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成果及论文

47. "Catalytic asymmetric functionalization and dearomatization of thiophenes"  Z. Zhao, Y. Li, S. Jia, L. Peng, Z. Zhang, F. Wu, P. Wang, W. Qin*, Y. Lan*, H. Yan* Chem. Sci., 2024, 15, 14295–14303, doi: 10.1039/d4cc02850c

46. "Catalytic asymmetric construction of bridged bicyclo[m.3.1] rings using an intramolecular Diels–Alder reaction"  K. Li, Z. Zhao, W. Qin, Y. Liu*, H. Yan*  Chem. Commun., 202460, 9570–9573doi: 10.1039/d4cc02850c


45. "Regiodivergent catalytic asymmetric dearomative cycloaddition of bicyclic heteroaromatics" L. Peng, Z. Zeng, K. Li, Y. Liu, Y. Lan*, H. Yan*  Sci. Adv2023, doi:10.1126/sciadv.adg1645.


44. "Mechanistic Features of Asymmetric Vinylidene ortho-Quinone Methide Construction and Subsequent Transformations" D. Xu, Y. Chang, Y. Liu, W. Qin,  H. Yan*  ACS Catal202313, 2957−2967doi.org/10.1021/acscatal.2c06272


43. "Organocatalytic asymmetric deoxygenation of sulfones to access chiral sulfinyl compounds" S. Huang, Z. Zeng, N. Zhang, W. Qin*Y. Lan*, H. Yan*  Nat. Chem. 2023, doi.org/10.1038/s41557-022-01120-x.


42. "Enantioselective Synthesis of Atropisomers via Vinylidene ortho-Quinone Methides (VQMs)" W. Qin, Y. Liu, H. Yan*  Acc. Chem. Res. 2022, 55, 2780-2795doi.org/10.1021/acs.accounts.2c00486


41. "Organocatalytic Asymmetric Construction of Tetrasubstituted Carbon Stereocenters Bearing Three Heteroatoms via Intramolecular Cyclization of Vinylidene ortho-Quinone Methide with Imidates" Y. Tian, F. Wu, S. Jia, X. Gong, H. Mao, P. Wang*, W. Qin*, H. Yan*  Org. Lett. 2022, 24, 5073−5077doi.org/10.1021/acs.orglett.2c01842


40. "Atroposelective Construction of Nine-Membered CarbonateBridged Biaryls " S. Jia, Y. Tian, X. Li, P. Wang, Y. Lan, H. Yan*  Angew. Chem. Int. Ed2022, DOI: anie.202206501.


39. "Organocatalytic Asymmetric Dearomatizing Hetero-Diels−Alder Reaction of Nonactivated Arenes" K. Li, S. Huang, T. Liu, S. Jia, H. Yan* J. Am. Chem. Soc. 2022, DOI:org/10.1021/jacs.2c01106.


38. "Organocatalytic atroposelective construction of axially chiral N, N- and N, S-1,2-azoles through novel ring formation approach" Y. Chang, C. Xie, H. Liu, S. Huang, W. Qin*, H. Yan* Nat. Commun. 2022, DOI:org/10.1038/s41467-022-29557-1.


37. "Organocatalytic atroposelective construction of axially chiral nonsymmetric biaryltriols and their applications in asymmetric synthesis and heavy metal ion detection" S. Jia, W. Qin,  P. Wang*, H. Yan* Org. Chem. Front. 20229, 923–928.


36. "An Isolable Vinylidene ortho-Quinone Methide: Synthesis, Structure and Reactivity-Quinone Methides " H. Liu, K. Li, S. Huang, H. Yan*  Angew. Chem. Int. Ed2022, DOI: anie.202117063.


35. "Organocatalytic Cascade Reactions to Multi-functionalized Chiral Cyclic Ethers through Vinylidene ortho-Quinone Methides " S. Jia, Y. Chang, Y. Tian, H. Mao, W. Qin, P. Wang,* H. Yan*  Chem. Commun., 2021, DOI: 10.1039/D1CC05340J.


34. "Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N-Aryl Indoles via Vinylidene Ortho-Quinone Methides" D. Xu, S. Huang, F. Hu, L. Peng, S. Jia, H. Mao, X. Gong, F. Li, W. Qin, H. Yan* CCS Chemistry20213, 2680-2691.


33. "Organocatalytic Enantioselective Construction of Chiral Azepine Skeleton Bearing Multiple-Stereogenic ElementsS. Huang, H. Wen, Y. Tian, P. Wang, W. Qin, H. Yan* Angew. Chem. Int. Ed. 202160, 21486-21493.


