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成果及论文

代表性学术论文：（*共同一作, #共同通讯）

2024

He, X.*, Yu, J.*, Jiang, J*. et al. Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection. Sig Transduct Target Ther 9, 180 (2024).

Fan J*, Zhang Y*, Li S*, Li Q*, Zi Q, Mou X, Zheng J, Wang X, Guo X, Chen J#, Yu J#. Immunogen characterization reveals an intrinsic hindrance in eliciting neutralizing antibodies against JN. 1 variant. iScience, 2024; doi: 10.1016/j.isci.2024.110405

Zhu Z*, Li S*, Fan J*, Shang S*, Zhang Y*, Zi Q*, Zheng J, Wang D, Mou X, Liu K, Lv M, Yuan J#, Wang Z#, Yu J#. Omicron breakthrough infected individuals show enhanced nasal antibody responses and preserved T cell responses against the EG.5.1 and BA.2.86. J Med Virol. 2024;96(3):e29537. doi:10.1002/jmv.29537

2023

Fan J, Li S, Zhang Y, Zheng J, Wang D, Liao Y, Cui Z, Zhao D, Barouch DH, Yu J#. Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Viruses. 2023; 15(12):2401. https://doi.org/10.3390/v15122401

Yu J, Thomas PV, Sciacca M, et al. Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques. Cell Rep Med. 2023;4(4):101018. doi:10.1016/j.xcrm.2023.101018

Solforosi L*, Costes LMM*, Tolboom JTBM, McMahan K, Anioke T, Hope D, Murdza T, Sciacca M, Bouffard E, Barrett J, Wu C, Hachmann N, Miller J, Yu J, He X, Jacob-Dolan C, Huber SKR, Dekking L, Chamanza R, Choi Y, Boer KF, Barouch DH, Schuitemaker H, Zahn RC, Wegmann F. Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques. Nat Commun. 2023;14(1):1944. Published 2023 Apr 7. doi:10.1038/s41467-023-37715-2

Vidal SJ, Sellers D, Yu J, et al. Attenuated Mycobacterium tuberculosis vaccine protection in a low-dose murine challenge model. iScience. 2023;26(6):106963. Published 2023 May 28. doi:10.1016/j.isci.2023.106963

Jacob-Dolan C*, Yu J*, McMahan K*, et al. Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques. NPJ Vaccines. 2023;8(1):23. Published 2023 Feb 23. doi:10.1038/s41541-023-00622-0

Nanishi E*, Borriello F*, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023;8(1):18. Published 2023 Feb 14. doi:10.1038/s41541-023-00610-4

2022

Cooper A, Sidaway A, Chandrashekar A, Latta E, Chakraborty K, Yu J, McMahan K, Giffin V, Manickam C, Kroll K, Mosher M, Reeves RK, Gam R, Arthofer E, Choudhry M, Henley T, Barouch DH. A genetically engineered, stem-cell-derived cellular vaccine. Cell Rep Med. 2022;3(12):100843. doi:10.1016/j.xcrm.2022.100843

Nilles EJ, Paulino CT, de St Aubin M, Restrepo AC, Mayfield H, Dumas D, Finch E, Garnier S, Etienne MC, Iselin L, Duke W, Jarolim P, Oasan T, Yu J, Wan H, Peña F, Iihoshi N, Abdalla G, Lopez B, Cruz L, Henríquez B, Espinosa-Bode A, Puello YC, Durski K, Baldwin M, Baez AA, Merchant RC, Barouch DH, Skewes-Ramm R, Gutiérrez EZ, Kucharski A, Lau CL. SARS-CoV-2 seroprevalence, cumulative infections, and immunity to symptomatic infection – A multistage national household survey and modelling study, Dominican Republic, June–October 2021. Lancet Reg Health Am. 2022;16:100390. doi:10.1016/j.lana.2022.100390

Yu J, Thomas PV, McMahan K, et al. Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN. Sci Adv. 2022;8(47):eade4433. doi:10.1126/sciadv.ade4433

Dagotto G*, Ventura JD*, Martinez DR, Anioke T, Chung BS, Siamatu M, Barrett J, Miller J, Schäfer A, Yu J, Tostanoski LH, Wagh K, Baric RS, Korber B, Barouch DH. Immunogenicity and protective efficacy of a rhesus adenoviral vaccine targeting conserved COVID-19 replication transcription complex. NPJ Vaccines. 2022;7(1):125. Published 2022 Oct 27. doi:10.1038/s41541-022-00553-2

