代表性论文与著作
1. Yang, L.; Tu, W.; Huang, L.; Miao, B.; Kaneshige, A.; Jiang, W.; Leng, L.; Wang, M.; Wen, B.; Sun, D.; Wang, S.* “Discovery of SMD-3040 as a potent and selective SMARCA2 PROTAC degrader with strong in vivo antitumor activity” J. Med. Chem. 2023, 66, 10761–10781.
2. Yang, L.; Wurm, T.; Poudel, B. S.; Krische, M. J.* “Enantioselective Total Synthesis of Andrographolide and 14-Hydroxy-Colladonin: Carbonyl Reductive Coupling and trans-Decalin Formation via Hydrogen Transfer” Angew. Chem. Int. Ed. 2020, 59, 59, 23169–23173. (Very Important Paper)
3. Yang, L.#; Kong, L.#; Gu, Q.#; Shao, S.; Lin, G.-Q.; Hong, R.* “Stereoselective Access to Polypropionates Expedited by the Double Hydroboration of Allenes: Total Synthesis of Antitumor (−)-Pironetin” CCS Chem. 2020, 2, 769–779. (# Equal contribution)
4. Yang, L.; Hong, R.* “Integration of Novel Strategy and Methods: Total Synthesis of Antitumor Lasonolide A” in “Strategies and Tactics in Organic Synthesis” (Chapter 4) 2019, Vol. 14, pp 107–138.
5. Yang, L.; Lin, Z.-M.; Shao, S,-J.; Zhao, Q.; Hong, R.* “Enantioconvergent and Concise Synthesis of Lasonolide A” Angew. Chem. Int. Ed. 2018, 57, 16200–16204.
6. Yang, L.; Lin, Z.-M.; Huang, S.-H.*; Hong, R.* “Stereodivergent Synthesis of Functionalized Tetrahydropyrans Accelerated by Mechanism-Based Allylboration and Bioinspired Oxa-Michael Cyclization” Angew. Chem. Int. Ed. 2016, 55, 6280–6284.7. Yang, L.#; He, G.-L.#; Yin, R.-F.#; Zhu, L.-L.; Wang, X.-X.; Hong, R.* “Synthesis of Polyketide Stereoarrays Enabled by a Traceless Oxonia-Cope Rearrangement” Angew. Chem. Int. Ed. 2014, 53, 11600–11604. (Highlighted by Chin. J. Org. Chem.，# Equal contribution)
8. Yang, L.; Lin, Z.; Zheng, K.; Kong, L.; Hong, R.* “A Modular Synthesis of Antitumor Macrolide (–)-Lasonolide A” Chin. J. Chem. 2020, 38, 725–736.
专利成果
1. Shaomeng Wang; Lingying Leng; Wenbin Tu; Lin Yang; Mi Wang; Paul Kirchhoff; Guozhang Xu; Zhenwu Li; Jelena Tosovic; Jeanne Stuckey “COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 INHIBITORS AND USES THEREOF” WO/2024/064316.
2. Shaomeng Wang; Lingying Leng; Lin Yang; Wenbin Tu; Liyue Huang; Mi Wang; Wei Jiang; Paul Kirchhoff; Guozhang Xu; Zhenwu Li; E., Scott Priestley; Jelena Tosovic; Jeanne Stuckey “COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF” WO/2024/064328.
学术交流
2024，杨林，Development of Potent, Highly Selective and Efficacious SMARCA2 Degraders，第115届美国癌症研究协会(AACR)年会，美国圣地亚哥，口头邀请报告。
