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Toxicology in Vitro
基本信息
期刊名称 Toxicology in Vitro
TOXICOL IN VITRO
期刊ISSN 0887-2333
期刊官方网站 https://www.sciencedirect.com/journal/toxicology-in-vitro
是否OA No
出版商 Elsevier Ltd
出版周期 Bimonthly
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始发年份 1987
年文章数 155
影响因子 2.6(2023)  scijournal影响因子  greensci影响因子
中科院SCI期刊分区
大类学科 小类学科 Top 综述
医学3区 TOXICOLOGY 毒理学3区
CiteScore
CiteScore排名 CiteScore SJR SNIP
学科 排名 百分位 6.5 0.656 0.702
Pharmacology, Toxicology and Pharmaceutics
Toxicology
41/133 69%
补充信息
自引率 6.00%
H-index 96
SCI收录状况 Science Citation Index Expanded
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PubMed Central (PMC) http://www.ncbi.nlm.nih.gov/nlmcatalog?term=0887-2333%5BISSN%5D
投稿指南
期刊投稿网址 https://www.editorialmanager.com/TIV
收稿范围
Affiliated with the American Association for Cellular and Computational Toxicology and the European Society for Toxicology in Vitro.

Toxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for toxicological evaluations (collectively described as New Approach Methodologies (NAM)). This includes the utilisation or the development of NAMs for assessing the potential adverse effects of chemicals for human safety assessment. In vitro techniques include primary cells, tissue slices, cell lines and stem cells (adult, embryonic and induced Pluripotent cells) or subcellular preparations thereof. Our journal strongly supports the Reduction, Refinement and Replacement (3R) of animals in toxicology evaluations.

This is a wide topic and thus we have certain preferences including:
Development of in vitro techniques and their application to research and regulatory use (i.e. 3R principle.
Mechanistic underpinning of data.
Ability to translate outcome to human safety assessment.
We strongly encourage :
The use of normal (non-transformed) human cells (where appropriate).
Reporting the Short Tandem Repeat (STR) profile of the cells used (especially when cells have been provided as a gift or generated in house).
Free access to raw (or primary) data.
Appropriate model characterisation.
The use (or reduction) of animal free components, including serum. [Especially when the system was already developed under such conditions, such as the HK-2 cell line].
Attention to detailed methodology and appropriate statistics. [Readers need to know how you did the experiment, how many times, how many replicates etc?]
Reporting the source of the compounded tested, catalogue no. and lot no. Where the chemical has been purified or synthesised a full analytical report is expected.
Quantification of compounds in exposure medium and/or cells over time (biokinetics).


We do not accept solely in vivo investigations and rarely accept animal in vivo, in vitro hybrid papers, except where the animal data was critical in the interpretation or validation of the in vitro data (and not merely confirmatory).

We generally discourage investigations relating:
Unidentified mixtures - for example in plant extracts.
Solely pharmacological investigations (e.g. demonstrating your chemical kills cancer cells in vitro is not generally acceptable).
Use of non-human cells when human equivalents exist and are available.
The lack of adherence to established protocols, without direct explanation.
Reporting cytotoxicity alone, with no mechanistic underpinning and/or no estimation of chemical exposure.
收录体裁
original research papers
reviews
Brief Communications
投稿指南 https://www.sciencedirect.com/journal/toxicology-in-vitro/publish/guide-for-authors
投稿模板
参考文献格式 https://www.elsevier.com/journals/toxicology-in-vitro/0887-2333/guide-for-authors
编辑信息
Editors-in-Chief

Bas J. Blaauboer

Inst. for Risk Assessment Sciences (IRAS), Universiteit Utrecht, P.O. Box 80177, 3508 TD, Utrecht, Netherlands 

Paul Jennings

Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan, 1108, 1081 HZ Amsterdam, The Netherlands
Associate Editors

Kerstin Stemmer

Institute for Diabetes and Obesity (IDO), Division of Metabolism and Cancer, Helmholtz Centre Munich, Business Campus Garching, Parkring 13, 85748 Garching, Germany
Mathieu Vinken
Teacher Education Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium 

Julio Davila

Dept. of Biochemistry, University of Puerto Rico School of Medicine, Medical Sciences Campus, San Juan, Puerto Rico 

Matteo Goldoni

Dept. of Medicine and Surgery and Centre of Toxicological Research (CERT), Università degli Studi di Parma, Via Gramsci 14, 43126, Parma, Italy 

Maxime Culot

BBB Laboratory - Laboratoire de la Barrière hémato-encéphalique, Université d'Artois, LBHE - EA2465, France 

