The Journal invites for review original papers dealing with interactions of chemicals with biological systems. All aspects of pharmacology and therapeutics are within the scope of the Journal. Research papers should provide rigorous quantitative analyses and/or new insights on pharmacological mechanisms. All manuscripts are initially screened by the Editorial Board to ensure that each manuscript meets the above criteria before peer review. Manuscripts that provide descriptive case reports, lack complete dose-response determinations, or do not communicate novel findings are not acceptable and will be rejected without peer review. Manuscripts dealing primarily with new methods will be reviewed only if data are presented showing that new or more reliable pharmacological information has been obtained with their use.