发表论文
1. Yang Y,Zhang B,Yu Z.An immunotherapeutic hydrogel booster inhibits tumor recurrence and promotes wound healing for postoperative management of melanoma.Bioactive Materials.2024;doi:10.1016/j.bioactmat.2024.08.028（IF:18,SCI一区）
2．Wu Z,Chen K,Mo W,Wang Y,Lin X,Lan Z,Mo C,Wang H,Li X,Fan X,Chen H,Shu Z,Wang S*,Yu Z*,Cui C*.Multimodal enhancement of ferroptosis for synergistic cascade colorectal cancer therapy.Chemical Engineering Journal.2024;doi:10.1016/j.cej.2024.155048（IF:13.3,SCI一区）
3. Zhang W,Chen G,Chen Z, Yang X,Zhang B,Wang S,Li Z,Yang Y,Wu Y*,Liu Z*,Yu Z*.Mitochondria-targeted polyprodrug nanoparticles induce mitochondrial stress for immunogenic chemo-photodynamic therapy of ovarian cancer.JCR.2024;doi:10.1016/j.jconrel.2024.06.014（IF:10.5,SCI一区）
4．Chen G,Lin L,Mai Z,Tang Y,Zhang Q,Chen G,Li Z,Zhang J,Wang Y*,Yang Y*,Yu Z*.Carrier-Free Photodynamic Bioregulators Inhibiting Lactic Acid Efflux Combined with Immune Checkpoint Blockade for Triple-Negative Breast Cancer Immunotherapy.ACS Nano.2024;doi:10.1021/acsnano.4c07213(IF:15.8,SCI一区）
5．Zhong M,Liang P,Feng Z,Yang X,Li G,Sun R,He L,Tan J,Xiao Y,Yu Z*,Yi M*,Wang X*.A nanocomposite competent to overcome cascade drug resistance in ovarian cancer via mitochondria dysfunction and NO gas synergistic therapy.Asian J Pharm Sci.2023;doi:10.1016/j.ajps.2023.100872（IF:10.7,SCI一区）
6．Fu H,Liang P,Chen Q,Wang Y,Li G,Cai X,Wang S,Chen K,Shi S*,Yu Z*.Wang X*.COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach.Chin. Chem. Lett.2023;doi:10.1016/j.cclet.2023.109241（IF:9.4,SCI一区）
7．Wang Y,Zhang B,Xi Q,Chen C,Wang Z,Li F,Wang S,Yang W,Liang X,Yu Z*,Yu M*.Gemcitabine nano-prodrug reprograms intratumoral metabolism and alleviates immunosuppression for hepatocellular carcinoma therapy.Nano Today.2023;doi:10.1016/j.nantod.2023.102009(1F:13.2,SCI一区）
8．Zhang B,Lin L,Mao J,Mo W,Li Z,Wang S,Tang Y,Cui C*,Wu Y*,Yu Z*.Self-oxygenated co-assembled biomimetic nanoplatform for enhanced photodynamic therapy in hypoxic tumor.Chin. Chem. Lett.2023;doi:10.1016/j.cclet.2023.108518（IF:9.4,SCI一区）
9．Ma W, Sun R, Tang L, Z Li, L Lin, Z Mai, G Chen,Yu Z*. Bioactivable STING nanoagonists to synergize Nir-Ii mild photothermal therapy primed robust and long-term anticancer immunity (published online ahead of print). Adv Mater. 2023; e2303149. doi:10.1002/adma.202303149. (IF:29.4, SCI 一区)
10．Feng, Z, Chen, G, Zhong, M, Lin, L, Mai, Z, Tang, Y, Chen, G, Li, G, Yang, Y*, Yu Z*, Yu, M*. An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway. Biomaterials, 2023: 122333. (IF:14, SCI 一区)
11．Zhang B, Wang Y, Wang S, Tang Y, Li Z, Lin L, Wu Y*, Yu Z*. Precise RNA editing: cascade self-uncloaking dual-prodrug nanoassemblies based on CRISPR/Cas13a for pleiotropic immunotherapy of PD-L1-resistant colorectal cancer. Advanced Functional Materials, 2023: 2305630. (IF:19, SCI 一区)
12．Mai Z, Zhong J, Zhang J, Chen G, Tang Y, Ma W, Li G, Feng Z, Li F, Liang XJ*, Yang Y*, Yu Z*. Carrier-free immunotherapeutic nano-booster with dual synergistic effects based on glutaminase inhibition combined with photodynamic therapy. ACS Nano. 2023,17, 2, 1583–1596. (IF:18.03，中科院 1 区)
13．Yang Y, Mai Z, Zhang Y, Yu Z, Li W, Zhang Y, Li F, Timashev P, Luan P, Luo D*, Liang XJ*, Yu Z*. A Cascade Targeted and Mitochondrion Dysfunctional Nanomedicine Capable of Overcoming Drug Resistance in Hepatocellular Carcinoma. ACS Nano. 2023, 17, 2, 1275–1286. (IF:18.03，中科院 1 区)