Martin Leonard

Centre for Radiation, Chemical and Environmental Hazards, Toxicology Department, Public Health England, Harwell Science and Innovation Campus, OX11 0RQ, Oxfordshire, England, UK 
International Editorial Board
James Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA

Armelle Baeza-Squiban

Inst. de Mathematiques de Jussieu, Université Paris Diderot (Paris 7), Paris, France

Gáspár Bánfalvi

Dept. of Microbial Biotechnology and Cell Biology, University of Debrecen, Debrecen, Hungary

Frank A. Barile

Dept. of Pharmaceutical Sciences, St. John's University, Queens, New York, USA

Martin D. Barratt

Marlin Consultancy, Bedford, England, UK

Robert L. Bronaugh

Office of Cosmetics and Colors, HFS-125, CPK2, Food and Drug Administration (FDA), College Park, Maryland, USA

Robert D. Combes

FRAME, 96-98 North Sherwood Street, Nottingham, NG1 4EE, UK

Gianni Dal Negro

Comparative Biology and Medicine, GlaxoSmithKline, Verona, Italy

George L. DeGeorge

Toxicology, MB Research Labs, Spinnerstown, Pennsylvania, USA

Marion Ehrich, PhD, DABT

Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute & State University, Blacksburg, Virginia, USA

Mary Beth Genter

College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

Mary Helen Grant

Bioengineering Unit, University of Strathclyde, Glasgow, Scotland, UK

Roberta L. Grant

Toxicology Section, Texas Commission on Environmental Quality, Austin, Texas, USA

Stephen G. Grant

Dept. of Environmental and Occupational Health, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA

Alison Gray

In Vitro Toxicology, Thor Personal Care SAS, Compiègne Cedex, France

Sjeng Horbach

Dept. of Toxicology and Drug Disposition, N.V. Organon, Oss, Netherlands

Ian Kimber

Fac. of Life Sciences, University of Manchester, Manchester, England, UK

Angela Mally

Dept. of Toxicology (Institut für Toxikologie), Julius-Maximilians-Universität Würzburg, Würzburg, Germany

José E. Manautou, PhD

Dept. of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA

Marina Marinovich

Dip. di Scienze Farmacologiche (Pharmacological Science), Università degli Studi di Milano, Milano, Italy

Russell Melchert

College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Ctr. for Chemical Toxicology Research and Pharmacokinetics (CCTRP), North Carolina State University, Raleigh, North Carolina, USA

Daniel Morgan

Respiratory Toxicology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA

Marek Murias

Dept. of Toxicology, Poznań University of Medical Sciences, Poznan, Poland

Minako Nagao

Div. of Biochemistry, National Cancer Center Research Institute, Tokyo, Japan

Andreas Natsch

Bioscience, Givaudan Scweiz AG, Dübendorf, Switzerland

Andreas K. Nüssler

Dept. of Traumatology - Abteilung für Unfallchirurgie, Technische Universität München, München, Germany

L. Garza Ocañas

Dept. of Pharmacology & Toxicology, Universidad Autónoma de Nuevo León, Garza Garcia, Nuevo León, Mexico

José-Enrique O'Connor

Centro de Citometría y Citómica, Universitat de València, Valencia, Spain

Alvaro Puga

Ctr. for Environmental Genetics, University of Cincinnati, Cincinnati, Ohio, USA

Ivonne M.C.M. Rietjens

Sectie Toxicologie, Wageningen Universiteit, Wageningen, Netherlands

Rosita Rodriguez Proteau

Pharmaceutics & Toxicology, Oregon State University, Corvalis, Oregon, USA

Hasso Seibert

Inst. fur Toxikologie und Pharmakologe fur Naturwissenschaftler, Universitätsklinikum Schleswig-Holstein, Kiel, Germany

Andrzej C. Skladanowski

Dept. of Molecular Enzymology, Medical University of Gdańsk, Gdansk, Poland

Miguel Sogorb

Instituto de Bioingeniería, Universidad Miguel Hernández de Elche (UMH), Elche, Spain

Emanuela Testai

Lab. TCE, Istituto Superiore di Sanità, Roma, Italy

Chiara Urani

Dept. of Earth and Environmental Sciences, Università degli Studi di Milano-Bicocca, Milano, Italy

Jan van Benthem

Dept. of Carcinogenesis, Mutagenesis and Reproduction Toxicology, Rijksinstituut voor Volksgezondheid en Milieu (RIVM), Bilthoven, Netherlands

Bart van der Burg

BioDetection Systems BV (BDS), Amsterdam, Netherlands

Remco Westerink, PhD

Inst. for Risk Assessment Sciences (IRAS), Universiteit Utrecht, Utrecht, Netherlands

Xiaozhong (John) Yu

College of Public Health, University of Georgia, Athens, Georgia, USA


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