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成果及论文

【代表性文章】

  1. Yan T, Yang P, Bai H, Song B, Liu Y, Wang J, Zhang Y, Tu W, Yu D, Zhang S*. Single-cell RNA-Seq analysis of molecular changes during radiation-induced skin injury: the involvement of Nur77. Theranostics. 2024;14(15):5809-5825. （入选封面论文）https://pubmed.ncbi.nlm.nih.gov/39346541/ 
  2. Yang T, Geng F, Tang X, Yu Z, Liu Y, Song B, Tang Z, Wang B, Ye B, Yu D, Zhang S*. UV radiation-induced peptides in frog skin confer protection against cutaneous photodamage through suppressing MAPK signaling. MedComm (2020). 2024;5(7):e625. https://pubmed.ncbi.nlm.nih.gov/38919335/
  3. Geng F, Chen J, Song B, Tang Z, Li X, Zhang S, Yang T, Liu Y, Mo W, Zhang Y, Sun C, Tan L, Tu W, Yu D, Cao J, Zhang S*. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cell Mol Immunol. 2024;21(8):856-872. https://pubmed.ncbi.nlm.nih.gov/38849539/
  4. Feng Y, Feng Y, Gu L, Mo W, Wang X, Song B, Hong M, Geng F, Huang P, Zhu W, Jiao Y, Zhang Q, Ding WQ, Cao J*, Zhang S*. Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury.Exp Mol Med. 2024; 56(5): 1107-1122. https://pubmed.ncbi.nlm.nih.gov/38689083/
  5.  Geng F, Zhong L, Yang T, Chen J, Yang P, Jiang F, Yan T, Song B, Yu Z, Yu D. Zhang J*, Cao J*, Zhang S*. A frog skin-derived peptide targeting SCD1 exerts radioprotective effects against skin injury by inhibiting STING-mediated inflammation. Adv Sci. 2024: e2306253. （入选封面论文）https://pubmed.ncbi.nlm.nih.gov/37924851/
  6. Tang X, Yang T, Yu D, Xiong H*, Zhang S*. Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin. Environment Int. 2024; 185: 108535. https://pubmed.ncbi.nlm.nih.gov/37814303/
  7. Song B, Yang P, Zhang S*. Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy. Cancer Commun(Lond). 2024; 44(3): 297-360.（入选封面论文） https://pubmed.ncbi.nlm.nih.gov/38311377/
  8. Yu Z, Xu C, Song B, Zhang S, Chen C, Li C*, Zhang S*. Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances. J Transl Med. 2023; 21(1): 708. https://pubmed.ncbi.nlm.nih.gov/38428192/
  9. Li X, Qian K, Zhang Y, Zhang Y, Liu Y, Sun C, Jiao Y, Yu D, Geng F*, Cao J*, Zhang S*. Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT). Toxicol Appl Pharmacol. 2023; 480: 116734. https://pubmed.ncbi.nlm.nih.gov/38582510/
  10. Jiao Y, Xu J, Song B, Wu A, Pan L, Xu Y, Geng F, Li X, Zhao C, Hong M, Meng X, Luo J, Liu P, Li M, Zhu W, Cao J*, Zhang S*. Interferon regulatory factor 1-triggered free ubiquitin protects the intestines against radiation-induced injury via CXCR4/FGF2 signaling. MedComm. 2022; 3(3): e168. https://pubmed.ncbi.nlm.nih.gov/36051984/ 

  11. Liu P, Yu D, Sheng W, Geng F, Zhang J*, Zhang S*. PPARα activation by fenofibrate ameliorates radiation‐induced skin injury. J Eur Acad Dermatol Venereol. 2022; 36(3): e207-e210. https://pubmed.ncbi.nlm.nih.gov/34657324/

  12. Yu D*, Zhang S, Mo W, Jiang Z, Wang M, An L, Wang Y, Liu Y, Jiang S, Wu A, Cao J, Zhang S*. Transplantation of the Stromal Vascular Fraction (SVF) Mitigates Severe Radiation-Induced Skin Injury. Radiat Res. 2021; 196(3): 250-260. https://pubmed.ncbi.nlm.nih.gov/34107043/

  13.  Feng Y, Feng Y, Gu L, Liu P, Cao J*, Zhang S*. The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil. Front Oncol.  2021; 11: 720632. https://pubmed.ncbi.nlm.nih.gov/34513700/

  14. Qiu Y, Gao Y, Yu D, Zhong L, Cai W, Ji J, Geng F, Tang G, Zhang H, Cao J, Zhang J*, Zhang S*. Genome-wide analysis reveals zinc transporter ZIP9 regulated by DNA methylation promotes radiation-induced skin fibrosis via the TGF-β signaling pathway. J Invest Dermatol. 2020; 140: 94-102. https://pubmed.ncbi.nlm.nih.gov/31254515/

