ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, drug interactome studies, and pharmacology of both small and large bioactive molecules.
Specific areas include but are not limited to:

Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)
Biological characterization of new molecular entities in the context of drug discovery towards delineating structure-activity relationship (SAR) trends
Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands, and their targets, etc.
Use of artificial intelligence and machine learning in drug discovery
Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry if the methods have been tested on relevant molecules. (e.g. DNA-encoded libraries, high-throughput experimentation, high-throughput parallel synthesis- compound library production, fragment-based drug discovery, covalent modulators.)
New developments in discovery screening and bioassay technologies for biologically active molecules from both synthetic and natural (plant and other) sources.
Chemistry patents relevant to the medicinal chemistry field
Studies involving proximity-inducing agents including targeted protein degradation and molecular glues.

Letters
Notes
Technology Notes
Innovations
Viewpoints
Letters to the Editor
Patent Highlights

Editor-in-Chief
Dennis C. Liotta
Department of Chemistry
Emory University
Editor’s Office: (404) 727-6602
E-mail: eic@medchemlett.acs.org
Associate Editors
Donna M. Huryn
University of Pittsburgh
E-mail: huryn@pitt.edu
Bruce E. Maryanoff
The Scripps Research Institute
E-mail: bmaryano@scripps.edu
Peter Wipf
University of Pittsburgh
E-mail: pwipf@pitt.edu
Innovations Editors
Stevan Djuric
High Point University
E-mail: djuric-office@medchemlett.acs.org
Ya-Qiu Long
Soochow University Medical College
E-mail: long-office@medchemlett.acs.org

Managing Editor
Lorraine Clark
Phone: (202) 872-6984
E-mail: l_clark@acs.org
Patent Panelists
Ahmed Abdel-Magid
Therachem Research Medilab (India), Pvt. Ltd.
Benjamin Blass
Temple University School of Pharmacy
Robert B. Kargbo
Usona Institute
Amy S. Ripka
Lucy Therapeutics
Gerard Rosse
Dart Neuroscience
Editorial Advisory Board
Courtney C. Aldrich
University of Minnesota
Lucia Altucci
Second University of Naples
Jeffrey Aubé
University of Kansas
Maria Letizia Barreca
University of Perugia
Anthony G. M. Barrett
Imperial College London
Annette Beck-Sickinger
University of Leipzig
Brian S. J. Blagg
University of Notre Dame
Maria-Jesus Blanco
Sage Therapeutics
Carsten Bolm
RWTH Aachen University
Joanne J. Bronson
Bristol-Myers Squibb
Duane A. Burnett
Arkuda Therapeutics
Erick Carreira
ETH Zürich
Nick I. Carruthers
Johnson & Johnson
Margaret Chu-Moyer
Amgen
Andrew P. Combs
Prelude Therapeutics
Pat N. Confalone
Dupont
Maria Paola Costi
University of Modena and Reggio Emilia
Zoe Cournia
Biomedical Research Foundation, Academy of Athens
Huw Davies
Emory University
William Denny
University of Auckland
Ke Ding
Chinese Academy of Sciences
George Fleet
University of Oxford
Gunda I. Georg
University of Minnesota
William J. Greenlee
MedChem Discovery Consulting, LLC
Yvan Guindon
Institut de recherches cliniques de Montréal
Stephen Hanessian
Université de Montréal
Amy Hauck Newman
National Institute of Drug Abuse-Intramural Research Program, NIH
Jennifer M. Heemstra
Emory University
Piet Herdewijn
KU Leuven
Kenneth Jacobson
National Institute of Diabetes & Digestive & Kidney Diseases
Mukul R Jain
Cadila Healthcare Ltd.
Hualiang Jiang
Chinese Academy of Sciences
Jagath Reddy Junutula
Cellerant Therapeutics, Inc.
John A. Katzenellenbogen
University of Illinois, Urbana-Champaign
Beate Koksch
Freie Universität Berlin
Povl Krogsgaard-Larsen
University of Copenhagen
Mark J. Macielag
Janssen Research & Development
Neeraj Mahindroo
University of Petroleum and Energy Studies
Ruth Nussinov
Leidos, National Cancer Institute, Frederick
Yu Rao
Tsinghua University
Daniel Rauh
Technische Universität Dortmund
Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Charles H. Reynolds
Gfree LLC
Ralph A. Rivero
GlaxoSmithKline Pharmaceuticals
Bryan L. Roth
University of North Carolina
Silvia Schenone
University of Genoa
Mario Sechi
University of Sassari
Fatih Sen
Dumlupinar University, Evliya Çelebi Campus
Peter Senter
Seattle Genetics, Inc.
Richard B. Silverman
Northwestern University
Romano Silvestri
Sapienza University of Rome
Mikiko Sodeoka
The Institute of Physical and Chemical Research (RIKEN)
Michael Joseph Sofia
Arbutus Biopharma, Inc.
Claudiu T. Supuran
University of Florence
Kiyoshi Tomioka
Kyoto University
Shaomeng Wang
University of Michigan
Wendy B. Young
Genentech
Nurulain T. Zaveri
Astraea Therapeutics
Zhong-Yin Zhang
Indiana University School of Medicine
Ming-Ming Zhou
Mount Sinai School of Medicine

Early Career Board
Ashley M. Adams
AbbVie
Ryan A. Altman
The University of Kansas
Annalaura Brai
Lead Discovery Siena s.r.l
Jennifer E. Golden
University of Wisconsin-Madison
Giuseppe La Regina
Sapienza Universita' di Roma
Zhengqiu Li
Jinan University
Terry W. Moore
University of Illinois at Chicago
William C.K. Pomerantz
University of Minnesota
Naomi S. Rajapaksa
Genentech, Inc.