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代表性论文

  1.  Zhou X, Kang X, Chen J, Song Y, Jia C, Teng L, Tang Y, Jiang Z, Peng X, Tao X, Xu Y, Huang L, Xu X, Xu Y, Zhang T, Yu S, Gong J, Wang S, Liu Y, Zhu G, Kehrenberg C, Weill FX, Barrow P, Li Y, Zhao G, Yue M* (20230902) Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response. National Science Review 10(10): nwad228. DOI: 10.1093/nsr/nwad228.

    Published by Oxford University Press

     BioArt Highlight [NSR | “以退为进”实现“双赢”，乐敏课题组揭示病原菌宿主适应新机制] 

     腾讯网-科研进展 [浙大乐敏课题组以鸡白痢沙门菌为模型提出病原菌宿主适应“以退为进”新机制] 

     ZJU Highlight [动科学院乐敏课题组揭示病原菌宿主适应“以退为进”新机制] 

  2. Feng Y, Pan H, Zheng B, Li F, Teng L, Jiang Z, Feng M, Zhou X, Peng X, Xu X, Wang H, Wu B, Xiao Y, Baker S, Zhao G, Yue M* (20231031) An integrated nationwide genomics study reveals transmission modes of typhoid fever in China. mBio 14(5):e0133323. DOI: 10.1128/mbio.01333-23. Published by American Society for Microbiology 

     iMeta Highlight [跨学科/单位联合揭示我国伤寒的“双重”传播模式] 

     ASM微生物 Highlight [跨学科/单位的基因组学综合研究揭示中国伤寒的“双重”传播模式] 

     入选ASM Journals’ Diversity, Equity, and Inclusion (DEI) Article Collection   

  3.  Jia C, Wang Z, Huang C, Teng L, Zhou H, An H, Liao S, Liu Y, Huang L, Tang B, Yue M* (20231221) Mobilome-driven partitions of the resistome in Salmonella. mSystems 8(6):e0088323. DOI: 10.1128/msystems.00883-23. Published by American Society for Microbiology 

    4. iMeta Highlight [浙大乐敏组揭示沙门菌可移动元件介导驱动耐药性传播的关键因素] 

  4. Li Y, Teng L, Xu X, Li X, Peng X, Zhou X, Du J, Tang Y, Jiang Z, Wang Z, Jia C, Müller A, Kehrenberg C, Wang H, Wu B, Weill FX, Yue M* (20221108) A non-typhoidal Salmonella serovar domestication accompanying enhanced niche adaptation. EMBO Molecular Medicine 14(11):e16366.DOI: 10.15252/emmm.202216366. Published by Wiley-Blackwell & European Molecular Biology Organization 

  5. Li Y, Ed-Dra A, Tang B, Kang X#, Müller A, Kehrenberg C, Jia C, Pan H, Yang H, Yue M* (20220915) Higher tolerance of predominant Salmonella serovars circulating in the antibiotic-free feed farms to environmental stresses. Journal of Hazardous Materials 438:129476. DOI: 10.1016/j.jhazmat.2022.129476. ESI highly cited paper Published by Elsevier 

  6. Peng X, Ed-Dra A, Yue M* (20220613) Application of Whole Genome Sequencing for the Risk Assessment of Probiotic Lactic Acid Bacteria. Critical Reviews in Food Science and Nutrition 63(32):11244-11262. DOI: 10.1080/10408398.2022.2087174. ESI highly cited paper / hot paper Published by Taylor & Francis

  7. Zhou X, Kang X, Zhou K, Yue M* (20220813) A global dataset for prevalence of Salmonella Gallinarum between 1945 and 2021. Scientific Data 9(1):495. DOI:10.1038/s41597-022-01605-x. ESI highly cited paper Published by Nature Portfolio 

  8. Paudyal N, Yue M* (20190702) Antibiotic resistance in the “dark matter”. Clinical Infectious Diseases 69(2):379-380. DOI: 10.1093/cid/ciz007. Published by Oxford University Press & Infectious Diseases Society of America 

  9. Liu Y, Peng Na, Yao Y, Zhang X, Peng X, Zhao L, Wang J, Peng L, Wang Z, Mochizuki K*, Yue M*, Yang S* (20220623) Breaking the Nanoparticle’s Dispersible Limit via Rotatable Surface Ligands. Nature Communications 13(1):3581. DOI: 10.1038/s41467-022-31275-7. Published by Nature Portfolio 

     【Editors’ Highlights: selected as 50 best papers in the field in NC】

     Highlighted News: Adaptable, Smart Nanoparticles that can Disperse in Liquids 

  10. Huang L, Zhou H, Chen J, Jia C, Siddique A, Wu B, Wang H, Tang B, He F, Zhao G, Yue M* (20240501) Impact of COVID-19-related Nonpharmaceutical Interventions on Diarrheal Diseases and Zoonotic Salmonella. hLife 2(5):XX DOI: 10.1016/j.hlife.2024.03.005. Published by Elsevier 

     当期封面论文（五月） 

     BioArtMED highlight [乐敏课题组《hLife》《mLife》研究成果揭示沙门菌中国流行新趋势]

    全部论文（其中SCI论文通讯作者* 85篇，第一作者# 9篇）:

    142. Wang Z, Zhou H, Liu Y, Huang C, Chen J, Siddique A, Ying R, Jia C, Li Y, Zhao G, Yue M* (2024) Nationwide trends and features of human salmonellosis outbreaks in China. Emerging Microbes & Infections DOI: 10.1080/22221751.2024.2372364. (IF5: 8.3)

    141. Xia L, Gui Y, Yin R, Li N, Yue M*, Mu Y* (2024) Concanavalin A-based multiplex digital PCR chip for rapid capture and accurate quantification detection of foodborne pathogens. Talanta  277: 126351. DOI: 10.1016/j.talanta.2024.126351. (IF5: 5)

    140. Wang H, Ye C, Lu Q, Jiang Z, Jiang C, Zhou C, Li N, Zhang C, Zhao G, Yue M*, Li Y*, (2024) Bacterial exonuclease Ⅲ expands its enzymatic activities on single-stranded DNA. eLife DOI: 10.7554/eLife.95648.3. (IF5: 7.2)

    139. Jin X, Peng N, Cui A, Liu Y, Peng X, Huang L, Ed-Dra A, He F, Li Y, Yang S*, Yue M*. (2024) Improving Antimicrobial Potential of Electrodeposited Silver Nanoparticles by Targeting Amphiphilic Membrane. mLife in press (IF5: 4.5)

    138. Kang X, An H, Wang B, Huang L, Huang C, Huang Y, Wang Z, He F, Li Y, Yue M* (2024) Integrated OMICs approach reveals energy metabolism pathway is vital for Salmonella Pullorum survival within the egg white. mSphere DOI: 10.1128/msphere.00362-24. (IF5: 4)

    137. Tang B#, Zhao H#, Li J, Liu N, Huang Y, Wang J*, Yue M* (2024) Detection of clinical Serratia marcescens isolates carrying blaKPC-2 in a hospital in China. Heliyon 10(8):E29702. DOI: 10.1016/j.heliyon.2024.e29702. (IF5: 3.9)

    136. Huang L#, Zhou H#, Chen J, Jia C, Siddique A, Wu B, Wang H, Tang B, He F, Zhao G, Yue M* (2024) Impact of COVID-19-related Nonpharmaceutical Interventions on Diarrheal Diseases and Zoonotic Salmonella. hLife 2(5):246-256. DOI: 10.1016/j.hlife.2024.03.005.

    当期封面论文（Vol.2|Issue 5|May 2024）

    135. Ed-Dra A*, Giarratana F, White A, Yue M*. (2024) Editorial: Zoonotic Bacteria: Genomic Evolution, Antimicrobial Resistance, Pathogenicity, and Prevention Strategies. Frontiers in Veterinary Science 11:1390732.DOI: 10.3389/fvets.2024.1390732. (IF5: 3.1)

    134. Iduu NV, Raiford D, Conley A, Scaria J, Nelson J, Ruesch L, Price S, Yue M, Gong J, Wei L, Wang C. (2024) Retrospective Analysis of Salmonella Isolates across 11 Animal Species (1982–1999) Led to the First Identification of Chromosomally Encoded blaSCO-1 in the USA. Microorganisms 12(3): 528. DOI: 10.3390/microorganisms12030528.

    133. Rinn N, Braun AS, Müller A, Wadepohl K, Gerulat B, Kumm F, Yue M, Kehrenberg C. Microbiological quality of raw beef imported into the European Union from third countries. Food Control 160: 110358. DOI: 10.1016/j.foodcont.2024.110358.

    132. Wang Z, Huang C, Liu Y, Chen J, Yin R, Jia C, Kang X, Zhou X, Liao S, Jin X, Feng M, Jiang Z, Song Y, Zhou H, Yao Y, Teng L, Wang B, Li Y, Yue M* (2024) Salmonellosis outbreak archive in China: data collection and assembly. Scientific Data 11(1):244. DOI: 10.1038/s41597-024-03085-7. (IF5: 8.9)

    131. Teng L#, Huang L#, Zhou H, Wang B, Yue M*, Li Y* (2024) Microbiological hazards in infant and toddler food in China: A comprehensive study between 2004 and 2022. Food Research International 180:114100. DOI: 10.1016/j.foodres.2024.114100. (IF5: 7.4)

    130. Gütgemann F, Heuvelink A, Müller A, Churin Y, Buter R, Jung A, Feberwee A, Wiegel J, Kumm F, Braun AS, Yue M, Soriano-Vargas E, Swanepoel S, Botteldoorn N, Kirchner M, Kehrenberg C. (2024) Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of Avibacterium paragallinarum and resistance monitoring. Journal of Clinical Microbiology e0101123. DOI: 10.1128/jcm.01011-23.

    129. Jia C, Cao Q, Wang Z, van den Dool A, Yue M*. (2024) Climate change affects the spread of typhoid pathogens. Microbial Biotechnology 17(2):e14417. DOI: 10.1111/1751-7915.14417. (IF5: 5.8)

    128. Jin C#, Jia C#, Hu W, Xu H, Shen Y, Yue M*. (2024) Predicting antimicrobial resistance in E. coli with discriminative position fused deep learning classifier (2023) Computational and Structural Biotechnology Journal 23:559-565. DOI: 10.1016/j.csbj.2023.12.041. (IF5: 5)

    127. Wang B#, Peng X#, Zhou X, Yao J, Zhang H, Li W, Li Y, Yue M*. Lacticaseibacillus rhamnosus P118-derived tryptophan/indole metabolites enhance host tolerance to Salmonella infection.

    126. Ke Y#, Teng L#, Zhu Z, Lu W, Liu W, Zhou H, Yu Q, Ye L, Zhu P, Zhao G, Yue M*. (20240329) Genomic investigation and nationwide tracking of pediatric invasive non-typhoidal Salmonella in China. mLife 3(1):156-160. DOI: 10.1002/mlf2.12117. (IF5: 4.5)

    125. Siddique A#, Gu G#, Zhang G#, Raheem A, Xu X, Jia L, Xu X, Yue M*. (2024) Global population genomics of Salmonella enterica subspecies enterica serovar Aberdeen Isolated from various sources indicates an environmental borne reservoir. ONE Health accepted (IF5: 4.3)

    124. Wang H#, Li H#, Tang B, Ye C, Han M, Teng L, Yue M, Li Y*. Fast and sensitive differential diagnosis of the pseudorabies virus-infected versus vaccinated swine using CRISPR-Cas12a. Microbiology Spectrum 12(1):e0261723. DOI: 10.1128/spectrum.02617-23. (IF5: 4.2)

    123. Wu-Chen RA#, Feng J#, Elhadidy M, Nambiar RB, Liao X, Yue M*, Ding T* (2023) Long-term exposure to food-grade disinfectants causes cross-resistance to antibiotics in Salmonella enterica serovar Typhimurium strains with different antibiograms and sequence types. Antimicrobial Resistance & Infection Control 12(1):145. DOI: 10.1186/s13756-023-01333-w. (IF5: 5.8)

    122. Wu-Chen RA#, Feng J#, Elhadidy M, Nambiar RB, Liao X, Yue M*, Ding T* (2023) Benzalkonium chloride forces selective evolution of resistance towards antibiotics in Salmonella enterica serovar Typhimurium. Journal of Infection and Public Health Suppl 1:225-235. DOI: 10.1016/j.jiph.2023.10.022. (IF5: 5.8)

    121. Kang X, Chen J, Zhou X, Ed-Dra A, Yue M* (2023) Allelic functional variation of FimH among Salmonella enterica subspecies. Animal Diseases 3:33. DOI: 10.1186/s44149-023-00101-y. Published by BMC, Highlight [XXX]

    120. Jia C#, Wang Z#, Huang C, Teng L, Zhou H, An H, Liao S, Liu Y, Huang L, Tang B, Yue M* (2023) Mobilome-driven partitions of the resistome in Salmonella. mSystems 8(6):e0088323. DOI: 10.1128/msystems.00883-23. (IF5: 6.1) Published by American Society for Microbiology.

    iMeta Highlight [浙大乐敏组揭示沙门菌可移动元件介导驱动耐药性传播的关键因素]

