Peer-Reviewed Journals (# denotes equal contribution, * denotes corresponding authors)
2024年
Wenmin Xiong, Na Song*, Xiaowei Mo, Zeyu Zhang, Jinyan Song, Yushi Wang, Junyu Li*, Zhilin Yu*. In Situ Formulation of Biomaterials for Disease Therapy: Recent Advances in Peptide Assembly Strategies. Coord. Chem. Rev. 2024, In Press.
Binbin Hu, Weida Qin, Yushi Wang, Zeyu Zhang, Ninglin Chen, Hongbo Wang, Gongyu Li, Yang Shi*, and Zhilin Yu*. Assembly-Glued Ligands and Warheads for Hypoxia Activatable Supramolecular Covalent Inhibitors. Adv. Funct. Mater. 2024, In Press.
Xin Liu, Feng Tian, Zeyu Zhang, Juanzu Liu, Shuya Wang, Ruo-Chen Guo, Binbin Hu, Hao Wang, Han Zhu, An-An Liu, Linqi Shi, Zhilin Yu*. In Vivo Self-Sorting of Peptides via In Situ Assembly Evolution. J. Am. Chem. Soc. 2024, 146, 24177-24187.
Feng Tian#, Ruo-Chen Guo#, Chunxia Wu, Xin Liu, Zeyu Zhang, Yamei Wang, Hao Wang, Gongyu Li, and Zhilin Yu*. Assembly of Glycopeptides in Living Cells Resembling Viral Infection for Cargo Delivery. Angew. Chem. Int. Ed. 2024, 63, e202404703.
Ninglin Chen#, Zeyu Zhang#, Xin Liu, Hongbo Wang, Ruo-Chen Guo, Hao Wang, Binbin Hu, Yang Shi*, Peng Zhang*, Zhonghua Liu, Zhilin Yu*. Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs. J. Am. Chem. Soc. 2024, 146, 10753-10766.
Na Song, Feng Tian, Yixuan Zou, Zhilin Yu*. Self-Assembly in Living Cells: Bottom-Up Syntheses in Natural Factory. ACS Appl. Mater. Interfaces 2024, 16, 45821-45829. Invited Perspective.
Xiaowei Mo, Jinyan Song, Xin Liu, Ruo-Chen Guo, Binbin Hu, and Zhilin Yu*. Redox-Regulated In Situ Seed-Induced Assembly of Peptides. Biomacromolecules, 2024, 25, 2497-2508. Published as part of Biomacromolecules virtual special issue "Peptide Materials".
Xiaowei Mo, Zeyu Zhang, Jinyan Song, Yushi Wang, and Zhilin Yu*. Self-Assembly of Peptides in Living Cells for Disease Theranostics. J. Mater. Chem. B 2024, 12, 4289-4306. Invited Reviews for the themed collection "Stimuli Responsive Materials for Biomedical Applications".
Jie Niu, Jie Yu, Xuan Wu, Ying-Ming Zhang*, Yong Chen, Zhilin Yu, and Yu Liu*. Host-Guest Binding Between Cucurbit[8]uril and Amphiphilic Peptides Achieved Tunable Supramolecular Aggregates for Cancer Diagnosis. Chemical Science 2024, 15, 13779-13787.
![Graphical abstract: Host–guest binding between cucurbit[8]uril and amphiphilic peptides achieved tunable supramolecular aggregates for cancer diagnosis](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D4SC04261A&imageInfo.ImageIdentifier.Year=2024)
2023年
Hao Wang#, Yanqiu Song#, Weishu Wang, Ninglin Chen, Binbin Hu, Xin Liu, Zeyu Zhang, and Zhilin Yu.* Organelle-Mediated Dissipative Self-Assembly of Peptides in Living Cells. J. Am. Chem. Soc. 2024, 146, 330-341.
Ruo-Chen Guo, Ning Wang, Weishu Wang, Zeyu Zhang, Wendi Luo, Yushi Wang, Haiqin Du, Yifei Xu, Gongyu Li,* and Zhilin Yu.* Artificial Peptide-Protein Necrosomes Promote Cell Death. Angew. Chem. Int. Ed. 2023, 62, e202314578.
