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成果及论文


2024 年发表


62.Mu X., Li Y., Zhai M., Gao M., Feng W., Han X., Wang Y., Lu Y., Zhou X., Albumin-mediated molecular competition of supramolecular photosensitizers for NIR-II imaging-guided phototherapy. Dyes and Pigments, 2024, 227, 112191.

61.Hao X, Tang Y, Zhang R, Wang Z, Gao M, Wei R, Zhao Y, Mu X, Lu Y, Zhou X. Cationized orthogonal triad as a photosensitizer with enhanced synergistic antimicrobial activity. Acta Biomater. 2024, 178, 287-295. 

60.Yajie Li, Xueluer Mu, Wenbi Feng, Min Gao, Zigeng Wang, Xue Bai, Xiangru Ren, Yingxi Lu, Xianfeng Zhou,Supramolecular prodrug-like nanotheranostics with dynamic and activatable nature for synergistic photothermal immunotherapy of metastatic cancer,Journal of Controlled Release 2024, 367 , 354-365.


  2023   年发表

59.Yang, G.; Xie, Y.; Wang, Y.; Tang, Y.; Chng, L. L.; Jiang, F.; Du, F.; Zhou, X.; Ying, J. Y.; Yuan, X. Water-soluble Cu30 nanoclusters as a click chemistry catalyst for living cell labeling via azide-alkyne cycloaddition. Nano Res 2023, 16, 1748-1754.

58.Wang, Z.; Tang, Y.; Gao, M.; Bai, X.; Li, Y.; Hao, X.; Lu, Y.; Zhou, X., Cell-Membrane Coated Self-Immolative Poly(thiourethane) for Cysteine/Homocysteine-Triggered Intracellular H(2)S Delivery. ACS Macro Lett 2023, 12 (11), 1583-1588.

57.Tang Y, Liu S, Hao X, et al. Near-Infrared Molecular Logic Gate for In Situ Construction and Quantification of Cell–Macromolecule Conjugates. Analytical Chemistry, 2023, 95, 42, 15818–15825


56. Yang, G.; Pan, X.; Feng, W.; Yao, Q.; Jiang, F.; Du, F.; Zhou, X.; Xie, J.; Yuan, X. Engineering Au44 Nanoclusters for NIR-II Luminescence Imaging-Guided Photoactivatable Cancer Immunotherapy. ACS Nano 2023, 17, 15605-15614 


55.Sun, S.; Feng, W.; Chen, Z.; Huang, Z.; Mu, X.; Lu, Y.; Zhou, X. Engineering thio-/seleno-ether linkers into zwitterionic small molecule nano-prodrugs for traceable cancer theranostics. Sens. Actuators, B 2023, 387, 133771

54. Liang, M.; Mu, X.; Li, Y.; Tan, Y.; Hao, X.; Tang, Y.; Wang, Z.; Feng, W.; Lu, Y.; Zhou, X. Heptamethine Cyanine-Based Nanotheranostics with Catalase-Like Activity for Synergistic Phototherapy of Cancer. Adv. Funct. Mater. 2023, 33, 2302112

53. Yang, G.; Mu, X.; Pan, X.; Tang, Y.; Yao, Q.; Wang, Y.; Jiang, F.; Du, F.; Xie, J.; Zhou, X.; Yuan, X. Ligand engineering of Au44 nanoclusters for NIR-II luminescent and photoacoustic imaging-guided cancer photothermal therapy. Chem. Sci. 2023, 14, 4308-4318

52.Ma, H.; Mu, X.; Tang, Y.; Li, C.; Wang, Y.; Lu, Y.; Zhou, X.; Li, Z. Programmable multistage small-molecule nano-photosensitizer for multimodal imaging-guided photothermal therapy. Acta Biomater. 2023, 157, 408-416.

51. Wang, X.; Sun, H.; Lu, Y.; Zhou, X. Facile preparation of fluorescent non-conjugated polymer films with tunable multicolor photoluminescence via layer-by-layer assembly. Mater. Chem. Front 2023, 7, 442-450.


50. Mu, X.; Huang, Z.; Feng, W.; Zhai, M.; Wang, Y.; Zhou, D.; Zhou, X. Zwitterionic rhodamine-CPT prodrug nanoparticles with GSH/H2O2 responsiveness for cancer theranostics. Theranostics 2023, 13, 267-277.


