科研项目：

1. 国家自然科学基金青年基金：基于多靶点调控神经元和小胶质细胞功能的中药骨碎补抗阿尔茨海默病物质基础及作用机制的研究(81803753),21万元，2019.1-2021.12,项目主持人

2. 湛江市科技发展专项资金：基于轴突再生的抗阿尔茨海默病药物太子参的物质基础、作用机制及其应用的研究(2018A01046),3万元，2018.9-2020.9,项目主持人
3. 广东省自然科学基金面上项目：基于轴突再生和神经免疫炎症的知母皂苷元抗帕金森病的研究(2020A1515010779),10万元，2019.10.1-2022.9.30,项目主持人
4. 深圳市协同创新科技计划国际合作研究项目: 最佳治疗、改善抑郁症和继发认知障碍omega-3不饱和脂肪酸配方的临床研究，60万元，2020.1.1-2021.12.31，主要完成人（排名第二）
5. 湛江市科技发展专项资金：DPA预防和缓解老年痴呆的作用及机制研究(2018A01045),3万元，2018.10.1-2020.9.30,参与（排名第四）
6. 深圳市大鹏新区产业发展专项资金项目：新一代预防和改善抑郁和痴呆海洋不饱和脂肪酸产品的研发及产业化关键技术研究(KY20180201),25万元，2018.12.20-2020.9.30,参与（排名第四）

发表论文:

1. Yang ZY, Jiang BH, Teng FK, Han N, Liu ZH, Zhou JJ, Wang Y, Guo DA, Yin J*. Ambiguanine A-G, hexahydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis, Phytochemistry, 105, 158-163, 2014.

2. Yang Z, Liu Z, Jiang B, Teng F, Wang Y, Han N, Guo D, Yin J*. Ambidalmines A-E and Ambidimerine F: bioactive dihydrobenzophenanthri- dine alkaloids from Corydalis ambigua var. amurensis, European Journal of Medicinal Chemistry, 84, 417-424, 2014.

3. Hu D, Yang Z, Yao X, Wang H, Han N, Liu Z, Wang Y, Yang J, Yin J*. Dibenzocyclooctadiene Lignans from Schisandra chinensis and Their Inhibitory Activity on NO Production in Lipopolysaccharide-Activated Microglia Cells, Phytochemistry, 104, 72–78, 2014.

4.  Yang ZY, Kuboyama T, Kazuma K, Konno K, Tohda C*. Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ25−35-Induced Axonal Atrophy. Journal of Natural Products, 78, 2297-2300, 2015.

5. Han N, Yang Z, Liu Z, Liu H, Yin J*. Research Progress on Natural Benzophenanthridine Alkaloids and their Pharmacological Functions: A Review, Natural product communications, 11 (8), 1181-1188, 2016.

6. Liu Z, Li Q, Chang S, Yang Z, Han N, Yin J*. Protective effect of hexahydrobenzo-[c]phenanthridine alkaloids isolated from Corydalis ambigua var. amurensis on myocardial ischemia-hypoxia cells, Phytochemistry Letters, 17, 258–262, 2016.

7. Yang Z, Kuboyama T, Tohda C*. A systematic strategy for discovering a therapeutic drug for Alzheimer’s disease and its target molecule, Frontiers in pharmacology, 8, 340, 2017.

8. Chang S, Yang Z, Han N, Liu Z, Yin J*. The antithrombotic, anticoagulant activity and toxicity research of ambinine, an alkaloid from the tuber of Corydalis ambigua var. amurensis, Regulatory Toxicology and Pharmacology, 95, 175-181, 2018.

9. Song C*, Wu YS, Yang ZY, Kalueff AV, Tsao YY, Dong Y, Su KP. Astrocyte-conditioned medium protects prefrontal cortical neurons from glutamate-induced cell death through inhibiting TNF-α expression. NeuroImmunoModulation, 26(1):33-42, 2019.

10. Yang Z, Kuboyama T*, Tohda C. Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression. Phytotherapy Research, 33 (4), 1114-1121, 2019.

11. Yang Z*, Liu B, Yang LE, Zhang C. Platycodigenin as Potential Drug Candidate for Alzheimer’s Disease via Modulating Microglial Polarization and Neurite Regeneration. Molecules, 24, 3207, 2019.

12. Wang H, Zhang C, Yang L, and Yang Z*. Hederagenin Modulates M1 Microglial Inflammatory Responses and Neurite Outgrowth. Natural product communications, 15 (8), 1-10, 2020.

13. Li K, Yan L, Zhang Y, Yang Z, Zhang C, Li Y, Kalueff AV, Li W, Song C*. Seahorse treatment improves depression-like behavior in mice exposed to CUMS through reducing inflammation/oxidants and restoring neurotransmitter and neurotrophin function. Journal of Ethnopharmacology, 250, 112487, 2020.

14. Peng Z, Zhang C, Yan L, Zhang Y, Yang Z, Wang J, Song C*. EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression. International Journal of Molecular Sciences, 21 (5), 1769, 2020.

15. Yan L, Gu MQ, Yang ZY, Xia J, Li P, Vasar E, Tian L, Song C*. Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice. Brain Behavior Immunity, 96: 143-153, 2021.

16. Li P, Zhang F, Li Y, Zhang C, Yang Z, Zhang Y, Song C*. Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway and suppressing microglia-induced apoptosis. Journal of Psychopharmacology, 35(10), 1285-1299, 2021.

17. Liu B, Zhang Y, Yang Z, Liu M, Zhang C, Zhao Y, Song C*. ω-3 DPA Protected Neurons from Neuroinflammation by Balancing Microglia M1/M2 Polarizations through Inhibiting NF-κB/MAPK p38 Signaling and Activating Neuron-BDNF-PI3K/AKT Pathways. Marine Drugs, 19(11), 587, 2021.

18. Yang Z*, Zhang C, Li X, Ma Z, Ge Y, Qian Z, Song C. Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, enhances cognitive function via neurite outgrowth and synaptic plasticity. Phytotherapy Research, 35(9), 5318-5329, 2021.

19. Ren Y, Li H, Piao X, Yang Z, Wang S, Ge Y*. Drug Affinity Responsive Target Stability (DARTS) Accelerated Small Molecules Target Discovery: Principles and Application. Biochemical Pharmacology, 194,114798, 2021.

20. Nie Y, Yang J, Zhou L, Yang Z, Liang J, Liu Y, Ma X, Qian Z, Hong P, Kalueff AV, Song C, Zhang Y*. Marine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish. J Neuroinflammation, 19(1):39, 2022.