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Binary Mixtures of Sodium Salt of Ibuprofen and Selected Bile Salts: Interface, Micellar, Thermodynamic, and Spectroscopic Study
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2017-08-11 00:00:00 , DOI: 10.1021/acs.jced.7b00298 Malik Abdul Rub 1 , Naved Azum 1 , Abdullah M. Asiri 1
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2017-08-11 00:00:00 , DOI: 10.1021/acs.jced.7b00298 Malik Abdul Rub 1 , Naved Azum 1 , Abdullah M. Asiri 1
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With the intention to explore bile salts applications as drug delivery vehicles, the mixed interfacial as well as micellar behavior of the sodium salt of ibuprofen (NaIbuF) and bile salts mixtures in aqueous/electrolyte solutions has been evaluated by tensiometric method at 298.15 K. Bile salts (sodium cholate (NaC) and sodium deoxycholate (NaDC)) used in the present study are anionic in nature and form small micelles. Various theoretical models such as Clint, Rubingh, and Rosen were utilized to acquire information concerning the nature of interaction among the components in the solution as well as at the interface. Because of the presence of inorganic salt (100 mmol·kg–1 NaCl) a decrease in the surface charge of the micelles takes place and ensuing micellization occurs at poorer concentration. The value of the micellar mole fraction (X1m) is found to be greater for NaIbuF + NaDC mixtures in comparison to NaIbuF + NaC mixtures, signifying that participation of NaDC is greater in mixed micelles as compared to NaC. An attractive interaction was obtained in the micelle and at the interface, because it is obvious from interaction parameters (βm, βσ). The values of ΔG0m for all systems was negative in the absence as well as in the occurrence of salt. Micelle aggregation number (Nagg), estimated by means of steady-state fluorescence quenching studies, suggests that the contribution of bile salts was always greater than that of the NaIbuF. The micropolarity (I1/I3), Stern–Volmer binding constants (Ksv), and dielectric constant (Dexp) of mixtures also supported the synergistic behavior of the drug–bile salts mixed systems.
中文翻译：
布洛芬钠盐和精选胆汁盐的二元混合物：界面，胶束，热力学和光谱学研究
为了探索胆盐作为药物传递载体的应用，已通过张力测定法在298.15 K下评估了布洛芬钠盐（NaIbuF）和胆盐混合物在水/电解质溶液中的混合界面以及胶束行为。本研究中使用的碳酸钠盐（胆酸钠（NaC）和脱氧胆酸钠（NaDC））本质上是阴离子性的，并形成小胶束。利用各种理论模型（例如Clint，Rubingh和Rosen）来获取有关溶液中以及界面上各组分之间相互作用的性质的信息。由于存在无机盐（100 mmol·kg –1NaCl）会降低胶束的表面电荷，从而在较差的浓度下会发生胶束化。发现与NaIbuF + NaC混合物相比，NaIbuF + NaDC混合物的胶束摩尔分数（X 1 m）更大，这表明与NaC相比，NaDC在混合胶束中的参与更大。在胶束和在界面处得到一个有吸引力的相互作用，因为它是从相互作用参数（β明显米，β σ）。在不存在盐和存在盐的情况下，所有系统的ΔG 0 m值均为负。胶束聚集数（N agg通过稳态荧光猝灭研究估算的）表明，胆汁盐的贡献总是大于NaIbuF的贡献。混合物的微极性（I 1 / I 3），斯特恩-沃尔默结合常数（K sv）和介电常数（D exp）也支持药物-胆盐混合系统的协同行为。
更新日期：2017-08-11
中文翻译：
布洛芬钠盐和精选胆汁盐的二元混合物：界面，胶束，热力学和光谱学研究
为了探索胆盐作为药物传递载体的应用，已通过张力测定法在298.15 K下评估了布洛芬钠盐（NaIbuF）和胆盐混合物在水/电解质溶液中的混合界面以及胶束行为。本研究中使用的碳酸钠盐（胆酸钠（NaC）和脱氧胆酸钠（NaDC））本质上是阴离子性的，并形成小胶束。利用各种理论模型（例如Clint，Rubingh和Rosen）来获取有关溶液中以及界面上各组分之间相互作用的性质的信息。由于存在无机盐（100 mmol·kg –1NaCl）会降低胶束的表面电荷，从而在较差的浓度下会发生胶束化。发现与NaIbuF + NaC混合物相比，NaIbuF + NaDC混合物的胶束摩尔分数（X 1 m）更大，这表明与NaC相比，NaDC在混合胶束中的参与更大。在胶束和在界面处得到一个有吸引力的相互作用，因为它是从相互作用参数（β明显米，β σ）。在不存在盐和存在盐的情况下，所有系统的ΔG 0 m值均为负。胶束聚集数（N agg通过稳态荧光猝灭研究估算的）表明，胆汁盐的贡献总是大于NaIbuF的贡献。混合物的微极性（I 1 / I 3），斯特恩-沃尔默结合常数（K sv）和介电常数（D exp）也支持药物-胆盐混合系统的协同行为。
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