A series of 5-phenyliminobenzo[a]phenoxazine derivatives were synthesized. The in vitro antiprotozoal activities were evaluated against Plasmodium falciparum K1, Trypanosoma cruzi, Leishmania donovani and Trypanosoma brucei rhodesiense. N,N-Diethyl-5-((4-methoxyphenyl)imino)-5H-benzo[a]phenoxazin-9-amine shows IC₅₀ = 0.040 μmol L⁻¹ with a selective index of 1425 against Plasmodium falciparum K1.

中文翻译：

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5-苯基亚氨基苯并[ a ]吩恶嗪衍生物的合成及体外抗原生动物活性

合成了一系列5-苯基亚氨基苯并[ a ]吩恶嗪衍生物。评价了对恶性疟原虫K1，克鲁斯锥虫，多氏利什曼原虫和杜氏布鲁氏锥虫的体外原生动物活性。N，N-二乙基-5-（（4-甲氧基苯基）亚氨基）-5 H-苯并[ a ]苯恶嗪-9-胺显示IC ₅₀  = 0.040μmolL ^-1，对恶性疟原虫K1的选择指数为1425 。