyl-5-hexenyl Radicals. J. Org. Chem. 2006, 71, 1984-1988. |
73. W. Chen , R. Li, B. Han, B.-J. Li , Y.-C. Chen *, Y. Wu, L.-S. Ding , D. Yang. The Design and Synthesis of Bis(thiourea) Ligands and Their Application in Pd-Catalyzed Heck and Suzuki Reactions Under Aerobic Conditions. Eur. J. Org. Chem. 2006, 1177-1184. |
72. D. Yang*, B.-F. Zheng, Q. Gao, S. Gu, N.-Y. Zhu. Enantioselective PhSe Group Transfer Tandem Radical Cyclization Reactions Catalyzed by a Chiral Lewis Acid. Angew. Chem., Int. Ed. 2006, 45, 255-258. |
71. D. S. S. Kumar, C. S. Lau*, J. M. F. Wan, D. Yang, K. D. Hyde. Immunomodulatory compounds from Pestalotiopsis leucothes, an endophytic fungus from Tripterygium wilfordii. Life Sciences 2005, 78, 147-156. |
70. K.-T. Yip, J.-H. Li, O.-Y. Lee, D. Yang*. Aerobic Oxidative Cyclization Under Pd(II) Catalysis: A Regioselective Approach to Heterocycles. Org. Lett. 2005, 7, 5717-5719. |
69. Li, J.-H.*; Zhu, Q.-M.; Liang, Y.; Yang, D. Efficient and Reusable PdCl2(MeCN)2/CuCl2/PEG-400 System for Cyclization of Alkenyl b-Keto Esters and Amides. J. Org. Chem. 2005, 70, 5347-5349. |
68. D. Yang*, X. Li, Y.-F. Fan, D.-W. Zhang. An Enantioselective Carboxylate Receptor Derived from a-Aminoxy Acids Functions as a Chiral Shift Reagent. J. Am. Chem. Soc. 2005, 127, 7996-7997. |
67. Q. Gao, B.-F. Zheng, J.-H. Li, D. Yang*. Ni(II)-Catalyzed Conia-Ene Reaction of 1,3-Dicarbonyl Compounds with Alkynes. Org. Lett. 2005, 7, 2185-2188. |
66. D. Yang*, X. Li, Y. Sha, Y.-D. Wu*. A Cyclic Hexapeptide Comprising Alternating a-Aminoxy Acids and a-Amino Acids is a Selective Chloride Anion Receptor. Chem. Eur. J. 2005, 11, 3005-3009. |
65. C.-Y. Ho, Y.-C. Chen, M.-K. Wong, D. Yang*. Epoxidation of Olefins Catalyzed by Chiral Fluorinated Secondary Amines. J. Org. Chem. 2005, 70, 898-906. |
64. F. Chen, N.-Y. Zhu, D. Yang*. g4-Aminoxy Peptides as New Peptidomimetic Foldamers. J. Am. Chem. Soc. 2004, 126, 15980-15981. |
63. D. Yang,* Q. Gao, B.-F. Zheng, N.-Y. Zhu. Et2AlCl-Promoted Asymmetric Phenylseleno Group Transfer Radical Cyclization Reactions of Unsaturated b-Hydroxy Esters. J. Org. Chem. 2004, 69, 8821-8828. |
62. D. Yang*, D.-W. Zhang, Y. Hao, Y.-D. Wu, S.-W. Luo, N.-Y. Zhu. b2, 3-Cyclic Aminoxy Acids: Rigid and Ring Size-Independent Building Blocks of Foldamers. Angew. Chem., Int. Ed. 2004, 43, 6719-6722. |
61. R.Y. Kao*, W.H.W. Tsui, T.S.W. Lee, J.A. Tanner, R.M. Watt, J.D. Huang, L.H. Hu, G.H. Chen, Z.W. Chen, L.Q. Zhang, T. He, K.H. Chan, H. Tse, A.P.C. To, L.W.Y. Ng, B.C.W. Wong, H.W. Tsoi, D. Yang, D.D. Ho, K.Y. Yuen. Identification of Novel Small Molecule Inhibitors of Severe Acute Respiratory Syndrome Associated Coronavirus by Chemical Genetics. Chem. Biol. 2004, 11, 1293-1299. |