    119. Jiang X*, Yu G, Zhu L, Siddique A, Zhan D, Zhou L, Yue M* (2023) Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition. Virulence 14(1):2249779. DOI: 10.1080/21505594.2023.2249779. (IF5: 5.4)

    118. Sun H, Yao W, Siddique A, He F*, Yue M* (2023) Genomic Characterization of Dengue Virus Serotype 2 during Dengue Outbreak and Endemics in Hangzhou, Zhejiang (2017-2019). Frontiers in Microbiology 14: 1245416. DOI: 10.3389/fmicb.2023.1245416. (IF5: 5.1)

    117. Feng Y#, Pan H#, Zheng B#, Li F, Teng L, Jiang Z, Feng M, Zhou X, Peng X, Xu X, Wang H, Wu B, Xiao Y, Baker S, Zhao G, Yue M* (2023) An integrated nationwide genomics study reveals transmission modes of typhoid fever in China. mBio 14(5):e0133323. DOI: 10.1128/mbio.01333-23. (IF5: 6.9) Published by American Society for Microbiology.

    iMeta Highlight [跨学科/单位联合揭示我国伤寒的“双重”传播模式]

    ASM微生物 Highlight [跨学科/单位的基因组学综合研究揭示中国伤寒的“双重”传播模式]

    116. Teng L#, Du J#, Xu X#, Pan H, Jia C, Jiang Z, Peng X, Zhou X, Dong C, Wu B, Wang H, Hu Q, Weill FX, Baker S, Yue M* (2023) Exploiting genomics reveals an emerging non-typhoidal Salmonella variant in asymptomatic carriers. Nature Communications in press (IF5: 17)

    115. Zhou X#, Kang X#, Chen J, Song Y, Jia C, Teng L, Tang Y, Jiang Z, Peng X, Tao X, Xu Y, Huang L, Xu X, Xu Y, Zhang T, Yu S, Gong J, Wang S, Liu Y, Zhu G, Kehrenberg C, Weill FX, Barrow P, Li Y, Zhao G, Yue M* (2023) Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response. National Science Review 10(10): nwad228. DOI: 10.1093/nsr/nwad228. (IF5: 18.6)

    BioArt Highlight [NSR | “以退为进”实现“双赢”，乐敏课题组揭示病原菌宿主适应新机制]

    腾讯网-科研进展 [浙大乐敏课题组以鸡白痢沙门菌为模型提出病原菌宿主适应“以退为进”新机制]

    ZJU Highlight [动科学院乐敏课题组揭示病原菌宿主适应“以退为进”新机制]

    114. Hu Y, Chen X, Ling Y, Zhou K, Han M, Wang X, Yue M, Li Y* (20230717) Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication PLoS Pathogens 19(7):e1011550. DOI: 10.1371/journal.ppat.1011550

    113. Cao G, Yang S, Wang H, Zhang R, Wu Y, Liu J, Qiu K, Dong Y, Yue M* (20230701) Effects of Bacillus licheniformis on the growth performance, antioxidant capacity, ileal morphology, intestinal short chain fatty acids, and colonic microflora in piglets challenged with lipopolysaccharide. Animals 13(13):2172. DOI: 10.3390/ani13132172. (IF5: 3)

    112. Sun J, Jia C, Tang B, Zhao G, Yue M* (2023) Research progress in a novel mobile RND efflux pump TMexCD-TOprJ. Acta Microbiologica Sinica 63(11):4101–4117.

          孙敬都，贾程皓，唐 标，赵国屏，乐敏* (2023) 新型可移动RND家族外排泵TMexCD-TOprJ的研究进展. 微生物学报 63(11):4101–4117. DOI: 10.13343/j.cnki.wsxb.20230191

    111. Ni J, Long X, Wang M, Ma J, Sun Y, Wang W, Yue M, Yang H, Pan D, Tang B (20230531) Transmission of linezolid-resistant Enterococcus isolates carrying optrA and poxtA genes in slaughterhouses. Frontiers in Sustainable Food Systems 7:1179078. DOI: 10.3389/fsufs.2023.1179078.

    110. Wang B#, Zhou Y#, Wang Q, Xu S, Wang F, Yue M, Zeng Z, Li W* (20230521) Lactiplantibacillus plantarum Lac16 Attenuates Enterohemorrhagic Escherichia coli O157:H7 Infection by Inhibiting Virulence Traits and Improving Intestinal Epithelial Barrier Function. Cells 12(10):1438. DOI:10.3390/cells12101438.

    109. Jiang Z#, Kang X#, Song Y, Zhou X, Yue M* (20230418) Identification and Evaluation of Novel Antigen Candidates against Salmonella Pullorum Infection Using Reverse Vaccinology. Vaccines 11(4):865. DOI: 10.3390/vaccines11040865. (IF5: 4.9)

    108. Jiang Z#, Teng L#, He A, Liu Y, Yue M*, He Q* (20230321) Genomic Analysis of Salmonella Typhimurium Isolates and Salmonella Serotype 4,[5],12:i:- Isolates from Pig-borne Food Chain. Acta Veterinaria et Zootechnica Sinica 54(3):1199-1209. DOI: 0.11843/j.issn.0366-6964.2023.02.031.

    蔣增海，滕霖，贺安文，刘言言，乐敏*，何启盖* （2023）猪产业链中鼠伤寒及沙门菌血清型4,[5],12:i:-基因学分析. 畜牧兽医学报 54(3): 1199-1209.

    107. Wu R, Feng J, Yue M, Liu D, Ding T (20230209) Overuse of food-grade disinfectants threatens a global spread of antimicrobial-resistant bacteria. Critical Reviews in Food Science and Nutrition. 1-10. DOI: 10.1080/10408398.2023.2176814.

    106. Wang Z#, Liao S#, Huang G#, Feng M, Yin R, Teng L, Jia C, Yao Y, Yue M*, Li Y* (20230316) Infant food production environments: A potential reservoir for vancomycin-resistant enterococci non-nosocomial infections. International Journal of Food Microbiology 389:110105. DOI: 10.1016/j.ijfoodmicro.2023.110105. (IF5: 5)

    105. 李红招; 王浩; 尹睿; 乐敏; 李艳* (2023) 基于CRISPR/Cas系统的病原核酸检测技术研究进展. 浙江大学学报（农业与生命科学版） 5:618-632. DOI: 10.3785/j.issn.1008-9209.2022.08.051.

    104. Gütgemann F, Müller A, Churin Y, Kumm F, Braun A, Yue M, Eisenberg T, Entorf M, Peters T, Kehrenberg C (20230713) Toward a Method for Harmonized Susceptibility Testing of Mycoplasma bovis by Broth Microdilution. Journal of Clinical Microbiology 61(8):e0190522.DOI: 10.1128/jcm.01905-22.

    103. Serian D, Churin Y, Hammerl JA, Rohde M, Jung A, Müller A, Yue M, Kehrenberg K* (20230501) Characterization of Temperate LPS-Binding Bordetella avium Phages That Lack Superinfection Immunity. Microbiology Spectrum 11(3):e0370222. DOI: 10.1128/spectrum.03702-22.

    102. Wei C, Chen J, Anwar TM, Huang L, Yang W, Dong X, Chen Q, Yue M*, Yu D* (20230512) Genomic Determinants of Pathogenicity and Antimicrobial Resistance of Nosocomial Acinetobacter baumannii Clinical Isolates of Hospitalized Patients (2019-2021) from a Sentinel Hospital in Hangzhou, China. Infection and Drug Resistance 16:2939-2952. DOI: 10.2147/IDR.S407577. (IF5: 3.6)

    101. Zeng J, Gao Q, Xu J, Xu X, Shan Y, Shi F, Yue M, He F, Fang W*, Li X* (20221031) DNAJA3 Interacts with PEDV S1 Protein and Inhibits Virus Replication by Affecting Virus Adsorption to Host Cells. Viruses 14(11):2413. DOI: 10.3390/v14112413.

    100. Chen J#, Zhou X#, Tang Y, Jiang Z, Kang X, Wang J, Yue M* (20230109) Characterization of Two-component System CitB family in Salmonella enterica serovar Gallinarum biovar Gallinarum. Veterinary Microbiology 278:109659. DOI: 10.1016/j.vetmic.2023.109659. (IF5: 2.6)

    99. Pan H#, Jia C#, Paudyal N, Li F, Mao J, Liu X, Dong C, Zhou K, Liao X, Gong J, Fang W, Li X, Kehrenberg C, Yue M* (20221026) Comprehensive Assessment of Subtyping Methods for Improved Surveillance of Foodborne Salmonella. Microbiology Spectrum 10(5):e0247922.DOI: 10.1128/spectrum.02479-22. (IF5: 4.2)

    98. Kang X#, Zhou X#, Tang Y, Jiang Z, Chen J, Mohsin M, Yue M* (20220905) Characterization of Two-component System CitB family in Salmonella Pullorum. International Journal of Molecular Sciences 23(17):10201. DOI: 10.3390/ijms231710201. (IF5: 5.6)

    97. Zhou W#, Lin R#, Zhou Z, Ma J, Lin H, Zheng X, Wang J, Wu J, Dong Y, Jiang H, Yang H, Yang Z*, Tang B*, Yue M* (20221024) Antimicrobial resistance and genomic characterization of Escherichia coli from pigs and chickens in Zhejiang, China. Frontiers in Microbiology 13:1018682. DOI: 10.3389/fmicb.2022.1018682. (IF5: 5.1)

    96. Ma J#, Tang B#, Lin J#, Ed-Dra A, Lin H, Wu J, Dong Y, Yang H*, Yue M* (20221103) Genome Assessment of Carbapenem- and Colistin-Resistant Escherichia coli from Patients in a Sentinel Hospital in China. Cells 11(21):3480. DOI: 10.3390/cells11213480. (IF5: 6)

    95. Tang B#, Siddique A#, Jia C#, Ed-Dra A, Wu J, Lin H, Yue M* (20230201) Genome-based Risk Assessment for Foodborne Salmonella enterica from Food Animals in China: A One Health Perspective. International Journal of Food Microbiology 390:110120. DOI: 10.1016/j.ijfoodmicro.2023.110120 (IF5: 5)

    94. Tang B#, Guan C#, Lin H, Liu C, Yang H, Zhao G, Yue M* (20230123) The emergence of co-existence of mcr-1 and blaNDM-5 in Escherichia fergusonii. International Journal of Antimicrobial Agents 61(3):106742 DOI: 10.1016/j.ijantimicag.2023.106742. (IF5: 5.6)

    93. Tang B#, Ni J#, Lin J#, Sun Y, Lin H, Wu Y, Yang H*, Yue M* (20220908) Genomic Characterization of Multidrug-Resistance Gene cfr in Escherichia coli Recovered from Food Animals in Eastern China. Frontiers in Microbiology 13:999778. DOI: 10.3389/fmicb.2022.999778. (IF5: 5.1)

    92., Wu X, Jia C, Wang J, Wang L, Yue M* (20221220) DNA polymerase IV - a potential drug target against bacteria. Microbiology China. Microbiology China 49(12): 5342-5358.DOI:10.13344/j.microbiol.china.220664.

    吴小磊, 贾程皓, 王剑峰, 王雷杰, 乐敏*. DNA 聚合酶IV：抗细菌的潜在药靶[J]. 微生物学通报, 2022, 49(12): 5342-5358.

    91. Chen J#, Ed-Dra A#, Zhou H#, Wu B, Zhang Y*, Yue M* (20220913) Antimicrobial resistance and genomic investigation of non-typhoidal Salmonella isolated from outpatients in Shaoxing city, China. Frontiers in Public Health 10:988317. DOI: 10.3389/fpubh.2022.988317. (IF5: 3.6)

    90. Li Y#, Teng L#, Xu X#, Li X, Peng X, Zhou X, Du J, Tang Y, Jiang Z, Wang Z, Jia C, Müller A, Kehrenberg C, Wang H, Wu B, Weill FX, Yue M* (20221108) A non-typhoidal Salmonella serovar domestication accompanying enhanced niche adaptation. EMBO Molecular Medicine 14(11):e16366.DOI: 10.15252/emmm.202216366. (IF5: 11)

    89. Ma F#, Xiao M#, Zhu L#, Jiang W, Jiang J, Zhang P, Li K, Yue M*, Zhang L* (20220914) An Integrated Platform for Brucella: From Genomic Analysis to Epidemiological Projection. Frontiers in Genetics 13:981633. DOI: 10.3389/fgene.2022.981633. (IF5: 3.3)

    88. Wang H#, Jia C#, Li H#, Yin R, Chen J*, Li Y*, Yue M* (20220812) Paving the Way for Precision Diagnostics of Antimicrobial-Resistant Bacteria. Frontiers in Molecular Biosciences 9:976705. DOI:10.3389/fmolb.2022.976705. (IF5: 4.4)

    87. Peng X#, Ed-Dra A#, Song Y, Elbediwi M, Nambiar R, Zhou X, Yue M* (20220811) Lacticaseibacillus rhamnosus alleviates intestinal inflammation and promotes microbiota-mediated protection against Salmonella fatal infection. Frontiers in Immunology 13:973224. DOI: 10.3389/fimmu.2022.973224. (IF5: 6.8)

    86. Chen J, Zhang J, Zhan L, Chen H, Zhang Z, Huang C*, Yue M* (20220715) Prevalence and Antimicrobial-resistant Characterization of Bacillus cereus Isolated from Ready-to-eat (RTE) Rice Products in Eastern China. Frontiers in Microbiology 13:964823. DOI: 10.3389/fmicb.2022.964823. (IF5: 5.1)

    85. Nambiar R#, Elbediwi M#, Ed-Dra A, Wu B, Yue M* (20240201) Epidemiology and Antimicrobial Resistance of Salmonella Serovars Typhimurium and 4,[5],12:i- Recovered from Hospitalized Patients in China. Microbiological Research 282:127631. DOI: 10.1016/j.micres.2024.127631. (IF5: 6.5)

    84. Teng L#, Feng M#, Liao S, Zheng Z, Jia C, Zhou Z, Nambiar R, Ma Z, Yue M* (20230222) A cross-sectional study of companion animal-derived multidrug-resistant Escherichia coli in Hangzhou, China. Microbiology Spectrum 11(2):e0211322. DOI: 10.1128/spectrum.02113-22 (IF5: 4.2)

    83. Gütgemann F, Müller A, Churin Y, Jung A, Kumm F, Heuvelink A, Yue M, Kehrenberg C* (20220817) Proposal of a method for harmonized broth microdilution antimicrobial susceptibility testing of Avibacterium Gallinarum. Journal of Clinical Microbiology 60(8):e0041922. DOI:10.1128/jcm.00419-22.

