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51. Cheng TF,  ...... Zhao L# (2024) Metabolic engineering of non-model microorganism Erwinia persicina for the high-level production of andrimid. In preparation

50. Deng BC, Hou YY......Zhao L# (2024) Construction of Chlamydomonas reinhardtii cell factories for crocin biosynthesis. In preparation

49. Wang Q, ...... Zhao L# (2024) Synergistic carbon and nitrogen metabolic modules coordinately stimulate the robust photosynthesis and productivity of field-grown gramineous and woody plantsNature Biotechnology, In preparation

48. Cui MJ, ...... Zhao L# (2024) An extra NADPH consumption ability enabled by the fine-tuning expression of native lactate dehydrogenase and transhydrogenase enhances the photosynthetic efficiency in Chlamydomonas. In preparation

47. Zhao YF, ...... Zhao L# (2024) Realizing the implementation of synthetic CO2-assimilation pathway into higher plants: Challenges and Perspectives. In preparation

46. Ge TL#, Cheng TF, Zhao XY, Zhao LQ, Zhao L# (2024) Biosynthesis of Andrimid and its Derivatives Enables the Versatile Erwinia persicina to Be a Potent Antimicrobial Agent. In preparation

45. Liu QL or Deng BC, Hou YY, Liu ZY, Zhao L# (2024) Chemistry for a Sustainable World – Celebrating Our Community Tackling Global Challenges. Chemical CommunicationIn preparation  (IF=4.90)

44. Liu ZY*, Hao NH*, Hou YY, Chen FJ, Zhao L# (2024) Promoting effect of small peptide on the growth and protein accumulation of Chlorella pyrenoidosaIn preparation

43. Lu SH, Hou YY......Zhao L# (2024) Artificial biosynthesis of recombinant human lactoferrin based on direct air capture of carbon dioxide. Plant Biotechnology JournalIn preparation (IF=13.80)

42. Li LY, Wang Q, Wang DF, Li ZF, Tang RM, Wang QB, Tian HL, Zhao L#, Niu YB(2024) Metabolome and transcriptome analysis reveals regulatory mechanism of triterpenoids and sesquiterpenoids biosynthesis in Codonopsis pilosula (Franch.) Nannf. Journal of Agricultural and Food Chemistry, Under review (IF=6.10)

41. Liu ZY*, Hao NH*, He CQ*, Hou YY, Cheng TF, Wang YH, Liu QL, Shen Q, Chen FJ, Fan ZH#Zhao L# (2024) Photosynthetic cultivation of Haematococcus pluvialis using monoethanolamine as a novel substrate for enhanced astaxanthin production. Chemical Engineering JournalUnder review  (IF=13.30)

40. Hou YY, Wang WQ, Liu ZY, Yu LJ#Zhao L# (2024) Boosting the Microalgae-based Carbon Sequestration with Artificial CO2 Concentration System. Critical Reviews in Biotechnology, Under review (IF=9.50)

39. Yan SH*, Hou YY*, Cui MJ, Cheng TF, Lu SH, Liu ZY, Deng BC, Liu WJ, Shi ML, Lin LC, Yu LJ #, Zhao L# (2024) Engineering microalgae for robust glycolate biosynthesis: Targeted knockout of hydroxypyruvate reductase 1 combined with optimized culture conditions enhance glycolate production in Chlamydomonas reinhardtii. Bioresource TechnologyUnder review (IF=11.40)

38. Liu Z, Zhang ZL, Rawat S, Wang LY, Cao PJ #Zhao L(2024) Editorial: Plant Chassis for Synthetic Biology and Its Application in BiomanufacturingFrontiers in Plant ScienceUnder review (IF=6.80)

37. Hou YY*Guo ZL*Liu ZY, Yan SH, Cui MJ, Chen FJ, Wang WJ#, Yu LJ#Zhao L# (2024) Enhancement of astaxanthin accumulation via energy reassignment by removing the flagella of Haematococcus pluvialis. Bioresources and Bioprocessing, accepted (IF=6.10)

36. Yang H, Lv HX, Zhao L# (2024) Cloning and functional characterization of hydroxypyruvate reductase 1 from Nicotiana benthamianaMolecular Plant Breeding (Chinese), accepted (CSCD)

35. Zhao XY, Cheng TF, Zhao L# (2024)  Exploring the life-saving antibiotic by digging it out of the earth. The Academic Press. https://theacademic.com/mining-antibiotic-andrimid-multidrug-resistant-bacteria/