  15. Xiao Y, Mo W, Jia H, Yu D, Qiu Y, Jiao Y, Zhu W, Koide H, Cao J*, Zhang S*. Ionizing radiation induces cutaneous lipid remolding and skin adipocytes confer protection against radiation-induced skin injury. J Dermatol Sci. 2020; 97(2): 152-160. https://pubmed.ncbi.nlm.nih.gov/32001116/

  16. Cao J, Zhu W, Yu D, Pan L, Zhong L, Xiao Y, Gao Y, Jiao Y, Zhang Q, Ji J, Yang H, Zhang S*, Cao J*. The Involvement of SDF-1α/CXCR4 Axis in Radiation-Induced Acute Injury and Fibrosis of Skin. Radiat Res. 2019; 192(4): 410-421. https://pubmed.ncbi.nlm.nih.gov/31390312/

  17. Gu C, Luo J, Lu X, Tang Y, Ma Y, Yun Y, Cao J, Cao J, Huang Z, Zhou X*, Zhang S*. REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2. Cancer Sci. 2019; 110(3): 962-972. https://pubmed.ncbi.nlm.nih.gov/30657231/

  18. Xue J, Zhu W, Song J, Jiao Y, Luo J, Yu C, Zhou J, Wu J, Chen M, Ding WQ, Cao J*, Zhang S*. Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway. Oncogene. 2018; 37(7): 953-962. https://pubmed.ncbi.nlm.nih.gov/29059162/

  19. Xue J, Yu C, Sheng W, Zhu W, Luo J, Zhang Q, Yang H, Cao H, Wang W, Zhou J, Wu J, Cao P, Chen M, Ding WQ, Cao J*, Zhang S*. The Nrf2/GCH1/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade. J Invest Dermatol. 2017; 137(10): 2059-2068. https://pubmed.ncbi.nlm.nih.gov/28596000/

  20. Nie J, Zhang J, Wang L, Lu L, Yuan Q, An F, Zhang S*, Jiao Y*. Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4. J Exp Clin Cancer Res. 2017; 36(1): 183. https://pubmed.ncbi.nlm.nih.gov/29237483/

  21. Wang W, Luo J, Sheng W, Xue J, Li M, Ji J, Liu P, Zhang X, Cao J, Zhang S*. Proteomic profiling of radiation-induced skin fibrosis in rats: targeting the ubiquitin-proteasome system. Int J Radiat Oncol*Biol*Phys. 2016; 95(2): 751-760. https://pubmed.ncbi.nlm.nih.gov/27045812/

  22. Tang Y, Cui Y, Li Z, Jiao Z, Zhang Y, He Y, Cheng G, Zhou Q, Wang W, Zhou X, Luo J*, Zhang S*. Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. J Exp Clin Cancer Res. 2016; 35(1): 7. https://pubmed.ncbi.nlm.nih.gov/26754670/

  23. Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ*. The superoxide dismutase 1 (SOD1) 3'UTR maintains High expression of the SOD1 gene in cancer cells: The involvement of the RNA binding protein AUF1. Free Radic Biol Med. 2015, 85: 33-44. https://pubmed.ncbi.nlm.nih.gov/25908445/

  24. Zhang S*, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J*, Zhou J, Wu J, Ding WQ. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 (PRDX-6) against ionizing radiation. Free Radical Biol & Med. 2014; 69: 96-107. https://pubmed.ncbi.nlm.nih.gov/24447893/

  25. Zhang S, Chen H, Zhao S, Cao J, Tong J, Lu J, Wu W, Shen H, Wei Q, Lu D*. REV3L 3’UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. Oncogene. 2013: 10; 32(2): 242-250. https://pubmed.ncbi.nlm.nih.gov/22349819/

  26. Zhang S*, Hao J, Xie F, Hu X, Liu C, Tong J, Zhou J, Wu J, Shao C*. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis. 2011; 32(8): 1183-1189. https://pubmed.ncbi.nlm.nih.gov/21665894/

  27. Zhang S, Lu J, Zhao X, Wu W, Wang H, Lu J, Wu Q, Chen X, Fan W, Wang F, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D*. A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer. Carcinogenesis. 2010; 31: 2151-2158. https://pubmed.ncbi.nlm.nih.gov/20462940/

【获得奖励】

  1. 2021年，中国核能行业协会，科技进步奖三等奖

  2. 2021年，中国核工业集团（原核工业部），科技进步奖三等奖

  3. 2022年，四川省医学科技奖，科技奖二等奖

  4. 2022年，中国辐射防护学会，科技进步二等奖

  5. 2023年，中国核工业集团（原核工业部），科技进步奖三等奖

  6. 2023年，华夏医学科技奖，科技奖三等奖

  7. 2023年，四川省医学科技奖，科技奖三等奖、青年科技奖三等奖

  8. 2023年，中国毒理学会，优秀青年科技奖

  9. 2024年，山东省科学技术奖，科技进步二等奖

  10. 2024年，四川省科学技术奖，科技进步二等奖