    82. Peng X#, Ed-Dra A#, Yue M* (20230613) Application of Whole Genome Sequencing for the Risk Assessment of Probiotic Lactic Acid Bacteria. Critical Reviews in Food Science and Nutrition 13:1-19. DOI: 10.1080/10408398.2022.2087174. (IF5: 10.3) ESI highly cited paper / hot paper

    81. Zhou X#, Kang X#, Zhou K, Yue M* (20220813) A global dataset for prevalence of Salmonella Gallinarum between 1945 and 2021. Scientific Data 9(1):495. DOI:10.1038/s41597-022-01605-x. (IF5: 8.9) ESI highly cited paper

    80. Anwar W#, Teng L#, Cai W#, Kang X, Rantsiou K, Kehrenberg C, Fang W, Li Y, Yue M* (2022) Genomic Characterization of Antimicrobial-resistant Listeria monocytogenes isolated between 2002 and 2019 in China. Food Control under review

    79. Shan Y, Gao Q, Mao J, Zheng J, Xu X, Zhang C, Huang X, Xu J, Shi F, Yue M, He F, Fang W, Li X* (20220427) Establishment of enzyme-linked immunosorbent assays based on recombinant S1 and its truncated proteins for detection of PEDV IgA antibody. BMC Veterinary Research 18(1):154. DOI: 10.1186/s12917-022-03262-z.

    78. Wu Y, Wang Y, Hu A, Shu X, Huang W, Liu J, Wang B, Zhang R, Yue M, Yang C* (20220728) Lactobacillus plantarum-Derived Postbiotics Prevent Salmonella-Induced Neurological Dysfunctions by Modulating Gut–Brain Axis in Mice. Frontiers in Nutrition 9:946096. DOI: 10.3389/fnut.2022.946096.

    77. Teng L#, Liao S#, Zhou X, Jia C, Feng M, Pan H, Ma Z, Yue M* (20220505) Prevalence and Genomic Investigation of Multidrug-resistant Salmonella Isolates from Companion Animals in Hangzhou, China. Antibiotics 11(5):625. DOI:10.3390/antibiotics11050625. (IF5: 4.6) ESI highly cited paper

    76. Zeng Z, Zhou Y, Xu Y, Wang S, Wang B, Zeng Z, Wang Q, Ye X, Jin L, Yue M, Tang L, Zou P, Zhao P*, Li W* (20220510) Bacillus amyloliquefaciens SC06 alleviates the obesity of ob/ob mice and improves their intestinal microbiota and bile acid metabolism. Food & Function 13(9):5381-5395. DOI:10.1039/D1FO03170H.

    75. Yu Y, Zeng X, Yue M, Yang C* (20210618) Research Progress on Probiotics Regulating Animal Bone Metabolism through Gut-Brain Axix. Chinese Journal of Animal Science 57(9):22-27. DOI: 10.19556/j.0258-7033.20200921-02.                        余洋,曾新福,乐敏,杨彩梅* (Jun 2021) 益生菌通过肠-脑轴调控动物骨代谢的研究进展. 中国畜牧杂志, 57(9):22-27. DOI: 10.19556/j.0258-7033.20200921-02.

    74. Li Y#, Kang X#, Ed-Dra A#, Zhou X#, Jia C, Müller A, Liu Y, Kehrenberg C, Yue M* (20220831) Genome-based assessment of antimicrobial resistance and virulence potential for non-Pullorum/Gallinarum Salmonella serovars recovered from dead poultry in China. Microbiology Spectrum 10(4):e0096522. DOI:10.1128/spectrum.00965-22. (IF5: 4.2)

    73. Wang H#, Feng M#, Anwar T#, Chai W, Dra-Ed A, Kang X, Rantsiou K, Yue M, Li Y* (2023) Change in antimicrobial susceptibility of Listeria spp. in response to stress conditions. Frontiers in Sustainable Food Systems 7:1179835. DOI: 10.3389/fsufs.2023.1179835. (IF5: 4.6)

    72. Liu Y, Peng Na, Yao Y, Zhang X, Peng X, Zhao L, Wang J, Peng L, Wang Z, Mochizuki K*, Yue M*, Yang S* (20220623) Breaking the Nanoparticle’s Dispersible Limit via Rotatable Surface Ligands. Nature Communications 13(1):3581. DOI: 10.1038/s41467-022-31275-7. (IF5: 16.1)

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    71. Wang C, Wei S, Jin M, Liu B, Yue M, Wang Y* (20220228) Integrated microbiomic and metabolomic dynamics of fermented corn and soybean by-product mixed substrate. Frontiers in Nutrition 9:831243. DOI: 10.3389/fnut.2022.831243.

    70. Zhang G#, Raheem A#, Gao X#, Zhang J, Shi L, Wang M, Li M, Yin Y, Li S, Cui X, Yan X, Yue M, Wen H*, Qin T* (20220227) Cytoprotective effects of Lactobacilli on mouse epithelial cells during Salmonella infection. Fermentation 8(3):101. DOI: 10.3390/fermentation8030101.

    69. Elbediwi M*, Tang Y, Yue M* (20230301) Genomic characterization of ESBL-producing Salmonella Thompson isolates harboring mcr-9 from dead chick embryos in China. Veterinary Microbiology 278:109634. DOI: 10.1016/j.vetmic.2022.109634. (IF5: 2.6) ESI highly cited paper / hot paper

    68. Tang B#, Elbediwi M#, Nambiar R, Yang H, Lin J, Yue M* (20221026) Genomic Characterization of antimicrobial-resistant Salmonella enterica in duck, chicken and pig farms and retail markets in Eastern China. Microbiology Spectrum 10(5):e0125722. DOI: 10.1128/spectrum.01257-22. (IF5: 4.2)

    67. Anwar W#, Pan H#, Cai W, Ed-Dra A, Fang W, Li Y, Yue M* (20220402) Genetic Diversity, Virulence Factors, and Antimicrobial Resistance of Listeria monocytogenes from Food, Livestock, and Clinical isolates between 2002 and 2019 in China. International Journal of Food Microbiology 366: 109572. DOI: 10.1016/j.ijfoodmicro.2022.109572. (IF5: 5)

    66. Li Y#, Ed-Dra A#, Tang B#, Kang X#, Müller A, Kehrenberg C, Jia C, Pan H, Yang H, Yue M* (20220915) Higher tolerance of predominant Salmonella serovars circulating in the antibiotic-free feed farms to environmental stresses. Journal of Hazardous Materials 438:129476. DOI: 10.1016/j.jhazmat.2022.129476. (IF5: 11.9) ESI highly cited paper

    65. Chen Q, Zhao L, Liu H, Ding Q, Jia C, Liao S, Cheng N, Yue M*, Yang S* (20220415) Nanoporous silver nanorods as surface-enhanced Raman scattering substrates. Biosensors and Bioelectronics 202:114004. DOI:10.1016/j.bios.2022.114004. (IF5: 9.9)

    64. Hu B#, Hou P#, Teng L#, Miao S, Zhao L, Ji S, Li T, Kehrenberg C, Kang D*, Yue M* (20220301) Genomic Investigation Reveals a Community Typhoid Outbreak Caused by Contaminated Drinking Water in China, 2016. Frontiers in Medicine 9:753085. DOI: 10.3389/fmed.2022.753085. (IF5: 3.4)

    63. Xu Y#, Zhou X#, Jiang Z, Qi Y, Ed-Dra A, Yue M* (20210924) Antimicrobial Resistance Profiles and Genetic Typing of Salmonella Serovars from Chicken Embryos in China. Antibiotics 10(10):1156. DOI: 10.3390/antibiotics10101156. (IF5: 4.6)

    62. Müller A, Seinige D, Grabowski NT, Ahlfeld B, Yue M, Kehrenberg C* (20211022) Characterization of Escherichia coli from Edible Insect Species: Detection of Shiga Toxin-Producing Isolate. Foods 10(11):2552. DOI: 10.3390/foods10112552.

    61. Gütgemann F, Müller A, Churin Y, Jung A, Braun AS, Yue M, Kehrenberg C* (20220301) Development of a harmonized method for antimicrobial susceptibility testing of Bordetella avium using broth microdilution and detection of resistance genes. Journal of Applied Microbiology 132(3):1775-1787. DOI: 10.1111/jam.15305.f

    60. Yue M*, Bai L, Song H, Fang W (20210831) Impacts of Microbial Food Safety in China and Beyond. Foodborne Pathogens and Disease 18(8):508-509. DOI: 10.1089/fpd.2021.29015.int. (IF5: 4.1)

    59. Shi D#, Anwar M#, Pan H, Chai W, Xu S, Yue M* (20211027) Genomic Determinants of Pathogenicity and Antimicrobial Resistance for 60 Global Listeria monocytogenes Isolates Responsible for Invasive Infections. Frontiers in Cellular and Infection Microbiology 11:718840. DOI: 10.3389/fcimb.2021.718840. (IF5: 5.1)

    58. Elbediwi M#, Tang Y#, Shi D#, Ramadan H, Xu Y, Xu S, Li Y, Yue M* (20210823) Genomic Investigation of Antimicrobial-Resistant Salmonella enterica Isolates from Dead Chick Embryos in China. Frontiers in Microbiology 12:684400. DOI: 10.3389/fmicb.2021.684400. (IF5: 5.1)

    57. Qiu Y#, Nambiar R#, Xu X#, Weng S, Pan H, Zheng K*, Yue M* (20210729)  Global Genomic Characterization of Salmonella enterica serovar Telelkebir. Frontiers in Microbiology 12:704152. DOI: 10.3389/fmicb.2021.704152. (IF5: 5.1)

    56. Elbediwi M#, Shi D#, Biswas S#, Xu X, Yue M* (20210729) Changing patterns of Salmonella enterica serovar Rissen from humans, food animals, and animal-derived foods in China, 1995–2019. Frontiers in Microbiology 12:702909. DOI: 10.3389/fmicb.2021.702909. (IF5: 5.1)

    55. Yang Y#, Li Q#, Zhang H#, Zhang R, Wu Y, Yue M, Yang C*, Cao G* (20220101) Effects of dietary Clostridium butyricum and 1, 25‐dihydroxyvitamin D3 on growth performance, immunity responses, antioxidation, bone development, and intestinal microflora in early-stage broilers. Journal of Applied Microbiology 132(1):155-166. DOI: 10.1111/jam.15180.

    54. Wu B#, Ed-Dra A#, Pan H#, Dong C, Jia C, Yue M* (20210708) Genomic assessment of antimicrobial-resistant Salmonella recovered from pigs slaughtering process in Hangzhou, China. Frontiers in Microbiology 12:704636. DOI: 10.3389/fmicb.2021.704636. (IF5: 5.1)

    53. Zeng X, Li Q, Yang C, Yu Y, Fu Z, Wang H, Fan X, Yue M, Xu Y* (20210524) Effects of Clostridium butyricum- and Bacillus spp.-Based Potential Probiotics on the Growth Performance, Intestinal Morphology, Immune Responses, and Caecal Microbiota in Broilers. Antibiotics 10(6):624; DOI: 10.3390/antibiotics10060624.

    52. Zhang B#, Zhang H#, Yu Y, Zhang R, Wu Y, Yue M, Yang C* (20210508) Effects of Bacillus coagulans on growth performance, antioxidant capacity, immunity function, and gut health in broilers. Poultry Science 100(6):101168. DOI: 10.1016/j.psj.2021.101168.

