2024
49. Mangang Zhang, Hui Li, Keqin Wu, Nianxin Rong, Shaoquan Lin, Hua Yang* and Qin Yin*, Asymmetric Transfer Hydrogenation of Stable NH Imines for the Synthesis of Enantiopure α-Chiral Primary Amines. Chin. J. Chem. 2024, 42, 2211—2216.
48. Xiaohang Zhan,‡ Zhiwen Nie,‡ Na Li,‡ Ao Zhou, Haotian Lv, Mingrong Liang, Keqin Wu, Gui-Juan Cheng,* and Qin Yin*, Catalytic Asymmetric Cascade Dearomatization of Indoles via a Photoinduced Pd-Catalyzed 1,2-Bisfunctionalization of Butadienes. Angew. Chem. Int. Ed. 2024, e202404388. (‡ equal contribution) (Selected as "Very Important Paper" paper by ANGEW)
47. Nianxin Rong,‡ Ao Zhou,‡ Mingrong Liang, Shou-Guo Wang, and Qin Yin*, Asymmetric Hydrogenation of Racemic 2-Substituted Indoles via Dynamic Kinetic Resolution: An Easy Access to Chiral Indolines Bearing Vicinal Stereogenic Centers. J. Am. Chem. Soc. 2024, 146, 5081–5087. (‡ equal contribution) (Highlighted by Chin. J. Org. Chem. 2024, 44, 1374.; Synfacts 2024; 20(06): 0604)
46. Juanjuan Wang, Mu-Peng Luo, Yi-Jie Gu, Yu-Ying Liu, Qin Yin, and Shou-Guo Wang*, Chiral CpxRhodium(III)-Catalyzed Enantioselective Aziridination of Unactivated Terminal Alkenes. Angew. Chem. Int. Ed. 2024, e202400502.
2023
45. Lei Xu,‡ Gang Wang,‡ Nianxin Rong, Yang Gu, Le’an Hu, Hengzhi You,* and Qin Yin*, Enantioselective and Step-Economic Synthesis of the Chiral Amine Fragment in the Tyrosine Kinase Inhibitor Repotrectinib by Direct Asymmetric Reductive Amination under Batch and Flow. Org. Process Res. Dev. 2023, DOI: 10.1021/acs.oprd.3c00152. (‡ equal contribution)
44. Yingying Tian, Yu-Yi Zhu, Jianchao Yu, Dong-Huang Liu, Qin Yin, Shao-Fei Ni, Shao-Tao Bai and Xumu Zhang*, Iridium-Catalyzed Asymmetric Hydrogenation of Tetrasubstituted Exocyclic Olefins: An Efficient Access to Dexmethylphenidate. CCS Chem. 2023, DOI: 10.31635/ccschem.023.202202601.
43. Ke-Qin Wu, Hui Li, Ao Zhou, Wei-Ran Yang,* Qin Yin*, Palladium-Catalyzed Chemo- and Regioselective C−H Bond Functionalization of Phenols with 1,3-Dienes. J. Org. Chem. 2023, 88, 2599−2604.
https://pubs.acs.org/doi/10.1021/acs.joc.2c02697?ref=PDF
42. Yongjie Shi, Nianxin Rong, Xumu Zhang*, Qin Yin*, Synthesis of Chiral Primary Amines via Enantioselective Reductive Amination: from Academy to Industry. Synthesis 2023, 55, 1053-1068. (Invited Review)
https://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2002-5733.pdf
2022
41. Zengjin Dai, Xumu Zhang*, Qin Yin*, Advances on Asymmetric Reductive Amination with Ammonium Salts as Amine Sources, <<铵盐为胺源的不对称还原胺化反应研究进展>>，Chin. J. Org. Chem. 2022, 42, 2261-2274. (Invited Account, Cover picture)
http://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202203058
(Selected as "VIP" paper by ANGEW, and highlighted as Frontispiece)
(Highlighted by Synfacts, 2022, DOI: 10.1055/s-0041-1737625.) 获得Wiley年度前Top10% 高下载量
39. Congcong Yin †, Yingmin Pan †, Xumu Zhang* and Qin Yin*, Catalytic Asymmetric Hydrogenation of Tetrasubstituted Unsaturated Lactams: An Efficient Approach to Enantioenriched 3,4-Disubstituted Piperidines, Org. Lett. 2022, 24, 675. (Featured in Org. Chem. Highlights)
https://pubs.acs.org/doi/full/10.1021/acs.orglett.1c04132
38. Yongjie Shi; Jingxin Wang; Feifan Yang; Chenhan Wang; Xumu Zhang*; Pauline Chiu; and Qin Yin*, Direct asymmetric reductive amination of a-keto acetals: a platform for synthesizing diverse afunctionalized amines, Chem. Commun., 2022, 58, 513-516. https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc06601c/unauth
2021
37. Zengjin Dai, Ying-Min Pan, Shou-Guo Wang, Xumu Zhang,* and Qin Yin*, Direct Reductive Amination of Ketones with Ammonium Salt Catalysed by Cp*Ir(III) Complexes Bearing an Amidato Ligand, Org. Biomol. Chem., 2021, 19, 8934-8939.
