萜类化合物是一大类天然次生植物代谢产物,其结构高度多样化,由异戊二烯单元 (C-5) 形成,与多种生物学特性相关,包括抗氧化、抗菌、抗炎、抗过敏、抗癌、抗转移等。 、抗血管生成和细胞凋亡诱导,并被认为在食品、化妆品、制药和医疗行业具有潜在应用。在植物中,萜类化合物在生长和发育中发挥多种基本功能。本综述提供了概述,强调了萜类化合物的当前知识以及我们对核心和专门萜类代谢途径的组织、调节和多样化的理解的最新进展,并解决了植物中挥发性和非挥发性专门萜类代谢物的最重要功能。将全面描述植物源萜类化合物作为生物活性化合物的可持续来源的不同方面、它们的生物合成途径、与促进健康作用相关的这些次生代谢物的几种生物学特性,以及它们在多个领域的潜在工业应用,以及新兴的绿色提取方法也将被讨论。此外,还将强调该框架内的未来研究观点。文献选择采用国家医学图书馆、PubMed 和 2010 年至 2024 年期间的国际参考数据,关键词为“萜类化合物”。共找到 177,633 篇已发表论文,其中 196 篇原创论文和综述论文根据其科学可靠性、完整性以及与所考虑主题的相关性标准纳入本次综述中。
"点击查看英文标题和摘要"
Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications—A Comprehensive Overview
Terpenoids are a large class of natural secondary plant metabolites which are highly diverse in structure, formed from isoprene units (C-5), associated with a wide range of biological properties, including antioxidant, antimicrobial, anti-inflammatory, antiallergic, anticancer, antimetastatic, antiangiogenesis, and apoptosis induction, and are considered for potential application in the food, cosmetics, pharmaceutical, and medical industries. In plants, terpenoids exert a variety of basic functions in growth and development. This review gives an overview, highlighting the current knowledge of terpenoids and recent advances in our understanding of the organization, regulation, and diversification of core and specialized terpenoid metabolic pathways and addressing the most important functions of volatile and non-volatile specialized terpenoid metabolites in plants. A comprehensive description of different aspects of plant-derived terpenoids as a sustainable source of bioactive compounds, their biosynthetic pathway, the several biological properties attributed to these secondary metabolites associated with health-promoting effects, and their potential industrial applications in several fields will be provided, and emerging and green extraction methods will also be discussed. In addition, future research perspectives within this framework will be highlighted. Literature selection was carried out using the National Library of Medicine, PubMed, and international reference data for the period from 2010 to 2024 using the keyword “terpenoids”. A total of 177,633 published papers were found, of which 196 original and review papers were included in this review according to the criteria of their scientific reliability, their completeness, and their relevance to the theme considered.