    51. Han X, Liu Y, Yin J, Yue M*, Mu Y* (20210401) Microfluidic devices for multiplexed detection of foodborne pathogens. Food Research International 143:110246. DOI: 10.1016/j.foodres.2021.110246. (IF5: 7.4)

    50. Liu Y#, Jiang J#, Ed-Dra A#, Li X, Peng X, Xia Q, Guo Q, Yao G*, Yue M* (20210302) Prevalence and Genomic Investigation of Salmonella Isolates Recovered from Animal Food-chain in Xinjiang, China. Food Research International 142:110198. DOI: 10.1016/j.foodres.2021.110198. (IF5: 7.4)

    49. Elbediwi M#, Pan H#, Zhou X, Rankin S, Schifferli D, Yue M* (20210312) Detection of mcr-9-harbouring ESBL-producing Salmonella Newport isolated from an outbreak in a large-animal teaching hospital in the USA. Journal of Antimicrobial Chemotherapy 76(4):1107-1109. DOI: 10.1093/jac/dkaa544. (IF5: 4.6)

    48. Jiang Z#, Anwar T#, Peng X, Biswas S, Elbediwi M, Li Y, Fang W, Yue M* (20210301) Prevalence and Antimicrobial Resistance of Salmonella Recovered from Pig-borne Food Products in Henan, China. Food Control 121:107535. DOI: 10.1016/j.foodcont.2020.107535. (IF5: 5.4)

    47. Liu Y, Yue M, Zhen X, Zhen X*, Dong P, Yao G* (20201115) Pathogenic characteristics and genomic analysis of a bovine Salmonella Y-21. Chinese Journal of Veterinary Science 40(11),2169-2175. DOI: 10.16303/j.cnki.1005-4545.2020.11.15.

    刘英玉, 乐敏, 郑晓风, 郑晓琴*, 佟盼盼, 姚刚* (Nov 2020) 1株牛源沙门菌Y-21的病原特征和基因组分析.中国兽医学报40(11),2169-2175. DOI: 10.16303/j.cnki.1005-4545.2020.11.15.

    46. Liu H, Ye C, Fu H, Yue M, Li X, Fang W* (20210301) Stk and Stp1 participate in Streptococcus suis serotype 2 pathogenesis by regulating capsule thickness and translocation of certain virulence factors. Microbial Pathogenesis 152:104607. DOI: 10.1016/j.micpath.2020.104607.

    45. Peng N#, Peng X#, Yue M* (20201224) The Application of Microbiome Culturomics in Veterinary Medicine. Acta Veterinaria et Zootechnica Sinica. 51(12):2942-2953. DOI: 10.11843/j.issn.0366-6964.2020.12.004. In Chinese

    彭娜,彭先启,乐敏*. 微生物菌群培养组学在动物医学中的应用 [J]. 畜牧兽医学报, 2020. 51(12):2942-2953. DOI: 10.11843/j.issn.0366-6964.2020.12.004.

    44. Xu Y#, Zhou X#, Jiang Z, Qi Y, Ed-Dra A, Yue M* (20200915) Epidemiological investigation and antimicrobial resistance profiles of Salmonella isolated from breeder chicken hatcheries in Henan, China. Frontiers in Cellular and Infection Microbiology 10:497. DOI: 10.3389/fcimb.2020.00497. (IF5: 5.1)

    43. Zhou K#, Wu B#, Pan H#, Paudyal N, Jiang J, Zhang L, Li Y*, Yue M* (20200902) ONE Health Approach to Address Zoonotic Brucellosis: A Spatiotemporal Associations Study between Animals and Humans. Frontiers in Veterinary Science 7:521. DOI: 10.3389/fvets.2020.00521. (IF5: 3.2)

    42. Liu Q#, Chen W#, Elbediwi M#, Pan H, Wang L, Zhou C, Zhao B, Xu X, Li D, Yan X, Han X, Li H, Li Y, Yue M* (20200911) Characterization of Salmonella Resistome and Plasmidome in Pork Production System in Jiangsu, China. Frontiers in Veterinary Science 7:617. DOI: 10.3389/fvets.2020.00617. (IF5: 3.2)

    41. Xu X#, Biswas S#, Gu G#, Elbediwi M, Li Y, Yue M* (20200930) Characterization of Multidrug Resistance Patterns of Salmonella enterica Serovar Rissen along the food chain in China. Antibiotics 9(10):660. DOI:10.3390/antibiotics9100660. (IF5: 4.6)

    40. Xu X#, Chen Y#, Pan H#, Pang Z, Li F, Peng X, Ed-dra A, Li Y, Yue M* (20200626) Genomic Characterization of Salmonella Uzaramo for Human Invasive Infection. Microbial Genomics 6(7): mgen000401. DOI: 10.1099/mgen.0.000401. (IF5: 4.7)

    39. Elbediwi M#, Wu B#, Pan H#, Jiang Z, Biswas S, Li Y, Yue M* (20200630) Genomic characterization of mcr-1-carrying Salmonella enterica serovar 4,[5],12:i:- ST34 clone isolated from pigs in China. Frontiers in Bioengineering and Biotechnology 8:663. DOI: 10.3389/fbioe.2020.00663. (IF5: 5.1)

    38. Yue M, Song H, Bai L (20200501) Food Safety in China: Current Practices and Future Needs. Foodborne Pathogens and Disease 17(5):295. DOI: 10.1089/fpd.2020.29013.cfp. (IF5: 4.1) five-times: from May to Sep.

    37. Paudyal N#, Pan H#, Wu B#, Zhou X, Zhou X, Chai W, Wu Q, Li S, Li F, Gu G, Wang H, Hu Q, Xu X, Li Y, Yue M* (20200527) Persistent Asymptomatic Human Infections by Salmonella enterica Serovar Newport in China. mSphere 5(3):e00163-20. DOI: 10.1128/mSphere.00163-20. (IF5: 4)

    36. Yu H#, Elbediwi M#, Zhou X, Shuai H, Lou X, Wang H, Li Y, Yue M* (20200424) Epidemiological and Genomic Characterization of Campylobacter jejuni Isolates from a Foodborne Outbreak at Hangzhou, China. International Journal of Molecular Sciences 21(8):3001. DOI: 10.3390/ijms21083001. (IF5: 5.6)

    35. Luo H#, Zheng J#, Chen Y, Wang T, Zhang Z, Shan Y, Xu J, Yue M, Fang W, Li X* (20200423) Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro. Frontiers in Microbiology 11:821. DOI: 10.3389/fmicb.2020.00821.

    34. Jiang J#, Pan H#, Yue M*, Zhang L* (20200315) The Study of Worldwide Brucella canis of Phylogenetic Group by Comparative Genomics-based Approaches. China Biotechnology 40(3):38-47. DOI: 10.13523/j.cb.1907053. In Chinese

    姜吉喆,潘航,乐敏*,章乐*. 基于比较基因组学方法的世界范围的犬布鲁氏菌系统发育群研究 [J]. 中国生物工程杂志 2020, 40(3):38-47. DOI: 10.13523/j.cb.1907053.

    33. Elbediwi M#, Pan H#, Biswas S#, Li Y, Yue M* (20200303) Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections. Emerging Microbes & Infections 9(1):535-538. DOI: 10.1080/22221751.2020.1733439. (IF5: 8.3)

    32. Biswas S#, Elbediwi M#, Gu G#, Yue M* (20200213) Genomic Characterization of New Variant of Hydrogen Sulfide (H2S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China. Antibiotics 9(2):80. DOI: 10.3390/antibiotics9020080. (IF5: 4.6)

    31. Wu Q, Zhou X, Peng X, Wu X, Yue M* (20200615) An Updated Knowledge for Salmonella Type I Fimbriae. Chinese Journal of Preventive Veterinary Medicine 42(6):625-631. DOI: 10.3969/j.issn.1008-0589.201907029. in Chinese

    吴青青,周潇,彭先启,吴小磊,乐敏*.沙门菌Ⅰ型菌毛研究进展[J].中国预防兽医学报 2020, 42(06):625-631.

    30. Elbediwi M#, Li Y#, Paudyal N#, Pan H#, Li X, Xie S, Rajkovic A, Feng Y, Fang W, Rankin S, Yue M* (20191016) Global Burden of Colistin Resistant Bacteria: Mobilized Colistin Resistant Genes Study (1980-2018). Microorganisms 7(10):461. DOI: 10.3390/microorganisms7100461. (IF5: 4.5)

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    https://mdpi.altmetric.com/details/69185946/twitter

    29. Paudyal N#, Pan H#, Elbediwi M, Zhou X, Peng X, Li X, Fang W, Yue M* (20191016) Characterization of Salmonella Dublin isolated from Bovine and Human Hosts. BMC Microbiology 19(1):226. DOI: 10.1186/s12866-019-1598-0. (IF5: 4.6)

    28. Liu H, Fu H, Jiang X, Liao X, Yue M, Li X, Fang W* (20190905) PrsA contributes to Streptococcus suis serotype 2 pathogenicity by modulating secretion of selected virulence factors. Veterinary Microbiology 236:108375. DOI: 10.1016/j.vetmic.2019.07.027.

    27. Biswas S#, Li Y#, Elbediwi M#, Yue M* (20190828) Emergence and Dissemination of mcr-Carrying Clinically Relevant Salmonella Typhimurium Monophasic Clone ST34. Microorganisms 7(9):298. DOI: 10.3390/microorganisms7090298. (IF5: 4.5)    【Highly cited papers in section Antimicrobial Agents and Resistance】https://mdpi.altmetric.com/details/65822846/twitter

    26. Jiang Z#, Paudyal N#, Xu Y, Deng T, Li F, Pan H, Peng X, He Q*, Yue M* (20190704) Antibiotic resistance profiles of Salmonella recovered from finishing pigs and slaughter facilities in Henan, China. Frontiers in Microbiology 10:1513. DOI: 10.3389/fmicb.2019.01513. (IF5: 5.1)

    25. Wang X#, Biswas S#, Paudyal N, Pan H, Li X, Fang W, Yue M* (20190507) Antibiotic Resistance in Salmonella Typhimurium Isolates Recovered From the Food Chain Through National Antimicrobial Resistance Monitoring System Between 1996 and 2016. Frontiers in Microbiology 10:985. DOI: 10.3389/fmicb.2019.00985. (IF5: 5.1)

    【Highly Cited Paper高被引论文】

    【Selected by Food and Agriculture Organization of the United Nations on 01 Mar 2022】

    24. Paudyal N, Yue M* (20190702) Antibiotic resistance in the “dark matter”. Clinical Infectious Diseases 69(2):379-380. DOI: 10.1093/cid/ciz007. (IF5: 8.2)

    23. Pan H, Zhou X, Chai W, Paudyal N, Li S, Zhou X, Zhou K, Wu Q, Wu B, Li G, Rajkovic A, Fang W, Rankin SC, Li Y, Xu X*, Schifferli DM*, Yue M* (20190301) Diversified Sources for Human Infections by Salmonella enterica serovar Newport. Transboundary and Emerging Diseases 66(2):1044-1048. DOI: 10.1111/tbed.13099. (IF5: 3.7)

    【Selected as Cover Story】 DOI: 10.1111/tbed.13159

    22. Yang C*, Zhang L, Cao G, Feng J, Yue M, Xu YL, Dai B, Han QJ, Guo XQ (20190101) Effects of dietary supplementation with essential oils and organic acids on the growth performance, immune system, faecal volatile fatty acids, and microflora community in weaned piglets. Journal of Animal Science 97(1):133-143. DOI: 10.1093/jas/sky426.

    21. Paudyal N#, Pan H#, Li X, Fang W, Yue M* (20181003) Antibiotic resistance in Salmonella Enteritidis isolates recovered from chicken, chicken breast and humans through NARMS between 1996 and 2014. Foodborne Pathogens and Disease DOI: 10.1089/fpd.2017.2402. (IF5: 4.1)

    20. Xu Y*, Zeng X, Yue M, Li Hui, Liu J (20181025) The biological function of Clostridium butyricum and its application in aquaculture. Journal of Fisheries Research 40(5): 408-412. DOI: 10.14012/j.cnki.fjsc.2018.05.011. In Chinese

    徐亚飞,曾新福,乐敏,李慧,刘金松.丁酸梭菌的生物学功能及其在水产养殖中的应用研究进展[J].渔业研究,2018,40(05):408-412.

    19. Xu Y*, Zeng X, Yue M, Li Hui, Liu J (20180710) The application of Enterococcus faecalis in aquaculture. Feed Additive 7:47-49. In Chinese

    徐亚飞,曾新福,乐敏,李慧,刘金松.粪肠球菌在水产养殖中的应用研究进展[J].饲料广角,2018(07):47-49.

    18. Pan H, Li X, Fang W, Yue M* (20180325) Analysis of major human and foodborne pathogens and their resistance to antimicrobials in the USA in the past two decades: Implications for surveillance and control of antimicrobial resistance in China. Journal of Zhejiang University (Agriculture & Life Sciences) 44(2):237-246. DOI: 10.3785/j.issn.1008-9209.2018.03.124. In Chinese

    潘航,李肖梁,方维焕,乐敏*.美国近20年主要食源性致病菌的分布及耐药性分析——对我国细菌耐药性监控工作的启示[J].浙江大学学报(农业与生命科学版),2018,44(02):237-246.