14．Zhang L, Chu C, Lin X, Sun R, Li Z, Chen S, Liu Y, Wu J*, Yu Z*, Liu X* Tunable Nanoparticles with Aggregation-Induced Emission Heater for Precise Synergistic Photothermal and Thermodynamic Oral Cancer Therapy of Patient-Derived Tumor Xenograft.. Adv Sci (Weinh). 2023, (17):e2205780. (IF:17.52，中科院1区，生物材料 TOP 期刊)
15．Li Y, Lin L, Xie J, Wei L, Xiong S, Yu K, Zhang B, Wang S, Li Z, Tang Y, Chen G, Li Z*, Yu Z*, Wang X*, ROS-Triggered Self-Assembled Nanoparticles Based on a Chemo-Sonodynamic Combinational Therapy Strategy for the Noninvasive Elimination of Hypoxic Tumors. ACS Appl Mater Interfaces. 2023 Mar 29;15(12):15893-15906. (IF:9.5，中科院 2 区, TOP 期刊)
16．Liu C, Fan L, Guan M, Zheng Q, Jin J, Kang X, Gao Z, Deng X, Shen Y, Chu G, Chen J, Yu Z*, Zhou L*, Wang Y*. A Redox Homeostasis Modulatory Hydrogel with GLRX3 Extracellular Vesicles Attenuates Disc Degeneration by Suppressing Nucleus Pulposus Cell Senescence. ACS Nano. 2023 Jul 25;17(14):13441-13460. (IF:18.03，中科院 1 区)
17．Yang Q, Su S, Liu S, Yang S, Xu J, Zhong Y, Yang Y, Tian L, Tan Z, Wang J, Yu Z*, Shi Z*, Liang F*, Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater. 2023; 26:194-215. (IF:16.874，中科院 1 区)
18．Ma Xiao, Liu Yangjia, Wu Hanmei, et al., Wang Zhenjie*, Yu Zhiqiang*, Wang Xuefeng*. Self-assembly nanoplatform of platinum (Ⅳ) prodrug for enhanced ovarian cancer therapy. Mater Today Bio. 2023;21:100698. doi:10.1016/j.mtbio.2023.100698
19．Yang Qinfeng, Su Shenghui, Liu Shencai, et al., Yu Zhiqiang*, Sun Zhanjun*, Liang Fangguo*. Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater. 2023;26:194-215. doi:10.1016/j.bioactmat.2023.02.024
20．Liang Fangguo, Yang Yusheng, Chen Yuyong, et al., Yu Zhiqiang*, Xie Peigen*, Ding Hong*, Yang Qinfeng*. Ropivacaine microsphere-loaded electroconductive nerve dressings for long-acting analgesia and functional recovery following diabetic peripheral nerve injury. Mater Today Bio. 2023;21:100712. doi:10.1016/j.mtbio.2023.100712
21．Liu Can, Fan Lei, Guan Ming, et al., Yu Zhiqiang*, Zhou Lei*, Wang Xue*. A Redox Homeostasis Modulatory Hydrogel with GLRX3+ Extracellular Vesicles Attenuates Disc Degeneration by Suppressing Nucleus Pulposus Cell Senescence. ACS Nano. 2023;17(14):13441-13460. doi:10.1021/acsnano.3c01713
22．Wang Shentao,Yu Kunyi, Yu Zhiyu, et al., Li zhongjun*, Zheng Yuhua*,Yu Zhiqiang*.Targeting self-enhanced ROS-responsive artesunatum prodrug nanoassembly potentiates gemcitabine activity by down-regulating CDA expression in cervical cancer. Chinese Chemical Letters. 2023;17(14):13441-13460. doi.org/10.1016/j.cclet.2023.108184
23．Zhao Zhiqiang, Luo Qin, Chu Shengjing, et al., Yu Zhiqiang, Xu Jijun*, Xu Weibing*, Yi Muhua*. Preparation and in vivo imaging of NIR-emissive carbonized polymer dots derived from biomass olive leaves with a quantum yield of 71.4. RSC Adv. 2023;13(22):15182-15189. doi:10.1039/d3ra01378b
24．Zhang Leitao, Chu Chengyan, Lin Xuefeng, et al., Wu jian*, Yu Zhiqiang*, Li Xiqiang*. Tunable Nanoparticles with Aggregation-Induced Emission Heater for Precise Synergistic Photothermal and Thermodynamic Oral Cancer Therapy of Patient-Derived Tumor Xenograft. Adv Sci. 2023;10(17):2205780. doi:10.1002/advs.202205780