32. "Chiral Naphthyl-C2-Indole as Scaffold for Phosphine Organocatalysis: Application in Asymmetric Formal [4 + 2] Cycloaddition Reactions " T. He, L. Peng, S. Li, F. Hu, C. Xie, S. Huang, S. Jia, W. Qin,* H. Yan*  Org. Lett. 2020, 22, 6966-6971.

 

31. "N‑Iodosuccinimide-Mediated Dimerization of 2‑Alkynylnaphthols: A Highly Diastereoselective Construction of Bridged PolycyclicCompounds via Vinylidene ortho-Quinone Methide Intermediate" Y. Tan,* Z. Zhao, Z. Chen, S. Huang, S. Jia, L. Peng, D. Xu,  W. Qin,* H. Yan*  Org. Lett. 2020, 22, 4461-4466.


30. "Organocatalytic Enantioselective γElimination: Applications in th Preparation of Chiral Peroxides and Epoxides" F. Hu, Z. Chen, Y. Tan, D. Xu, S. Huang, S. Jia, X. Gong, W. Qin, H. Yan*  Org. Lett. 202022, 1934−1940.


29. "Enantioselective control of both helical and axial stereogeni elements via an organocatalytic approach"   S. Jia, S. Li, Y. Liu, W. Qin, H. Yan* Angew. Chem. Int. Ed201958, 18496−18501.


28. "Organocatalytic Asymmetric Annulation of ortho-Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-Indoles"   L. Peng, K. Li, C. Xie, S. Li, D. Xu, W. Qin, H. Yan* Angew. Chem. Int. Ed201958, 17199−17204.


27. "Organocatalytic Enantioselective Selenosulfonylation of a C-C Double Bond To Form Two Stereogenic Centers in an Aqueou Medium" Z. Chen, F. Hu, S. Huang, Z. Zhao, H. Mao* and W. Qin* J. Org. Chem. 2019, 84, 8100−8111.


26. "Metal-free difunctionalization of alkynes to access tetrasubstituted olefins through spontaneous selenosulfonylation of vinylidene ortho-quinone methide (VQM)" S. Huang, Z. Chen, H. Mao, F. Hu, D. Li, Y. Tan, F. Yang, W. Qin* Org. Biomol. Chem201917, 1121–1129.


25. "Organocatalytic Atropo- and E/Z-selective Michael Addition Reaction of Ynones with α-Amido Sulfones as Sulfone-type Nucleophile" N. Zhang, T. He, Y. Liu, S. Li, Y. Tan, L. Peng, D. Li,  C. Shan, H. YanOrg. Chem. Front. 20196, 451–455. 


24. "Asymmetric One-Pot Construction of Three Stereogenic Elements: Chiral Carbon Center, Stereoisomeric Alkenes, and Chirality of Axial Styrenes" A. Huang, Li. Zhang, D. Li, Y. Liu*, H. Yan* and W. Li* Org. Lett. 201921, 95−99. 


23. "Kinetic Resolution of Allylic Alcohol with Chiral BINOL-based Alkoxides: A Combination of Experimental and Theoretical Studies" Y. Liu, S. Liu, D. Li, N. Zhang, L. Peng, J. Ao,  C. E. Song, Y. Lan and H. YanJ. Am. Chem. Soc. 2019141, 1150−1159.  


22. "Enantioselective Construction of Vicinal Diaxial Styrenes and Multiaxis System via Organocatalysis" Y. Tan, S. Jia, F. Hu, Y. Liu, L. Peng, D. Li and H. YanJ. Am. Chem. Soc. 2018140, 16893−16898. 


21. "Organocatalytic Asymmetric Atroposelective Construction of Axially Chiral 1,4-Distyrene 2,3-Naphthalene Diols" S. Li, D. Xu, F. Hu, D. Li, W. Qin, H. YanOrg. Lett. 201820, 7665−7669.


20. "Organocatalytic Asymmetric One-Step Desymmetrizing Dearomatization Reaction of Indoles: Development and Bioactivity Evaluation"  L. Peng, D. Xu, X. Yang, J. Tang, X. Feng*, S. Zhang*, H. YanAngew. Chem. Int. Ed. 2019, 58, 216–220. 


19. "Asymmetric Mannich Reaction and Construction of Axially Chiral Sulfone-Containing Styrenes in One Pot from α‑Amido Sulfones Based on the Waste-Reuse Strategy" D. Li, Y. Tan, L. Peng, S. Li, N. Zhang, Y. Liu, H. YanOrg. Lett. 201820, 4959-4963.  


18. "Direct Preparation of Indole Hemiaminals through Organocatalytic Nucleophilic Addition of Indole to Aldehydes" N. Zhang, Y. Li, Z. Chen, W. Qin Synthesis 2018,  50, 4063-4070.