Liu J, Yu J, McMahan K, et al. CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques. Sci Immunol. 2022;7(77):eabq7647. doi:10.1126/sciimmunol.abq7647

Nanishi E*, McGrath ME*, O'Meara TR, Barman S, Yu J, Wan H, Dillen CA, Menon M, Seo HS, Song K, Xu AZ, Sebastian L, Brook B, Bosco AN, Borriello F, Ernst RK, Barouch DH, Dhe-Paganon S, Levy O, Frieman MB, Dowling DJ. mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant. Commun Biol. 2022;5(1):790. Published 2022 Aug 6. doi:10.1038/s42003-022-03765-3

Tan CS, Collier AY, Yu J, et al. Durability of Heterologous and Homologous COVID-19 Vaccine Boosts. JAMA Netw Open. 2022;5(8):e2226335. Published 2022 Aug 1. doi:10.1001/jamanetworkopen.2022.26335

Gebre MS, Rauch S, Roth N, Gergen J, Yu J, Liu X, Cole AC, Mueller SO, Petsch B, Barouch DH. mRNA vaccines induce rapid antibody responses in mice. NPJ Vaccines. 2022;7(1):88. Published 2022 Aug 1. doi:10.1038/s41541-022-00511-y

Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity. Sci Transl Med. 2022;14(654):eabn1413. doi:10.1126/scitranslmed.abn1413

Nkolola JP, Yu J, Wan H, et al. A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques. Sci Transl Med. 2022;14(665):eabo6160. doi:10.1126/scitranslmed.abo6160

Hachmann NP, Miller J, Collier AY, Ventura JD, Yu J, Rowe M, Bondzie EA, Powers O, Surve N, Hall K, Barouch DH. Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5. N Engl J Med. 2022;387(1):86-88. doi:10.1056/NEJMc2206576

Piedra-Mora C, Robinson SR, Tostanoski LH, Dayao DAE, Chandrashekar A, Bauer K, Wrijil L, Ducat S, Hayes T, Yu J, Bondzie EA, McMahan K, Sellers D, Giffin V, Hope D, Nampanya F, Mercado NB, Kar S, Andersen H, Tzipori S, Barouch DH, Martinot AJ. Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments. Vet Pathol. 2022;59(4):648-660. doi:10.1177/03009858221095794

Zhu DY, Gorman MJ, Yuan D, Yu J, Mercado NB, McMahan K, Borducchi EN, Lifton M, Liu J, Nampanya F, Patel S, Peter L, Tostanoski LH, Pessaint L, Van Ry A, Finneyfrock B, Velasco J, Teow E, Brown R, Cook A, Andersen H, Lewis MG, Lauffenburger DA, Barouch DH, Alter G. Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates. PLoS Biol. 2022;20(5):e3001609. Published 2022 May 5. doi:10.1371/journal.pbio.3001609

Chandrashekar A, Yu J, McMahan K, et al. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques. Cell. 2022;185(9):1549-1555.e11. doi:10.1016/j.cell.2022.03.024

Yu J, Collier AY, Rowe M, et al. Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants. N Engl J Med. 2022;386(16):1579-1580. doi:10.1056/NEJMc2201849

Collier AY, Yu J, McMahan K, et al. Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals. J Infect Dis. 2022;225(7):1124-1128. doi:10.1093/infdis/jiab569

Liu J*, Chandrashekar A*, Sellers D, Barrett J, Jacob-Dolan C, Lifton M, McMahan K, Sciacca M, VanWyk H, Wu C, Yu J, Collier AY, Barouch DH. Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron. Nature. 2022;603(7901):493-496. doi:10.1038/s41586-022-04465-y

Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, Bowman L, Naranjo CA, Yun D, Flinchbaugh Z, Pessaint L, Brown R, Velasco J, Teow E, Cook A, Andersen H, Lewis MG, Camp DL, Silverman JM, Nagar GS, Rao HD, Lothe RR, Chandrasekharan R, Rajurkar MP, Shaligram US, Kleanthous H, Joshi SB, Volkin DB, Biswas S, Love JC, Barouch DH. SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques. Sci Adv. 2022;8(11):eabl6015. doi:10.1126/sciadv.abl6015

