Scientific Papers
71. A pH-Responsive, Surface Charge-Switchable Nanosystem with Enhanced Biofilm Penetration for Synergistic Photodynamic and Antibiotic Therapy of Diabetic Wounds
Zhencheng Sun, Minghui Xiao, Shuyi Lv, Cheng Wang, Hao Fu, Liang Tian, Linqi Shi, and Chunlei Zhu*
Adv. Funct. Mater. 2024, accepted.
70. A straightforward strategy to modulate ROS generation of AIE photosensitizers for type-I PDT
Zhencheng Sun, Jiaxin Wang, Minghui Xiao, Kaiyu Wu, Cheng Wang, Hao Fu, Shuyi Lv, Linqi Shi, and Chunlei Zhu*
Chem. Eng. J. 2024, 499, 155782.
DOI: 10.1016/j.cej.2024.155782.
69. Ultrasensitive Ratiometric Fluorescent Nanothermometer with Reverse Signal Changes for Intracellular Temperature Mapping
Ke Xue#, Siwei Huang#, Kaiyu Wu, Zhencheng Sun, Hao Fu, Cheng Wang, Chao Wang, and Chunlei Zhu*
Anal. Chem. 2024, 96, 11026–11035.
DOI: 10.1021/acs.analchem.4c01803.
68. A Self-Regulated Phototheranostic Nanosystem with Single Wavelength-Triggered Energy Switching and Oxygen Supply for Multimodal Synergistic Therapy of Bacterial Biofilm Infections
Cheng Wang, Shuyi Lv, Zhencheng Sun, Minghui Xiao, Hao Fu, Liang Tian, Xianhao Zhao, Linqi Shi, and Chunlei Zhu*
Aggregate 2024, 5, e587.
67. A Universal Strategy to Enhance Photothermal Conversion Efficiency by Regulating the Molecular Aggregation States for Safe Photothermal Therapy of Bacterial Infections
Hao Fu, Yongxin Zhang, Cheng Wang, Zhencheng Sun, Shuyi Lv, Minghui Xiao, Kaiyu Wu, Linqi Shi, and Chunlei Zhu*
Biomater. Sci. 2024, 12, 2914–2929.
66. 2023年度有机高分子材料学科国家自然科学基金管理工作综述及相关领域近期重要研究进展
丁玉琴,* 马劲, 饶静一, 朱春雷, 蔡芸皓
《高分子通报》, 2024, 37, 419–429.
DOI: 10.14028/j.cnki.1003-3726.2024.23.407.
65. Bacterial Patterning: A Promising Biofabrication Technique
Minghui Xiao, Shuyi Lv, and Chunlei Zhu*
ACS Appl. Bio Mater. 2024, 7, 8008–8018. (Invited for Early Career Forum 2024)
64. Photodynamic Patterning of Living Bacterial Biofilms with High Resolutions for Information Encryption and Antibiotic Screening
Minghui Xiao, Ke Xue, Hao Fu, Jiaxin Wang, Shuyi Lv, Zhencheng Sun, Cheng Wang, Linqi Shi, and Chunlei Zhu*
Aggregate 2024, 5, e532.
63. Reconstituting Low-Density Lipoprotein with NIR-Absorbing Organic Photothermal Agents for Targeted Killing of Cancer Cells
Jiaxin Wang#, Liang Tian#, Kaiyu Wu, Chao Wang, and Chunlei Zhu*
Macromol. Rapid Commun. 2023, 44, 2300395.
62. Activated alkyne-enabled turn-on click bioconjugation with cascade signal amplification for ultrafast and high-throughput antibiotic screening
Shuyi Lv, Chao Wang, Ke Xue, Jiaxin Wang, Minghui Xiao, Zhencheng Sun, Lei Han, Linqi Shi, and Chunlei Zhu*
Proc. Natl. Acad. Sci. U.S.A. 2023, 120, e2302367120.
