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成果及论文

2022:

[1] Rui Tian,  Jiatai Yin, Qingqing Yao,  Taotao Wang, Jiahuan Chen, Qi Liang, Qian Li*Xinfeng Zhao*. Development of an allostery responsive chromatographic method for screening potential allosteric modulator of beta2-adrenoceptor from a natural product-derived DNA-encoded chemical library, Analytical Chemistry, 2022, XXX, XXXX.

[2] Qi Liang, Haiyue Zuo, Tian Yang, Jiatai Yin, Xiaomin Huang, Jing Wang, Qian Li, Guowei Yin*, Xinfeng Zhao*. Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library, European Journal of Medicinal Chemistry, 2022, 233, 11421.

2021:

[1] Xinxin Zheng, Hushuai Fan, Ze Song, Peixuan Cheng, Hongmei Jiang, Wenhua Shi, Chaoni Xiao, Jing Wang, Qian Li, Guowei Yin*, Xinfeng Zhao*. Immobilized beta 2-adrenergic receptor: A powerful chromatographic platform for drug discovery and evaluation of drug-like property for natural products, Journal of Chromatography A, 2021, 1659, 462635.

[2] Juan Gao, Xinyi Yuan, Xinxin Zheng, Xue Zhao, Taotao Wang, Qi Liang, Chaoni Xiao, Jing Wang, Qian Li, Xinfeng Zhao. Two-point immobilization of a conformation-specific beta2-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly, Biomaterials Science, 2021, 10.1039/d1bm01222c.

[3] Xue Zhao, Xiaoying Fu, Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Fang Cao, Jianping Ren, Qi Liang*, XinfengZhao*. Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor, Journal of Chromatography A, 2021, 1653, 462443.

[4] Qi Liang, Jianyu He, Xue Zhao, Yan Xue, Haiyue Zuo, Ru Xu, Yan Jin, Jing Wang, Qian Li, Xinfeng Zhao*. Selective Discovery of GPCR Ligands within DNA-Encoded Chemical Libraries Derived from Natural Products: A Case Study on Antagonists of Angiotensin II Type I Receptor, Journal of Medicinal Chemistry, 2021, 64, 7, 4196–4205.

[5] Xiaoying Fu, Linkang Li, Xin Wen, Ru Xu, Yan Xue, Haiyue Zuo, Qi Liang, Gangjun Feng, Jing Wang, Xinfeng Zhao*. Halo-tagged protein immobilization: Effect of halide linkers on peak profile and drug-protein interaction, Journal of Chromatography A, 2021, 1640, 461946.

[6] Gangjun Feng, Xinyi Yuan, Ping Li, Rui Tian, Zhaoling Hou, Xiaoying Fu, Zhongman Chang, Jing Wang, Qian Li, Xinfeng Zhao*. G protein-coupled receptor-in-paper, a versatile chromatographic platform to study receptor-drug interaction, Journal of Chromatography A, 2021, 1637, 461835.

2020:

[1] Qian Li, Longfei Liu, Dake Mao, Yuyan Yu, Xinfeng Zhao*, Chengde Mao*, ATP-triggered, allosteric self-assembly of DNA nanostructures, Journal of the American Chemical Society, 2020, 142(2): 665-668.

[2] Xinfeng Zhao*, Yahui Jin, Xinyi Yuan, Zhaoling Hou, Ziyue Chen, Xiaoying Fu, Qian Li, Jing Wang, Yajun Zhang*, Covalent inhibitor-based one-step method for endothelin receptor A immobilization: from ligand recognition to lead identification, Analytical Chemistry, 2020, 92, 13750-13758.

[3] Qi Liang, Xiaoying Fu, Jianfeng Zhang, Jiaxue Hao, Gangjun Feng, Jing Wang, Qian Li, Faizan Ahmad, Xinfeng Zhao*, Immobilized angiotensin II type I receptor: A powerful method of high throughput screening for antihypertensive compound identification through binding interaction analysis, Journal of Chromatography A, 2020, 1622, 461003.

[4] Juan Gao, Zhongman Chang, Rui Tian, Ping Li, Faizan Ahmad, Xiaoni Jia, Qi Liang, Xinfeng Zhao*, Reversible and site-specific immobilization of β2 -adrenergic receptor by aptamer-directed method for receptor-drug interaction analysis, Journal of Chromatography A, 2020, 1622, 461091.

Before 2019:

[1] Jing Wang, Yuxin Wang, Jiajun Liu, Qian Li, Guowei Yin, Yajun Zhang, Chaoni Xiao, Taiping Fan, Xinfeng Zhao*, Xiaohui Zheng. Site-specific immobilization of β2-AR using O6-benzylguanine derivative-functionalized supporter for high throughput receptor-targeting lead discovery. Analytical Chemistry, 2019, 91(11): 7385-7393.

[2] Kaizhu Zeng, Qian Li, Jing Wang, Guowei Yin, Yajun Zhang, Chaoni Xiao, Taiping Fan, Xinfeng Zhao*, Xiaohui Zheng. One-step methodology for the direct covalent capture of GPCRs from complex matrices onto solid surfaces based on the bioorthogonal reaction between haloalkane dehalogenase and chloroalkanes. Chemical Science, 2018, 9(2): 446-456.

[3] Qian Li, Xiaohui Ning, Yuxin An, Brett J. Stanley, Yuan Liang, Jing Wang, Kaizhu Zeng, Fuhuan Fei, Ting Liu, Huanmei Sun, Jiajun Liu, Xinfeng Zhao*, Xiaohui Zheng. Reliable analysis of the interaction between specific ligands and immobilized beta-2-adrenoceptor by adsorption energy distribution. Analytical Chemistry, 2018, 90(13): 7903-7911.

[4] Yuan Liang, Jing Wang, Fuhuan Fei, Huanmei Sun, Ting Liu, Qian Li, Xinfeng Zhao*, Xiaohui Zheng. Binding kinetics of five drugs to beta2-adrenoceptor using peak profiling method and nonlinear chromatography. Journal of Chromatography A, 2018, 1538: 17-24.

[5] Xinfeng Zhao, Xiaohui Zheng, Tai-Ping Fan, Zijian Li, Youyi Zhang, Jianbin Zheng, A novel drug discovery strategy inspired by traditional medicine philosophies, Science, 2015, 347 (6219): S38-S40.

[6] Qian Li, Jing Wang, Yuqing Yuan Zheng, Lingjian Yang, Yajun Zhang, Liujiao Bian, Jianbin Zheng, Zijian Li, Xinfeng Zhao*, Youyi Zhang,   Comparison of zonal elution and nonlinear chromatography in determination of the interaction between seven drugs and immobilised β2-adrenoceptor, Journal of Chromatography A, 2015 1401, 75-83.