    17. Xu C, Yang X, Yue M, Zhu S* (20180325) Progress on bacteria promoting enterovirus infection and its mechanism. Journal of Zhejiang University (Agriculture & Life Sciences) 44(2): 140-148. DOI: 10.3785/j.issn.1008-9209.2018.03.121. In Chinese

    徐超,杨晓炼,乐敏,朱书*.细菌促进肠道病毒感染及其机制研究进展[J].浙江大学学报(农业与生命科学版),2018,44(02):140-148.

    16. Paudyal N, Pan H, Liao X, Zhang X, Li X, Fang W*, Yue M* (20180405) A meta-analysis of major foodborne pathogens in Chinese food commodities between 2006 and 2016. Foodborne Pathogens and Disease 15(4):187-197. DOI: 10.1089/fpd.2017.2417. (IF5: 4.1)

    15. Pan H#, Paudyal N#, Li X, Fang W, Yue M* (20180123) Multiple Food-Animal-Borne Route in Transmission of Antibiotic-Resistant Salmonella Newport to Humans. Frontiers in Microbiology 9:23. DOI: 10.3389/fmicb.2018.00023. (IF5: 5.1)

    14. Tian Q* #, Zhou W#, Si W, Yi F, Hua X, Yue M, Chen L, Liu S*, Yu S* (20180105) Construction of Salmonella Pullorum ghost by co-expression of lysis gene E and the antimicrobial peptide SMAP29 and evaluation of its immune efficacy in specific-pathogen-free chicks. Journal of Integrative Agriculture 17(1):60345-7. DOI: 10.1016/S2095-3119(17)61696-4.

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    13. Masi LD#, Yue M# (Co-first author), Hu C, Rakov A, Rankin S, Schifferli DM* (20170308) Cooperation of adhesin alleles in Salmonella-host tropism. mSphere 2(2):e00066-17. DOI: 10.1128/mSphere.00066-17. (IF5: 4)

    12. Yue M* (20160515) Bacterial Persistent Infection at the Interface between Host and Microbiota. Clinical Infectious Diseases 62(10):1325-6. DOI: 10.1093/cid/ciw136. (IF5: 8.2)

    11. Hayden HS*, Matamouros S, Hager KR, Brittnacher MJ, Rohmer L, Radey MC, Weiss EJ, Kim KB, Jacobs MA, Sims-Day EH, Yue M, Zaidi MB, Schifferli DM, Manning SD, Walson JL, Miller SI (20160308) Genomic analysis of Salmonella Typhimurium characterizes strain diversity for recent U.S. Salmonellosis cases and identifies mutations linked to loss of fitness under nitrosative and oxidative stress. mBio 7(2):e00154-16. DOI: 10.1128/mBio.00154-16.

    10. Zhu C#, Yue M# (Co-first author), Rankin S, Weill FX, Frey J, Schifferli DM* (20151201) One-step identification of five prominent chicken Salmonella serovars and biotypes. Journal of Clinical Microbiology 53(12): 3881-3883. DOI: 10.1128/JCM.01976-15. (IF5: 5.8)

    9. Yue M, Han X, Masi LD, Zhu C, Ma X, Zhang J, Wu R, Schmieder R, Kaushik RS, Fraser GP, Zhao S, McDermott PF, Weill FX, Mainil JG, Arze C, Fricke WF, Edwards RA, Brisson D, Zhang NR, Rankin SC, Schifferli DM* (20151030) Allelic variation contributes to bacterial host specificity. Nature Communications 6:8754. DOI: 10.1038/ncomms9754. (IF5: 16.1)

    8. Nair MK#, Masi LD#, Yue M# (Co-first author), Galván EM#, Chen H#, Wang F, Schifferli DM* (20150501) Adhesive properties of YapV and paralogous autotransporter proteins of Yersinia pestis. Infection and Immunity 83(5):1809-19. DOI: 10.1128/IAI.00094-15. (IF5: 3.1)

    7. Yue M, Schifferli DM* (20140107) Allelic variation in Salmonella: an underappreciated driver of adaptation and virulence. Frontiers in Microbiology 4:419. DOI: 10.3389/fmicb.2013.00419. (IF5: 5.1) Selected by Faculty of 1000

    6. Yue M, Schmieder R, Edwards RA, Rankin SC, Schifferli DM* (20121001) Microfluidic PCR combined with pyrosequencing for identification of allelic variants with phenotypic associations among targeted Salmonella genes. Applied and Environmental Microbiology 78(20):7480-2. DOI: 10.1128/AEM.01703-12. (IF5: 4.6)

    5. Yue M, Rankin SC, Blanchet RT, Nulton JD, Edwards RA, Schifferli DM* (20120612) Diversification of the Salmonella fimbriae: a model of macro- and microevolution. PLoS ONE 7(6):e38596. DOI: 10.1371/journal.pone.0038596. (IF5: 3.3)

    4. Xu Z#, Yue M# (Co-first author), Zhou R, Jin Q, Yang F, Bei W*, Chen H* (20110517) Genome biology of Haemophilus parasuis SH0165, a highly virulent strain of serotype 5 prevalent in China. PLoS ONE 6(5):e19631. DOI: 10.1371/journal.pone.0019631. (IF5: 3.3)

    3. Yue M, Yang F, Yang J, Bei W*, Cai X, Chen L, Dong J, Zhou R, Jin M, Jin Q*, Chen H (20090201) Complete genome sequence of Haemophilus parasuis SH0165. Journal of Bacteriology 191(4):1359-60. DOI: 10.1128/JB.01682-08. (IF5: 3.0)

    2. Yue M, Qiu D*, Chen H, Jiang Z (20041030) Expression of the Combined orf7 and orf5 Genes of Porcine Reproductive and Respiratory Syndrome. Virologica Sinica 19(5):476-480. In Chinese

          乐敏，邱德新，陈焕春，蒋增海（2004）猪繁殖与呼吸综合征病毒orf7和orf5双基因的原核表达研究. 中国病毒学 19(5):476-480.

    1. Yue M, Chen H, Qiu D*, Qian P (20040620) Research Progress on Molecular Biology of Porcine Reproductive and Respiratory Syndrome Virus. Shanghai Journal of Animal Husbandry and Veterinary Medicine 3:1-8. In Chinese

          乐敏，陈焕春，邱德新，钱平 （2004）上海畜牧兽医通讯 3:1-8.

    学术论著（章节）：

    6. Jia C, Wang Z, Zhou H, Liu Y, Yue M*. Chapter 13. Salmonella Phylogenomic. Phylogenomics: Foundations, Methods, and Pathogen Analysis (ISBN: 9780323998864), Elsevier/Academic Press; 1st edition (December 15, 2023)

    5. Pan H, Yue M*. Chapter 32 Salmonella. Molecular detection of foodborne pathogens 2nd edition, 2022 in press

    4. Yue M*. Chapter 26 Enterobacter. Molecular detection of foodborne pathogens 2nd edition, 2022 in press.

    3. Nambiar R, Yue M*. Chapter 15. Persistence Phenotype. Page 433-460. Stress Response of Foodborne Pathogens (ISBN 978-3-030-90577-4), Springer Nature Press. 2022. DOI: 10.1007/978-3-030-90578-1_15.

    2. Zhu C, Yue M, Zhu G. From the known to the unknown: a comparative analysis of Salmonella enterica fim and its ortholog sfm in Escherichia coli. In: Shulin Liu Editor. Salmonella and Escherichia coli: Genomic and Pathogenic Evolution. In Press

    1. Bei W, Chen H, Zhou R, Fu S, Yue M. Advance in Genome of Haemophilus parasuis. Ziduo Liu Editor. China Microbial Genome Research p107-115 (Oct 2012) (Book chapter in Chinese).

    学术交流（口头报告）：

    83. 传染病 湖南长沙

    82. 第八届动物健康与食品安全大会 四川成都

    81. “两病防控” 山西太原

    80. 苏州大学，特邀报告，传染病大数据与病原基因组

    79. 昆山杜克大学，特邀报告，生物安全与病原基因组学

    78. 中国畜牧兽医学会2023动物传染病分年会会，大会报告，基因组“退化”介导病原菌致病行为改变

    77. 2023第六届噬菌体国际学术研讨会暨第六届超级细菌感染与噬菌体防治前沿论坛，大会报告，鼠伤寒沙门菌全球大流行克隆形成机制

    76. 全国微生物学会2023学术年会，主旨报告，基因组退化介导沙门菌致病行为变化

    75. 2023 China International Food Safety & Quality Conference, Microbial Hazards Along the Infant Food Chains, Beijing. 2023.11.03

    74. 动物源性食品安全2023学术年会，主题报告，沙门菌风险评估

    73. 深圳CDC，呼吸道和人兽共患病原体检测和溯源技术，特邀报告，沙门菌基因组学与生物安全

    72. 华中农业大学，创新创造创业论坛，特邀报告，外膜蛋白重构介导沙门菌适应性进化

    71. 湖北省农业科学研究院，特邀报告，外膜蛋白重构介导沙门菌适应性进化

    70. 2023年全国微生物与人体健康学术论坛，外膜蛋白重构介导沙门菌适应性进化

    69. 第七届中国动物健康与食品安全大会，沙门菌的分类防治策略

    68. 上海兽医研究所，鸡白痢沙门菌的菌毛基因缺失介导致病行为变化

    67. 2023年山东省禽病会年会，外膜蛋白重构介导鸡白痢沙门菌适应性进化

    66. 2022年动物传染病学分会第二届流行病学学术研讨会（武汉online），传染病分类防治

    65. 2022年吉林农业大学动物科学学院 特邀报告（长春online），传染病的分类识别与靶向防控

    64. International Forum on Animal Science and Veterinary Medicine (online), WGS Aids One Health Surveillance, Virtual Meeting, 20220816

    63. 第七届全国人兽共患病学术研讨会（青岛）, 病原菌的分类识别与防控

    62. 第17届益生菌与健康国际研讨会（杭州）, 益生菌的安全性评价

    61. 兽医微生物学会专委会学术年会（长春）, 高致病病原菌的快速识别

    60. 2022浙江省致病菌识别网技术培训／重要细菌性传染病病原体监测技术培训

    59. 2022年浙江省医学会医学微生物与免疫学分会年会，无症状感染沙门菌的发现、解读与控制措施

    58. 动物疾病与健康国际研讨会（武汉）, Animal Disease and Health Forum, WGS accelerate One Health Surveillance, 20220516

    57. 第四届免疫治疗及伴随诊断合作峰会（上海），病原基因组流行病学与精准诊疗

    56. 齐鲁国际讲堂（济南），病原基因组流行病学

    55. 第七届全国计算生物学与生物信息学学术会议

    54. 国际兽医检测诊断大会3th International Annual Veterinary Diagnostic Conference（杭州）Precision Diagnostics of Bacterial Antimicrobial Resistance, Hangzhou, 20210625

    53. 河南农业大学，沙门菌流行病基因组学

    52. 中国微生物学会兽医微生物学专业委员会暨中国畜牧兽医学会生物制品学，沙门菌流行病基因组学进展

    51. 河南牧业经济学院，沙门菌流行病基因组学

    50. 郑州轻工业大学，沙门菌流行病基因组学

    49. 广东海洋大学,沙门菌流行病基因组学

    48. 大会报告，Salmonella Goldcoast: an emerging threat to the global public health, The 4th International Conference on Microbiology, Virology and Immunology (CMVI 2020), Sanya, 20201206

    47. 大会报告，Genomic epidemiology identifies emergence of distinct geospatial multi-drug resistant Salmonella Goldcoast in China, Global virtual summit on Healthcare & Management, Healthcare Summit, USA, 20201106

    46. 特邀报告，传染病基因组学-诊断与溯源技术（国家级）研讨班，杭州CDC，微生物大数据的应用，20201028

    45. 特邀报告，Bacterial Big Data Applications，山东省农业科学院，济南，20200803

    44. 特邀报告，Bacterial Big Data Applications，浙江省农业科学院，杭州，20200711

    43. 大会报告，中国畜牧兽医学会兽医食品卫生学分会第十五次学术交流会，多重耐药优势克隆在食物链传播中的分子机制，济南，20191214

    42. 大会主旨报告，第二届“长三角畜牧兽医科技论坛”，传染病精准诊疗，南京，20191109

    41. 浙江省畜牧兽医中青年技术骨干培训班，浙江省畜牧兽医推广总站，食源性人畜共患病，杭州，20190926

    40. 特邀报告，中国微生物学会兽医微生物专业委员会&中国畜牧兽医学会兽医公共卫生学分会，Genomic Epidemiology: From Pathogenesis to Diagnostics. 中国农业科学院上海兽医研究所，20190908

    39. 传染病基因组学-诊断与溯源技术（国家级）研讨班，杭州CDC，Bacterial Big Data: From Pathogenesis to Diagnostics. 杭州，20190905

    38. Invited Lecture, 四川农业大学预防兽医研究所，Bridging the Genotype–Phenotype Gap via Big Data. 四川成都，20190401

    37. Keynote Speech，第六届全国计算生物学与生物信息学学术会议，Precision Medicine Platform for Infectious Diseases Aims to Streamline Molecular Testing, Therapy Decision-Making. 四川成都，20190330

    36. Keynote Speech，Annual Biobank China 2018& International Symposium on Data Intelligence in Life Science. Shenzhen (Bacterial Big Data Application: From Pathogenesis to Precision Medicine) China National Genbank 20181130