61. 非电荷型AIE光敏剂的纳米封装及光动力抗菌研究
武凯宇, 孙振程, 符豪, 肖铭慧, 朱春雷*
60. Differentiation Therapy for Murine Myelofibrosis Model with MLN8237 Loaded Low-density Lipoproteins
Binghong He#, Chao Wang#, Fuping Wang, Liang Tian, Haitao Wang, Chunling Fu, Jin Liu, Chao Xi, Chunlei Zhu,* and Qiong Yang*
J. Control. Release 2023, 356, 554–566.
DOI: 10.1016/j.jconrel.2023.03.024.
59. Informatics colourizes polymers
Xiaolin Liu,* Chunlei Zhu,* and Ben Zhong Tang*
Nat. Rev. Chem. 2023, 7, 232–233.
DOI: 10.1038/s41570-023-00484-z.
58. Thermoresponsive Hydrogel-Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria-Infected Wounds
Hao Fu, Ke Xue, Yongxin Zhang, Minghui Xiao, Kaiyu Wu, Linqi Shi, and Chunlei Zhu*
Adv. Sci. 2023, 10, 2206865.
57. Holdase/Foldase Mimetic Nanochaperone Improves Antibody-Based Cancer Immunotherapy
Yongxin Zhang, Hao Fu, Jiajing Chen, Linlin Xu, Yingli An, Rujiang Ma, Chunlei Zhu,Yang Liu, Feihe Ma*, and Linqi Shi*
Small Methods 2023, 7, 2201051.
56. NIR-II organic dyes: Get brighter and see clearer
Xiaolin Liu,* Jianhui Liu, and Chunlei Zhu*
Matter 2022, 5, 3583–3585.
DOI: 10.1016/j.matt.2022.10.005.
55. A Smart Photothermal Nanosystem with an Intrinsic Temperature-Control Mechanism for Thermostatic Treatment of Bacterial Infections
Jiaxin Wang, Boyi Hao, Ke Xue, Hao Fu, Minghui Xiao, Yongxin Zhang, Linqi Shi, and Chunlei Zhu*
Adv. Mater. 2022, 34, 2205653.
54. A Ratiometric Organic Fluorescent Nanogel Thermometer for Highly Sensitive Temperature Sensing
Chao Wang#, Xianhao Zhao#, Kaiyu Wu, Shuyi Lv, and Chunlei Zhu*
Biosensors 2022, 12, 702.
53. A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome
Cheng Wang, Jiaxin Wang, Ke Xue, Minghui Xiao, Zhencheng Sun, and Chunlei Zhu*
Chem. Commun. 2022, 58, 7058–7061. (HOT Article)
52. Bridging D‒A type photosensitizers with the azo group to boost intersystem crossing for efficient photodynamic therapy
Boyi Hao, Jiaxin Wang, Chao Wang, Ke Xue, Minghui Xiao, Shuyi Lv, and Chunlei Zhu*
Chem. Sci. 2022, 13, 4139–4149.
51. Polarity-Sensitive Fluorescent Probe for Reflecting the Packing Degree of Bacterial Membrane Lipids
Chao Wang, Jiaxin Wang, Ke Xue, Minghui Xiao, Kaiyu Wu, Shuyi Lv, Boyi Hao, and Chunlei Zhu*
Anal. Chem. 2022, 94, 3303–3312.
DOI: 10.1021/acs.analchem.1c05268.
50. Bringing Inherent Charges into Aggregation-Induced Emission Research
Xiaolin Liu, Chunlei Zhu,* and Ben Zhong Tang*
Acc. Chem. Res. 2022, 55, 197–208. (Supplementary Cover)
DOI: 10.1021/acs.accounts.1c00630.