2022年发表


49.Lin, P.; Xue, Y.; Mu, X.; Shao, Y.; Lu, Q.; Jin, X.; Yinwang, E.; Zhang, Z.; Zhou, H.; Teng, W.; Sun, H.; Chen, W.; Shi, W.; Shi, C.; Zhou, X.; Jiang, X.; Yu, X.; Ye, Z. Tumor Customized 2D Supramolecular Nanodiscs for Ultralong Tumor Retention and Precise Photothermal Therapy of Highly Heterogeneous Cancers. Small 2022, 18, 2200179.


48. Mu, X.; Feng, W.; Li, C.; Li, K.; Li, Y.; Jing, X.; Lu, Y.; Zhou, X.; Li, Z. Lighting up Self-Quenching Nanoaggregates with Protein Corona for Simultaneous Intraoperative Imaging and Photothermal Theranostics of Metastatic Cancer. Anal. Chem. 2022, 94, 9775-9784.


47.  Mu, X.; Wu, F.; Tang, Y.; Wang, R.; Li, Y.; Li, K.; Li, C.; Lu, Y.; Zhou, X.; Li, Z. Boost photothermal theranostics via self-assembly-induced crystallization (SAIC). Aggregate 2022, 3, e170.

46.Wang, R.; Wang, X.; Mu, X.; Feng, W.; Lu, Y.; Yu, W.; Zhou, X. Reducing thermal damage to adjacent normal tissue with dual thermo-responsive polymer via thermo-induced phase transition for precise photothermal theranosis. Acta Biomater. 2022, 148, 142-151.



2021年发表


45.Ma, H.; Sun, Y.; Tang, Y.; Shen, Y.; Kan, Z.; Li, Q.; Fang, S.; Lu, Y.; Zhou, X.; Li, Z. Robust Electrospun Nanofibers from Chemosynthetic Poly(4-hydroxybutyrate) as Artificial Dural Substitute. Macromol. Biosci. 2021, 21, 2100134.

44.Tang, Y.; Wang, H.; Sun, Y.; Jiang, Y.; Fang, S.; Kan, Z.; Lu, Y.; Liu, S.; Zhou, X.; Li, Z. Using Platelet-Rich Plasma Hydrogel to Deliver Mesenchymal Stem Cells into Three-Dimensional PLGA Scaffold for Cartilage Tissue Engineering. ACS Applied Bio Materials 2021, 4, 8607-8614.

43. Wang, X.; Wang, R.; Wu, F.; Yue, H.; Cui, Z.; Zhou, X.; Lu, Y. Mussel-inspired layer-by-layer assembled polymeric films with fast growing and NIR light triggered healing capabilities. Eur. Polym. J. 2021, 158,110689.

     

42.Wang, X.; Wang, Z.; Fang, S.; Hou, Y.; Du, X.; Xie, Y.; Xue, Q.; Zhou, X.; Yuan, X. Injectable Ag nanoclusters-based hydrogel for wound healing via eliminating bacterial infection and promoting tissue regeneration. Chem. Eng. J. 2021, 420, 127589.

41. Mu, X.; Tang, Y.; Wu, F.; Ma, H.; Huang, S.; Liang, M.; Yang, J.; Lu, Y.; Zhou, X.; Li, Z. A Simple Small Molecule with Synergistic Passive and Active Dual-Targeting Effects for Imaging-Guided Photothermal Cancer Therapy. ACS Appl. Mater. Interfaces 2021, 13, 36958-36966.

40.Mu, X.; Wu, F.; Wang, R.; Huang, Z.; Lv, T.; Lu, Y.; Liu, B.; Zhou, X. A cyanine-derived NIR molecular rotor for ratiometric imaging of amyloid-β aggregates. Sens. Actuators, B 2021, 338, 129842.


2020年发表


39. Duan, W.; Ji, S.; Guan, Y.; Mu, X.; Fang, S.; Lu, Y.; Zhou, X.; Sun, J.; Li, Z. Esterase-Responsive Polypeptide Vesicles as Fast-Response and Sustained-Release Nanocompartments for Fibroblast-Exempt Drug Delivery. Biomacromolecules 2020, 21, 5093-5103.

38. Liu, Y.; Wang, S.; Wang, Z.; Yao, Q.; Fang, S.; Zhou, X.; Yuan, X.; Xie, J. The in situ synthesis of silver nanoclusters inside a bacterial cellulose hydrogel for antibacterial applications. J. Mater. Chem. B 2020, 8, 4846-4850.