25．Li Yibing, Lin Ling, Xie Jiashan, et al., Li zhongjun*, Yu Zhiqiang*, Wang Xuefeng*. ROS-Triggered Self-Assembled Nanoparticles Based on a Chemo-Sonodynamic Combinational Therapy Strategy for the Noninvasive Elimination of Hypoxic Tumors. ACS Appl Mater Interfaces. 2023;15(12):15893-15906. doi:10.1021/acsami.3c00990
26．Cai Xuzi, Shi Si, Chen Gui, et al., Cui Chunhui*, Yu Zhiqiang*, Wang Xuefeng*. Glutamine metabolism targeting liposomes for synergistic chemosensitization and starvation therapy in ovarian cancer. Acta Biomater. 2023;158:560-570. doi:10.1016/j.actbio.2022.12.052
27．Mai Ziyi, Zhong Jing, Zhang Jiasi, et al., Liang Xie-jie*, Yang Yuanyuan*, Yu Zhiqiang*. Carrier-Free Immunotherapeutic Nano-Booster with Dual Synergistic Effects Based on Glutaminase Inhibition Combined with Photodynamic Therapy. ACS Nano. 2023; published online ahead of print. doi:10.1021/acsnano.2c11037
28．Wang, Zhenjie, Yu, Ling, Wang, Yuehua, et al., Yu Zhiqiang*. Dynamic Adjust of Non-Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR-II Imaging Mediated Photothermal Therapy and Immunotherapy. Adv Sci. 2022;9(8), doi.org/10.1002/advs.202104793
29．Wang, Yuehua, Wang, Zhenjie, Jia, Fei, et al., Yu Zhiqiang*. CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment. Bioactive Materials, (2022), 17, 147-161, doi.org/10.1016/j.bioactmat.2022.01.003
30．Chen, Gui, Xu, Qing, Feng, Zhenzhen, et. al., Yu Zhiqiang*, Meng Yu*, Glutamine antagonist synergizes with electrodynamic therapy to induce tumor regression and systemic antitumor immunity, ACS Nano, 2022, 16, 1, 951–962., doi.org/10.1021/acsnano.1c08544
31. Sun Rui, Ma Wen, Ling Mingjian, Tang Chenhong, Zhong Min, Dai Jingyue, Zhu Meiyan, Cai Xuzi, Li Guang, Xu Qing, Tang Longguang, Yu Zhiqiang*, Zhenwei Peng, J Control Release, 350 (2022) 525–537., doi.org/10.1016/j.jconrel.2022.08.050
32. Xu, Qing, Chen, Gui, Chen, Guimei, et al., Yu Zhiqiang*. NO-dependent vasodilation and deep tumor penetration for cascade-amplified antitumor performance. J Control Release. 2022;347:389-99., doi.org/10.1016/j.jconrel.2022.05.022
33．Gong, Wanjun, Jiang, Lingdong, Zhu, Yanxia, Yu Zhiqiang*, et al. An Activity-Based Ratiometric Fluorescent Probe for In Vivo Real-Time Imaging of Hydrogen Molecules. Angew Chem Int Edit. 2022;61(9)., doi.org/10.1002/anie.202114594
34. Cai, Xuzi, Wang, Kang-Nan, Ma, Wen, Yu Zhiqiang*, et al. Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy. Journal of Nanobiotechnology. 2021;19(1)., doi.org/10.1186/s12951-021-01001-4
35. Ma, Wen, Chen, Qiling, Xu, Weiguo, et al., Yu Zhiqiang*. Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer. Nano Research. 2021;14(3):846-57., doi.org/10.1007/s12274-020-3124-y
36. Yang Yuanyuan, Liu Xin, Ma Wen, et al., Liang Xing-jie*, Yu Meng*, Yu Zhiqiang*. Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy. Biomaterials. 2021;265:120456. doi:10.1016/j.biomaterials.2020.120456
37. Yang, Yuanyuan, Yu, Yingjie, Chen, Hao, et al., Yu Zhiqiang*. Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging. Acs Nano. 2020;14(10):13536-47., dx.doi.org/10.1021/acsnano.0c05541
38. Longguang Tang, Zhantong Wang, Qingchun Mu, Zhiqiang Yu*, Orit Jacobson, Ling Li, Weijing Yang, Chunming Huang, Fei Kang, Wenpei Fan, Ying Ma, Maosheng Wang*, Zijian Zhou*, Xiaoyuan Chen*，Targeting Neutrophils for Enhanced Cancer Theranostics, Advanced Materials, 2020, 32 (33), 2002739, doi.org/10.1002/adma.202002739.
