研究领域
课题组致力于通过合成生物学技术、代谢工程手段设计和构建高效细胞工厂用于生产各类高附加值产品(维生素、生物药、天然产物、化工品等);生物传感器用于菌株进化高通量筛选和生物检测;肠道益生菌的精准治疗策略。
具体研究内容包括:
a) 代谢调控优化细胞工厂;
b) 级联生物催化途径的设计与开发;
c) 生物传感器的设计与开发;
d) 植物天然产物生源途径的解析与微生物异源合成;
e) 益生菌的精准设计与疾病治疗。
关键词:合成生物学、代谢调控、基因线路设计、生物传感器、肠道益生菌、天然产物、生物制造。
RESEARCH AREA:
By employing synthetic biology and metabolic engineering principles, our group focuses on devising efficient microbial cell factory for chemical productions, developing biosensors for highthroughput screening and bio-detection and probiotics-based disease treatment. More specifically, a) metabolic regulation toward more efficient cell factories; b) cascaded enzyme catalysis; c) biosensor design; d) pathway elucidation and microbial synthesis of plant natural products; e) probiotics-based disease treatment.
KEYWORDS: Synthetic Biology, Metabolic Regulation, Genetic Circuit, Biosensor, Probiotics, Natural Products, Bio-manufacturing.