37.Lu, Y.; Wu, F.; Duan, W.; Mu, X.; Fang, S.; Lu, N.; Zhou, X.; Kong, W. Engineering a “PEG-g-PEI/DNA nanoparticle-in- PLGA microsphere” hybrid controlled release system to enhance immunogenicity of DNA vaccine. Mater. Sci. Eng., C 2020, 106, 110294.


36.Wang, Z.; Fang, Y.; Zhou, X.; Li, Z.; Zhu, H.; Du, F.; Yuan, X.; Yao, Q.; Xie, J. Embedding ultrasmall Ag nanoclusters in Luria-Bertani extract via light irradiation for enhanced antibacterial activity. Nano Res 2020, 13, 203-208.


35.Wu, F.; Lu, Y.; Mu, X.; Chen, Z.; Liu, S.; Zhou, X.; Liu, S.; Li, Z. Intriguing H-Aggregates of Heptamethine Cyanine for Imaging-Guided Photothermal Cancer Therapy. ACS Appl. Mater. Interfaces 2020, 12, 32388-32396.


34. Zhou, X.; Dalai, P.; Sahai, N. Semipermeable Mixed Phospholipid-Fatty Acid Membranes Exhibit K+/Na+ Selectivity in the Absence of Proteins. Life 2020, 10, 39.


33. Mu, X.; Lu, Y.; Wu, F.; Wei, Y.; Ma, H.; Zhao, Y.; Sun, J.; Liu, S.; Zhou, X.; Li, Z. Supramolecular Nanodiscs Self-Assembled from Non-Ionic Heptamethine Cyanine for Imaging-Guided Cancer Photothermal Therapy. Adv. Mater. 2020, 32, 1906711.


2019年发表


32.  Liu, H.; Zhang, Z.; Zhao, Y.; Zhou, Y.; Xue, B.; Han, Y.; Wang, Y.; Mu, X.; Zang, S.; Zhou, X.; Li, Z. A water-soluble two-dimensional supramolecular organic framework with aggregation-induced emission for DNA affinity and live-cell imaging. J. Mater. Chem. B 2019, 7, 1435-1441.

31.Xu, Z.; Qin, T.; Zhou, X.; Wang, L.; Liu, B. Fluorescent probes with multiple channels for simultaneous detection of Cys, Hcy, GSH, and H2S. TrAC, Trends Anal. Chem. 2019, 121, 115672.

30. Liu, H.; Pan, Q.; Wu, C.; Sun, J.; Zhuang, T.; Liang, T.; Mu, X.; Zhou, X.; Li, Z.; Zhao, Y. Construction of two-dimensional supramolecular nanostructure with aggregation-induced emission effect via host–guest interactions. Mater. Chem. Front 2019, 3, 1532-1537.

29. Zhang, R.; Mankoci, S.; Walters, N.; Gao, H.; Zhang, H.; Hou, X.; Qin, H.; Ren, Z.; Zhou, X.; Doll, G. L.; Martini, A.; Sahai, N.; Dong, Y.; Ye, C. Effects of laser shock peening on the corrosion behavior and biocompatibility of a nickel–titanium alloy. J. Biomed. Mater. Res., Part B 2019, 107, 1854-1863.


28. Lu, N.; Lu, Y.; Liu, S.; Jin, C.; Fang, S.; Zhou, X.; Li, Z. Tailor-Engineered POSS-Based Hybrid Gels for Bone Regeneration. Biomacromolecules 2019, 20, 3485-3493.

27. Mu, X.; Liu, Y.; Liu, S.; Sun, Y.; Lu, N.; Lu, Y.; Li, W.; Zhou, X.; Liu, B.; Li, Z. A cyanine-derived near-infrared molecular rotor for ratiometric imaging of mitochondrial viscosity in cells. Sens. Actuators, B 2019, 298, 126831.

26.Lu, Y.; Yang, H.; Wu, W.; Zhang, X.; Yue, H.; Wei, Y.; Xue, D.; Sui, N.; Zhou, X.; Du, F. Healable Layer-by-Layer Assembled WO3-Polymeric Composite Films: Undergraduate Experiments for Nanomaterials. Journal of Laboratory Chemical Education 2019, 7, 45−49.


2018年发表


25.Hou, X.; Mankoci, S.; Walters, N.; Gao, H.; Zhang, R.; Li, S.; Qin, H.; Ren, Z.; Doll, G. L.; Cong, H.; Martini, A.; Vasudevan, V. K.; Zhou, X.; Sahai, N.; Dong, Y.; Ye, C. Hierarchical structures on nickel-titanium fabricated by ultrasonic nanocrystal surface modification. Mater. Sci. Eng., C 2018, 93, 12-20.