49. A Sensitive and Reliable Organic Fluorescent Nanothermometer for Noninvasive Temperature Sensing
Ke Xue, Chao Wang, Jiaxin Wang, Shuyi Lv, Boyi Hao, Chunlei Zhu,* and Ben Zhong Tang*
J. Am. Chem. Soc. 2021, 143, 14147–14157. (Front cover)
48. Heteroaromatic Hyperbranched Polyelectrolytes: Multicomponent Polyannulation and Photodynamic Biopatterning
Xiaolin Liu#, Minghui Xiao#, Ke Xue, Mingzhao Li, Dongming Liu, Yong Wang, Xinzhe Yang, Yubing Hu, Ryan T. K. Kwok, Anjun Qin, Chunlei Zhu,* Jacky W. Y. Lam,* and Ben Zhong Tang*
Angew. Chem. Int. Ed. 2021, 60, 19222–19231. (HOT paper & inside back cover)
47. Bringing naturally-occurring saturated fatty acids into biomedical research
Ke Xue#, Shuyi Lv#, and Chunlei Zhu*
J. Mater. Chem. B 2021, 9, 6973–6987. (Invited for 2021 Emerging Investigator Themed Issue & HOT paper)
46. Augmenting Tendon-to-Bone Repair with Functionally-Graded Scaffolds
Chunlei Zhu, Jichuan Qiu, Stavros Thomopoulos, and Younan Xia*
Adv. Healthcare Mater. 2021, 10, 2002269.
45. An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria
Ke Xue#, Cuihong Yang#, Chun Wang, Yang Liu, Jianfeng Liu,* Linqi Shi,* and Chunlei Zhu*
CCS Chem. 2022, 4, 272–285. (Front Cover)
DOI: 10.31635/ccschem.021.202000714.
44. Transporting mitochondrion-targeting photosensitizers into cancer cells by low-density lipoproteins for fluorescence-feedback photodynamic therapy
Chao Wang, Xianhao Zhao, Haoyu Jiang, Jiaxin Wang, Weixiu Zhong, Ke Xue, and Chunlei Zhu*
Nanoscale 2021, 13, 1195–1205. (Invited for 2021 Emerging Investigator Themed Issue)
43. Self-assembly of virulent amyloid-derived peptides into nanoantibacterials
Wenlu Tu, Ke Xue, Shaofeng Lou, Chunlei Zhu, and Zhilin Yu*
Nanoscale 2021, 13, 9864–9872.
42. 天然来源相转变材料在生物医药领域中的应用
朱春雷*
41. Self-Reporting and Photothermally Enhanced Rapid Bacterial Killing on a Laser-Induced Graphene Mask
Libei Huang, Siyu Xu, Zhaoyu Wang, Ke Xue, Jianjun Su, Yun Song, Sijie Chen, Chunlei Zhu,* Ben Zhong Tang,* and Ruquan Ye*
ACS Nano 2020, 14, 12045–12053.
40. Aggregation-induced emission: A trailblazing journey to the field of biomedicine
Chunlei Zhu, Ryan T. K. Kwok, Jacky W. Y. Lam, and Ben Zhong Tang*
ACS Appl. Bio Mater. 2018, 1, 1768–1786. (ACS Editor’s Choice)
Book Chapter
1. Chapter 9: Engineering the bioprobes with AIE properties to study tumor hypoxia
Jiaxin Wang and Chunlei Zhu*
Aggregation-Induced Emission: Applications in Biosensing, Bioimaging and Biomedicine–Volume I, Walter de Gruyter GmbH, 2022.
2. Chapter 11: Nanomedicine
Shuyi Lv and Chunlei Zhu
Handbook of Nanomaterials, Volume 2: Biomedicine, Environment, Food, and Agriculture, Elsevier, 2024.
Prior to joining Nankai University
39. Jiajia Xue, Tong Wu, Jianhua Li, Chunlei Zhu, and Younan Xia,* “Promoting the outgrowth of neurites on electrospun microfibers by functionalization with electrosprayed microparticles of fatty acids,” Angew. Chem. Int. Ed. 2019, 58, 3948–3951.