39. Li, Zibo, Xu, Qing, Lin, Xuefeng, Yu Zhiqiang*, et al. Integrating of lipophilic platinum(IV) prodrug into liposomes for cancer therapy on patient-derived xenograft model. Chinese Chemical Letters. 2022;33(4):1875-9. (IF:8.455，中科院1区)
40. Sun, Rui, Dai, Jingyue, Ling, Mingjian, Yu, Ling, Yu Zhiqiang*, Tang, Longguang*. Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine. Journal of Nanobiotechnology. 2022;20(1). (IF:9.429，中科院1区)
41. Li Guang, et al., Yu Zhiqiang*. Synergetic Delivery of Artesunate and Isosorbide 5-Mononitrate with Reduction-Sensitive Polymer Nanoparticles for Ovarian Cancer Chemotherapy, Journal of Nanobiotechnology, 2022. (IF:9.429，中科院1区)
42. Ling, Mingjian, Sun, Rui, Li, Guang, et al., Yu Zhiqiang*. NIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics. Nano Research. 2022;15(7):6288-96. (IF:10.269，中科院1区)
43. YuanYuan Yang etal, Xingjie Liang*, Meng Yu*, Zhiqiang Yu*, Photo-triggerable Liposomes for Repeatable and Adjustable Drug Delivery and Effective Cancer Therapy, Biomaterials, 2021, 265,120456（生物材料领域Top, IF 10.317, 中科院大小类一区）
44. Liu, Xin, Yang, Yuanyuan, Ling, Mingjian, Yu Zhiqiang*, et al. Near-Infrared II Light-Triggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors. Adv Funct Mater. 2021;31(24). (IF:18.836，中科院1区，生物材料TOP期刊)
45. Chen, Hongliang, Zheng, Donghui, Pan, Wenzhen, Yu Zhiqiang*, et al. Biomimetic Nanotheranostics Camouflaged with Cancer Cell Membranes Integrating Persistent Oxygen Supply and Homotypic Targeting for Hypoxic Tumor Elimination. Acs Applied Materials & Interfaces. 2021;13(17):19710-25. (IF:10.383，中科院1区)
46. Wang, Kang-Nan, Liu, Liu-Yi, Qi, Guobin, Yu Zhiqiang*, et al. Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation. Adv Sci. 2021;8(8). (IF:17.52，中科院1区，生物材料TOP期刊)
47. Yu, Ling, Wang, Zhenjie, Mo, Zhuomao, et al., Yu Zhiqiang*. Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy. Acta Pharm Sin B. 2021;11(7):2004-15. (IF:14.89，中科院1区，药学TOP期刊)
48. Liu, Xin, Meng, Fanyu, Sun, Rui, Wang, Kangnan, Yu, Zhiqiang*, Miao, Peng*. Three-dimensional bipedal DNA walker enabled logic gates responding to telomerase and miRNA. Chemical Communications. 2021;57(21):2629-32. (IF:6.065，中科院2区)
49. Gong, Wanjun, Luo, Jiabao, Zhou, Weiying, Yu Zhiqiang*, et al. Thermal-stable blue-red dual-emitting Na2Mg2Si6O15: Eu2+, Mn2+phosphor for plant growth lighting. Journal of Luminescence. 2021;239. (IF:4.171，中科院2区)
50. Xiao, Ya-Fang, An, Fei-Fei, Chen, Jia-Xiong, Yu Zhiqiang*, et al. The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics. Small. 2019;15(38). (IF:15.153，中科院1区)
51. Xiao YF, An FF*, Chen JX, Yu J, Tao WW, Yu Z*, Ting R, Lee CS, Zhang XH*, The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics, Small, 2019, 15(38)1903121. (IF:11.486 中科院大小类一区)