Cobb RR, Nkolola J, Gilchuk P, Chandrashekar A, Yu J, House RV, Earnhart CG, Dorsey NM, Hopkins SA, Snow DM, Chen RE, VanBlargan LA, Hechenblaickner M, Hoppe B, Collins L, Tomic MT, Nonet GH, Hackett K, Slaughter JC, Lewis MG, Andersen H, Cook A, Diamond MS, Carnahan RH, Barouch DH, Crowe JE Jr. A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques. Med. 2022;3(3):188-203.e4. doi:10.1016/j.medj.2022.01.004

Mahrokhian SH*, Tostanoski LH*, Jacob-Dolan C*, Zahn RC, Wegmann F, McMahan K, Yu J, Gebre MS, Bondzie EA, Wan H, Powers O, Ye T, Barrett J, Schuitemaker H, Barouch DH. Durability and expansion of neutralizing antibody breadth following Ad26.COV2.S vaccination of mice. NPJ Vaccines. 2022;7(1):23. Published 2022 Feb 23. doi:10.1038/s41541-022-00454-4

He X, Aid M, Chandrashekar A, Yu J, McMahan K, Wegmann F, Jacob-Dolan C, Maron JS, Atyeo C, Wan H, Sellers D, Liu J, Lifton M, Gardner S, Bondzie EA, Barrett J, Ahmad K, Anioke T, Yalley-Ogunro J, Muench J, Goode A, Andersen H, Lewis MG, Alter G, Schuitemaker H, Zahn R, Barouch DH. A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2–specific immune responses in rhesus macaques. Sci Transl Med. 2022;14(638):eabm4996. doi:10.1126/scitranslmed.abm4996

Chang A, Yu J. Fighting Fire with Fire: Immunogenicity of Viral Vectored Vaccines against COVID-19. Viruses. 2022 Feb 12;14(2):380. doi: 10.3390/v14020380. PMID: 35215973; PMCID: PMC8874888.

Yu J*, Collins ND*, Mercado NB, et al. Protective Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques. J Virol. 2022;96(2):e0159921. doi:10.1128/JVI.01599-21

Gebre MS*, Rauch S*, Roth N, Yu J, Chandrashekar A, Mercado NB, He X, Liu J, McMahan K, Martinot A, Martinez DR, Giffin V, Hope D, Patel S, Sellers D, Sanborn O, Barrett J, Liu X, Cole AC, Pessaint L, Valentin D, Flinchbaugh Z, Yalley-Ogunro J, Muench J, Brown R, Cook A, Teow E, Andersen H, Lewis MG, Boon ACM, Baric RS, Mueller SO, Petsch B^#, Barouch DH^#. Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine. Nature. 2022;601(7893):410-414. doi:10.1038/s41586-021-04231-6

Tostanoski LH, Chandrashekar A, Patel S, Yu J, Jacob-Dolan C, Chang A, Powers OC, Sellers D, Gardner S, Barrett J, Sanborn O, Stephenson KE, Ansel JL, Jaegle K, Seaman MS, Porto M, Lok M, Spence B, Cayer K, Nase D, Holman S, Bradette H, Kar S, Andersen H, Lewis MG, Cox F, Tolboom JTBM, de Groot AM, Heerwegh D, Le Gars M, Sadoff J, Wegmann F, Zahn RC, Schuitemaker H, Barouch DH. Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters. NPJ Vaccines. 2022;7(1):2. Published 2022 Jan 10. doi:10.1038/s41541-021-00427-z

2021

Rodrigues KA, Rodriguez-Aponte SA, Dalvie NC, Lee JH, Abraham W, Carnathan DG, Jimenez LE, Ngo JT, Chang JYH, Zhang Z, Yu J, Chang A, Nakao C, Goodwin B, Naranjo CA, Zhang L, Silva M, Barouch DH, Silvestri G, Crotty S, Love JC, Irvine DJ. Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2. Sci Adv. 2021;7(50):eabj6538. doi:10.1126/sciadv.abj6538

