51）Chemoenzymatic Synthesis of Fluorinated Mycocyclosin Enabled by the Engineered Cytochrome P450-Catalyzed Biaryl Coupling Reaction.
J. Am. Chem. Soc. 2024, 10.1021/jacs.4c03499.
Shuo-Han Li,† Xue Zhang,† Ze-Long Mei, Yongjun Liu,* Jun-An Ma,* and Fa-Guang Zhang*
50）Enzymatic Stereodivergent Access to Fluorinated β‑Lactam Pharmacophores via Triple-Parameter Engineered Ketoreductases.
ACS Catal. 2024, 14, 6358−6368.
Ze-Long Mei,† Cong-Cong Li,† Xu Han,† Yu-Chen Tian, Shuo-Han Li, Weidong Liu, Ge Qu, Manfred T. Reetz, Zhoutong Sun,* Jun-An Ma,* and Fa-Guang Zhang*
49）The Smallest Monofluorodiazoethane Reagent and Its [3 + 2] Cycloaddition Reactions.
CCS Chemistry 2024, 6, 10.31635/ccschem.024.202403849.
Xiaodong Tang†, Ming-Yue He†, Ran Guo, Hao-Nan Liu, Jing Nie, Ilan Marek, Jun-An Ma, Fa-Guang Zhang*
48）Regioselective Synthesis of Multisubstituted Fluoropyrazoles via Silver-Catalyzed One-Pot Cyclization Reaction of Diazo Reagents with Fluoronitroalkenes.
Adv. Synth. Catal. 2024, 366, doi.org/10.1002/adsc.202400385 .
Rong Wang, Jing Nie,* Xiaojuan Deng, Guosheng Ding, Fa-Guang Zhang,* and Jun-An Ma*
47）Copper-Catalyzed Regio- and Enantioselective Hydroboration of Difluoroalkyl-Substituted Internal Alkenes.
Adv. Sci. 2023, 10, 2304194.
Tao-Qian Zhao, Hui Xu, Yu-Chen Tian, Xiaodong Tang, Yandeng Dang, Shaozhong Ge,* Jun-An Ma,* and Fa-Guang Zhang*
46）Programmable synthesis of difluorinated hydrocarbons from alkenes through a photocatalytic linchpin strategy.
Chem. Sci. 2023, 14, 11546–11553.
Zhi-Qi Zhang, Cheng-Qiang Wang, Long-Ji Li, Jared L. Piper, Zhi-Hui Peng,* Jun-An Ma,* Fa-Guang Zhang,* and Jie Wu*
45）Tetrazole Diversification of Amino Acids and Peptides via Silver-Catalyzed Intermolecular Cycloaddition with Aryldiazonium Salts.
Angew. Chem. Int. Ed. 2023, 62(37), e202304740。
Xuan-Yu Liu,† Yi-Lin Yang,† Yanfeng Dang, Ilan Marek,* Fa-Guang Zhang,* and Jun-An Ma*
44） Dirhodium(II)-catalyzed enantioselective cyclopropenation of internal alkynes with trifluoromethyl carbene.
Chem. Catal. 2023, 3， 10637.
Xiu-Qing Cui,† Meng-Meng Zheng,† Xiaodong Tang, Zhi-Qi Zhang, Ilan Marek*, Jun-An Ma*, and Fa-Guang Zhang*
43） Highly Enantio- and Diastereoselective Hydrogenation of Cyclic Tetra-Substituted β-Enamido Phosphorus Derivatives.
Angew. Chem., Int. Ed. 2023, 62(28), e20230531.
Jun-Hao Zhang,† Hui Xu,† Xiaodong Tang, Yanfeng Dang*, Fa-Guang Zhang*, and Jun-An Ma*
42) Synthesis of di/trifluoromethyl cyclopropane-dicarbonitriles via [2+1] annulation of fluoro-based diazoethanes with (alkylidene)malononitriles.
Chem. Commun. 2023, 59, 11664-11667.
Cheng-Feng Gao,‡ Yue-Ji Chen,‡ Jing Nie, Fa-Guang Zhang,* Chi Wai Cheung,* and Jun-An Ma*
41) Electron Donor−Acceptor Complex Enabled Radical Cyclization of α‑Diazodifluoroethyl Sulfonium Salt with Unactivated Alkynes.
Org. Lett. 2023, 25(50), 9041−9046.
Ming-Yue He,‡ Xiaodong Tang,‡,* Hao-Yan Wu, Jing Nie, Jun-An Ma,* and Fa-Guang Zhang,*
40) Photoinduced Defluorinative Branch-Selective Olefination of Multifluoro (Hetero)arenes.
