(13) Wan, W.;╪ Zeng, L.;╪ Jin, W.; Chen, X.; Shen, D.; Huang, Y.; Wang, M.; Bai, Y.; Lyu, H.; Dong, X.; Gao, Z.; Wang, L.; Liu, X.; Liu, Y.*; A Solvatochromic Fluorescent Probe Reveals Polarity Heterogeneity upon Protein Aggregation in Cells. Angew. Chem. Int. Ed., 2021,60,25865–25871 60, 25865-25871.

 (12) Shen, D.; Jin, W.; Bai, Y.; Huang, Y.; Lyu, H.; Zeng, L.; Wang, M.; Tang, Y.; Wan, W.; Dong, X.; Gao, Z.; Piao, H.; Liu, X.; Liu, Y.*; Rational Design of Crystallization Induced Emission Probes to Detect Amorphous Protein Aggregation in Live Cells. Angew. Chem. Int. Ed., 2021, 60, 16067-16076.

(11) Wan, W.;  Huang, Y.; Xia, Q.; Bai, Y.;Jin, W.;Wang, M.; Lyu, H.; Tang, Y.; Dong, X.; Gao, Z.; Zhao, Q.; Zhang, L.; Liu, Y.*; Covalent Probes for Aggregated Protein Imaging via Michael Addition. Angew. Chem. Int. Ed., 2021, 60, 11335-11343.(Hot paper)

(10) Bai, Y.; Wan, W.*; Huang, Y.; Jin, W.; Lyu, H.; Xia, Q.; Dong, X.; Gao, Z.; Liu, Y.*; Quantitative Interrogation of Protein Co‐aggregation using Multicolor Fluorogenic Protein Aggregation Sensors. Chem.Sci., 2021, 12, 8468–8476. (Most popular 2021 chemical biology articles)

(9) Wan, W.; Jin, W.; Huang, Y.; Xia, Q.; Bai, Y.; Lyu, H.; Liu, D.; Dong, X.; Li, W.*; Liu, Y.*; Monitoring the Dynamics of Proteome Aggregation in Live Cells Using a Solubilized and Noncovalent Analogue of Fluorescent Protein Chromophores. Anal. Chem., 2021, 93(3), 1717-1724.

(8) Bai, Y.; Huang, Y.; Wan, W.; Jin, W.; Shen, D.; Lyu, H.; Zeng, L.; Liu, Y.*; Derivatizing Merocyanine Dyes to Balance Their Polarity and Viscosity Sensitivities for Protein Aggregation Detection. Chem. Commun. 2021, 57, 13313-13316.

(7) Huang, Y.;╪ Bai, Y.;╪ Jin, W.; Shen, D.; Lyu, H.; Zeng, L.; Wang, M.; Liu, Y.*; Common Pitfalls and Recommendations for using Turbidity Assay to Study Protein Phase Separation.Biochemistry, 2021, 60 (32), 2447-2456.

(6) Bai, Y.; Liu, Y.*; Illuminating Protein Phase Separation: Reviewing Aggregation-Induced Emission, Fluorescent Molecular Rotor and Solvatochromic Fluorophore based Probes. Chem. - Eur. J., 2021, 27, 1-14.

(5) Shen, D.; Bai, Y.; Liu, Y.*; Chemical Biology Toolbox to Visualize Protein Aggregation in Live Cells. ChemBioChem, 2021, accepted.

(4) Dong, X.;╪ Wan, W.;╪ Zeng, L.; Jin, W.; Huang, Y.; Shen, D.; Bai, Y.; Zhao, Q.; Zhang, L.; Liu, Y.*; Gao, Z.*; Regulation of Fluorescence Solvatochromism to Resolve Cellular Polarity upon Protein Aggregation. Anal. Chem., 2021, 93 (49), 16447-16455.

(3) Liu, L.; Jin, W.; Huang, Y.; Dai, J.; Zheng, X.; Liu, Y.; Ju, M.; Shen, B.*; Detecting the Insoluble Protein Aggregates in Live Cells Using an AIE Derivative of Fluorescent Protein Chromophore. Sens. Actuators, B 2022, 353, 131098.

(2) Liu, J.;╪ Xiong, Y.;╪ Huang, Y.; Zhu, X.; Liu, Y.; Zhang, L.; Yan, J*; A quinoline–benzothiazole hybrid as the first near-infrared fluorescent probe for transthyretin. New J. Chem. 2021, 45, 18453-18458.

(1) Sun, F.; Liu, J.; Huang, Y.; Zhu, X.; Liu, Y.; Zhang, L.; Yan, J.*; A quinoline derived D-A-D type fluorescent probe for sensing tetrameric transthyretin. Bioorganic Med. Chem. Lett., 2021, 52, 128408.