Collier AY, Yu J, McMahan K, et al. Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines. N Engl J Med. 2021;385(21):2010-2012. doi:10.1056/NEJMc2115596

Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022;14(629):eabj5305. doi:10.1126/scitranslmed.abj5305

Tostanoski LH*, Gralinski LE*, Martinez DR*, Schaefer A*, Mahrokhian SH, Li Z, Nampanya F, Wan H, Yu J, Chang A, Liu J, McMahan K, Ventura JD, Dinnon KH, Leist SR, Baric RS, Barouch DH. Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2. J Virol. 2021;95(23):e0097421. doi:10.1128/JVI.00974-21

Nilles EJ, Siddiqui SM, Fischinger S, Bartsch YC, de St Aubin M, Zhou G, Gluck MJ, Berger S, Rhee J, Petersen E, Mormann B, Loesche M, Hu Y, Chen Z, Yu J, Gebre M, Atyeo C, Gorman MJ, Zhu AL, Burke J, Slein M, Hasdianda MA, Jambaulikar G, Boyer EW, Sabeti PC, Barouch DH, Julg B, Kucharski AJ, Musk ER, Lauffenburger DA, Alter G, Menon AS. Epidemiological and Immunological Features of Obesity and SARS-CoV-2. Viruses. 2021;13(11):2235. Published 2021 Nov 6. doi:10.3390/v13112235

Langellotto F, Dellacherie MO, Yeager C, Ijaz H, Yu J, Cheng CA, Dimitrakakis N, Seiler BT, Gebre MS, Gilboa T, Johnson R, Storm N, Bardales S, Graveline A, White D, Tringides CM, Cartwright MJ, Doherty EJ, Honko A, Griffiths A, Barouch DH, Walt DR, Mooney DJ. A Modular Biomaterial Scaffold‐Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS‐CoV‐2 Antigens. Adv Healthc Mater. 2021;10(22):e2101370. doi:10.1002/adhm.202101370

Roozendaal R*, Solforosi L*, Stieh DJ*, Serroyen J, Straetemans R, Dari A, Boulton M, Wegmann F, Rosendahl Huber SK, van der Lubbe JEM, Hendriks J, Le Gars M, Dekking L, Czapska-Casey DN, Guimera N, Janssen S, Tete S, Chandrashekar A, Mercado NB, Yu J, Koudstaal W, Perez-Ruixo JJ, Sadoff J, Barouch DH, Schuitemaker H, Zahn R. SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques. Nat Commun. 2021;12(1):5877. Published 2021 Oct 7. doi:10.1038/s41467-021-26117-x

Chandrashekar A, Liu J, Yu J, et al. Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against reinfection with B.1.1.7 and B.1.351 variants. Sci Transl Med. 2021;13(618):eabj2641. doi:10.1126/scitranslmed.abj2641

Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru OS, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Brunette N, Wang JY, Walkey C, Fiala B, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice. Proc Natl Acad Sci U S A. 2021;118(38):e2106845118. doi:10.1073/pnas.2106845118

Zeng C, Waheed AA, Li T, Yu J, Zheng YM, Yount JS, Wen H, Freed EO, Liu SL. SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways. Sci Signal. 2021;14(700):eabc7611. doi:10.1126/scisignal.abc7611

Tostanoski LH, Yu J, Mercado NB, et al. Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern. Sci Transl Med. 2021;13(618):eabj3789. doi:10.1126/scitranslmed.abj3789

Barouch DH, Stephenson KE, Sadoff J, Yu J, Chang A, Gebre M, McMahan K, Liu J, Chandrashekar A, Patel S, Le Gars M, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H. Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination. N Engl J Med. 2021;385(10):951-953. doi:10.1056/NEJMc2108829

Yu J*, Tostanoski LH*, Mercado NB*, McMahan K*, Liu J*, Jacob-Dolan C*, Chandrashekar A*, Atyeo C, Martinez DR, Anioke T, Bondzie EA, Chang A, Gardner S, Giffin VM, Hope DL, Nampanya F, Nkolola J, Patel S, Sanborn O, Sellers D, Wan H, Hayes T, Bauer K, Pessaint L, Valentin D, Flinchbaugh Z, Brown R, Cook A, Bueno-Wilkerson D, Teow E, Andersen H, Lewis MG, Martinot AJ, Baric RS, Alter G, Wegmann F, Zahn R, Schuitemaker H, Barouch DH. Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques. Nature. 2021;596(7872):423-427. doi:10.1038/s41586-021-03732-8

