主要学术成果：

（1）针对零级药物释放难实现的问题，提出了动态膜解离释放药物的新机理，发展了动态膜零级药物释放平台，实现了多肽等多种药物的零级释放。

（2）针对水凝胶传感器响应慢的问题，提出了Fabry-Perot薄膜干涉等多种光学传感新方法，实现了水凝胶快速光学传感。

（3）针对多细胞球制备难的问题，提出了温敏可逆水凝胶及溶胀起皱图案化水凝胶膜制备多细胞球的新方法，实现了多细胞球的大量、可控制备。

（4）针对蛋白印迹聚合物领域面临的两大难题，利用多肽的helix-coil转变，实现了印迹空腔的纳米形状记忆，同时解决了蛋白印迹聚合物模板去除难和印迹效率低的难题，发展了选择性高、吸附容量大、可在温和条件下洗脱的新型蛋白印迹聚合物。

（5）提出了添加剂-高分子相互作用的距离效应理论，通过缩短分子间距离极大提高了添加剂对高分子温敏行为的影响，实现了高分子从非温敏到温敏的转变。

近三年代表性研究论文：

(1) Wang, S.; Lu, W. J.; Wang, Y. F.; Guan, Y.; Zhang, Y. J. Construction of shape memorable imprinted cavities for protein recognition using oligo-L-lysine-based peptide crosslinker. Journal of Colloid and Interface Science 2021, 595, 118-128.

(2) Wang, H. Z.; Liu, R.; Wang, S.; Guan, Y.; Zhang, Y. J. A highly programmable platform for sequential release of protein therapeutics. Journal of Materials Chemistry B 2021, 9, 1616-1624.

(3) Lu, W. J.; Wang, S.; Liu, R.; Guan, Y.; Zhang, Y. J. Human serum albumin-imprinted polymers with high capacity and selectivity for abundant protein depletion. Acta Biomaterialia 2021, 126, 249-258.

(4) Liu, R.; Wang, H. Z.; Lu, W. J.; Cui, L.; Wang, S.; Wang, Y. F.; Chen, Q. B.; Guan, Y.; Zhang, Y. J. Highly tough, stretchable and resilient hydrogels strengthened with molecular springs and their application as a wearable, flexible sensor. Chemical Engineering Journal 2021, 415.

(5) Zhang, M. X.; Wang, R. Q.; Wang, Z. W.; Guan, Y.; Zhang, Y. J. Periodic pattern of iron oxide using 2D microgel colloidal crystal as template. Applied Surface Science 2020, 513.

(6) Wang, Y. P.; Wang, H. Z.; Zhu, X. X.; Guan, Y.; Zhang, Y. J. Smart microneedle patches for rapid, and painless transdermal insulin delivery. Journal of Materials Chemistry B 2020, 8, 9335-9342.

(7) Wang, Y. P.; Fu, M. A.; Wang, Z. W.; Zhu, X. X.; Guan, Y.; Zhang, Y. J. A sustained zero-order release carrier for long-acting, peakless basal insulin therapy. Journal of Materials Chemistry B 2020, 8, 1952-1959.

(8) Wang, Q. X.; Wang, H. Z.; Chen, Q. B.; Guan, Y.; Zhang, Y. J. Glucose-Triggered Micellization of Poly(ethylene glycol)-b-poly(N-isopropylacrylamide-co-2-(acrylamido)phenylboronic acid) Block Copolymer. Acs Applied Polymer Materials 2020, 2, 3966-3976.

(9) Wang, Q. X.; Fu, M.; Guan, Y.; James, T. D.; Zhang, Y. J. Mechanistic insights into the novel glucose-sensitive behavior of P(NIPAM-co-2-AAPBA). Science China-Chemistry 2020, 63, 377-385.

(10) Shi, A. P.; Guan, Y.; Zhang, Y. J. A new emulsification-crosslinking technique for preparation of physically crosslinked chitosan microspheres. Journal of Bioactive and Compatible Polymers 2020, 35, 289-300.

(11) Fu, M.; Zhuang, X. M.; Zhang, T. H.; Guan, Y.; Meng, Q. B.; Zhang, Y. J. Hydrogen-Bonded Films for Zero-Order Release of Leuprolide. Macromolecular Bioscience 2020, 20.

(12) Wang, Y.; Chen, Q. B.; Chen, M.; Guan, Y.; Zhang, Y. PHEMA hydrogel films crosslinked with dynamic disulfide bonds: synthesis, swelling-induced mechanical instability and self-healing. Polymer Chemistry 2019, 10, 4844-4851.

(13) Wang, R. Q.; Zhang, M. X.; Guan, Y.; Chen, M.; Zhang, Y. J. A CO2-responsive hydrogel film for optical sensing of dissolved CO2. Soft Matter 2019, 15, 6107-6115.