Org. Lett. 2023, 25(5), 883–888.
Ye Yuan,† Muliang Zhang,† Xiaodong Tang, Jared L. Piper, Zhi-Hui Peng, Jun-An Ma*, Jie Wu*, and Fa-Guang Zhang*,
39) Silver-catalysed [3 + 2] annulation reaction of aryldiazonium salts with allenes enabled by boronate direction.
Org. Chem. Front. 2023, 10(1), 74–82.
Xing Peng,† Meng-Meng Zheng,† Pei Qin, Xiao-Song Xue,* Fa-Guang Zhang,* and Jun-An Ma*,
38） Difluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer.
J. Am. Chem. Soc. 2022, 144(31), 14288−14296.
Zhi-Qi Zhang,† Yue-Qian Sang,† Cheng-Qiang Wang, Peng Dai, Xiao-Song Xue, Jared L. Piper, Zhi-Hui Peng, Jun-An Ma,* Fa-Guang Zhang,* and Jie Wu*
37） Dual Incorporation of Trifluoromethyl and Cyano Groups into Pyrazole Pharmcophores via Silver-Catalyzed Cycloaddition Reaction of Trifluorodiazoethane
CCS Chem. 2022, 4(12), 3693–3704.
Cheng-Feng Gao, Yin Zhou, Hai Ma, Yue Zhang, Jing Nie, Fa-Guang Zhang,* and Jun-An Ma*
36) Metal-free regioselective construction of 2-aryl-2H-tetrazol-5-yl difluoromethylene phosphonates”
Chin. Chem. Lett. 2022, 33(2), 863–866.
Shi-Jing Zhai, Dominique Cahard, Fa-Guang Zhang,* and Jun-An Ma*
35） Quadruple Functionalized Pyrazole Pharmacophores via One-pot Regioselective [3 + 2] Cycloaddition of Fluorinated Nitrile Imines and Dicyanoalkenes.
Chem. Asian J. 2022, 17, e202200436 .
Yin Zhou, Cheng-Feng Gao, Hai Ma, Jing Nie,* Jun-An Ma*, and Fa-Guang Zhang*
34）Enantioselective Construction of Amino Carboxylic-Phosphonic Acid Derivatives Enabled by Chiral Amino Thiourea-Catalyzed Decarboxylative Mannich Reaction.
Adv. Synth. Catal. 2022, 364(11), 1908−1912.
Xue-Qi Wang, Fang-Fang Feng, Jing Nie, Fa-Guang Zhang,* and Jun-An Ma*
33）Triazines: Syntheses and Inverse Electron-demand Diels−Alder Reactions.
Chem. Rev. 2021, 121(23), 14555–14593.
Fa-Guang Zhang,*,† Zhen Chen,† Xiaodong Tang, and Jun-An Ma*
32) Catalytic regioselective construction of phenylthio- and phenoxyldifluoroalkyl tetrazoles from difluorodiazoketones.
Chem. Commun. 2021, 57(100), 13744–13747.
Hong-Song Shi, Shuo-Han Li, Fa-Guang Zhang,* and Jun-An Ma*
31) N‑Iodosuccinimide-Promoted [3 + 2] Annulation Reaction of Aryldiazonium Salts with Guanidines To Construct Aminotetrazoles.
Org. Lett. 2021, 23, 8894−8898.
Yi-Lin Yang, Shen Li, Fa-Guang Zhang,* and Jun-An Ma*
30) Zinc-Enabled Annulation of Trifluorodiazoethane with 2H‑Azirines to Construct Trifluoromethyl Pyrazolines, Pyrazoles, and Pyridazines.
Org. Lett. 2021, 23, 6062−6066.
Yue-Ji Chen, Fa-Guang Zhang,* and Jun-An Ma*
29) From Chemical Synthesis to Biosynthesis： New Trends toward Total Synthesis of Natural Products.
Synthetic Biology Journal 2021, 2(5), 674-696.
Fa-Guang Zhang, Ge Qu, Zhou-Tong Sun,* and Jun-An Ma*
28) Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3-CF3-Pyrazoles from Nitrilimines and Isoxazolidinediones”
Adv. Synth. Catal. 2021, 363 (8), 2093–2097.
Yu-Chen Tian,† Jun-Kuan Li,† Fa-Guang Zhang,* and Jun-An Ma*
27) Asymmetric Synthesis of Chiral Amino Carboxylic-Phosphonic Acid Derivatives
Adv. Synth. Catal. 2021, 363, 688−729.