https://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01710A
36. Yingying Tian,+ Le’an Hu,+ Yuan-Zheng Wang, Xumu Zhang* and Qin Yin*, Recent advances on transition-metal-catalysed asymmetric reductive amination, Org. Chem. Front, 2021, 8, 2328-2342. https://pubs.rsc.org/en/content/articlelanding/2021/qo/d1qo00300c#!divAbstrac
35. Yongjie Shi, Jingxin Wang, Qin Yin, Xumu Zhang*, and Pauline Chiu*, Copper-Catalyzed Enantioselective 1,2-Reduction of Cycloalkenones. Org. Lett. 2021, 23, 15, 5658–5663. https://pubs.acs.org/doi/10.1021/acs.orglett.1c01744
2020
34. Yao Zhang, Yun-Qi Liu, Le’an Hu, Xumu Zhang,* and Qin Yin*, Asymmetric Reductive Amination/Ring-Closing Cascade: Direct Synthesis of Enantioenriched Biaryl-Bridged NH Lactams, Org. Lett. 2020, 22, 6479–6483. https://pubs.acs.org/doi/abs/10.1021/acs.orglett.0c02282?
33. Qin Yin*; Yong-Jie Shi; Jingxin Wang; Xumu Zhang*, Direct Catalytic Asymmetric Synthesis of α-Chiral Primary Amines, Chem. Soc. Rev., 2020, 49,6141-6153.https://pubs.rsc.org/en/content/articlelanding/2020/CS/C9CS00921C#!divAbstract
32. Yongjie Shi,+ Xuefeng Tan,+ Shuang Gao,+ Yao Zhang, Jingxin Wang, Xumu Zhang, and Qin Yin*, Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters, Org. Lett. 2020, 22, 2707−2713. (IF 6.091, 2020-03-19)
(Highlighted by Org. Process Res. Dev. 2020, 24, 2394−2406.and 2020, 24, 885−896). https://pubs.acs.org/doi/10.1021/acs.orglett.0c00669
31. Le’ an Hu, Yao Zhang, Qing-Wen Zhang, Qin Yin,* and Xumu Zhang, Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2, Angew. Chem. Int. Ed. 2020, 59, 5321-5325. (Highlighted by Chin. J. Org. Chem. 2020, 40, 1802) https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915459
30. Gen-Qiang Chen*; Jia-Ming Huang; Bi-Jin Lin; Chuan Shi; Ling-Yu Zhao; Bao-De Ma; Xiao-Bing Ding; Qin Yin; Xumu Zhang*, Highly Enantioselective Hydrogenation of tetra- and tri-Substituted α,β-Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands, CCS Chem. 2020, 2, 468–477.