Alter G*, Yu J*, Liu J*, Chandrashekar A*, Borducchi EN*, Tostanoski LH*, McMahan K*, Jacob-Dolan C*, Martinez DR, Chang A, Anioke T, Lifton M, Nkolola J, Stephenson KE, Atyeo C, Shin S, Fields P, Kaplan I, Robins H, Amanat F, Krammer F, Baric RS, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H, Barouch DH. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Nature. 2021;596(7871):268-272. doi:10.1038/s41586-021-03681-2

Vidal SJ*, Collier AY*, Yu J, et al. Correlates of Neutralization against SARS-CoV-2 Variants of Concern by Early Pandemic Sera. J Virol. 2021;95(14):e0040421. doi:10.1128/JVI.00404-21

He X, Chandrashekar A, Zahn R, Wegmann F, Yu J, Mercado NB, McMahan K, Martinot AJ, Piedra-Mora C, Beecy S, Ducat S, Chamanza R, Huber SR, van Heerden M, van der Fits L, Borducchi EN, Lifton M, Liu J, Nampanya F, Patel S, Peter L, Tostanoski LH, Pessaint L, Van Ry A, Finneyfrock B, Velasco J, Teow E, Brown R, Cook A, Andersen H, Lewis MG, Schuitemaker H, Barouch DH. Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques. Cell. 2021;184(13):3467-3473.e11. doi:10.1016/j.cell.2021.05.040

Collier AY, McMahan K, Yu J, et al. Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women. JAMA. 2021;325(23):2370-2380. doi:10.1001/jama.2021.7563

Yu J, Li Z, He X, et al. Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays. J Virol. 2021;95(11):e00044-21. doi:10.1128/JVI.00044-21

Jacob-Dolan C, Feldman J, McMahan K, Yu J, Zahn R, Wegmann F, Schuitemaker H, Schmidt AG, Barouch DH. Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques following SARS-CoV-2 Vaccination and Infection. J Virol. 2021;95(11):e00117-21. doi:10.1128/JVI.00117-21

Stephenson KE, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Truyers C, Atyeo C, Loos C, Chandrashekar A, McMahan K, Tostanoski LH, Yu J, Gebre MS, Jacob-Dolan C, Li Z, Patel S, Peter L, Liu J, Borducchi EN, Nkolola JP, Souza M, Tan CS, Zash R, Julg B, Nathavitharana RR, Shapiro RL, Azim AA, Alonso CD, Jaegle K, Ansel JL, Kanjilal DG, Guiney CJ, Bradshaw C, Tyler A, Makoni T, Yanosick KE, Seaman MS, Lauffenburger DA, Alter G, Struyf F, Douoguih M, Van Hoof J, Schuitemaker H, Barouch DH. Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19. JAMA. 2021;325(15):1535-1544. doi:10.1001/jama.2021.3645

Yu KK, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko N, Choi RY, Wald A, Barouch DH, Koelle DM, Lauffenburger D, Chu HY, Alter G, Seshadri C. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2. JCI Insight. 2021;6(6):e146242. Published 2021 Mar 22. doi:10.1172/jci.insight.146242

McMahan K*, Yu J*, Mercado NB*, Loos C*, Tostanoski LH*, Chandrashekar A*, Liu J*, Peter L*, Atyeo C, Zhu A, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Li Z, Nampanya F, Patel S, Pessaint L, Van Ry A, Blade K, Yalley-Ogunro J, Cabus M, Brown R, Cook A, Teow E, Andersen H, Lewis MG, Lauffenburger DA, Alter G, Barouch DH. Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature. 2021;590(7847):630-634. doi:10.1038/s41586-020-03041-6

Bartsch YC*, Fischinger S*, Siddiqui SM*, Chen Z, Yu J, Gebre M, Atyeo C, Gorman MJ, Zhu AL, Kang J, Burke JS, Slein M, Gluck MJ, Beger S, Hu Y, Rhee J, Petersen E, Mormann B, Aubin MS, Hasdianda MA, Jambaulikar G, Boyer EW, Sabeti PC, Barouch DH, Julg BD, Musk ER, Menon AS, Lauffenburger DA, Nilles EJ, Alter G. Discrete SARS-CoV-2 antibody titers track with functional humoral stability. Nat Commun. 2021;12(1):1018. Published 2021 Feb 15. doi:10.1038/s41467-021-21336-8