34. Wu HM*, Ren YL*, Dong H*, Xie C, Zhao L, Wang X, Zhang FL, Zhang BL, Huang YS, Jing RN, Wang J, Miao R, Bao XH, Yu MZ, Nguyen T, Mou CL, Wang YL, Wang YH, Lei CL, Cheng ZJ, Jiang L#, Wan JM(2024)  FLOURY ENDOSPERM24, a heat shock protein 101 (HSP101), is required for starch biosynthesis and endosperm development in riceNew Phytologist, 242(6): 2635-2651 (IF=10.50)

33. Cheng TF, Ge TL, Zhao XY, Liu Z, Zhao L# (2024) Efficient Genetic Transformation and Suicide Plasmid-mediated Genome Editing System for Non-model Microorganism Erwinia persicina. Bio-protocol, 14(6): e4956 (IF=1.30)

32. Cui MJ, Yan SH, Wang Q, Hou YY, Guo ZL, Ma YB, Deng BC, Lu SH, Lv HX#Zhao L# (2024) Functional characterization of hydroxypyruvate reductase 4 in ChlamydomonasMolecular Plant Breeding (Chinese), Accepted (CSCD)

31. Yang H, Wang Q, Zhang JF, Hou YY, Dai QL, Lv HX, Cao PJ#Zhao L# (2023) Hydroxypyruvate reductase gene family in Nicotiana benthamiana: genome-wide identification and bioinformatics analysisCurrent Plant Biology, 35-36: 100305 (IF=5.39)

30. Wang Q, Zhang JF, Dai QL, Cui MJ, Yang H, Cao PJ #Zhao L# (2023) When Green Carbon Plants Meet Synthetic Biology. Modern Agriculture, 2023:1-14

29. Zhao LQ*, Ge TL*, Cheng TF, Wang Q, Cui MJ, Yuan HL, Zhao L# (2023) Fine-tuning gene expression of the transcriptional regulator AdmX for improved biosynthesis of andrimid in Erwinia persicina strain BST187. Applied Microbiology Biotechnology, 107: 6775-6788 (IF=5.20)

28. Hou YY*, Han T*, Wu RR, Liu ZY, Ma YB, Guo ZL, Hao NH, Wang WJ, Ji X, Zhu ZG, Chen FJ#Zhao L# (2023) A Novel System Integrating Electrolysis and Ionic Membranes (EIMs) Enabling the Artifical Carbon Concentration and Alleviation of Metal Cation Stress in Microalgae Cultivation. Green Chemistry25: 7273-7282 (IF=9.80)

27. Liu ZY*, Hao NH*, Hou YY, Wang Q, Liu QL, Yan SH, Chen FJ, Zhao L# (2023) Technologies for the harvesting of microalgae for industrial applications: Current Trends and Perspective. Bioresource Technology, 387: 129631 (IF=11.40)

26. Cheng TF, Ge TL, Zhao LQ, Hou YY, Xia JY#Zhao L# (2023) Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimizationBMC Microbiology, 23 (1): 268 (IF=4.70) 

25Wang Q, He H, Xiong W, Cao PJ, Cheng J#Zhao L# (2023) Editorial: Synthetic Metabolism for the Third-Generation (3G) Biorefineries. Frontiers in Bioengineering Biotechnology, 11: 1214729 (IF=6.20)

24. Ma YB*, Hou YY*, Wang WJ, Cui MJ, Guo ZL, Han T, Liu ZY, Hao NH, Chen FJ, Zhao L# (2023) Insights into Carbon Utilization Under Mixotrophic Conditions in Chlamydomonas. Bioresource Technology, 374: 128788 (IF=11.40)

23Hao NH*, Liu ZY*, Hou YY, Fan ZH, Li Y, Chen FJ# , Zhao L (2022) Small peptide glutathione-induced bioflocculation for enhancing the food application potential of Chlorella pyrenoidosaBioresource Technology, 365: 128138 (IF=11.40)

22. Guo ZL*, Hou YY*, Liu ZY, Ma YB, Han T, Hao NH, Yao YJ, Lan CX, Ge TL, Wang WJ#, Zhao L#, Chen FJ# (2022) Combination of bicarbonate and low temperature stress induces the biosynthesis of both arachidonic and docosahexaenoic acids in alkali-halophilic microalgae. Frontiers in Marine Science, 9: 971441  (IF=4.70)