2019
29. Le’an Hu, Yao Zhang, Gen-Qiang Chen, Bi-Jin Lin, Qing-Wen Zhang,* Qin Yin,*and Xumu Zhang*, CuH-Catalyzed Atropoenantioselective Reduction of Bringmann’s Lactones via Dynamic Kinetic Resolution, Org. Lett. 2019, 21, 5575-5580. https://pubs.acs.org/doi/10.1021/acs.orglett.9b01907
28.Tao Yang, Xiaochong Guo, Qin Yin* and Xumu Zhang*, Intramolecular Asymmetric Reductive Amination: Synthesis of Enantioenriched Dibenz[c,e]azepines, Chem. Sci. 2019, 10, 2473-2477. https://pubs.rsc.org/en/content/articlelanding/2019/SC/C8SC04482A#!divAbstract
2018
27. Yazhou Lou, Yutao Hu, Jiaxiang Lu, Fanfu Guan, Gelin Gong, Qin Yin*, Xumu Zhang*, Dynamic Kinetic Asymmetric Reductive Amination: Synthesis of Chiral Primary β-amino Lactams, Angew. Chem. Int. Ed. 2018, 57, 14193-14197. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201809719
26. Gen-Qiang Chen, Bi-Jin Lin, Jia-Ming Huang, Ling-Yu Zhao, Qi-Shu Chen, Shi-Peng Jia, Qin Yin* and Xumu Zhang*; Design and Synthesis of Chiral oxa-Spirocyclic Ligands for Ir-Catalyzed Direct Asymmetric Reduction of Bringmann’s Lactones with Molecular H2. J. Am. Chem. Soc. 2018, 140, 8064–8068. (Highlighted by Synfacts 2018, 14, 1050.) https://pubs.acs.org/doi/10.1021/jacs.8b03642
25. Qiwei Lang, Guoxian Gu, Yaoti Cheng, Qin Yin* and Xumu Zhang*; Highly Enantioselective Synthesis of Chiral γ-Lactams by Rh-Catalyzed Asymmetric Hydrogenation. ACS Catal. 2018, 8, 4824−4828. (Highlighted by Synfacts 2018, 14, 0832.) https://pubs.acs.org/doi/10.1021/acscatal.8b00827
24. Xuefeng Tan, Shuang Gao, Weijun Zeng, Shan Xin, Qin Yin* and Xumu Zhang*; Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H2. J. Am. Chem. Soc. 2018, 140, 2024–2027. (Highlighted by Synfacts 2018, 14, 0504. and Org. Process Res. Dev. 2018, 22, 421−429.) https://pubs.acs.org/doi/10.1021/jacs.7b12898
23. Guoxian Gu, Jiaxiang Lu, Ouran Yu, Jialin Wen,* Qin Yin* and Xumu Zhang*; Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of α‑Substituted β‑Ketoesters via Dynamic Kinetic Resolution. Org. Lett. 2018, 20, 1888−1892. https://pubs.acs.org/doi/10.1021/acs.orglett.8b00433
22. Tao Yang, Qin Yin, Guoxian Gu and Xumu Zhang *, A one-pot process for the enantioselective synthesis of tetrahydroquinolines and tetrahydroisoquinolines via asymmetric reductive amination (ARA), Chem. Commun., 2018, 54, 7247. (IF 5.996)
Before 2018 (Supervised work)
21. Qin Yin, Hendrik F. T. Klare*, and Martin Oestreich*; Catalytic Friedel–Crafts C–H Borylation of Electron-Rich Arenes: Dramatic Rate Acceleration by Added Alkenes. Angew. Chem. Int. Ed. 2017, 56, 3712–3717. （Highlighted in SYNFACTS 2017, 13, 529. and Org. Process Res. Dev. 2017, 21, 675–688.）
20. Qin Yin* and M. Oestreich*; Photocatalysis Enabling Acceptorless Dehydrogenation of Benzofused Saturated Rings at Room Temperature, Angew. Chem. Int. Ed. 2017, 56, 7716–7718.
19. Qin Yin, Hendrik F. T. Klare, and Martin Oestreich*; Friedel‒Crafts-type Intermolecular C–H Silylation of Electron-Rich Arenes Initiated by Base Metal Salts. Angew. Chem. Int. Ed. 2016, 55, 3204–3207.
18. Qin Yin, Shou-Guo Wang, Xiao-Wei Liang, De-Wei Gao, Jun Zheng and Shu-Li You*; Organocatalytic Asymmetric Chlorinative Dearomatization of Naphthols. Chem. Sci. 2015, 6, 4179–4183.
17. Qin Yin and Shu-Li You*; Chiral Phosphoric Acid-Catalysed Friedel–Crafts Alkylation Reaction of Indoles with Racemic Spiro Indolin-3-ones. Chem. Sci. 2011, 2, 1344–1348.
16. Qin Yin, Yashar Soltani, Rebecca Melen,* and Martin Oestreich*; BArF3-Catalyzed Imine Hydroboration with Pinacolborane Not Requiring the Assistance of an Additional Lewis Base. Organometallics 2017,36, 2381–2384. (Top 2 most accessed paper in July, 2017.)