38. Qiaoshan Chen, Da Huo, Haoyan Cheng, Zhiheng Lyu, Chunlei Zhu, Baohong Guan, and Younan Xia,* “Near-infrared-triggered release of Ca2+ ions for potential application in combination cancer therapy,” Adv. Healthcare Mater. 2019, 8, 1801113.
37. Chunlei Zhu#, Suphannee Pongkitwitoon#, Jichuan Qiu, Stavros Thomopoulos, and Younan Xia,* “Design and fabrication of a hierarchically structured scaffold for tendon-to-bone repair,” Adv. Mater. 2018, 30, 1707306. (Back cover)
36. Chunlei Zhu#, Jichuan Qiu#, Suphannee Pongkitwitoon#, Stavros Thomopoulos, and Younan Xia,* “Inverse opal scaffolds with gradients in mineral content for spatial control of osteogenesis,” Adv. Mater. 2018, 30, 1706706.
35. Jiajia Xue, Chunlei Zhu, Jianhua Li, Haoxuan Li, and Younan Xia,* “Integration of phase-change materials with electrospun fibers for promoting neurite outgrowth under controlled release,” Adv. Funct. Mater. 2018, 28, 1705563.
34. Qiaoshan Chen, Chunlei Zhu, Da Huo, Jiajia Xue, Haoyan Cheng, Baohong Guan and Younan Xia,* “Continuous processing of phase-change materials into uniform nanoparticles for near-infrared-triggered drug release,” Nanoscale, 2018, 10, 22312–22318.
33. Haoyan Cheng, Da Huo, Chunlei Zhu, Song Shen, Wenxia Wang, Haoxuan Li, Zhihong Zhu, Younan Xia,* “Combination cancer treatment through photothermally controlled release of selenous acid from gold nanocages,” Biomaterials 2018, 178, 517–526.
32. Ji Qi, Chaowei Sun, Dongyu Li, Hequn Zhang, Wenbin Yu, Abudureheman Zebibula, Jacky W. Y. Lam, Wang Xi, Liang Zhu, Fuhong Cai, Peifa Wei , Chunlei Zhu, Ryan T. K. Kwok , Lina L. Streich, Robert Prevedel, Jun Qian,* and Ben Zhong Tang,* “Aggregation-induced emission luminogen with near-infrared-II excitation and near-infrared-I emission for ultradeep intravital two-photon microscopy,” ACS Nano 2018, 12, 7936–7945.
31. Tong Wu, Jiajia Xue, Haoxuan Li, Chunlei Zhu, Xiumei Mo, Younan Xia,* “A general method for generating circular gradients of active proteins on nanofiber scaffolds sought for wound closure and related applications,” ACS Appl. Mater. Interfaces 2018, 10, 8536–8535.
30. Chunlei Zhu and Younan Xia,* “Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications,” Chem. Soc. Rev. 2017, 46, 7668–7682.
29. Chunlei Zhu, Pallab Pradhan, Da Huo, Jiajia Xue, Song Shen, Krishnendu Roy, and Younan Xia,* “Reconstitution of low density lipoproteins with fatty acids for the targeted delivery of drugs into cancer cells,” Angew. Chem. Int. Ed. 2017, 56, 10399–10402.
28. Chunlei Zhu, Da Huo, Qiaoshan Chen, Jiajia Xue, Song Shen, and Younan Xia,* “A eutectic mixture of natural fatty acids can serve as the gating material for near-infrared-triggered drug release,” Adv. Mater. 2017, 29, 1703702.
27. Yu Shrike Zhang#, Chunlei Zhu#, and Younan Xia,* “Inverse opal scaffolds and their biomedical applications,” Adv. Mater. 2017, 29, 1701115.