21. Wang Q, Yang H, Cao PJ, Chen FJ, Zhao L# (2022) Biosynthetic approaches to efficient assimilation of CO2 by reducing carbon release via photorespiration modification in plant chassis. Frontiers in Bioengineering Biotechnology10: 979627  (IF=6.20)

20. Wu D*, Hou YY*, Cheng J, HanT, Hao NH, Zhang BJ, Fan X, Ji X#, Chen FJ#Gong DH, Wang L, Patrick M, Zhao L#, Chen SL (2022) Transcriptome analysis of lipid metabolism in response to cerium stress in the oleaginous microalga Nannochloropsis oculata. Science of Total Environment838 (Pt3): 156420  (IF=10.75)

19Hou YY*, Liu CC*, Liu ZY, Han T, Hao NH, Guo ZL, Wang WJ, Chen SL, Zhao L#, Safavi M, Ji X#, Chen FJ# (2022) A Novel Salt-bridge Electroflocculation Technology for Harvesting Microalgae. Frontiers in Bioengineering Biotechnology10: 902524  (IF=6.30)

18Shi ML, Zhou L, Wang Qing, Zhao L# (2022) Advances in the study on the modification of carbon dioxide metabolic pathways by synthetic biology in plant. Synthetic Biology Journal (Chinese), 3: 1-20

17. Shi ML, Ge TL, Wang Y#, Zhao L# (2022) Photorespiration is essential for acclimation to salt stress under high carbon availability in Chlamydomonas. Algal Research, 64, 102687  (IF=5.50)

16. Shi ML, Zhou L, Cui MJ, Ge TL, Chen FJ, Zhao L# (2022) Roles of Light-Harvesting Complex Stress-Related Proteins in the Stress Responses of Chlamydomonas. Journal of Plant Sciences, 10 (1): 1-11

15. Zhou L, Liang XM, Zhao L# (2022) Biosynthesis of natural carotenoids: Progress and Perspective. Biotechnology Bulletin (Chinese), 38 (7): 61-69

14. Kai Cai, Zhao YH*, Zhao L*, Hou YQ, Cheng X, Daniela N, Witman G (2021) Structural organization of the C1b projection within the ciliary central apparatus. The Journal of Cell Science, jcs.254227  (IF=6.13)

13. Zhang L, Qi YZ, Wu MM, Zhao L, Zhao ZC, Lei CL, Hao YY, Yu XW, Sun YL, Zhang X, Guo XP, Ren YL, Wan JM (2021) Mitochondrion-targeted PENTATRICOPEPTIDE REPEAT5 is required for cis-splicing of nad4 intron 3 and endosperm development in rice. The Crop Journal, 9: 282-296  (IF=6.60)

12. Shi ML, Zhao L#, Wang Y# (2021) Identification and characterization of the genes encoding hydroxypyruvate reductase in Chlamydomonas. Frontiers in Plant Science, 12:690296  (IF=6.80)

11. Cai MH, Zhu SS, Wu MM, Zheng XM, Wang JC, Zhou L, Zheng TH, Cui S, Zhou SR, Li CN, Zhang H, Chai JT, Zhang XY, Jin X, Cheng ZJ, Zhang X, Lei CL, Ren YL, Lin QB, Guo XP, Zhao L, Wang J, Zhao ZC, Jiang L, Wang HY, Wan JM# (2021) DHD4, a CONSTANS-like family transcription factor, delays heading date by affecting the formation of the FAC complex in rice. Molecular Plant,14 (2):330-343  (IF=27.45)

10. Hou YQ*, Zhao L*, Kubo T, Cheng X, McNeill N, Oda T, Witman G# (2021) Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a. The Journal of Cell Science, 134 (12): jcs258540  (IF=6.13)

9. Yu MZ, Wu MM, Ren YL, Wang YH, Li JF, Lei CL, Sun YL, Bao XH, Wu HM, Yang H, Pan T, Wang YF, Jing RN, Yan MY, Zhang HD, Zhao L, Zhao ZC, Zhang X, Guo XP, Cheng ZJ, Yang B, Jiang L, Wan JM# (2021) Rice FLOURY ENDOSPERM 18 encodes a pentatricopeptide repeat protein required for 5' processing of mitochondrial nad5 messenger RNA and endosperm development. Journal of Integrative Plant Biology, 63:834-847  (IF=11.40)

8Zhao L, Hou YQ, McNeill N, Witman G#  (2020) The unity and diversity of the ciliary central apparatus. Philosophical Transactions B., 375(1792):20190164  (IF=7.20)