24.Zhou, X.; Li, Z. Advances and Biomedical Applications of Polypeptide Hydrogels Derived from α-Amino Acid N-Carboxyanhydride (NCA) Polymerizations. Adv Healthc Mater 2018, 7, 1800020.

23.Lu, Y.; Zhou, X. Synthesis and characterization of nanorod-structured vanadium oxides. Thin Solid Films 2018, 660, 180-185.

22.Zhang, R.; Zhou, X.; Gao, H.; Mankoci, S.; Liu, Y.; Sang, X.; Qin, H.; Hou, X.; Ren, Z.; Doll, G. L.; Martini, A.; Dong, Y.; Sahai, N.; Ye, C., The effects of laser shock peening on the mechanical properties and biomedical behavior of AZ31B magnesium alloy. Surf. Coat. Technol. 2018, 339, 48-56.

2017年发表


21. Hou, X.; Qin, H.; Gao, H.; Mankoci, S.; Zhang, R.; Zhou, X.; Ren, Z.; Doll, G. L.; Martini, A.; Sahai, N.; Dong, Y.; Ye, C. A systematic study of mechanical properties, corrosion behavior and biocompatibility of AZ31B Mg alloy after ultrasonic nanocrystal surface modification. Mater. Sci. Eng., C 2017, 78, 1061-1071.


20. Liu, B.; Luo, Z.; Si, S.; Zhou, X.; Pan, C.; Wang, L. A photostable triphenylamine-based flavonoid dye: Solvatochromism, aggregation-induced emission enhancement, fabrication of organic nanodots, and cell imaging applications. Dyes Pigm. 2017, 142, 32-38.

19.Zhou, X.; Zhang, N.; Mankoci, S.; Sahai, N. Silicates in orthopedics and bone tissue engineering materials. Journal of Biomedical Materials Research Part A 2017, 105, 2090-2102.



2016年之前发表


     

18. Zhou, X.; Moussa, F. M.; Mankoci, S.; Ustriyana, P.; Zhang, N.; Abdelmagid, S.; Molenda, J.; Murphy, W. L.; Safadi, F. F.; Sahai, N. Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. Acta Biomater. 2016, 39, 192-202.

17. Ye, C.; Zhou, X.; Telang, A.; Gao, H.; Ren, Z.; Qin, H.; Suslov, S.; Gill, A. S.; Mannava, S. R.; Qian, D.; Doll, G. L.; Martini, A.; Sahai, N.; Vasudevan, V. K. Surface amorphization of NiTi alloy induced by Ultrasonic Nanocrystal Surface Modification for improved mechanical properties. J. Mech. Behav. Biomed. Mater. 2016, 53, 455-462.

16. Zhou, X.; Sahai, N.; Qi, L.; Mankoci, S.; Zhao, W. Biomimetic and nanostructured hybrid bioactive glass. Biomaterials 2015, 50, 1-9.

15.Zhou, X.; Su, F.; Tian, Y.; Meldrum, D. R. Dually Fluorescent Core-Shell Microgels for Ratiometric Imaging in Live Antigen-Presenting Cells. PLoS ONE 2014, 9, e88185.

14. Zhou, X.; Liang, F. Application of Graphene/Graphene Oxide in Biomedicine and Biotechnology. Curr. Med. Chem. 2014, 21, 855-869.

13.  Zhang, N.; Molenda, J. A.; Mankoci, S.; Zhou, X.; Murphy, W. L.; Sahai, N. Crystal structures of CaSiO3 polymorphs control growth and osteogenic differentiation of human mesenchymal stem cells on bioceramic surfaces. Biomater. Sci. 2013, 1, 1101-1110.

12.Zhu, H.; Zhou, X.; Su, F.; Tian, Y.; Ashili, S.; Holl, M. R.; Meldrum, D. R. Micro-patterning and characterization of PHEMA-co-PAM-based optical chemical sensors for lab-on-a-chip applications. Sens. Actuators, B 2012, 173, 817-823.

11.Zhou, X.; Su, F.; Lu, H.; Senechal-Willis, P.; Tian, Y.; Johnson, R. H.; Meldrum, D. R. An FRET-based ratiometric chemosensor for in vitro cellular fluorescence analyses of pH. Biomaterials 2012, 33, 171-180.

10. Lu, H.; Su, F.; Mei, Q.; Zhou, X.; Tian, Y.; Tian, W.; Johnson, R. H.; Meldrum, D. R. A series of poly[N-(2-hydroxypropyl)methacrylamide] copolymers with anthracene-derived fluorophores showing aggregation-induced emission properties for bioimaging. J. Polym. Sci., Part A: Polym. Chem. 2012, 50, 890-899.