    35. Keynote Speech，浙江省畜牧兽医学会青年学者论坛, 临安 (Salmonella in Animal, Environment, and Human) 20180828

    34. Workshop Talk, International Committee on Food Microbiology & Hygiene (ICFMH) 2018’ Southeast Asian Workshop on Microbial Food Safety Programs.  Siem Reap, Cambodia (Meta-analysis for Food Safety) 20180814

    33. Keynote Speech，4th AFSA International Conference on Food Safety and Food Security (AFSA2018). Siem Reap, Cambodia (Global dissemination of multidrug-resistant Salmonella food-animal clone ST45: A potential threat for food safety)  20180812

    32. Invited lecture, Bacterial Big Data: From Pathogenesis to Precision Medicine. BGI Shenzhen, 20180615

    31. Keynote Speech, 安徽农业大学90年校庆特邀学术报告：Bacterial SNPs Links Pathogenesis and Diagnostics, 20180609

    29. Keynote Speech，2018年中国畜牧兽医学会第二届“青年拔尖人才”学术研讨会，浙江大学，杭州 (Big Data Applications: Veterinary Public Health and Food Safety) 20180111

    28. Keynote Speech，2017年兽医生物技术国际学术研讨会，上海交通大学，上海 (Bacterial SNPs: From Pathogenesis to Diagnostics) 20171217

    27. Invited Lecture，中国农业大学，北京 (Bacterial SNP and Infection: from pathogenesis to diagnosis) 20171107

    26. Oral Presentation，中国毒理学会兽医毒理学委员会与中国畜牧兽医学会兽医食品卫生学分会, (中国畜牧兽医学会兽医食品卫生学分优秀论文) ，北京，分会场报告(美国近二十年主要食源性微生物的分布及系统分析——对我国兽医食品卫生监测工作的启示) 20170923

    25. Invited Lecture，黑龙江八一农垦大学，大庆 (From Bacterial SNPs to Infection: Can Genotype Predict Phenotype) 20170904

    24. Invited Lecture，哈尔滨兽医研究所，哈尔滨 (Big Data Connects Genotype and Phenotype in Infectious Diseases) 20170901

    23. Invited Lecture，哈尔滨医科大学，哈尔滨 (Bacterial SNPs and Infection: Application in Precision Medicine) 20170830

    22. Invited Lecture，吉林农业大学，长春 (Bacterial SNPs and Infection: Application in Precision Medicine) 20170830

    21. Invited Lecture， 吉林大学，长春 (From Bacterial SNPs to Infection: Can Genotype Predict Phenotype) 20170828

    20. Invited Lecture，中国农业科学院兰州兽医研究所，兰州 (Can “Big Data” Connect Genotype and Phenotype) 20170706

    19. Invited Lecture，四川大学生命科学学院，成都 (Can “Big Data” Connect Genotype and Phenotype) 20170704

    18. Keynote Speech，中国微生物学会第五届全国人兽共患病学术研讨会，南京 (Molecular Determinants for Salmonella cross-species infections) 20170422

    17. Invited Lecture，深圳CDC (Salmonella: an evolving pathogen causing significant public health concern) 20161209

    16. Invited Lecture，华南农业大学-兽医101著名专家学术论坛 (Big Data Connecting Genotype and Phenotype) 20161207

    15. Invited Lecture，武汉大学附属人民医院 (Forecasting Infectious Diseases with Big Data) 20160410

    14. Invited Lecture，南京农业大学动物医学院 (Connecting Genotype to Phenotype: Salmonella infection model) 20160328

    13. Invited Lecture，中国农业科学院家禽研究所 (Salmonella：host，disease and ecology) 20160324

    12. Invited Lecture，扬州大学兽医学院 (Connecting genotype to phenotype in the era of Big Data) 20160324

    11. Invited Lecture，上海交通大学农业与生物学院 (Salmonella, host and ecology) 20160323

    10. Invited Lecture，中国农业科学院上海兽医研究所 (Big Data：Connecting Between Genotype and Phenotype) 20160322

    9. Yong Investigator Seminar，浙江大学动物科技学院 (Big Data Connecting Between Genotype and Phenotype) 20160317

    8. Invited Lecture，华中科技大学，同济医学院附属协和医院 (Connecting Genotype and Phenotype: the Paradigm in Infectious Disease) 20160309

    7. Invited Lecture，华中农业大学，农业微生物学国家重点实验室 (Connecting the Dots Between Genotype and Phenotype: Salmonella as a Model) 20160308

    6. Oral Presentation，24届费城感染与免疫学年会，美国微生物学会宾州分会 (Salmonella allelic variation contributes to host specificity) 20151211

    5. Oral Presentation，2015年秋原核生物seminar，宾夕法尼亚大学医学院 (Tell Me Your Sequence, So I Can Forecast Your TYPE) 20151113

    4. Oral Presentation，微生物基因组group meeting，宾夕法尼亚大学兽医学院(GWAS to understand Salmonella virulence)  20150216

    3. Oral Presentation，Fluidigm应用seminar，宾夕法尼亚大学医学院 (Salmonella target PCR using Fluidigm Access Array system with next generation sequencing) 20130514

    2. Oral Presentation，2013年春原核生物seminar，宾夕法尼亚大学医学院 (Bacterial SNPs and infection) 20130412

    1. Oral Presentation，第四届美国博士后研究论坛，美国Rutgers大学药学院 (Targeted Massive Parallel Sequencing as a Diagnostic Tool to correlate Salmonella SNPs with Host Origin and Antimicrobial Resistance) 20120920

    所获学术荣誉及奖励

    35. 江西省引进培养创新创业高层次人才“千人计划”，创先领军人才短期项目(2023-)

    34. 联合国世界粮农组织/世界卫生组织，微生物风险评估联席会议（FAO/WHO JEMRA）专家 （2023-2027）

    33. Duke Kunshan University Interview Confirmation: interview study on antimicrobial resistance in China. (January 17) at 13:00-14:00 Beijing time with Dr. Annemieke van den Dool

    32. 常务理事（2022-2026），中国畜牧兽医学会兽医食品卫生学分会

    31. 委员（2021.10-2026.10），中国微生物学会兽医微生物学专业委员会

    30. 浙江省引进培育领军型创新创业团队（2022-2025） 核心成员

    29. 海外华人微生物学会会员（2020-）

    28. 大英抗菌化学治疗学会 British Society for Antimicrobial Chemotherapy, elected member 会士 （2020-）

    27. 高级会员（2018-），中国畜牧兽医学会

    26. 理事（2022-2026），中国畜牧兽医学会兽医公共卫生学分会

    25. 委员（2020.6-2024.5），浙江省生物信息学会首届微生物组学专业委员会

    24. （青年）常务委员（2018.9-2021.9），中国微生物学会兽医微生物学专业委员会

    23. 流行病专业组委员（2019.8-2023.7），中国畜牧兽医学会动物传染病学分会

    22.学术委员会委员（2020.8-2023.8），深圳市未知病原体应急检测重点实验室／深圳市病原组学与感染干预重点实验室

    21. 浙江省科学技术进步奖，二等奖（排名第五），冷鲜鸡质量安全控制关键技术集成与示范（2019），浙江省人民政府

    （1）乐敏（5/14），冷鲜鸡质量安全控制关键技术集成与示范，浙江省科学技术进步奖，二等奖，2019（李肖梁;杨华;朱俭军;罗金文;乐敏;单颖;钱鸣蓉;陈有亮;陈万勤;卢立志;沈泓;陈斌;肖英平;黄琦）

    20. 固定人员（2020.7-2025.6），浙江大学医学院附属第一医院·传染病诊治国家重点实验室

    19.  2019年年会优秀论文奖, 中国畜牧兽医学会兽医食品卫生学分会 （2019），济南

    18. “南太湖精英计划”领军人才(短期)（2019），浙江湖州

    17. 江苏农林职业技术学院，外聘专家（2019-）, 江苏

    16. Global Peer Review Awards in Microbiology 2019, Publons, 杭州

    15. 浙江大学奖教金 2018，浙江大学，杭州

    14. 浙江省杰出青年基金获得者（2019-2022），杭州

    13. 深圳华大生命科学研究院，外聘专家（2018-），深圳

    12. 浙江省海外高层次人才引进计划特聘专家 2018，省特聘专家，杭州

    11. 2017年会优秀论文奖, 中国畜牧兽医学会兽医食品卫生学分会，北京               [27位获奖人之一] (27/149)

    10. 中组部特聘专家（青年）2017，国家“千人计划”专家，北京

    9. 2016 Outstanding Contribution Award of ERHM，美国费城 [16位获奖人之一]

    8. 大会报告奖，24届费城感染与免疫年会，美国微生物学会宾州分会，美国费城(20151211) [五位获奖人之一]

    7. 美国微生物学会少数族裔杰出导师奖，美国微生物学会，美国费城(2012)

    6. 2009-2010 Novus 国际研究生奖学金，华中农业大学，武汉(2009.10) [四位获奖人之一]

    5. 华中农业大学十大科技新星，华中农业大学，武汉（2006.05)

    4. 第九届“挑战杯”飞利浦全国大学生课外学术科技作品竞赛三等奖，中国科学技术协会，上海（2005.12） [排名第一]

    3. 第五届“神农杯”大学生课外学术科技作品竞赛特等奖，华中农业大学，武汉（2005.09) [排名第一]

    2. 湖北省第五届“挑战杯”弘博大学生课外学术科技作品竞赛特等奖，湖北省科学技术协会，武汉（2005.07） [排名第一]

    1. 湖北省2004年度大学生优秀科研成果一等奖，湖北省教育厅，武汉（2004.12） [排名第一]


    标准

    3. 配方奶粉中蜡样芽孢杆菌的分离鉴定和定量方法. 浙江大学、浙江省农科院、贝因美股份有限公司，团体标准 T /ZNZ XXXXX—XXXX（乐敏、廖思豪、唐标、滕霖、李艳、熊丽娜；已提交浙江省农产品质量安全学会）2023-05-31

    2. 配方奶粉中PCR法鉴定蜡样芽孢杆菌及其毒力基因. 浙江大学、浙江省农科院，团体标准 T /ZNZ XXXXX—XXXX （乐敏、唐标、冯梦瑶、尹睿、李艳；已提交浙江省农产品质量安全学会）2023-05-31

    1. 【团体标准】浙江省农产品质量安全学会: T/ZNZ 252—2024.《配方乳粉中蜡样芽胞杆菌的分离鉴定和毒力基因的检测》乐敏、唐标、尹睿、滕霖、廖思豪、冯梦瑶、李艳、熊丽娜、高悦华、张艺

    专利 （专利类型、发明人、专利名称、授权时间、专利号）

    11. 乐敏，王佰魁，王浩；一种检测鸡白痢沙门菌的引物和探针、试剂盒; 发明专利2024107440627. 2024-06-19

    10. 李艳，李娜，尹睿，乐敏；基于CRISPR-Cas12a-RAA技术检测奶粉中呕吐型蜡样芽胞杆菌的方法; 发明专利202410191681.8. 2024-02-21

    9. 李艳，尹睿，李娜，乐敏；一种基于qPCR技术检测奶粉中蜡样芽胞杆菌的方法; 发明专利 202410191777.4. 2024-02-21

    8. 李卫芬、金茜、乐敏、付爱坤、靳明亮、蓝华平、韩森、刘斯开、张浩、汪棋；一种复合益生菌及其应用；发明专利 2023107330961. 2023-06-20

    7.  李艳、韩美晴、李卫芬、乐敏；益生菌双菌组合制剂及其在拮抗流感中的应用；发明专利202310626050X. 2023-05-31

    6. 乐敏、安洪丽、李卫芬、李艳、彭先启；预防鸡沙门菌感染的鼠李糖乳杆菌及其应用；发明专利 202310579203X. 2023-05-23

    5. 杨士宽、刘悦、赵丽妍、彭娜、乐敏；一种具有万能分散特性银纳米颗粒的制备方法及应用；发明专利ZL202111485278.9.授权2022-09-27

    4. 乐敏、杜佳欣；实用专利；一种可调节的隔离加样槽；201921384769.2

    3. 乐敏、方维焕、潘航、李芳、李渊；发明专利；一种沙门氏菌快速鉴定与分型方法及试剂盒；201811191746.X

    2. 龚建森、韩先干、张萍、张笛、炊慧霞、乐敏、卢劲晔、沈海玉、朱春红、许明、苗晋锋、窦新红、刘学贤；发明专利；一种鸡白痢琼扩原及其制备方法和应用；201510157906.9

    1. 龚建森、苗晋锋、赵旭、炊慧霞、张笛、乐敏、张萍、韩先干、窦新红、刘学贤；发明专利；一种鸡白痢沙门氏菌SP9905及应用；201510159247.2

    主持(参与)研究项目（类型、来源、项目负责人、题目、资助年限、金额）

    28. 浙江省自然科学基金 重点项目，浙江省科技厅LZ24C180002，鼠伤寒沙门菌单相变种DinB基因突变介导耐药性增强，2024-2026，30万，主持

    27. 国家重点研发计划子课题，科技部-2022YFC2604201，跨境跨种传播的新特征及决定因素和作用机制研究，2023-2025，93.94万子课题，主持

    26. 杭州市科学技术局，杭州市重点研发计划项目2022ZDSJ0135 畜禽细菌耐药性传播机制和控制技术研究与应用，2022-2023，20万（子课题）／100万元