7. Zhao L, Hou YQ, Picariello T, Craige B, Witman G# (2019) Proteome of the central apparatus of a ciliary axoneme. The Journal of Cell Biology 218 (6) 2051-2070  (IF=8.80)

6. Fu G*, Zhao L*, Dymek E, Hou YQ, Song KK, Phan N, Shang ZG, Smith EF, Witman G, Nicastro Daniela# (2019) Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus. The Journal of Cell Biology, 218 (12) 4236-4251  (IF=8.80)

5. Xing JL, Liu P, Zhao L, Huang F# (2017) Deletion of CGLD1 Impairs PSII and Increases Singlet Oxygen Tolerance of Green Alga Chlamydomonas reinhardtii. Frontiers in Plant Science, 8: 2154  (IF=6.80)

4. Zhao L, Cheng DM, Huang XH, Chen M, Dall’Osto L, Xing JL, Gao LY, Li LY, Wang YL, Bassi R, Peng LW, Wang YC, Rochaix JD, Peng LW, Wang YC, Huang F# (2017) A light harvesting complex-like protein inmaintenance of photosynthetic components in Chlamydomonas. Plant Physiology, 174: 2419-2433  (IF=8.67)

3. Chen M, Zhang J, Zhao L, Xing JL, Peng LW, Kuang TY, Rochaix JD, Huang F# (2016) Loss of algal Proton Gradient Regulation 5 increases reactive oxygen species scavenging and H2 evolution. Journal of Integrative Plant Biology, 58: 943-946  (IF=11.40)

2. Yang HM, Liao LB, Bo TT, Zhao L, Sun XW, Norling B, Huang F# (2014) Slr0151 in Synechocystis sp.PCC 6803 is required for efficient repair of photosystem II under high-light condition. Journal of Integrative Plant Biology, 56: 1136-1150  (IF=11.40)

1Zhao L*, Chen M*, Cheng DM, Yang HM, Sun YL, Zhou HY, Huang F# (2013) Different B-type methionine sulfoxide reductases in Chlamydomonas may protect the alga against high-light, sulfur-depletion or oxidative stress. Journal of Integrative Plant Biology, 55: 1053-1067  (IF=11.40)


参编教材

《微藻生物技术(第一版)》 参编,中国轻工业出版社:中国轻工业“十四五”规划教材  高等学校专业教材

  

申请专利

26.  赵磊、程庭峰、葛同玲、赵心玥、刘柱,适用于桃色欧文氏菌的基因组编辑系统及其构建方法与应用,专利申请:CN2024104953679

25.  赵磊、王庆、刘柱、戴秋兰,信号肽编码基因的用途,专利申请:CN2024104632502

24.  赵磊、刘柱、程庭峰、葛同玲,提高桃色欧文氏菌安吉菌素产量的方法,专利申请号:CN2024103862333

23.  赵磊、杨浩、王庆,农杆菌介导的本氏烟草遗传转化方法,专利申请号:CN202310576370.9

22.  赵磊、葛同玲、赵伦强、程庭峰,一株桃色欧文氏菌2022TIBBST187及其应用,专利申请号:CN2023102264910 

21.  赵磊、赵伦强、葛同玲、程庭峰,Admx基因作为正调控因子在桃色欧文氏中提高安吉菌素产量的应用,专利申请号:CN202310731643.2

20.  赵磊、陈方见、刘智永、郝那辉、侯余勇,微藻絮凝剂及采收微藻的方法,专利申请号:CN202211233679.X

19.  赵磊、葛铜铃、王庆、韩童,雨生红球藻发酵产虾青素方法,专利申请号:CN202211127577.X

18.  赵磊、程庭峰、葛同玲、赵伦强、杨作仁,一株多黏芽孢杆菌及其在农业领域的应用,专利申请号:CN202211405946

17.  赵磊、葛同玲、程庭峰、赵伦强、侯余勇,桃色欧文氏菌产安吉菌素的方法,专利授权号:ZL202310226524.1

16赵磊、程庭峰、葛同玲,一株生防深绿木霉及其在农业领域的应用,专利授权号:ZL2022107186754

15.  赵磊、葛同玲、程庭峰,一株贝莱斯芽孢杆菌及其在农业领域的应用,专利授权号:ZL2022107179430

14.  万建民、赵磊任玉龙、伍洪铭、周春雷、雷德坤、张欣、雷财林、郭秀萍、林启冰、朱杉杉、程治军、赵志超,王洁,一种水稻原生质体高效生物素标记体系的建立及应用,专利授权号ZL202010320853.9

