本课题组以抗病毒、抗肿瘤等重大疾患治疗药物及医药活性中间体制备为目标，以“创新是灵魂，应用是归宿”为宗旨，针对传统有机合成途径存在的步骤繁琐、产率低、三废污染等技术瓶颈，致力于研发高效、环境友好的合成新方法。目前，本课题组采用可见光催化，水相合成等手段发展了一系列简单、高效、环保的药物合成新策略，制备了多样性取代的吲哚酮、喹喔啉酮、咪唑并吡啶、香豆素、螺环三烯酮、有机砜、氨基硫醚等一系列具有抗肿瘤等生物活性的药物中间体，取得了一批原创性的研究成果。

2024年度

1.  Guo, G.;  Ma, J.;  Dong, Y.; Wu, Q.; Lv, J.; Shi, Y.;* Yang, D.* Visible Light/Copper Catalysis-Enabled Arylation and Alkenylation of Phosphorothioates via Site-Selective C−H Thianthrenation. Org. Lett. 2024, 26, 8382.

2.  Wu, Q.; Li, X.; Ma, J.; Shi, Y.; Lv, J.; Yang, D.* Arylcyanation of Styrenes by Photoactive Electron Donor–Acceptor Complexes/Copper Catalysis. Org. Lett. 2024, 26, 7949.

3.  Ma, J.; Li, X.; Chen, Y.; Shi, Yong, Song, X.; Lv, J.; Yang, D.*  Annulation cascades of cyclosulfonium salts and alkenes towards sulfur-containing N-heterocycles by visible light/copper catalysis. Chin. J. Chem. 2024, 42, 1637.

4.  Xu, H.; Li, X.; Wang, Y.; Song, X.; Shi, Y.; Lv, J.; Yang, D.* Arylthianthrenium Salts as the Aryl Sources: Visible Light/Copper Catalysis-Enabled Intermolecular Azidosulfonylation of Alkenes. Org. Lett. 2024, 26, 1845. Highlighted by Synfacts, 2024, 20, 0490

5.  Liu, X.; Li, X.; Wang, L.; Shi, Y.; Lv, J.; Yang, D.*  Visible light/copper catalysis enabled Heck-like coupling between alkenes and cyclic sulfonium salts via selective C–S bond cleavage. Org. Chem. Front., 2024, 11, 2195.

6.  Guo, G.; Li, X.; Ma, J.; Shi, Y.; Lv, J.; Yang, D.* Photocatalyst/metal-free sequential C–N/C–S bond formation: Synthesis of Sarylisothioureas via photoinduced EDA complex activation.  Chin. Chem. Lett., 2024,  26, 110024.

7.  Zuo, J.; Li, X.; Shi, Y.; Lv, J.; Yang, D.* Synthesis of Sulfur-Containing Trisubstituted Imidazoles by One-Pot,  Multicomponent Reaction via Electron Donor–Acceptor Complex Photoactivation. Org. Lett. 2024. 26, 3541.

8.  Li, J.; Chen, C.;, Li, X.; Wang, L.; Shi, Y.; Lv, J.; Jiang, Y.; Yang, D.*  Ligand-Promoted Reductive Coupling between Aryl Iodides and Cyclic Sulfonium Salts by Nickel Catalysis. Chin. Chem. Lett., 2024, 35, 109732.

9. 杨道山*，左峻泽．光诱导基于EDA机理构建 S-芳基黄原酸酯新策略[J]．河南师范大学学报(自然科学版), 2024, 52(3): 1-9. (特约论文,专栏：光促进有机转化和应用).

2023年度

1.  H. Xu, X. Li, Y. Dong, S. Ji, J. Zuo, J. Lv,  D. Yang.* Thianthrenium-Enabled Phosphorylation of Aryl C–H Bonds via Electron Donor–Acceptor Complex Photoactivation.  Org. Lett., 2023, 25, 3784-3789.

2. X. Li, M. Jiang, J. Zuo, X. Song, J. Lv, D. Yang.* Anti-Markovnikov Ring-Opening of Sulfonium Salts with Alkynes by Visble Light/Copper Catalysis. Sci. China Chem. 2023, 66, 791-798.  

首次实现了环硫鎓盐的“自由基型开环”反应模式

3. X. Li, X. Li, W. Cui, Q. Wu, L. Wang, J. Lv, D. Yang* Visible-Light Copper Catalysis for the Synthesis of α-Alkyl-Acetophenones by the Radical Type Ring Opening of Sulfonium Salts and Oxidative Alkylation of Alkenes. Org. Lett., 2023, 25, 3260-3265.