2020

Martinot AJ, Blass E, Yu J, et al. Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice. PLoS Pathog. 2020;16(12):e1009096. Published 2020 Dec 14. doi:10.1371/journal.ppat.1009096

Zohar T, Loos C, Fischinger S, Atyeo C, Wang C, Slein MD, Burke J, Yu J, Feldman J, Hauser BM, Caradonna T, Schmidt AG, Cai Y, Streeck H, Ryan ET, Barouch DH, Charles RC, Lauffenburger DA, Alter G. Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality. Cell. 2020;183(6):1508-1519.e12. doi:10.1016/j.cell.2020.10.052

Tostanoski LH*, Wegmann F*, Martinot AJ*, Loos C*, McMahan K*, Mercado NB*, Yu J*, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, Ali V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nat Med. 2020;26(11):1694-1700. doi:10.1038/s41591-020-1070-6

Mercado NB*, Zahn R*, Wegmann F*, Loos C*, Chandrashekar A*, Yu J*, Liu J*, Peter L*, McMahan K*, Tostanoski LH*, He X*, Martinez DR*, Rutten L, Bos R, van Manen D, Vellinga J, Custers J, Langedijk JP, Kwaks T, Bakkers MJG, Zuijdgeest D, Rosendahl Huber SK, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Hoffman E, Jacob-Dolan C, Kirilova M, Li Z, Lin Z, Mahrokhian SH, Maxfield LF, Nampanya F, Nityanandam R, Nkolola JP, Patel S, Ventura JD, Verrington K, Wan H, Pessaint L, Van Ry A, Blade K, Strasbaugh A, Cabus M, Brown R, Cook A, Zouantchangadou S, Teow E, Andersen H, Lewis MG, Cai Y, Chen B, Schmidt AG, Reeves RK, Baric RS, Lauffenburger DA, Alter G, Stoffels P, Mammen M, Van Hoof J, Schuitemaker H, Barouch DH. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. 2020;586(7830):583-588. doi:10.1038/s41586-020-2607-z

Iyer AS*, Jones FK*, Nodoushani A*, Kelly M, Becker M, Slater D, Mills R, Teng E, Kamruzzaman M, Garcia-Beltran WF, Astudillo M, Yang D, Miller TE, Oliver E, Fischinger S, Atyeo C, Iafrate AJ, Calderwood SB, Lauer SA, Yu J, Li Z, Feldman J, Hauser BM, Caradonna TM, Branda JA, Turbett SE, LaRocque RC, Mellon G, Barouch DH, Schmidt AG, Azman AS, Alter G, Ryan ET, Harris JB^#, Charles RC^#. Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients. Sci Immunol. 2020;5(52):eabe0367. doi:10.1126/sciimmunol.abe0367

Atyeo C, Fischinger S, Zohar T, Slein MD, Burke J, Loos C, McCulloch DJ, Newman KL, Wolf C, Yu J, Shuey K, Feldman J, Hauser BM, Caradonna T, Schmidt AG, Suscovich TJ, Linde C, Cai Y, Barouch D, Ryan ET, Charles RC, Lauffenburger D, Chu H, Alter G. Distinct Early Serological Signatures Track with SARS-CoV-2 Survival. Immunity. 2020;53(3):524-532.e4. doi:10.1016/j.immuni.2020.07.020

Dagotto G, Yu J, Barouch DH. Approaches and Challenges in SARS-CoV-2 Vaccine Development. Cell Host Microbe. 2020;28(3):364-370. doi:10.1016/j.chom.2020.08.002

Li A, Xue M, Attia Z, Yu J, Lu M, Shan C, Liang X, Gao TZ, Shi PY, Peeples ME, Boyaka PN, Liu SL, Li J. Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection. J Virol. 2020;94(17):e00048-20. Published 2020 Aug 17. doi:10.1128/JVI.00048-20

