Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome. 

In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.

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Editor
Christopher D. Lima, PhD
Christopher D. Lima is an Investigator of the Howard Hughes Medical Institute and member of the Structural Biology Program at Memorial Sloan Kettering Cancer Center in New York City. He received his PhD in 1994 from Northwestern University. After completing his postdoctoral studies in 1998 as a Helen Hay Whitney Fellow at Columbia University, he joined the faculty of Weill Medical College at Cornell University. He moved his laboratory to the Sloan Kettering Institute in 2003. Dr. Lima's research focuses on pathways that contribute to RNA processing and decay and on mechanisms underlying post-translational protein modification and regulation by ubiquitin and ubiquitin-like proteins. He has been an Editor of Structure since 2002.

Andrej Sali, PhD
Andrej Sali received his PhD from Birkbeck College, University of London, in molecular biophysics in 1991. His postdoctoral research at Harvard University focused on lattice Monte Carlo models of protein folding. As a faculty member at The Rockefeller University, he continued to develop and apply computational methods for determining structures and functions of proteins and their assemblies. In 2003, he moved to University of California, San Francisco, as a Professor of Computational Biology in the Department of Bioengineering and Therapeutic Sciences. He has been an Editor of Structure since 2002.

Associate Editor
Mishtu Dey, PhD
Mishtu Dey is the in-house Editor of Structure and also holds an appointment as an Adjunct Professor at the University of Iowa. Most recently, she was on the faculty in the University of Iowa's Department of Chemistry, where she developed a federally-funded research program in metalloenzyme structure-function and chemical biology of key metabolic pathway enzymes. She left on good terms pre-tenure to relocate to Boston for personal reasons. She received her PhD in Chemistry from the Indian Institute of Technology Bombay followed by postdoctoral research in mechanistic enzymology at the University of Nebraska-Lincoln and the University of Michigan. She then continued her postdoctoral studies as an HHMI research scientist at MIT in structural enzymology. She is also the in-house Editor of Cell Chemical Biology.