60. D. Yang*, Y.-H. Zhang, B. Li, D.-W. Zhang. The Synthesis of Chiral b3-Aminoxy Peptides. J. Org. Chem. 2004, 69, 7577-7581. |
59. D. Yang. Ketone-Catalyzed Asymmetric Epoxidation Reactions. Acc. Chem. Res. 2004, 37, 497-505. (Invited article to a special issue entitled “Enantioselective Organocatalysis”) |
58. D. Yang*, Y.-H. Zhang, B. Li, D.-W. Zhang, J. C.-Y. Chan, N.-Y. Zhu, S.-W. Luo, Y.-D. Wu*. Effect of Side Chains on Turns and Helices in Peptides of b3-Aminoxy Acids. J. Am. Chem. Soc. 2004, 126, 6956-6966. |
57. D. Yang*, Y.-C. Chen, N.-Y. Zhu. Sterically Bulky Thioureas as Air and Moisture Stable Ligands for Pd-Catalyzed Heck Reactions of Aryl Halides. Org. Lett. 2004, 6, 1577-1580. |
56. D. Yang*, F. Chen, Z.-M. Dong, D.-W. Zhang. Ruthenium-Catalyzed Oxidative Cleavage of Alkynes to Carboxylic Acids. J. Org. Chem. 2004, 69, 2221-2223. |
55. D. Yang*, J. Qu, D.-P. Wang, Y. Ren, Y.-D. Wu*. A Reverse Turn Structure Induced by Two Consecutive D,L-a-Aminoxy Acids. J. Am. Chem. Soc. 2003, 125, 14452-14457. |
54. D. Yang*, M. Yang, N.-Y. Zhu. Chiral Lewis Acid-Catalyzed Enantioselective Intramolecular Carbonyl Ene Reactions of Unsaturated α-Keto Esters. Org. Lett. 2003, 5, 3749-3752. |
53. D. Yang*, B.-F. Zheng, S. Gu, P. W. H. Chan, N.-Y. Zhu. Lewis Acid-Catalyzed Asymmetric Atom Transfer Radical Cyclization Reactions of a-Bromo Oxazolidinones. Tetrahedron: Asymmetry 2003, 14, 2927-2937. (Invited article to a special edition entitled “Stereoselective Radical Reactions”) |
52. D. Yang*, Y.-L. Yan, K.-L. Law, N.-Y. Zhu. Lewis Acid-Catalyzed Atom Transfer Radical Cyclization of Unsaturated b-Keto Amides. Tetrahedron 2003, 59, 10465-10475. (Invited article to a special edition entitled “Recent Advances in Rare Earth Chemistry”) |
51. D. Yang*, W. Li, J. Qu, S.-W. Luo, Y.-D. Wu*. A New Strategy to Induce g-Turns: Peptides Composed of Alternating a-Aminoxy Acids and a-Amino Acids. J. Am. Chem. Soc. 2003, 125, 13018-13019. |
50. D. Yang*, J.-H. Li, Q. Gao, Y.-L. Yan. Lanthanide Triflate-Promoted Palladium-Catalyzed Cyclization of Alkenyl b–Keto Esters and Amides. Org. Lett. 2003, 5, 2869-2871. |
49. M.-K. Wong, N.-W. Chung, L. He, X.-C. Wang, Z. Yan, Y.-C. Tang, D. Yang*. Investigation on the Regioselectivities of Intramolecular Oxidation of Unactivated C-H Bonds by Dioxiranes Generated in Situ. J. Org. Chem. 2003, 68, 6321-6328. |
48. M.-K. Wong, N.-W. Chung, L. He, D. Yang*. Substituent Effects on Regioselective Intramolecular Oxidation of Unactivated C-H Bonds: Stereoselective Synthesis of Substituted Tetrahydropyrans. J. Am. Chem. Soc. 2003, 125, 158-162. |
47. D. Yang*, Y.-L. Yan, B. Lui. Mild a-Halogenation Reactions of 1,3-Dicarbonyl Compounds Catalyzed by Lewis Acids. J. Org. Chem. 2002, 67, 7429-7431. |