Na Song, Zhe Sun, Bo Wang, Xin Liu, Binbin Hu, Sihe Zhang,* and Zhilin Yu.* Suicide Gene Delivery by Morphology-Adaptable Enantiomeric Peptide Assemblies for Combined Ovarian Cancer Therapy. Acta Biomaterialia 2024, 175, 250-261.
Jinyan Song, Xiaowei Mo, Xin Liu, Binbin Hu, Zeyu Zhang, and Zhilin Yu.* Arginine Methylation Regulates Self-Assembly of Peptides. Macromol. Rapid Commun. 2023, 44, 2300308.
2022年
Yanqiu Song, Mingming Li, Na Song, Xin Liu, Guangyao Wu, Hao Zhou, Jiafu Long, Linqi Shi, and Zhilin Yu.* Self-Amplifying Assembly of Peptides in Macrophages for Enhanced Inflammatory Treatment. J. Am. Chem. Soc. 2022, 144, 6907–6917.
Xin Liu#, Mingming Li#, Juanzu Liu, Yanqiu Song, Binbin Hu, Chunxia Wu, An-An Liu, Hao Zhou, Jiafu Long, Linqi Shi, and Zhilin Yu.* In Situ Self-Sorting Peptide Assemblies in Living Cells for Simultaneous Organelle-Targeting. J. Am. Chem. Soc. 2022, 144, 9312-9323.
Xiunan Yu,# Hao Wang,# Xin Liu, Le Huang, Na Song, Yanqiu Song, Xiaowei Mo, Shaofeng Lou, Linqi Shi, and Zhilin Yu.* Assembling Synergistic Peptide-Drug Conjugates for Dual-Targeted Treatment of Cancer Metastasis. Nano Today, 2022, 46, 101594.
Na Song, Yanqiu Song, Binbin Hu, Xin Liu, Xiunan Yu, Hao Zhou, Jiafu Long, Zhilin Yu.* Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy. Adv. Healthcare Mater. 2023, 12, 2202039.
Yanqiu Song, Zeyu Zhang, Yawei Cao, and Zhilin Yu.* Stimulus-Responsive Amino Acids Behind In Situ Assembled Bioactive Peptide Materials. ChemBioChem 2022, e202200497. Invited Reviews for the special Collection of ChemBioTalents2022.
Peng Zhang,* Saizhi Wu,# Jinting Li,# Xiaoshuang Bu,# Xiaoping Dong, Ninglin Chen, Fengjiao Li, Jingyu Zhu, Longkang Sang, Youlin Zeng, Songping Liang, Zhilin Yu,* Zhonghua Liu.* Dual-sensitive Antibacterial Peptide Nanoparticles Prevent Dental Caries. Theranostics 2022, 12, 4818-4833.
Mian Tang, Yanqiu Song, Yi-Lin Lu, Ying-Ming Zhang,* Zhilin Yu, Xiufang Xu, and Yu Liu.* Cyclodextrin-Activated Porphyrin Photosensitization for Boosting Self-Cleavable Drug Release. J. Med. Chem. 2022, 65, 6764-6774.
2021年
Binbin Hu, Na Song, Yawei Cao, Mingming Li, Xin Liu, Zhifei Zhou, Linqi Shi, and Zhilin Yu.* Noncanonical Amino Acids for Hypoxia-Responsive Peptide Self-Assembly and Fluorescence. J. Am. Chem. Soc. 2021, 143, 13854–13864.
Mingming Li, Yanqiu Song, Na Song, Guangyao Wu, Hao Zhou, Jiafu Long, Pengcheng Zhang, Linqi Shi, Zhilin Yu.* Supramolecular Antagonists Promote Mitochondrial Dysfunction. Nano Letters 2021, 21, 5730-5737.
Na Song,# Zhifei Zhou,# Yanqiu Song, Mingming Li, Xiunan Yu, Binbin Hu, Zhilin Yu.* In situ oxidation-regulated self-assembly of peptides into transformable scaffolds for cascade therapy. Nano Today 2021, 38, 101198.
