通过合成生物学技术、代谢工程手段改造和设计高效细胞工厂（光合细菌、蓝藻等），用于以可再生的生物质为原料生产高附加值药物中间体、香精香料、精细化学品、天然产物等。
By employing synthetic biology and metabolic engineering, our group focuses on engineering and devising efficient microbial cell factory (such as photosynthetic bacteria, cyanobacteria, et.ac) for cost-effective biosynthesis of high-value pharmaceutical intermediates, fragrance and flavors, fine chemicals and natural products from renewable feedstocks.
1. Yang Zhang*, Xinyu Wang, Jifeng Yuan*, Liejin Guo*. Multidimensional engineering of Rhodobacter sphaeroides for enhanced photo-fermentative hydrogen production. Chemical Engineering Journal, 2024, 488: 150852
2. Yang Zhang#, Cheng Cheng#, Bixia Fu#, Teng Long, Ning He, Jianqiang Fan*, Zheyong Xue*, Anqi Chen*, Jifeng Yuan*. Microbial upcycling of depolymerized lignin into value-added chemicals. BioDesign Research, 2024, 6: 0027
3. Jian Fan#, Yang Zhang#, Wenhao Li, Zhizhen Li, Danli Zhang, Qiwen Mo, Mingfeng Cao, Jifeng Yuan*. Multidimensional optimization of Saccharomyces cerevisiae for carotenoid overproduction. BioDesign Research, 2024, 6: 0026
4. Yang Zhang, Wenchang Meng, Yuting He, Yuhui Chen, Mingyu Shao, Jifeng Yuan*. Multidimensional optimization for accelerating light-powered biocatalysis in Rhodopseudomonas palustris. Biotechnology for Biofuels and Bioproducts, 2023, 16: 160
5. Yang Zhang*, Jie Cheng, Yuting He, Jifeng Yuan*. Photo-fermentative hydrogen production performance of a newly isolated Rubrivivax gelatinosus YP03 strain with acid tolerance. International Journal of Hydrogen Energy, 2022, 47(48): 20784-20792
6. Yang Zhang, Xiaohui Song, Yumeng Lai, Qiwen Mo, Jifeng Yuan*. High-yielding terpene-based biofuel production in Rhodobacter capsulatus. ACS Synthetic Biology, 2021, 10(6): 1545-1552
7. Yang Zhang, Jifeng Yuan*. CRISPR/Cas12a-mediated genome engineering in the photosynthetic bacterium Rhodobacter capsulatus. Microbial Biotechnology, 2021, 14(6): 2700-2710
8. Zuoxi Mao#, Lijun Liu#, Yang Zhang#, Jifeng Yuan*. Efficient synthesis of phenylacetate and 2-phenylethanol via modular cascade biocatalysis. ChemBioChem, 2020, 21(8): 2676-2679
9. Yang Zhang*, Jifeng Yuan*, Liejing Guo. Enhanced bio-hydrogen production from cornstalk hydrolysate pretreated by alkaline-enzymolysis with orthogonal design method. International Journal of Hydrogen Energy, 2020, 45 (6): 3750-3759
10. Yang Zhang#, Crysten E. Blaby-Haas#, Stefan Steimle, Andreia F. Verissimo, Victor A. Garcia-Angulo, Hans-Georg Koch, Fevzi Daldal* & Bahia Khalfaoui-Hassani. Cu transport by the extended Family of CcoA-like transporters (Calt) in proteobacteria. Scientific Reports, 2019, 9
11. Yang Zhang, Qing Li, Xueqing Wang, Honghui Yang, Liejin Guo*. Enhanced biohydrogen production from cornstalk through a two-step fermentation: Dark- and photo-fermentation. International Journal of Energy Research, 2017, 41 (15): 2491-2501
12. Yang Zhang, Liejin Guo*, Honghui Yang. Enhancement of hydrogen production through a mixed culture of Enterobacter cloacae and Rhodobacter sphaeroides. Energy & Fuels, 2017, 31 (7): 7234-7240
13. Yang Zhang, Jun Hu, Hongyu Ma, Honghui Yang*, Liejin Guo*. Overexpressing atpXF enhanced photo-fermentative hydrogen production performance of Rhodobacter sphaeroides. International Journal of Hydrogen Energy, 2017, 42 (15): 9641-9649
14. Yang Zhang, Honghui Yang*, Jiali Feng, Liejin Guo*. Overexpressing F0/F1 operon of ATPase in Rhodobacter sphaeroides enhanced its photo-fermentative hydrogen production. International Journal of Hydrogen Energy, 2016, 41 (16): 6743-6751.
15. Yang Zhang, Honghui Yang*, Liejin Guo*. Enhancing photo-fermentative hydrogen production performance of Rhodobacter capsulatus by disrupting methylmalonate-semialdehyde dehydrogenase gene. International Journal of Hydrogen Energy, 2016, 41 (1):190-197
BioDesign Research（中国科技期刊卓越行动计划高起点新刊）编委
2022年获得福建省级高层次C类人才
2023年获得厦门市高层次C类人才