Yu J*, Tostanoski LH*, Peter L*, Mercado NB*, McMahan K*, Mahrokhian SH*, Nkolola JP*, Liu J*, Li Z*, Chandrashekar A*, Martinez DR, Loos C, Atyeo C, Fischinger S, Burke JS, Slein MD, Chen Y, Zuiani A, Lelis FJN, Travers M, Habibi S, Pessaint L, Van Ry A, Blade K, Brown R, Cook A, Finneyfrock B, Dodson A, Teow E, Velasco J, Zahn R, Wegmann F, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kirilova M, Kordana N, Lin Z, Maxfield LF, Nampanya F, Nityanandam R, Ventura JD, Wan H, Cai Y, Chen B, Schmidt AG, Wesemann DR, Baric RS, Alter G, Andersen H, Lewis MG, Barouch DH. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020;369(6505):806-811. doi:10.1126/science.abc6284

Chandrashekar A*, Liu J*, Martinot AJ*, McMahan K*, Mercado NB*, Peter L*, Tostanoski LH*, Yu J*, Maliga Z, Nekorchuk M, Busman-Sahay K, Terry M, Wrijil LM, Ducat S, Martinez DR, Atyeo C, Fischinger S, Burke JS, Slein MD, Pessaint L, Van Ry A, Greenhouse J, Taylor T, Blade K, Cook A, Finneyfrock B, Brown R, Teow E, Velasco J, Zahn R, Wegmann F, Abbink P, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kordana N, Li Z, Lifton MA, Mahrokhian SH, Maxfield LF, Nityanandam R, Nkolola JP, Schmidt AG, Miller AD, Baric RS, Alter G, Sorger PK, Estes JD, Andersen H, Lewis MG, Barouch DH. SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Science. 2020;369(6505):812-817. doi:10.1126/science.abc4776

2019

Yu J, Murthy V, Liu SL. Relating GPI-Anchored Ly6 Proteins uPAR and CD59 to Viral Infection. Viruses. 2019;11(11):1060. Published 2019 Nov 14. doi:10.3390/v11111060

Yu J, Liu SL. Emerging Role of LY6E in Virus–Host Interactions. Viruses. 2019;11(11):1020. Published 2019 Nov 3. doi:10.3390/v11111020

Lu W*, Chen S*, Yu J, et al. The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association. J Virol. 2019;93(7):e02128-18. Published 2019 Mar 21. doi:10.1128/JVI.02128-18

Yu J, Liang C, Liu SL. CD4-Dependent Modulation of HIV-1 Entry by LY6E. J Virol. 2019;93(7):e01866-18. Published 2019 Mar 21. doi:10.1128/JVI.01866-18

Li M, Waheed AA, Yu J, et al. TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins. Proc Natl Acad Sci U S A. 2019;116(12):5705-5714. doi:10.1073/pnas.1819475116

Before 2019

Yu J, Liu SL. The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage. Viruses. 2018;10(8):413. Published 2018 Aug 7. doi:10.3390/v10080413

Li A, Yu J, Lu M, et al. A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein. Nat Commun. 2018;9(1):3067. Published 2018 Aug 3. doi:10.1038/s41467-018-05276-4

Miller AD, De Las Heras M, Yu J, et al. Evidence against a role for jaagsiekte sheep retrovirus in human lung cancer. Retrovirology. 2017;14(1):3. Published 2017 Jan 20. doi:10.1186/s12977-017-0329-6

Wang Y, Pan Q, Ding S, Wang Z, Yu J, Finzi A, Liu SL, Liang C. The V3 Loop of HIV-1 Env Determines Viral Susceptibility to IFITM3 Impairment of Viral Infectivity. J Virol. 2017;91(7):e02441-16. Published 2017 Mar 13. doi:10.1128/JVI.02441-16

Yu J, Liang C, Liu SL. Interferon-inducible LY6E Protein Promotes HIV-1 Infection. J Biol Chem. 2017;292(11):4674-4685. doi:10.1074/jbc.M116.755819

Wilkins J, Zheng YM, Yu J, Liang C, Liu SL. Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV. PLoS One. 2016;11(6):e0156739. Published 2016 Jun 3. doi:10.1371/journal.pone.0156739

Yu J, Li M, Wilkins J, et al. IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein. Cell Rep. 2015;13(1):145-156. doi:10.1016/j.celrep.2015.08.055