26. Song Shen, Chunlei Zhu, Da Huo, Miaoxin Yang, Jiajia Xue, and Younan Xia,* “A hybrid nanomaterial for the controlled generation of free radicals and oxidative destruction of hypoxic cancer cells,” Angew. Chem. Int. Ed. 2017, 56, 8801-8804. (HOT paper & back cover)
25. Haoxuan Li, Chunlei Zhu, Jiajia Xue, Qinfei Ke, and Younan Xia,* “Enhancing the mechanical properties of electrospun nanofiber mats through controllable welding at the cross points,” Macromol. Rapid Commun. 2017, 38, 1600723.
24. Jiajia Xue, Junyu Yang, Deirdre Margaret O’Connor, Chunlei Zhu, Da Huo, Nicholas M. Boulis, and Younan Xia,* “Differentiation of bone marrow stem cells into Schwann cells for the promotion of neurite outgrowth on electrospun fibers,” ACS Appl. Mater. Interfaces 2017, 9, 12299−12310.
23. Chunlei Zhu, Jiajia Xue, Kyle D. Gilroy, Da Huo, Song Shen, and Younan Xia,* “Micropatterned polymer nanorod forests and their use for dual drug loading and regulation of cell adhesion,” ACS Appl. Mater. Interfaces 2016, 8, 34194-34197.
22. Jianhua Li, Stephen W. Linderman, Chunlei Zhu, Hong Liu, Stavros Thomopoulos, and Younan Xia,* “Surgical sutures with porous sheaths for the sustained release of growth factors,” Adv. Mater. 2016, 28, 4620-4624.
21. Shan Zhou, Jianhua Li, Kyle D. Gilroy, Jing Tao, Chunlei Zhu, Xuan Yang, Xiaojun Sun, and Younan Xia,* “Facile synthesis of silver nanocubes with sharp corners and edges in an aqueous solution,” ACS Nano 2016, 10, 9861-9870.
20. Jianhua Li, Miaoxin Yang, Xiaojun Sun, Xuan Yang, JiaJia Xue, Chunlei Zhu, Hong Liu, and Younan Xia,* “Micropatterning of the ferroelectric phase in a poly(vinylidenedifluoride) film by plasmonic heating with gold nanocages,” Angew. Chem. Int. Ed. 2016, 55, 13828-13832. (Back cover)
19. Chunlei Zhu, Qiong Yang,* Fengting Lv, Libing Liu, and Shu Wang,* “Conjugated polymer-coated bacteria for multimodal intracellular and extracellular anticancer activity,” Adv. Mater. 2013, 25, 1203-1208.
18. Liheng Feng, Chunlei Zhu, Huanxiang Yuan, Libing Liu,* Fengting Lv, and Shu Wang,* “Conjugated polymer nanoparticles: Preparation, properties, functionalization and biological applications,” Chem. Soc. Rev. 2013, 42, 6620-6633.
17. Chenyao Nie, Chunlei Zhu, Liheng Feng, Fengting Lv,* Libing Liu, and Shu Wang,* “Synthesis of a new conjugated polymer for DNA alkylation and gene regulation,” ACS Appl. Mater. Interfaces 2013, 5, 4549-4554.
16. Bing Wang, Chunlei Zhu, Libing Liu, Fengting Lv, Qiong Yang, and Shu Wang,* “Synthesis of a new conjugated polymer for cell membrane imaging by using an intracellular targeting strategy,” Polym. Chem. 2013, 4, 5212-5215.
15. Hui Chong, Chunlei Zhu, Jinzhao Song, Liheng Feng, Qiong Yang,* Libing Liu, Fengting Lv, and Shu Wang,* “Preparation and optical property of new fluorescent nanoparticles,” Macromol. Rapid Commun. 2013, 34, 736-742.
14. Chunlei Zhu, Libing Liu, Qiong Yang, Fengting Lv, and Shu Wang,* “Water-soluble conjugated polymers for imaging, diagnosis, and therapy,” Chem. Rev. 2012, 112, 4687-4735.