Hao-Qiang Cao, Jun-Kuan Li, Fa-Guang Zhang,* Dominique Cahard,* and Jun-An Ma*
26) Remote Fluorination and Fluoroalkyl(thiol)ation Reactions
Chem.-Eur. J. 2020, 26, 15378–15396.
Fa-Guang Zhang,* Xue-Qi Wang, Yin Zhou, Hong-Song Shi, Zhe Feng, Jun-An Ma, and Ilan Marek*
25) Aryl Diazonium Salt-Triggered Cyclization and Cycloaddition Reactions: Past, Present, and Future
Chin. J. Chem. 2020, 38(10), 1132–1152.
Fa-Guang Zhang,† Zhen Chen,† Chi Wai Cheung,* and Jun-An Ma*
24) Potassium Acetate-Catalyzed Double Decarboxylative Transannulation To Access Highly Functionalized Pyrroles.
Org. Lett. 2020, 22(24), 9585–9590.
Jun-Kuan Li, Biying Zhou, Yu-Chen Tian, Chunman Jia, Xiao-Song Xue, Fa-Guang Zhang,* and Jun-An Ma*
23) Catalytic Enantioselective Synthesis of Difluoromethylated Tetrasubstituted Stereocenters in Isoindolones Enabled by a Multiple-Fluorine System.
Org. Lett. 2020, 22(22), 9010–9015.
Meng-Yu Rong,† Jin-Shan Li,† Yin Zhou, Fa-Guang Zhang,* and Jun-An Ma*
22) Catalytic Direct Construction of Cyano-tetrazoles
Org. Lett. 2020, 22(19), 7762–7767.
Ming-Yang Xiao,† Meng-Meng Zheng,† Xing Peng, Xiao-Song Xue, Fa-Guang Zhang,* and Jun-An Ma*
21) “Silver-Catalyzed [3 + 2] Cycloaddition Approach to Coumarin-Decorated Tetrazoles
ChemCatChem 2020, 12, 5623–5626.
Xuan-Yu Liu, Shi-Jing Zhai, Fang-Fang Feng, Fa-Guang Zhang,* and Jun-An Ma*
20) Cu-Catalysed Three-Component Reaction of Aryldiazonium Salts with Fluorinated Diazo Reagents and Nitriles: Access to Difluoro- and Trifluoromethylated N1-Aryl-1,2,4-triazoles”
Adv. Synth. Catal. 2020, 362, 4432–4437.
Xing Peng, Fa-Guang Zhang,* and Jun-An Ma*
19) Direct Enamido C(sp2)-H Diphosphorylation Enabled by PCET-triggered Double Radical Relay: Access to gem-Bisphosphonates
Chem.-Eur. J. 2020, 26, 5515–5521.
Hao-Qiang Cao, Hao-Nan Liu, Zhe-Yuan Liu, Bao-Kun Qiao, Fa-Guang Zhang,* and Jun-An Ma*
18） Phosphorylation of Bulky C(sp2)−H Bond to Build Fully Substituted β‑Phosphonodehydroamino Acids
Org. Lett. 2020, 22(16), 6414–6419.
Hao-Qiang Cao, Hao-Nan Liu, Zhe-Yuan Liu, Baokun Qiao, Fa-Guang Zhang,* and Jun-An Ma*
17）Catalytic Enantioselective Cyclopropenation of Internal Alkynes: Access to Difluoromethylated Three-Membered Carbocycles
Angew. Chem., Int. Ed. 2019, 58(50), 18191–18196.
Zhi-Qi Zhang, Meng-Meng Zheng, Xiao-Song Xue, Ilan, Marek,* Fa-Guang Zhang,* and Jun-An Ma*
16) Silver-Catalyzed [3 + 3] Dipolar Cycloaddition of Trifluorodiazoethane and Glycine Imines: Access to Highly Functionalized Trifluoromethyl-Substituted Triazines and Pyridines
ACS Catal. 2019, 9, 4600−4608. (Impact factor 11.384)
Zhen Chen, Nan Ren, Xiaoxiao Ma, Jing Nie, Fa-Guang Zhang,* and Jun-An Ma*
15) Catalytic Direct Regioselective Synthesis of Phosphonylated Tetrazoles from Aryl Diazonium Salts and Seyferth-Gilbert Reagent
Org. Lett. 2019, 21(24), 9884–9888.
Shi-Jing Zhai, Xing Peng, Fa-Guang Zhang,* and Jun-An Ma*
14) Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents
Org. Lett. 2019, 21(20), 8244–8249.