46. D. Yang*, J. Qu, W. Li, Y.-H. Zhang, D.-P. Wang, Y.-D. Wu*. A Cyclic Hexapeptide of D,L-a-Aminoxy Acids as a Selective Receptor for Chloride Ion. J. Am. Chem. Soc. 2002, 124, 12410-12411. |
45. D. Yang*, Q. Gao, C.-S. Lee, K.-K. Cheung. A Novel Intramolecular Cyclopropanation Reaction of Unsaturated b-Keto Esters. Org. Lett. 2002, 4, 3271-3274. |
44. D. Yang*, Y.-H. Zhang, N. Y. Zhu. β2,2-Aminoxy Acids: A New Building Block for Turns and Helices. J. Am. Chem. Soc. 2002, 124, 9966-9967. |
43. D. Yang*, S. Gu, H.-W. Zhao, Y.-L. Yan, N.-Y. Zhu. Atom-Transfer Tandem Radical Cyclization Reactions Promoted by Lewis Acids. Angew. Chem., Int. Ed. 2002, 41, 3014-3017. |
42. D. Yang*, Q. Gao, O.-Y. Lee. Lewis Acid-Promoted Phenylseleno Group Transfer Tandem Radical Cyclization Reactions. Org. Lett. 2002, 4, 1239-1241. |
41. D. Yang*, B. Li, F.-F. Ng, Y.-L. Yan, J. Qu, Y.-D. Wu. Synthesis and Characterization of Chiral N-O Turns Induced by a-Aminoxy Acids. J. Org. Chem. 2001, 66, 7303-7312. |
40. X.-H. Jiang, B. C.-Y. Wong*, M. C.-M. Lin, G.-H. Zhu, H.-F. Kung, S.-H. Jiang, D. Yang, S.-K. Lam. Functional p53 is required for Triptolide-induced apoptosis and AP-1 and Nuclear Factor-kB activation in gastric cancer cells. Oncogene, 2001, 20, 8009-8018. |
39. D. Yang*, S. Gu, Y.-L. Yan, N.-Y. Zhu, K.-K. Cheung. Highly Enantioselective Atom-transfer Radical Cyclization Reactions Catalyzed by Lewis Acids. J. Am. Chem. Soc. 2001, 123, 8612-8613. |
38. M.-K. Wong*, L.-M. Ho, Y.-S. Zheng, C.-Y. Ho, D. Yang*. Asymmetric Epoxidation of Olefins Catalyzed by Chiral Iminium Salts Generated in situ from Amines and Aldehydes. Org. Lett. 2001, 3, 2587-2590. |
37. D. Yang*, C. Zhang. Ruthenium-Catalyzed Oxidative Cleavage of Olefins to Aldehydes. J. Org. Chem. 2001, 66, 4814-4818. |
36. D. Yang*, M. Xu. First Enantioselective Syntheses of (+) and (-)-Wilforonide by Using Chiral Auxiliaries Derived from the Same Chiral Source. Org. Lett. 2001, 3, 1785-1788. |
35. D. Yang*, G.-S. Jiao, Y.-C. Yip, T.-H. Lai, M.-K. Wong. Kinetic Resolution of Acyclic Secondary Allylic Silyl Ethers Catalyzed by Chiral Ketones. J. Org. Chem. 2001, 66, 4619-4624. |
34. M.-K. Wong*, C.-W. Yu, W.-H. Yuen, D. Yang*. Synthesis of a-Keto Esters and Amides via Oxidative Cleavage of Cyanoketophosphoranes by Dimethyldioxirane. J. Org. Chem. 2001, 66, 3606-3609. |
33. D. Yang*, Y.-C. Yip, G.-S. Jiao, M.-K. Wong. In Situ Catalytic Epoxidation of Olefins with Tetrahydrothiopyran-4-one and Oxone: 2-Methyl-2,3-Diphenyloxirane. Org. Syn. 2001, 78, 225-233. |
32. D. Yang*, M. Xu, M.-Y. Bian. Chiral Auxiliaries for Asymmetric Radical Cyclization Reactions: Application to the Enantioselective Synthesis of (+)-Triptocallol. Org. Lett. 2001, 3, 111-114. |
31. D. Yang*, G.-S. Jiao. Highly b-Selective Epoxidation of D5-Unsaturated Steroids Catalysed by Ketones. Chem. Eur. J. 2000, 6, 3517-3521. |
