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[20] Chun-Yu Gao, Gui-Ying Yang, Xu-Wei Ding, Jian-He Xu, Xiaolin Cheng*, Gao-Wei Zheng*, Qi Chen*. Engineering of Halide Methyltransferase BxHMT through Dynamic Cross-Correlation Network Analysis. Angew. Chem. Int. Ed. 2024, e202401235. 

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[19] Chen FF #, He XF#, Zhu XX, Zhang Z, Shen XY, Chen Q, Xu JH*, Turner NJ* and Zheng GW*. Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines. J. Am. Chem. Soc., 2023, 145 (7), 4015-4025. https://doi.org/10.1021/jacs.2c11354.

[18] Zhang M, Huang ZY, Su Y, Chen FF, Chen Q, Xu JH, Zheng GW*. Engineering a norcoclaurine synthase for one-step synthesis of (S)-1-aryl-tetrahydroisoquinolines. Bioresour. Bioprocess. 2023, 10 (1): 15. DOI:10.1186/s40643-023-00637-4

[17] Chen Q#, Li BB#, Zhang L#, Chen XR, Zhu XX, Chen FF, Shi M, Chen CC, Yang Y, Guo RT*, Liu  W, Xu JH, Zheng GW*. Engineered Imine Reductase for Larotrectinib Intermediate Manufacture. ACS Catal. 2022, 12: 14795–14803. DOI:10.1021/acscatal.2c03783

[16] Su Y, Li HP, Zhang M, Ding XW, Xu JH, Chen Q, Zheng GW*. Regioselectivity Inversion of an O-Methyltransferase via Semi-rational Mutagenesis Combined with Metal Ion Substitution. ChemCatChem, 2022, https://doi.org/10.1002/cctc.202200844.

[15] Dong-Hao Wang#, Qi Chen#, Sai-Nan Yin#, Xu-Wei Ding, Yu-Cong Zheng, Zhi Zhang, Yu-Hui Zhang, Fei-Fei Chen*, Jian-He Xu*, and Gao-Wei Zheng*. Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase. ACS Catal. 2021, 11, 14274–14283. DOI:10.1021/acscatal.1c04324

[14] Bo-Bo Li, Jing Zhang, Fei-Fei Chen, Qi Chen, Jian-He Xu, Gao-Wei Zheng*. Direct reductive amination of ketones with amines by reductive aminases. Green Synthesis and Catalysis, 2021, 2, 345–349. https://doi.org/10.1016/j.gresc.2021.08.005

[13] Rui-Feng Cai, Lei Liu, Fei-Fei Chen, Aitao Li, Jian-He Xu,* Gao-Wei Zheng*. Reductive amination of biobased levulinic acid to unnatural chiral γ‑amino acid using an engineered amine dehydrogenase. ACS Sustainable Chem. Eng. 2020, 8, 17054−17061. DOI:10.1021/acssuschemeng.0c04647

[12] Wen-Zhuo Qian, Ling Ou, Chun-Xiu Li, Jiang Pan, Jian-He Xu, Qi Chen,* and Gao-Wei Zheng*. Evolution of Glucose Dehydrogenase for Cofactor Regeneration in Bioredox Processes with Denaturing Agents. ChemBioChem 2020, 21, 2680–2688. DOI: 10.1002/cbic.202000196

[11] He-Wen Jiang, Qi Chen, Jiang Pan, Gao-Wei Zheng*, Jian-He Xu*. Rational Engineering of Formate Dehydrogenase Substrate/Cofactor Affinity for Better Performance in NADPH Regeneration. Applied Biochemistry and Biotechnology, 2020, 192, 530–543. DOI:10.1007/s12010-020-03317-7

[10] Yu-Hui Zhang#, Fei-Fei Chen#, Bo-Bo Li, Xin-Yi Zhou, Qi Chen, Jian-He Xu, and Gao-Wei Zheng*. Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases. Org. Lett. 2020, 22, 3367−3372. DOI:10.1021/acs.orglett.0c00802

[9] Lei Liu, Dong-Hao Wang, Fei-Fei Chen, Zhi-Jun Zhang, Qi Chen, Jian-He Xu, and Gao-Wei Zheng* Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines. Catalysis Science & Technology (back cover), 2020, 10, 2353–2358. DOI:10.1039/d0cy00071j

[8] Yao Xu, Qi Chen, Zhi-Jun Zhang, Jian-He Xu, and Gao-Wei Zheng*. Coevolution of the Activity and Thermostability of an e-Keto Ester Reductase for Better Synthesis of an (R)-a-Lipoic Acid Precursor. ChemBioChem 2020, 21, 1341–1346. DOI:10.1002/cbic.201900693

[7] Fei-Fei Chen, Sebastian C. Cosgrove, William R. Birmingham, Juan Mangas-Sanchez, Joan Citoler, Matthew P. Thompson, Gao-Wei Zheng,* Jian-He Xu,* Nicholas J. Turner*. Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases. ACS Catal. 2019, 9, 11813–11818. DOI:10.1021/acscatal.9b03889

[6] Hao-Yu Jia, Min-Hua Zong, Gao-Wei Zheng,* Ning Li*. One-Pot Enzyme Cascade for Controlled Synthesis of Furancarboxylic Acids from 5-Hydroxymethylfurfural by H2O2 Internal Recycling. ChemSusChem 2019, 12, 4764–4768. DOI:10.1002/cssc.201902199

[5] Fei-Fei Chen, Yu-Hui Zhang, Zhi-Jun Zhang, Lei Liu, Jian-Ping Wu, Jian-He Xu,* Gao-Wei Zheng*. An Ammonium-Formate-Driven Trienzymatic Cascade for ω‑Transaminase-Catalyzed (R)‑Selective Amination. J. Org. Chem. 2019, 84, 14987−14993. DOI:10.1021/acs.joc.9b02445

[4] Yuan-Yang Liu, Chun-Xiu Li, Jian-He Xu, Gao-Wei Zheng*. Efficient Synthesis of Methyl 3-Acetoxypropionate by a Newly Identified Baeyer-Villiger Monooxygenase. Appl. Environ. Microb. 2019, 85(11): e00239-19. (Spotlight) DOI:10.1128/AEM.00239-19

[3] Xu-Min Gong, Zhen Qin, Fu-Long Li, Bu-Bing Zeng, Gao-Wei Zheng*, Jian-He Xu*. Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor. ACS Catal., 2019, 9, 147–153. DOI:10.1021/acscatal.8b03382

[2] Qin-Hua Li, Yuan Dong, Fei-Fei Chen, Lei Liu, Chun-Xiu Li, Jian-He Xu, Gao-Wei Zheng*, Reductive Amination of Ketones with Ammonium Catalyzed by A Newly Identified Brevibacterium Epidermidis Strain for the Synthesis of (S)-Chiral Amines. Chin. J. Catal. 2018, 39(10), 1625−1632. DOI10.1016/S1872-2067(18)63108-0

[1] Fei-Fei Chen,† Gao-Wei Zheng,† Lei Liu, Hao Li, Qi Chen, Fu-Long Li, Chun-Xiu Li, and Jian-He Xu*. Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines. ACS Catal. 2018, 8, 2622−2628. DOI10.1021/acscatal.7b04135