    25. 海南省自然科学基金（海南省科技计划三亚崖州湾科技城联合项目）2021JJLH0083，沙门菌定植因子FimH的功能研究，8万元，主持 （2022-06-28至2025-06-28）The research was supported by the Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City (2021JJLH0083)

    24. 企业横向课题，防控家禽肠道细菌性疾病生物饲料添加剂研制，2022-2023，55万元

    23. 企业横向课题-泰和乌鸡全产业链科技创新研发与应用／泰和乌鸡禽白血病和鸡白痢净化研究与应用，2021-2026，300（60/430）（子课题）／2150万元

    22. 浙江省重点研发计划-2022C02024，养猪场生物安全智能防控技术平台，2022-2024，100（课题）／306万元

    21. 浙江省重大项目-2021C02008，猪肉健康生产与保障提升关键技术- 3000万（省拨800万）, 2020-2023，100万（课题）／800万，（课题）主持

    20. 企业横向课题-518001-I22005，青莲黑猪培育与配套系综合开发应用（疾病控制研究与应用推广），2020-2025，270万（课题）／1000万，（任务）主持

    19. 国家基金，食源性金黄色葡萄球菌在酸胁迫下的交叉适应机制研究，2019-2022，8/58，参加

    18. 浙江省微生物技术与生物信息研究重点实验室开放课题，伤寒沙门菌流行病基因组学研究，2020，5万，主持

    17. 浙江省重点研发计划-2020C02032，新型兽药研制及耐药性控制技术研发-新型绿色兽药创制及畜禽重要病原菌耐药性控制技术研究，食源性耐药菌流行分布规律（课题3），2020-2023，25万（子课题），主持

    16. 企业横向课题，益生菌的开发与安全性评价，2020.1-12，15万，主持

    15. 江苏省人兽共患病学重点实验室开放研究项目-R1902，鸡白痢沙门菌与宿主时空互作网络研究，2019-2021，5万，主持

    14. 企业横向课题，面向重大动物疫病的核酸精准诊断方法，2019-2021，40万，主持

    13. 企业横向课题，（畜禽用）基因诊断试剂盒，2019-2023，100万，主持

    12. 浙江省杰出青年基金，浙江省基金委-LR19C180001，禽特异沙门氏菌菌毛定植因子的致病作用机制，2019-2022，80万，主持

    11. 国家重点研发计划，科技部-2018YFD0500501，重要人畜共患食源性病原新型快速精准检测和分子溯源技术及其产品创制，2018-2020，229万（25万子课题），主持

    10. 教学建设，浙江大学，分子细菌学全英文课程，2018-2020，8万，主持

    9. 一般课题，浙江大学农生环学部，学部优秀青年培养计划，2018-2019，25万，主持

    8. 一般课题，科技部-2-2050205-18-237，中央高校基本业务费，2018-2019，15万，主持

    7. 国家重点研发计划，科技部- 2017YFC1600103，食品全产业链中重要耐药致病菌耐药性的传播规律，2018-2021，528万（144万子课题），主持

    6. 人才项目、中组部/国家基金委、国家“千人计划”青年项目（十三批）、2017-2019、100 万，主持

    5. 人才项目，浙江大学- 2016111，“百人计划”项目，2016-2022，200万，主持

    4. 美国国立卫生研究院National Institute of Health (NIH) 1R21AI117135-01A1，Genetic determinants of systemic host-adapted Salmonella. 2016-2017，44万美元，参加

    3. 美国农业部United States Department of Agriculture 2013–67015–21285、Allelic variation of Salmonella colonization factors. 2014-2016，50万美元，参加

    2. 美国国立卫生研究院National Institute of Health (NIH) 5R21AI098041、Allelic variants of Salmonella fimbrial adhesins. 2012-2013，42.8万美元，参加

    1. 美国国立卫生研究院National Institute of Health (NIH) 1R21AI076695、The Psa fimbriae of Yersinia pestis, an adhesin with protective immunogenic properity. 2009-2010，44.7万美元，参加

    教学改革：

    校级：

    杜爱芳，乐敏，马光旭，方维焕，杨怡 《兽医公共卫生学》思政课程项目

    乐敏，李艳 《动物病原学实验技术》思政课程项目

    院级：

    乐敏，综合性院校《兽医公共卫生学》教学改革与实践

    乐敏，《兽医微生物学》思政课程项目

    乐敏，《兽医公共卫生学实践指导》教材

    乐敏，优质课程《动物病原学实验技术》（2020，2021）

     

    教材名称／出版社／时间／排序／成效／证明材料

    乐敏（副主编）《兽医公共卫生学概论》  编写大纲

     

    教学实践基地：

    浙江省农业科学院农产品质量标准研究所

    浙江省动物疾病预防控制中心

    浙江省疾病预防控制中心

    杭州市疾病预防控制中心

    杭州市海关检验检疫研究院

     

    Joint WHO/FAO Expert: Candidate, Microbiological Risk Assessment

     

    期刊论文评审：

     

    编委（2024-），PLoS Pathogens（IF5=6.7); Academic Editor

    编委（2023-2026），mSystems (IF5=7.3); Board of Editors

    编委（2022-），Microorganisms (IF5=4.8); Editorial Board Member

    编委（2022-），Animal Research and One Health（畜牧兽医所）; Editorial Board Member

    编委（2022-），Frontiers in Marine Science (IF5=4.7); Review Editor

    副主编（2022-），Frontiers in Microbiology (IF5=6.2); Associate Editor

    编委（2021-2023），Animal Diseases（华中农业大学）; Editorial Broad Member

    编委（2017-），Foodborne Pathogens and Disease (IF5=3.2); Editorial Broad Member

    编委（2018-），Frontiers in Microbiology (IF5=6.2); Review Editor

    编委（2018-2020），Frontiers in Nutrition; Review Editor

    编委（2019-2020），Frontiers in Veterinary Science; Review Editor

    副主编（2020-），Frontiers in Veterinary Science (IF5=3.5); Associate Editor

    编委（2019-），浙江大学学报(农业与生命科学版)

    编委（2015-2019），Exploratory Research and Hypothesis in Medicine

     

    Frontiers in Microbiology (IF5= 6.843); Research Topics Editor (The antimicrobial resistance and mechanism in Enterobacteriaceae among animals, humans and environments: Concern one-Health),  2022

    Frontiers in Veterinary Science (3.821); Research Topics Editor (Zoonotic Bacteria: Genomic Evolution, Antimicrobial Resistance, Pathogenicity, and Prevention Strategies),  2022

    Animal Diseases（2022年度“中国科技期刊卓越行动计划”高起点新刊项目）; Guest Editor (Emerging and re-emerging infectious diseases),  2022

    Microorganisms (5.143); Special Issue Editor (Impact and Applications of Probiotics, Prebiotics and Postbiotics in Animal Feed), 2022

    Antibiotics（5.396）; Special Issue Editor (Modern Approaches for Understanding Foodborne Pathogens: Antimicrobial Resistance and Genomics), 2022

    Foodborne Pathogens and Disease（3.583）; Special Issue Leading Editor（Food Safety in China: Current Practices and Future Needs），2020

    Joint WHO/FAO Expert: Candidate, Microbiological Risk Assessment

     

    标准评审：

    鸡白痢／禽伤寒检测与控制团体标准

    农畜产品质量与安全国家标准

    畜禽养殖场细菌耐药性水平评价技术规范

     

    基金／项目评审：

    长江学者计划项目

    国家重点研发计划项目（会评）

    四川省QianRen计划（会评）

    广东省自然科学基金／人才项目（会评）

    金华市重点（大）科技项目（会评）

    海南省自然科学基金／人才项目

    浙江省自然科学基金／重点研发计划项目

    重庆市自然科学基金

    河北省自然科学基金

    美国农业科学基金

    Medjaden 国际基金

     

    论文评审：

    教育部学位（博士／硕士）研究生论文

    中国科学院（博士／硕士）研究生论文

    University of Copenhagen, Na Pei博士答辩委员会委员(2022年3月-5月)

    National University of Sciences and Technology, Abubakar Siddique博士答辩委员会委员(2022年6月-8月)

    Auburn University, Nneka Vivian Iduu博士答辩委员会委员(2024年1月-2025月1月)

     

    Elsevier book (Aptasensors for Food-Contaminant Analysis: Fundamentals and Applications) 评审委员(2022年2月)

     

    动物医学专业本科毕业答辩委员会组长，2020

    指导／培养学生 (答辩评审委员会)

    Post-doc. Thesis Committee:

    2021-, Guangtian Chao, China Jiliang University

     

    2021-, Mohammed Elbediwi, Zhejiang University College of Animal Sciences

     

    2021-, Hang Pan, College of Animal Sciences

     

    2020-, Lin Teng, Zhejiang University College of Animal Sciences

    Bacterial hazards dynamics along the infant food chain, power milk formula.

     

    2020-, Reshma Nambiar, Zhejiang University College of Animal Sciences

    Population Genomics of Salmonella Typhimurium in China

    2018-, Silpak Biswas, Zhejiang University College of Animal Sciences

    Antibiotic Resistance and Population Genomics of Foodborne Bacterial Transmission

    -2018, 何珂 (Ke He), Zhejiang University College of Animal Sciences

    Anti-stress Mechanism of SigB in Listeria monocyotogens

    Ph.D. Thesis Committee:

    -2022, Na Pei, University of Copenhagen, Department of Biology                  Population genomics and antimicrobial resistance in Klebsiella pneumoniae

    -2022, Zeeshan Zhejiang University School of Medicine                   

    Discovery of tigecycline resistance tet(X)-like genes from the waterfowl pathogen Riemerella anatipestifer

    -2022, Tanveer Muhammad Anwar Zhejiang University College of Animal Science     Genetic diversity and genomic characterization of Listeria monocytogenes isolates from Foods, Animals and Humans

    -2021,

    -2020， 潘航（Hang Pan），Zhejiang University College of Animal Sciences

    Genomic epidemiology of Salmonella enterica serovar Newport

    -2020， MOHAMMED ELBEDIWI，Zhejiang University College of Animal Sciences

    Molecular investigation on acquired and adaptive colistin resistance in Salmonella

    -2020， Saif Ulah， Zhejiang University School of Medicine

    Biochemical mechanism and characterization of non-mobile colistin resistance NMCR-2 protein

     

    -2020， 胡竟进（Jinjin Hu），Zhejiang University College of Food Science

    The regulation function of transcription factor Dal80p in the nitrogen metabolism of Saccharomyces cerevisiae was investigated based on comparative transcriptomics and ChIP-Seq

     

    -2020， 周万怡（Wanyi Zhou），Zhejiang University College of Food Science

    Application pf food-derived phenolic compounds to the process of Chinese yellow rice wine fermentation for ethyl carbamate regulation and its mitigation mechanism

     

    -2020，徐勇昌（Yongchang XU）, Zhejiang University School of Medicine

    Biochemical Mechanisms for MCR Colistin Resistance

     

    -2019，何波 (Bo He), Zhejiang University College of Animal Sciences

    Transcriptomics discovery and ultimate of cellulase genes from rumen microbiota of Hu sheep

     

    -2019, Narayan Paudyal (尼泊尔农业部), Zhejiang University College of Animal Sciences

    Meta-analytical Prevalence of Foodborne Pathogens and Comparative Pathogenomics of Salmonella Dubin

    -2019, 曹统 (Tong Cao), Zhejiang University College of Animal Sciences

    Genetic Rescuing and Immunogenecity of Cell-adapted Classical Swine Fever Virus C-strain and Recombinant Marker Vaccine Candidates

    -2019, 陈向峰 (Xiangfeng Chen), Zhejiang University College of Animal Sciences

    Role of Non-coding RNAs in the Activation of Macrophages Induced by Actinidia eriantha Polysaccharide and its Mechanisms

    -2019, 董雨豪 (Yuhao Dong), Nanjing Agricultural University College of Veterinary Medicine. Functional Characteristics of TonB Energy System in Iron Utilization and Virulence of Aeromonas hydrophila

    -2019, 张越 (Yue Zhang), Nanjing Agricultural University College of Veterinary Medicine

    Pathogenic Mechanism of SecY2/A2 Secretion System in Streptococcus suis Serotype Chz and Screening the Candidate Immunogens

    -2019, 朱寅初 (Yingchu Zhu), Nanjing Agricultural University College of Veterinary Medicine

    Functional Characteristics of Streptococcus suis Competence System and Development of a ComRS Based Genetic Modification Method

    -2019, Shipra Roy, Nanjing Agricultural University College of Veterinary Medicine

    Role of the ATP-dependent Proteases in Stress Tolerance and Virulence of Streptococcus suis Serotype 2

    -2017, 张晓峰 (Xiaofeng Zhang) (杭州海关), Zhejiang University College of Animal Sciences