30. D. Yang*, M.-K. Wong, Z. Yan. Regioselective Intramolecular Oxidation of Phenols and Anisols by Dioxiranes Generated in situ. J. Org. Chem. 2000, 65, 4179-4184. |
29. D. Yang*, C. Zhang, X.-C. Wang. A Novel Epoxidation Reaction of Olefins Using a Combination of Chloramine-M, Benzaldehyde, and Benzyltriethylammonium Chloride. J. Am. Chem. Soc. 2000, 122, 4039-4043. |
28. D. Yang*, X.-Y. Ye, M. Xu. Enantioselective Total Synthesis of (-)-Triptolide, (-)-Triptonide, and (+)-Triptophenolide, and (+)-Triptoquinonide. J. Org. Chem. 2000, 65, 2208-2217. |
27. D. Yang*, X.-Y. Ye, M. Xu, K.-W. Pang, K.-K. Cheung. Investigation of Mn(III)-Based Oxidative Free Radical Cyclization Reactions toward the Synthesis of Triptolide: The Effects of Lanthanide Triflates and Substituents on Stereoselectivity. J. Am. Chem. Soc. 2000, 122, 1658-1663. |
26. D. Yang*, Y.-C. Tang, J. Chen, X.-C. Wang, M. D. Bartberger, K. N. Houk*, L. Olson. Ketone-Catalyzed Decomposition of Peroxynitrite via Dioxirane Intermediates. J. Am. Chem. Soc. 1999, 121, 11976-11983. |
25. Y.-D. Wu*, D.-P. Wang, K. W. K. Chan, D. Yang*. Theoretical Study of Peptides Formed by Aminoxy Acids. J. Am. Chem. Soc. 1999, 121, 11189-11196. |
24. K. K. Tong, D. Yang, E. Y. T. Chan, P. K. Y. Chiu, K. S. Yau, C. S. Lau*. Down Regulation of Lymphocyte Activity and Human Synovial Fibroblast Growth in Rheumatoid Arthritis by Triptolide. Drug Dev. Res. 1999, 47, 144-53. |
23. D. Yang*, X.-Y. Ye, S. Gu, M. Xu. Lanthanide Triflates Catalyze Mn(III)-Based Oxidative Radical Cyclization Reactions. Enantioselective Synthesis of (–)-Triptolide, (–)-Triptonide, and (+)-Triptophenolide. J. Am. Chem. Soc. 1999, 121, 5579–5580. |
22. D. Yang*, G.-S. Jiao, Y.-C. Yip, M.-K. Wong. Diastereoselective Epoxidation of Cyclohexene Derivatives by Dioxiranes Generated in situ. Importance of Steric and Field Effects. J. Org. Chem. 1999, 64, 1635–1639. |
21. D. Yang*, J. Qu, B. Li, F.-F. Ng, X.-C. Wang, K.-K. Cheung, D.-P. Wang, Y.-D. Wu*. Novel Turns and Helices in Peptides of Chiral a-Aminoxy Acids. J. Am. Chem. Soc. 1999, 121, 589–590. |
20. D. Yang*, Y.-C. Yip, M.-W. Tang, M.-K. Wong, K.-K. Cheung. Novel Cyclic Ketones for Catalytic Oxidation Reactions. J. Org. Chem. 1998, 63, 9888–9894. |
19. D. Yang*, Y.-C. Yip, G.-S. Jiao, M.-K. Wong. Design of Efficient Ketone Catalysts for Epoxidation by Using the Field Effect. J. Org. Chem. 1998, 63, 8952–8956. |
18. D. Yang*, X.-Y. Ye, M. Xu, K.-W. Pang, N. Zou, R. M. Letcher. A Concise Total Synthesis of Triptolide. J. Org. Chem. 1998, 63, 6446–6447. |
17. D. Yang*, Y.-C. Yip, J. Chen, K.-K. Cheung. Significant Effects of Non-Conjugated Remote Substituents in Catalytic Asymmetric Epoxidation. J. Am. Chem. Soc. 1998, 120, 7659–7660. |