Mingming Li,# Zhongyan Wang,# Xin Liu, Na Song, Yanqiu Song, Xuefeng Shi, Jinjian Liu,* Jianfeng Liu,* and Zhilin Yu.* Adaptable Peptide-Based Therapeutics Modulating Tumor Microenvironment for Combinatorial Radio-Immunotherapy. J. Control. Release 2021, 340, 35-47.
Yanqiu Song, Qi Su, Huijuan Song, Xiaoguang Shi, Mingming Li, Na Song, Shaofeng Lou, Weiwei Wang,* and Zhilin Yu.* Precisely Shaped Self-Adjuvanting Peptide Vaccines with Enhanced Immune Responses for HPV-Associated Cancer Therapy. ACS. Appl. Mater. Interfaces. 2021, 13, 49737-49753.
Wenlu Tu, Ke Xue, Shaofeng Lou, Chunlei Zhu, Zhilin Yu.* Self-assembly of virulent amyloid-derived peptides into nanoantibacterials. Nanoscale 2021, 13, 9864-9872.
2020年
Zhifei Cheng,# Yuanyuan Cheng,# Qian Chen, Mingming Li, Jie Wang, Hui Liu, Mengwen Li, Yashan Ning, Zhilin Yu,* Yinsong Wang,* Hao Wang.* Self-assembly of pentapeptides into morphology-adaptable nanomedicines for enhanced combinatorial chemo-photodynamic therapy. Nano Today 2020, 33, 100878.
Shuxin Song, Jingyu Wang,* Zhifei Cheng, Zhimou Yang, Linqi Shi, Zhilin Yu.* Directional molecular sliding movement in peptide hydrogels accelerates cell proliferation. Chemical Science 2020, 11, 1383-1393.
Shuxin Song, Jingyu Wang, Na Song, Huixia Di, Dingbin Liu, Zhilin Yu.* Peptide interdigitation-induced twisted nanoribbons as chiral scaffolds for supramolecular nanozymes. Nanoscale 2020, 12, 2422-2433.
Binbin Hu, Zhengwen Lian, Zhifei Zhou, Linqi Shi, Zhilin Yu.* Reactive Oxygen Species-Responsive Adaptable Self-Assembly of Peptides toward Advanced Biomaterials. ACS Applied Bio Materials 2020, 3, 5529-5551.
Zhifei Cheng,# Shanshan Nai,# Shuxin Song, Lingyi Chen,* Zhilin Yu.* Photoinduced directional domain sliding motion in peptide hydrogels promotes ectodermal differentiation of embryonic stem cells. Science China Materials 2020, 63, 467–478.
2019年
Mingming Li,# Yashan Ning,# Jialiang Chen, Xingchen Duan, Na Song, Dan Ding,* Xuncheng Su,* Zhilin Yu.* Proline Isomerization-Regulated Tumor Microenvironment-Adaptable Self-Assembly of Peptides for Enhanced Therapeutic Efficacy. Nano Letters 2019, 19, 7965-7976.
Shaofeng Lou, Xinmou Wang, Zhilin Yu,* Linqi Shi.* Peptide Tectonics: Encoded Structural Complementarity Dictates Programmable Self‐Assembly. Advanced Science 2019, 6, 1802043.
Huiru Zhang, Shaofeng Lou, Zhilin Yu.* Polar−π Interactions Promote Self-assembly of Dipeptides into Laminated Nanofibers. Langmuir 2019, 35, 4710-4717.
Mingming Li, Xinran Zhao, Jianfang Dai, Zhilin Yu.* Peptide therapeutics and assemblies for cancer immunotherapy. Science China Materials 2019, 62, 1759-1781.
2017年
Zhilin Yu,# Aykut Erbas,# Faifan Tantakitti, Liam C. Palmer, Joshua A. Jackman, Monica Olvera de la Cruz,* Nam-Joon Cho,* Samuel I. Stupp.* Co-Assembly of Peptide Amphiphiles and Lipids into Supramolecular Nanostructures Driven by Anion-π Interactions. J. Am. Chem. Soc. 2017, 139, 7823-7830.