Jun-Liang Zeng,† Yue Zhang,† Meng-Meng Zheng, Zhi-Qi Zhang, Xiao-Song Xue, Fa-Guang Zhang,* and Jun-An Ma*
13) Construction of Difluoromethylated Tetrazoles via Silver-Catalyzed Regioselective [3 + 2] Cycloadditions of Aryl Diazonium Salts
Org. Lett. 2019, 21(12), 4808–4811.
Xing Peng, Ming-Yang Xiao, Jun-Liang Zeng, Fa-Guang Zhang,* and Jun-An Ma*
12) Construction of Chiral β‑Trifluoromethyl Alcohols Enabled by Catalytic Enantioselective Aldol-Type Reaction of CF3CHN2
Org. Lett. 2019, 21(11), 4280–4283.
Meng-Yu Rong,† Lijun Yang,† Jing Nie, Fa-Guang Zhang,* and Jun-An Ma*
11) Zinc-Mediated Mannich-Type Reaction of 2,2,2-Trifluorodiazoethane with Imines: Access to β‑CF3‑Amines
Org. Lett. 2018, 20, 6994–6997.
Ran Guo, Ning Lv, Fa-Guang Zhang,* and Jun-An Ma,*
10) Direct Regioselective [3 + 2] Cycloaddition Reactions of Masked Difluorodiazoethane with Electron-Deficient Alkynes and Alkenes: Synthesis of Difluoromethyl-Substituted Pyrazoles
Org. Lett. 2018, 20(15), 4562–4565.
Jun-Liang Zeng, Zhen Chen, Fa-Guang Zhang,* and Jun-An Ma*
9) Telescoping Reactions with Trifluorodiazoethane-Derived Aza-Wittig Reagents and Allenyl esters
Chem. Eur. J. 2018, 24(30), 7749–7754.
Fa-Guang Zhang,† Jun-Liang Zeng,† Yi-Qiang Tian, Yan Zheng, Dominique Cahard, and Jun-An Ma*
8)“Phosphine-Relayed Aldehyde-Olefination and Aza-Wittig Reaction with 2,2,2-Trifluorodiazoethane
Chin. J. Chem. 2018, 36, 723–730.
Fa-Guang Zhang,†* Ning Lv,† Yan Zheng, and Jun-An Ma*
7) One-Pot Cascade Transformations of Zinc Trifluorodiazoethylide and α,β-Unsaturated Enones: Access to Trifluoromethylated Polycyclic Pyrazolines
Org. Lett. 2017, 19(13), 3406–3409.
Shuang Qin, Yan Zheng, Fa-Guang Zhang,* and Jun-An Ma*
6) Brook Rearrangement as Trigger for Carbene Generation: Synthesis of Stereodefined and Fully Substituted Cyclobutenes
J. Am. Chem. Soc. 2017, 139, 8364−8370.
Fa-Guang Zhang and Ilan Marek*
5) Brook Rearrangement as a Trigger for Ring-Opening of strained Carbocycles
Angew. Chem., Int. Ed. 2016, 55, 714–718.
Fa-Guang Zhang, Guillaume Eppe and Ilan Marek*
4) Enantioselective Base-Free Electrophilic Amination of Benzofuran-2(3H)-ones: Catalysis by Binol-Derived P-Spiro Quaternary Phosphonium Salts
Angew. Chem., Int. Ed. 2011, 50, 5869–5872.
Chuan-Le Zhu, Fa-Guang Zhang, Wei Meng, Jing Nie, Dominique Cahard, and Jun-An Ma*
3) Regioselective Cycloaddition of Trifluorodiazoethane with Electron-Deficient Allenic Esters and Ketones: Access to CF3‑Substituted Pyrazolines and Pyrazoles
Org. Lett. 2014, 16, 3122–3125.
Fa-Guang Zhang, Yi Wei, Yu-Ping Yi, Jing Nie, and Jun-An Ma*
2) Enantioselective Diynylation of Cyclic N-Acyl Ketimines: Access to Chiral Trifluoromethylated Tertiary Carbinamines
Adv. Synth. Catal. 2012, 354, 1422–1428.
Fa-Guang Zhang, Hai Ma, Jing Nie, Yan Zheng, Qingzhi Gao and Jun-An Ma*
1) Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083.
Chem. Commun. 2012, 48, 11552–11554.
Fa-Guang Zhang, Xiao-Yan Zhu, Shen Li, Jing Nie and Jun-An Ma*