52. Peng Wu#, Xuefeng Wang#, Zigui Wang, Wen Ma, Jianjun Chen, Zhiqiang Yu*, Jizhen Li*, Dongfang Zhou*, Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for In Situ Dual-Drug Tracking and Combination Therapy, ACS Appl Mater Interfaces, 2019, 11(20), 18691-18700.（IF: 8.758 中科院大类一区）
53. Chen Q, Yang Y, Lin X, Ma W, Chen G, Li W, Wang X*, Yu Z*，Platinum(iv) prodrugs with long lipid chains for drug delivery and overcoming cisplatin resistance.. Chem Commun (Camb). 2018, 54(42):5369-5372
54. Yu Z, Schmaltz RM, Bozeman TC, Paul R, Rishel MJ, Tsosie KS, Hecht SM*. Selective tumor cell targeting by the disaccharide moiety of Bleomycin. J. Am. Chem. Soc, 2013, 135, 2883−2886
55. Gui Chen, Yuanyuan Yang, etal, Nan Li, Zhiqiang Yu *, Meng Yu*, Self-amplification of Tumor Oxidative Stress with Degradable Metallic Complexes for Synergistic Cascade Tumor Therapy, Nano Lett. 2020, 20(11), 8141–8150 (IF:11.34, 中科院大小类一区)
56. Yang, Yuanyuan, Yu, Yingjie, Chen, Hao, et al., Yu Zhiqiang*. Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging. Acs Nano. 2020;14(10):13536-47. (IF:18.03，中科院1区)
57. Sun, Yongbing, Ke, Yu, Li, Chunshi, et al., Yu Zhiqiang*. Bifunctional and Unusual Amino Acid beta- or gamma-Ester Prodrugs of Nucleoside Analogues for Improved Affinity to ATB(0,+) and Enhanced Metabolic Stability: An Application to Floxuridine. J Med Chem. 2020;63(19):10816-28. (IF:8.039，中科院1区，药物化学TOP期刊)
58. He, Mengxue, Yu, Ling, Yang, Yuanyuan, Yu Zhiqiang*, et al. Delivery of triptolide with reduction-sensitive polymer nanoparticles for liver cancer therapy on patient-derived xenografts models. Chinese Chemical Letters. 2020;31(12):3178-82. (IF:8.455，中科院1区)
59. Yu, Ling, He, Ping, Xu, Yuchun, Yu Zhiqiang*, et al. Manipulations of DNA four-way junction architecture and DNA modified Fe3O4@Au nanomaterials for the detection of miRNA. Sensors and Actuators B-Chemical. 2020;313. (IF:9.221，中科院1区)
60. Wang, Kangnan, Ma, Wen, Xu, Yuchun, et al., Yu Zhiqiang*. Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications. Chinese Chemical Letters. 2020;31(12):3149-52. (IF:8.455，中科院1区)
主持课题
1. 国家自然科学基金面上项目(81541086) 基于细胞表面和线粒体双重靶向的阿霉素新型载药体系构建及肿瘤耐药逆转的研究（2016,01-2016,12） 主持
2. 国家自然科学基金面上项目(81773642) 多层次双细胞器靶向的新型顺铂载药体系构建及耐药研究（2018,01-2021,12） 主持
3. 国家自然科学基金面上项目（52073139） 近红外二区响应性高分子纳米复合材料的构建及其性能研究（2021,01-2024,12） 主持
4. 广东省粤港联合创新基金(2017A050506016)项目共同主持光控纳米颗粒诱发细胞自噬及其在肿瘤靶向治疗中的应用研究 (2017,01-2019,12) 共同主持
5. 广东省自然科学基金面上项目 抗癌新药斑铂载药体系构建及抗耐药机制研究（2019,10-2022,09） 主持
6. 广东省自然资源厅项目 共同主持 海藻来源抗肿瘤环肽GLD规模化制备、作用机制及成药性研究（2020,01-2021,12） 共同主持
7. 高分子材料工程国家重点实验室（长春）科学基金， 高分子铂前药载药体系及抗顺铂耐药研究（2018,10-2021,09） 主持