Lee, S. S.; Fyrner, T.; Chen, F.; Álvarez, Z.; Sleep, E.; Chun, D. S.; Weiner, J. A.; Cook, R. W.; Freshman, R. D.; Schallmo, M. S.; Katchko, K. M.; Schneider, A. D.; Smith, J. T.; Yun, C.; Singh, G.; Hashmi, S. Z.; McClendon, M. T.; Yu, Z.; Stock, S. R.; Hsu, W. K.; Hsu, E. L.; Stupp, S. I.* Sulfated glycopeptide nanostructures for multipotent protein activation. Nature Nanotechnology 2017, 12, 821-829.
2016年
Zhilin Yu, Faifan Tantakitti, Tao Yu, Liam C. Palmer, George Schatz, Samuel I. Stupp.* Simultaneous Covalent and Non-Covalent Hybrid Polymerizations. Science, 2016, 351, 497-502.
Zhilin Yu, Faifan Tantakitti, Liam C. Palmer, Samuel I. Stupp.* Asymmetric Peptide Nanoribbons. Nano Letters 2016, 16, 6967-6974.
Sabrina Steinwand, Zhilin Yu, Stefan Hecht,* Josef Wachtveitl.* Ultrafast dynamics of the photoisomerization and Subsequent Unfolding of an Oligo-azobenzene Foldamer. J. Am. Chem. Soc. 2016, 138, 12997-13005.
Zhilin Yu, Stefan Hecht.* Remote Control Over Folding by Light. Chemical Communication 2016, 52, 6639-6653.
2015年
Zhilin Yu, Stefan Hecht.* Influence of Linkage Chemistry on Folding, Self-Assembly, and Photoresponse of Amphiphilic Azobenzene Main Chain Polymers. J. Polym. Sci. A Polym Chem 2015, 53, 313-318.
2013年
Zhilin Yu, Stefan Hecht.* Control over Unfolding Pathways by Localizing Photoisomerization Events within Heterosequence Oligoazobenzene Foldamers. Angew. Chem. Int. Ed. 2013, 52, 13740-13744.
Zhilin Yu, Steffen Weidner, Thomas Risse,* Stefan Hecht.* The Role of Statistics and Microenvironment for The Photoresponse in Multi-Switch Architectures: The Case of Photoswitchable Oligoazobenzene Foldamers. Chemical Science 2013, 4, 4156-4167.
Sérgio R. Domingos, Steven J. Roeters, Saeed Amirjalayer, Zhilin Yu, Stefan Hecht,* Sander Woutersen*. Elucidating the backbone conformation of photoswitchable foldamers using vibrational circular dichroism. Phys. Chem. Chem. Phys. 2013, 15, 17263-17267.
2012年
Zhilin Yu, Stefan Hecht.* Cooperative Switching Events in Azobenzene Foldamer Denaturation. Chem. Eur. J. 2012, 18, 10519-10524.
2011年
Zhilin Yu, Stefan Hecht.* Reversible and Quantitative Denaturation of Amphiphilic Oligo(azobenzene) Foldamers. Angew. Chem. Int. Ed. 2011, 50, 1640-1643.
David Bléger,* Zhilin Yu, Stefan Hecht,* Toward optomechanics: Maximizing the photodeformation of individual molecules. Chemical Communication 2011, 47, 12260-12266.
2008年
Yu Liu,* Zhilin Yu, Yingming Zhang, Dongsheng Guo, Yuping Liu, Supramolecular Architectures of beta-Cyclodextrin-Modified Chitosan and Pyrene Derivatives Mediated by Carbon Nanotubes and their DNA Condensation. J. Am. Chem. Soc. 2008, 130, 10431-10439.
Peng Liang, Hengyi Zhang, Zhilin Yu, Yu Liu,* Solvent-Controlled Photoinduced Electron Transfer between Porphyrin and Carbon Nanotubes. J. Org. Chem. 2008, 73, 2163-2168.