Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers, inflammasomes and the family of cell adhesion-promoting molecules. We are particularly interested in papers that make a significant impact to move the field of inflammatory mediators forward. Descriptive articles, without novel applications or insights may not be considered.