4. W. Cui, G. Guo, Y. Wang, X. Song, J. Lv, D. Yang* Visible light/copper catalysis enabled alkylation of silyl enol ether via selective C−S bond cleavage of arylsulfonium salts. Chem. Commun., 2023, 59, 6367 - 6370.

5. W. Cui, Y . Li,  X. Li,  J. Li,  X. Song,  J. Lv,  Y.-Y. Jiang,*  D. Yang.* Rapid  Formation  of  Csp3–Csp3  Bonds  through  Copper - Catalyzed  Decarboxylative Csp3–H Functionalization. Chin. Chem. Lett., 2023, 34, 107477.

6. H. Xu, X. Li, J. Ma, J. Zuo, X. Song, J. Lv,  D. Yang*. An Electron Donor–Acceptor Photoactivation Strategy for the Synthesis of S-Aryl Dithiocarbamates Using Thianthrenium Salts under Mild Aqueous Micellar Conditions. Chin. Chem. Lett., 2023, 34, 108403.

2022年度

1. W. Cui, X. Li, G. Guo, X. Song, J. Lv, D. Yang.* Radial Type Ring-Opening of Sulfonium Salts with Dichalcogenides by Visible Light/Copper Catalysis. Org. Lett., 2022, 24, 5391-5396.  

2. X. Li, M. Jiang, X. Zhu, X. Song, Q. Deng, J. Lv, D. Yang.* A desulphurization strategy for Sonogashira couplings by visible light/copper catalysis. Org. Chem. Front., 2022, 9, 386-393.

3. X. Zhu, X. Song, X. Li, F. Wang, J. Lv, M. Jiang, D. Yang* Visible-Light-Induced Radical Type Ring-Opening of Sulfonium Salts with Heteroarenes by Copper Photocatalyst. Adv. Synth. Catal., 2022, 364, 4384-4391.

4. X. Li,   W. Cui,   Q. Deng,   X. Song,   J. Lv,   D. Yang.* Three-component reaction access to S-alkyl dithiocarbamates under visible-light irradiation conditions in water. Green Chem., 2022, 24, 1302-1307.

5. X. Zhu, M. Jiang, X. Li, E. Zhu, Q. Deng, X. Song, J. Lv, D. Yang.* Alkylsulfonium salts for the photochemical desulphurizative functionalization of heteroarenes. Org. Chem. Front., 2022, 9, 347-355.

6. D. Yang,* Q. Yan, E. Zhu, J Lv, W-M. He.* Carbon–sulfur bond formation via photochemical strategies: An efficient method for the synthesis of sulfur-containing compounds. Chin. Chem. Lett., 2022, 33, 1798–1816.

7. Q. Yan, W. Cui, J. Li, G. Xu, X. Song, J. Lv, D. Yang.* C–H benzylation of quinoxalin-2(1H)-ones via visible-light riboflavin photocatalysis. Org. Chem. Front., 2022, 9, 2653–2658.

8. H. Xu, J. Zhang, J. Zuo, F. Wang, J. Lv, X. Hun, D. Yang.* Recent Advances in Visible-Light-Catalyzed C-C Bonds and C-Heteroatom Bonds Formation Using Sulfonium Salts. Chin. J. Org. Chem., 2022, 42, 4037-4059.

2021年度

1. Q. Yan, W. Cui, X. Song, G. Xu, M. Jiang, K. Sun, J. Lv, D. Yang.* Sulfonylation of Aryl halides by Visible Light/Copper Catalysis. Org. Lett., 2021, 23, 3663.

2. X. Zhu, X. Li, X. Li, J. Lv, K. Sun, X. Song, D. Yang.* Decarboxylative C–H Alkylation of Heteroarenes by Copper Catalysis. Org. Chem. Front., 2021, 8, 3128.

2020年度

1. Z. Gan, G. Li, X. Yang, Q. Yan, G. Xu, G, Li, Y-Y. Jiang, D. Yang.* Visible-Light-Induced Regioselective Cross-Dehydrogenative Coupling of 2-Isothiocyanatonaphthalenes with Amines Using Molecular Oxygen. Sci China Chem. 2020, 63, 1652.

2.  Z. Gan, G. Li,  Q. Yan, W. Deng, Y.-Y. Jiang, D. Yang.Visible-Light-Promoted Oxidative Desulphurisation: A Strategy for the Preparation of Unsymmetrical Ureas from Isothiocyanates and Amines Using Molecular Oxygen. Green Chem., 2020, 22, 2956.

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