9.  Zhou, X.; Su, F.; Tian, Y.; Youngbull, C.; Johnson, R. H.; Meldrum, D. R. A New Highly Selective Fluorescent K+ Sensor. J. Am. Chem. Soc. 2011, 133, 18530-18533.

8.  Zhou, X.; Su, F.; Tian, Y.; Johnson, R. H.; Meldrum, D. R. Platinum (II) porphyrin-containing thermoresponsive poly(N-isopropylacrylamide) copolymer as fluorescence dual oxygen and temperature sensor. Sens. Actuators, B 2011, 159, 135-141.

7.  Zhou, X.; Su, F.; Gao, W.; Tian, Y.; Youngbull, C.; Johnson, R. H.; Meldrum, D. R. Triazacryptand-based fluorescent sensors for extracellular and intracellular K+ sensing. Biomaterials 2011, 32, 8574-8583.

6. Tian, Y.; Su, F.; Weber, W.; Nandakumar, V.; Shumway, B. R.; Jin, Y.; Zhou, X.; Holl, M. R.; Johnson, R. H.; Meldrum, D. R. A series of naphthalimide derivatives as intra and extracellular pH sensors. Biomaterials 2010, 31, 7411-7422.

5. Zhou, X.; Zhang, X.; Yu, X.; Zha, X.; Fu, Q.; Liu, B.; Wang, X.; Chen, Y.; Chen, Y.; Shan, Y.; Jin, Y.; Wu, Y.; Liu, J.; Kong, W.; Shen, J. The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine. Biomaterials 2008, 29, 111-117.

4.Zhou, X.; Liu, B.; Yu, X.; Zha, X.; Zhang, X.; Wang, X.; Jin, Y.; Wu, Y.; Chen, Y.; Shan, Y.; Chen, Y.; Liu, J.; Kong, W.; Shen, J. Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime. Eur. J. Pharm. Biopharm. 2008, 68, 589-595.

3. Zhou, X.; Liu, B.; Yu, X.; Zha, X.; Zhang, X.; Wang, X.; Jin, Y.; Wu, Y.; Jiang, C.; Chen, Y.; Chen, Y.; Shan, Y.; Liu, J.; Kong, W.; Shen, J. Using Magnetic Force to Enhance Immune Response to DNA Vaccine. Small 2007, 3, 1707-1713.

2. Zhou, X.; Liu, B.; Yu, X.; Zha, X.; Zhang, X.; Wang, X.; Chen, Y.; Chen, Y.; Chen, Y.; Shan, Y.; Jin, Y.; Wu, Y.; Liu, J.; Kong, W.; Shen, J. Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly. Biomaterials 2007, 28, 4684-4692.

1. Zhou, X.; Liu, B.; Yu, X.; Zha, X.; Zhang, X.; Chen, Y.; Wang, X.; Jin, Y.; Wu, Y.; Chen, Y.; Shan, Y.; Chen, Y.; Liu, J.; Kong, W.; Shen, J. Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine. J. Control. Release 2007, 121, 200-207



授权专利

授权专利13件(2017年以来):

1)周现锋,李志波,卢迎习,牟雪璐尔,“一种近红外比率型荧光分子转子、制备方法及其在检测细胞内黏度和蛋白变性中的应用”,ZL201811373943.3

2)周现锋,卢迎习,李志波,芦娜娜,“低聚倍半硅氧烷基的有机/无机杂化材料、制备方法及其在骨组织工程中的应用”,ZL201811553179.8

3)周现锋,李志波,牟雪璐尔,有机小分子荧光化合物在光治疗中的用途 ZL201811400036.3.

4)周现锋,李志波,牟雪璐尔,由有机小分子化合物自组装形成的微纳结构及其应用ZL201811399021.X

5)周现锋,李志波,牟雪璐尔,光热效应优异的有机小分子化合物ZL201811399004.6

6)周现锋,李志波,牟雪璐尔,由有机小分子化合物自组装形成的微纳结构及其应用WO 2020/103762 A1 PCT

7)周现锋,牟雪璐尔,卢迎习,李志波,一种具有主动被动双重靶向的化合物及其药物组合物和应用ZL202110702738.2.

8)周现锋,牟雪璐尔,卢迎习,李志波,“一种具有刺激响应性的超分子光热剂化合物及其组合物和应用”,ZL202110702806.5.