16. D. Yang*, M.-K. Wong, X.-C. Wang, Y.-C. Tang. Regioselective Intramolecular Oxidation of Unactivated C–H Bonds by Dioxiranes Generated in situ. J. Am. Chem. Soc. 1998, 120, 6611–6612. |
15. D. Yang*, M.-K. Wong, Y.-C. Yip, X.-C. Wang, M.-W. Tang, J.-H. Zheng, K.-K. Cheung. Design and Synthesis of Chiral Ketones for Catalytic Asymmetric Epoxidation of Unfunctionalized Olefins. J. Am. Chem. Soc. 1998, 120, 5943–5952. |
14. D. Yang*, Y.-C. Yip, X.-C. Wang. Oxidative Cleavage of Aryl Oxazolines Using Methyl(trifluoromethyl)dioxirane Generated in situ. Tetrahedron Lett. 1997, 38, 7083–7086. |
13. D. Yang*, M.-K. Wong, K.-K. Cheung, E. W. C. Chan, Y. Xie. Studies on Triepoxide Analogs of Triptolide. Tetrahedron Lett. 1997, 38, 6865–6868. |
12. D. Yang*, X.-C. Wang, M.-K. Wong, Y.-C. Yip, M.-W. Tang. Highly Enantioselective Epoxidation of Trans-Stilbenes Catalyzed by Chiral Ketones. J. Am. Chem. Soc. 1996, 118, 11311–11312. |
11. D. Yang*, F.-F. Ng, Z.-J. Li, Y.-D. Wu*, K. W.-K. Chan, D.-P. Wang. An Unusual Turn Structure in Peptides Containing a-Aminoxy Acids. J. Am. Chem. Soc. 1996, 118, 9794–9795. |
10. D. Yang*, Y.-C. Yip, M.-W. Tang, M.-K. Wong, J.-H. Zheng, K.-K. Cheung. A C2 Symmetric Chiral Ketone for Catalytic Asymmetric Epoxidation of Unfunctionalized Olefins. J. Am. Chem. Soc. 1996, 118, 491–492. |
9. D. Yang*, M.-K. Wong, Y.-C. Yip. Epoxidation of Olefins Using Methyl(trifluoromethyl)dioxirane Generated in situ. J. Org. Chem. 1995, 60, 3887–3889. |
8. S.-H. Kim, D. Augeri, D. Yang, D. Kahne*. Concise Synthesis of the Calicheamicin Oligosaccharide Using the Sulfoxide Glycosylation Method. J. Am. Chem. Soc. 1994, 116, 1766–1775. |
7. M. K. Rosen, D. Yang, P. K. Martin, S. L. Schreiber*. Activation of an Inactive Immunophilin by Mutagenesis. J. Am. Chem. Soc. 1993, 115, 821–822. |
6. D. Yang, M. K. Rosen, S. L. Schreiber*. The Composite FKBP-FK506 Surface That Contacts Calcineurin. J. Am. Chem. Soc. 1993, 115, 819–820. |
5. S. Walker, D. Yang, D. Kahne*, D. Gange. Conformational Analysis of the N–O Bond in the Calicheamicin Oligosaccharides. J. Am. Chem. Soc. 1991, 113, 4716–4717. |
4. D. Yang, S. H. Kim, D. Kahne*. Construction of Glycosidic N–O Linkages in Oligosaccharides. J. Am. Chem. Soc. 1991, 113, 4715–4716. |
3. R. Breslow*, J. W. Canary, M. Varney, S. T. Waddell, D. Yang. Artificial Transaminases Linking Pyridoxamine to Binding Cavities: Controlling the Geometry. J. Am. Chem. Soc. 1990, 112, 5212–5219. |
2. D. Kahne*, D. Yang, M. D. Lee. Preparation of the 4-Ethylamino Sugar of Calicheamicin: Assignment of Absolute Configuration. Tetrahedron Lett. 1990, 31, 21–22. |
1. D. Kahne*, D. Yang, J. J. Lim, R. Miller, E. Paguaga. The Use of Alkoxy Substituted Anomeric Radicals for the Construction of b-Glycosides. J. Am. Chem. Soc. 1988, 110, 8716–8717. |