    基于肽核酸荧光原位杂交技术的食源性致病菌鉴定系统研究及其应用

    -2017, 蒋小武 (Xiaowu Jiang) (宜春学院), Zhejiang University College of Animal Sciences

    Streptococcus suis type 2 : Cross - protection by a type 5 avirulent strain and roles of type IV-like Secrection system in pathogenesis

    Master Thesis Committee:

    -2022, 吴小雨（Xiaoyu Wu），Zhejiang University College of Control Science and Engineering An integrated digital PCR system with nucleic acid extraction

     

    -2021, 陈文静（Wenjing Chen）, Zhejiang University College of Animal Sciences

    Antimicrobial resistance investigation and genome sequencing analysis of Salmonella enterica serovar Weltevreden in some regions of China

     

    -2021, 李芳（Fang Li），Zhejiang University College of Animal Sciences

    Genomic sequencing and antimicrobial resistance detection of Chinese invasive Salmonella isolates

     

    -2021, 杜佳欣（Jiaxin Du），Zhejiang University College of Animal Sciences

    Genomic epidemiology of Salmonella Goldcoast

     

    -2021, 唐燕婷（Yanting Tang），Zhejiang University College of Animal Sciences

    Preliminary Investigation of CitB Family Two-Component System in Avian-Specific Salmonella

     

    -2020, 杜开乾(Kaiqian Du), Zhejiang University School of Animal Sciences

    Comparative study on the gut microbiota and gut transcriptome of the silkworm (Bombyx mori) under individual and group rearing conditions

     

    -2020, 柴文琴(Wenqing Chai), Zhejiang University College of Animal Sciences

    The investigation of survival rate and antibiotic resistance of Listeria spp. in response to the various environment stress during the food processing

     

    -2020, 周鑫(Xin Zhou), Zhejiang University College of Animal Sciences

    Characterization, Antimicrobial Resistance and Genotyping analysis of Important Intestinal Bacteria Recovered From Companion Animals in Hangzhou

     

    -2020, 吴青青(Qingqing Wu), Zhejiang University College of Animal Sciences

    Preliminary Investigation of the Function of Salmonella Fimbriae Adhesin

    -2020, 侯梦云(Mengyun Hou), Zhejiang University School of Medicine

    The Mechanism of MCR-4 Colistin Resistance Enzyme

     

    -2019, 刘子琦 (Ziqi Liu), Zhejiang University College of Animal Sciences

    Molecular Evolution Analysis of PEDV S Gene and Establishment of ELISA for Detecting IgA Antibody Based on its Truncated Protein

    -2019, 廖夏旖 (Xiayi Liao) (美国Purdue University普渡大学 PhD), Zhejiang University College of Animal Sciences

    Study on Biological Function of lacD.1 and rgg Knock-out Mutants of Streptococcus suis Serotype 2

    -2019, 李平 (Ping Li), Zhejiang University School of Medicine

    Comparative Functional Genomics of Hypervirulent Klebsiella pneumoniae with Carbapenem-resistance

    -2019, 王欢 (Huan Wang), Zhejiang A&F University College of Animal Sciences and Technology Exploration of the Candidate Genes Related with Mating-type Substances of Paramecium caudatum by Transcriptome

    -2019, 贾宇坤 (Yukun Jia), Zhejiang A&F University College of Animal Sciences and Technology

    BufoWap cDNA Screening and Function Analysis of Recombinant WAP

    -2019, 韩乾杰 (Qianjie Han), Zhejiang A&F University College of Animal Sciences and Technology

    Effects of Plant Polysaccharides on Growth Performance, Immune Function and Intestinal Health in Weaned Piglets

    -2019, 郭锡钦 (Xiqing Guo), Zhejiang A&F University College of Animal Sciences and Technology

    Effects of Glyceryl Monolaurate on Immune Function and Porcine Reproductive and Respiratory Syndrome Virus in Piglets

    -2018, 周晶晶 (Jingjing Zhou), Zhejiang University College of Animal Sciences

    Comparison of Biological Functions of Serine/threonine Phosphatases 1 and 2 in Streptococcus suis Type 2

    -2018, 王航 (Hang Wang), Zhejiang A&F University College of Animal Sciences and Technology

    Listeria monocytogenes: Biological Functions of Aminopeptidase Lmo1711 and Flagellar Structural Protein FlhB

    -2017, 李国炜 (Guowei Li), Zhejiang University College of Animal Sciences

    Complete Genome Cloning of Porcine Epidemic Diarrhea Virus Field Strain and Preparation of Monoclonal Antibody against its S1 Protein

    -2017, 辛永萍 (Yongping Xin), Zhejiang University College of Animal Sciences

    Rsbs Regulate Sodium Resistance of Listeria monocytogenes via SigB

    -2017, 姜莉 (Li Jiang), Zhejiang A&F University College of Animal Sciences

    Novel Function on Immunity of Listeria monocytogenes Listeriolysion O (LLO)

    -2017, 杨云凯 (Yunkai Yang), Zhejiang University College of Animal Sciences

    Streptococcus suis type 2 Strains Isolation from Healthy Pigs and Immuno-Protective Efficacy of PrsA

    -2017, 郑秀平 (Xiuping Zhen), Zhejiang University College of Animal Sciences

    Effect of Hc-DAF-22 Functional Site Mutation on the Biological Function of Proteins in Haemonchus contortus

    -2017, 丁豪杰 (Haojie Ding), Zhejiang University College of Animal Sciences

    Characterization and Function Analysis of a Novel Gene, Hc-maoc-1, in Parasitic Nematode Haemonchus contortus

    Undergraduate Thesis Committee: （13人）

    -2025，许益豪（竺可桢学院）coding/genomic epidemiology

    -2022，周海洋，绍兴市2020年沙门菌耐药性及基因组分析（浙大动科院）

    -2022，黄冠文，2020-2021年杭州沙门菌基于全基因组测序的基因组学分析

    -2022，郑智杰，宠物源产碳青霉烯酶大肠杆菌的耐药特性和全基因组序列分析（浙大动科院）

    -2021，陶晓茜，不同禽源沙门菌生化代谢物的比较分析（菲拉启杭宠物医院，住院医师）

    -2021，徐一苇，鸡白痢沙门菌生物被膜多样性研究（良渚-圣庭医学检验所）

    -2021，李筱萌，沙门菌Livingstone全球流行病基因组学及其生物学表型研究（爱丁堡）

    -2021，庞雨晨，利用沙门菌基因组数据预测其血清型（香港大学公共卫生学院Master）

    -2021，刘淑奇，利用基因组数据预测细菌耐药性

    -2020，方可馨，杭州地区犬源大肠杆菌分离鉴定以及耐药性分析 （美国DVM）

    -2020，董成航，杭州地区犬布鲁氏菌携带的流行病学调查 （University of Edinburgh，Master）

    -2020，毛俊勇，鸡源沙门菌分离鉴定、耐药性检测和全基因组测序分析 （浙大动科院）

    -2020，王昕茹，mcr阳性细菌的鉴定以及耐药性分析 （浙大医学院）

    SRTP Project Advisor (15人):

    2021-2022  菌毛定植因子功能研究（X20210227）陈水晶-袁晶城-沈亿

    2020-2021  宠物源产碳青霉烯酶菌的全基因组测序分析和生物学特性鉴定 （Y202004156）郑冰青-郑智杰（本院研究生）

    2020-2021  杭州地区宠物细菌性腹泻主要病因调查以及主要病原的耐药性研究（） 毛俊勇（海南院研究生）

    2019-2020   杭州地区宠物（犬和猫）产超广谱β-内酰胺酶肠杆菌科细菌耐药情况及其流行病学研究（X2019235）李筱萌（国际学院研究生）-姚一诚-叶欣怡

    2019-2020  鼠伤寒沙门菌变种ST34的耐药性调查（Y201934266）夏洁 （申请DVM，本院研究生）-蔡厚利-倪晓芸

    2017-2018  沙门氏菌快速鉴定，分型及其耐药谱分子检测方法的建立（Y34004）周坤（本院研究生）（布鲁氏菌流行的荟萃分析）-方一帆-杨璟

     

     

    1科技成果：

    高生物利用度水溶型氟苯尼考粉

    乐敏;杨彪;赵琨发;郜进;胡巧玲;孔随飞

    浙江万方生物科技有限公司   2017-10-22 科技成果

    简要技术说明：

    项目产品选择β环糊精作为辅料,聚乙二醇6000及聚氧乙烯(20)山梨醇酐单油酸酯作为乳化剂。冷热配料缸开启搅拌,先投入倍他环糊精,再投氟苯尼考,然后投入乳化剂,最后补热水冲掉粘壁物料,60℃以上保温1小时,然后进行离心喷雾,得到固体粉末。将粉末过80目筛后,加入干法造粒机中,第一遍干法造粒,拆掉破碎网片,压力控制在2000左右;第二遍干法造粒,装上破碎网片,压力控制在1200左右。该工艺提升了氟苯尼考的溶解和药效,同时也提升了产品的密度。产品在合成工艺技术方面有创新,相关技术获实用新型专利3件、软件著作权2件,技术处国内领先水平。 项目产品经浙江省兽药饲料监督所检测(报告号：SF17195),所测指标符合《中国兽药典》2015年版一部,达到计划任务书要求;经用户使用,反映良好。

    主要技术指标完成情况：

    (1)经过研究成功筛选出了与氟苯尼考包合的辅料--倍他环糊精,并对其包合效果、水溶性和药物动力学等特性进行了实验。 (2)通过研究得出了氟苯尼考的加工工艺,利用包合及热喷工艺得出的氟苯尼考产品,水溶性为原粉的50倍,并且明显优于市场上同类产品。 (3)已经建立一套高效水溶性氟苯尼考粉的应用配套技术,通过使用高效水溶型氟苯尼考粉,显著提高动物生产能力10-20%,降低仔猪腹泻率10-20%。

     

    2科技成果：

    水解小肽螯合复合微量元素

    杨彩梅;乐敏;冯杰;范艳萍;田树清

    浙江惠嘉生物科技股份有限公司; 2018-12-27 科技成果

    简要技术说明： 项目产品以植物或动物性蛋白为主要原材料,筛选出了多种酶组合,确定了其最佳配比后,采用水解工艺提高了蛋白的水解度,达到螯合所需小肽的要求;通过螯合工艺及参数优化、干燥工艺等试验,制备出高稳定性高螯合率的复合有机微量元素。产品在螯合工艺技术方面有创新,相关技术获国家发明专利1件,实用新型专利2件,达到国内领先水平。项目产品经浙江国正检测技术有限公司检测(报告号：WV184015),所测指标符合《饲料添加剂小肽螯合复合微量元素》(Q/ZHJ 317-2017)企业标准,达到计划任务书要求;经用户使用,反映良好。 主要技术指标完成情况： (1)顺利筛选出了多种酶组合,确定了其最佳配比后,采用水解工艺提高了蛋白的水解度,达到螯合所需小肽的要求,其水解度达到75%以上。 (2)通过螯合工艺及参数优化、干燥工艺等试验,制备出高稳定性,高螯合率的复合有机微量元素,螯合率≥80%,有机微量元素总含量9%-11%。 (3)已建立完整的应用配套技术,从推广试用反馈情况来看,复合微量元素制剂产品能替代无机微量元素,降低使用量,和提高生物利用率的效果,可有效提升养殖效益和降低环境污染。 (4)已完成2项相关专利,一种分离提取装置(ZL201720989068.6)、一种用于饲料的喷雾干燥系统(ZL201721324958.1)。

     

    3 科技成果

    粪污处理专用益生菌

    曾新福;崔艳军;乐敏;郗洪生;李慧;夏月峰;陈宇琪;邵彦婕

    浙江惠嘉生物科技股份有限公司; 2018-12-27 科技成果

    简要技术说明： 项目产品通过体外评估不同菌株堆肥发酵能力,定向筛选了具备堆肥发酵能力的三个菌株;通过复合微生物连续发酵法,对枯草芽孢杆菌、地衣芽孢杆菌、解淀粉芽孢杆菌进行连续混合发酵,避免了单独发酵过程中灭菌次数多、进料次数多的缺点,简化了发酵过程。产品在发酵工艺技术方面有创新,相关技术获国家发明专利1项,实用新型专利2件,达到国内领先水平。 项目产品经浙江国正检测技术有限公司检测(报告号：WV184041),所测指标符合《环境改良剂枯草芽孢杆菌+地衣芽孢杆菌+解淀粉芽孢杆菌》(Q/ZHJ 314-2017)企业标准,达到计划任务书要求;经用户使用,反映良好。 主要技术指标完成情况： (1)顺利筛选出了具有强大产酶特性、抑菌特性及耐高温的三株优势芽孢杆菌,通过模拟堆肥发酵,确定了适宜的复合菌配方浓度和比例,结合适宜的发酵条件及后处理工艺形成产品。 (2)已建立完整的应用配套技术,从推广试用反馈情况来看,复合菌制剂产品具有较好的堆肥的效果,显著改善养殖场环境,提高养殖的效益。 (3)相关专利已被国家知识产权局受理：发明专利--复合菌剂及所采用的复合微生物的连续发酵法(ZL 2014 10662273.2);实用新型专利--发酵液消泡回收装置(ZL201620978669.8);实用新型专利--新型液体发酵罐(ZL 201520014534.X)。