13.  万建民、江玲、伍洪铭、任玉龙、赵磊、王洁、雷财林、赵志超、程治军、张欣、郭秀平、林启冰、朱杉杉,一种水稻胚乳淀粉颗粒发育相关的蛋白FLO24及其编码基因与应用,专利申请号:CN202211263286.3

12.  万建民、赵志超、张龙、任玉龙、雷财林、赵磊郭秀萍、张欣,一种与水稻胚乳淀粉颗粒发育相关的蛋白FSE5及其编码基因和应用,专利授权号ZL202010767148.3

11.  黄芳、赵磊、程冬梅,一种能提高植物光合效率的莱茵衣藻蛋白E6及其编码基因与应用,专利授权号:ZL201410490550.6

10.  黄芳、赵磊、陈梅、张锦,一株超高放氢藻株及其应用,专利授权号:ZL201410014492.X

9.  黄芳、陈梅、赵磊、张锦,一种高产氢莱茵衣藻蛋白及其编码基因与应用,专利授权号ZL201410108048.4

8.  黄芳、赵磊、杨浩萌,抗氧化及营养胁迫相关蛋白及其编码基因与应用,专利授权号ZL201210479314.5

7.  黄芳、赵磊、程冬梅,具有光保护功能的蛋白及其编码基因与应用,专利授权号ZL201210479164.8

6.  黄芳、赵磊,提高衣藻产氢量的培养基及其制备方法, 专利授权号:ZL201110230908.8

5.  黄芳、赵磊、杨浩萌,用于扩增产氢微藻莱茵衣藻插入突变基因侧翼序列的引物及方法,专利授权号:ZL201110026604.X

4.  黄芳、吴骊珠、王红艳、陈梅、孙永乐、赵磊、陈彬,一种利用光合产氢微藻高效筛选放氢催化剂的方法专利授权号:ZL201110100773.3 

3.  黄芳、赵磊、陈梅、孙永乐,一种高效筛选衣藻放氢突变体的方法,专利授权号ZL201010233108.7

2.  黄芳、张锦、陈梅、赵磊,蛋白质PGR5在调控藻类抗氧化性中的应用,专利授权号ZL201510727193.5

1.  黄芳、程冬梅、赵磊、陈梅,一种能提高植物光合效率的莱茵衣藻蛋白F6及其编码基因与应用,专利申请号:ZL201410490347.9


科研项目

1、天津市合成生物技术创新能力提升行动,创新人才团队项目,负责人:赵磊  研究员(2021-2024)

2、国家重点研发计划,合成生物学专项, 微生物光合系统的重构与再造,子课题负责人:侯余勇  助理研究员(2020-2024)

3、天津市合成生物技术创新能力提升行动,COMMSATS国际联合中心建设-微藻项目,负责人:陈方见  副研究员(2021-2024)

4、国家自然科学基金面上项目,水稻淀粉合成调控基因OsCLPB的作用机制研究,负责人:赵磊  研究员(2021-2024)

5、中国博士后国际交流计划人才引进\中国科学院特别研究助理项目,负责人:葛同玲  博士(2022-2024)

6、中国科学院率先行动引才计划择优支持,植物细胞工程与代谢研究项目,负责人:赵磊  研究员(2023-2025)

7、国家烟草专卖局\中国烟草总公司,首席科学家创新专项项目,藏红花素在烟草中异源合成研究,参加人:赵磊  研究员(2022-2024)

8、天津市合成生物技术创新能力提升行动,重大科技攻关项目,乳铁蛋白植物表达底盘设计及改造,负责人:赵磊  研究员(2023-2024)

9、北京生命科技研究院(重点实验室),重点项目,基于烟草底盘中间体强化以提高其重组蛋白生物合成效能,联合负责人:赵磊  研究员(2024-2025)

10、人工合成淀粉关键技术与应用,中国科学院先导专项(C类),子课题负责人:赵磊  研究员(2024-2026)

11、科技部国家重点研发计划,前沿生物技术专项,人工生物叶片项目,课题负责人:侯余勇  助理研究员(2022-2027)

12、伊朗自然科学基金项目,基于生物反应器培养微藻的类菌胞素氨基酸提取及其对皮肤细胞紫外线防护功效的研究,课题负责人:Maliheh Safavi教授(伊朗科学技术研究组织)、赵磊  研究员  (2024-2026)