15. Qin Yin, Sebastian Kemper, Hendrik F. T. Klare, and Martin Oestreich*, Boron Lewis Acid-Catalyzed Hydroboration of Alkenes with Pinacolborane: BArF3 Does What B(C6F5)3 Cannot Do! Chem. Eur. J. 2016, 22, 13840–13844.
14. Qin Yin and Shu-Li You*; Asymmetric Chlorocyclization of Indole-3-yl-benzamides for the Construction of Fused-indolines. Org. Lett. 2014, 16, 2426–2429.
13. Qin Yin and Shu-Li You*; Asymmetric Chlorination/Ring Expansion for the Synthesis of α-Quaternary Cycloalkanones. Org. Lett. 2014, 16, 1810–1813.
12. Qin Yin and Shu-Li You*; Enantioselective Chlorocyclization of Indole Derived Benzamides for the Synthesis of Spiro-indolines. Org. Lett. 2013, 15, 4266–4269.
11. Qin Yin, Shou-Guo Wang and Shu-Li You*; Asymmetric Synthesis of Tetrahydro-β-carbolines via Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation Reaction. Org. Lett. 2013, 15, 2688-2691.
10. Qin Yin and Shu-Li You*; Intramolecular Alkene Electrophilic Bromination Initiated ipso-Bromocyclization for the Synthesis of Functionalized Azaspirocyclohexadienones. Org. Lett. 2012, 14, 3526–3529.
9. Shou-Guo Wang, Qin Yin, Chun-Xiang Zhuo, Shu-Li You*; Asymmetric Dearomatization of β-Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid. Angew. Chem. Int. Ed. 2015, 54, 647–650.
8. Chuan Liu, Qin Yin, Li-Xin Dai, Shu-Li You*; Synthesis of Pyrroloindolines and Furoindolines via Cascade Dearomatization of Indole Derivatives with Carbenium Ion. Chem. Commun. 2015, 51, 5971–5974.
7. De-He Duan; Qin Yin; Shou-Guo Wang and Shu-Li You*; Chiral Phosphoric Acid-Catalyzed Asymmetric Cascade Reaction of C(3) Substituted Indoles and Methyl Vinyl Ketone. Acta Chim. Sinica 2014, 72, 1001–1004.
6. De-Wei Gao, Qin Yin, Qing Gu* and Shu-Li You*; Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C-H Bond Arylation. J. Am. Chem. Soc. 2014, 136, 4841–4844.
5. Yan-Chao Shi, Shou-Guo Wang, Qin Yin and Shu-Li You*; N-Alkylation of Indole via Ring-closing Metathesis/Isomerization/Mannich Cascade under Ruthenium/Chiral Phosphoric Acid Sequential Catalysis. Org. Chem. Front. 2014, 1, 39–42.
4. Quan Cai, Qin Yin and Shu-Li You*; Chiral-Amine-Catalyzed Asymmetric Bromocyclization of Tryptamine Derivatives. Asian J. Org. Chem. 2013, 3, 408–411.
3. Qin Yin and Shu-Li You*; Synthesis by Addition to π-Type C-C Bonds (Update), Science of Synthesis, 2014.( Book chapter)
2. Bo-Xiao Tang, Qin Yin, Ri-Yuan Tang and Jin-Heng Li*; Electrophilic ipso-Cyclization of N-(p-Methoxyaryl)propiolamides Involving an Electrophile-Exchange Process. J. Org. Chem. 2008, 73, 9008–9011.
1. Quan-Fu Yu, Yue-Hua Zhang, Qin Yin, Bo-Xiao Tang, Ri-Yuan Tang, Ping Zhong and Jin-Heng Li*; Electrophilic ipso-Iodocyclization of N-(4-Methylphenyl)propiolamides: Selective Synthesis of 8-Methyleneazaspiro[4,5]trienes. J. Org. Chem. 2008, 73, 3658–3661.
Book Chapter
1. Qin Yin,* Xumu Zhang*, Industrial Applications of Asymmetric Reduction of C=C Bonds (Update). A Chapter in Comprehensive Chirality, 2nd edition, 2023. (Invited book chapter).
2. Qin Yin and Shu-Li You*; Synthesis by Addition to π-Type C-C Bonds (Update), Science of Synthesis, 2014.