13 Qiong Yang, Ying Dong, Wei Wu, Chunlei Zhu, Hui Chong, Jiangyang Lu,* Dehai Yu, Libing Liu, Fengting Lv, and Shu Wang,* “Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation,” Nat. Commun. 2012, 3, 1206.
12. Huanxiang Yuan, Hui Chong, Bing Wang, Chunlei Zhu, Libing Liu,* Qiong Yang, Fengting Lv, and Shu Wang,* “Chemical molecule-induced light-activated system for anticancer and antifungal activities,” J. Am. Chem. Soc. 2012, 134, 13184-13187.
11. Quanshan Wen, Chunlei Zhu, Libing Liu,* Qiong Yang, Shu Wang,* and Daoben Zhu,* “Synthesis of a bifunctional fluorescent polymer for cell imaging and enzyme detection,” Macromol. Chem. Phys. 2012, 213, 2486-2491.
10. Hui Chong, Chenyao Nie, Chunlei Zhu, Qiong Yang,* Libing Liu, Fengting Lv, and Shu Wang,* “Conjugated polymer nanoparticles for light-activated anticancer and antibacterial activity with imaging capability,” Langmuir 2012, 28, 2091-2098.
9. Bing Wang, Huanxiang Yuan, Chunlei Zhu, Qiong Yang,* Fengting Lv, Libing Liu, and Shu Wang,* “Polymer-drug conjugates for intracellar molecule-targeted photoinduced inactivation of protein and growth inhibition of cancer cells,” Sci. Rep. 2012, 2, 766.
8. Gaomai Yang, Huanxiang Yuan, Chunlei Zhu, Libing Liu,* Qiong Yang, Fengting Lv, and Shu Wang,* “New conjugated polymers for photo-induced unwinding of DNA supercoiling and gene regulation,” ACS Appl. Mater. Interfaces 2012, 4, 2334-2337.
7. Chunlei Zhu, Qiong Yang,* Libing Liu, and Shu Wang,* “Rapid, simple and high-throughput antimicrobial susceptibility testing and antibiotics screening,” Angew. Chem. Int. Ed. 2011, 50, 9607-9610.
6. Chunlei Zhu, Qiong Yang,* Libing Liu, Fengting Lv, Shayu Li, Guoqiang Yang, and Shu Wang,* “Multifunctional cationic poly(p-phenylene vinylene) polyelectrolytes for selective recognition, imaging and killing of bacteria over mammalian cells,” Adv. Mater. 2011, 23, 4805-4810. (Frontispiece)
5. Chunlei Zhu, Qiong Yang,* Libing Liu, and Shu Wang,* “A potent fluorescent probe for the detection of cell apoptosis,” Chem. Commun. 2011, 47, 5524-5526.
4. Chunlei Zhu, Qiong Yang,* Libing Liu, and Shu Wang,* “Visual optical discrimination and detection of microbial pathogens based on diverse interactions of conjugated polyelectrolytes with cells,” J. Mater. Chem. 2011, 21, 7905-7912. (HOT paper & front cover)
3. Chunlei Zhu, Qiong Yang, Libing Liu, and Shu Wang,* “Conjugated polymers for sensitive chemical sensors,” Prog. Chem. 2011, 23, 1993-2002.
2. Qiong Yang,* Tian Qiu, Wei Wu, Chunlei Zhu, Libing Liu, Jianming Ying,* and Shu Wang,* “Simple and sensitive method for detecting point mutations of epidermal growth factor receptor using cationic conjugated polymers,” ACS Appl. Mater. Interfaces 2011, 3, 4539-4545.
1. Qingling Xu, Chunxian Wu, Chunlei Zhu, Xinrui Duan, Libing Liu,* Yuchun Han, Yilin Wang,* and Shu Wang,* “A water-soluble conjugated polymer for protein identification and denaturation detection,” Chem. Asian J. 2010, 5, 2524-2529.