17. "Organocatalytic Enantioselective Construction of Axially Chiral Sulfone-Containing Styrenes" S. Jia, Z. Chen, N. Zhang, Y. Tan, Y. Liu, J. Deng, H. Yan* J. Am. Chem. Soc. 2018140, 7056−7060.


16. "Organocatalytic Atroposelective Intramolecular [4+2] Cycloaddition: Synthesis of Axially Chiral Heterobiaryls" Y. Liu, X. Wu, S. Li, L. Xue, C. Shan, Z. Zhao, H. Yan* Angew. Chem. Int. Ed. 201857, 6491 –6495.


15. "Enantioselective Addition of Selenosulfonates to α,β-unsaturated Ketones" S. Luo, N. Zhang, Z. Wang, H. Yan* Org. Biomol. Chem. 201816, 2893–2901.  


14. "Enantioselective one-pot synthesis of β-sulfonyl ketones and trisubstituted tetrahydrothiophenes via β-elimination/cycloaddition sequence" L. Xue, Y. Liu, W. Qin, H. Yan* Chinese Chemical Letters 201829, 1215-1218.


13. "Acid-promoted furan annulation and aromatization: an access to benzo[b]furan derivatives" J. Ao, Y. Liu, S. Jia, L. Xue, D. Li, Y. Tan, W. Qin*, H. Yan* Tetrahedron 201874, 433-440. 


12. "Organocatalytic Intramolecular [4+2] Cycloaddition Between In-situ Generated Vinylidene ortho-Quinone Methide and Benzofuran" X. Wu, L. Xue, D. Li, S. Jia, J. Ao, J. Deng, H. Yan* Angew. Chem. Int. Ed. 201756,  13722 –13726. 


11.  "Asymmetric Aminalization via Cation-Binding Catalysis "  S. Y. Park, Y. Liu, J. S. Oh, Y. K. Kweon,. Y. B. Jeong, M. Duan, Y. Tan,. J.-W. Lee,* H. Yan,* C. E. Song* Chem. Eur. J2018, 24, 1020 – 1025. Cover Paper  


10. "K2S2O8 Activated Friedel-Crafts Type Alkylation of Indoles with α-Amido Sulfones" X. Wu, L. Xue, S. Luo, S. Jia, J. Ao, W. Qin* Synthesis201749, 5017-5024. 


9. "Fluoride Anions in Self-Assembled Chiral Cage for the Enantioselective Protonation of Silyl Enol Ethers"  S. Paladhi, Y. Liu, B. S. Kumar, M.-J. Jung, S. Y. Park, H. Yan* and C. E. Song* Org. Lett. 201719, 3279-3282. 


8. "Enantioselective Synthesis of anti-syn-Trihalides and anti-syn-anti-Tetrahalides via Asymmetric β-Elimination," Y. Tan, S. Luo, D. Li, N. Zhang, S. Jia, Y. Liu, W. Qin, C. E. Song and H. Yan* J. Am. Chem. Soc. 2017139, 6431-6436.  


7.  "Asymmetric Synthesis of Trisubstituted Tetrahydrothiophenes via in-situ Generated Chiral Fluoride Catalyzed Cascade Sulfa-Michael/Aldol Reaction of 1,4-dithiane-2,5-diol and α,β-Unsaturated Ketones," M. Duan, Y. Liu, J. Ao, L. Xue, S. Luo, Y. Tan, W. Qin, C. E. Song and H. Yan* Org. Lett. 201719, 2298-2301   


6.  "Asymmetric Synthesis of 2-Thiocyanato-2-(1-aminoalkyl)-substituted 1-Tetralones and 1-Indanones with Tetrasubstituted Carbon Stereogenic Centers via Cooperative Cation-Binding Catalysis, " L. Yu, X. Wu, M. J. Kim, V. Vaithiyanathan, Y. Liu, Y. Tan, W. Qin, C. E. Song* and H. Yan*  Adv. Synth. Catal. 2017359, 1879-1891. 

5. "Cooperative Cation-Binding Catalysis as an Efficient Approach for Enantioselective Friedel-Crafts Reaction of Indoles and Pyrrole," M. J. Kim; L. Xue; Y. Liu; S. Paladhi; S. J. Park; H. Yan* and C. E. Song*  Adv. Synth. Catal.  2017359, 811-823. 


4. "Direct Access to Chiral β-Fluoroamines with Quaternary Stereogenic Center through Cooperative Cation-Binding Catalysis,"  V. Vaithiyanathan; M. J. Kim; Y. Liu; H. Yan* and C. E. Song* Chem. Eur. J. 201723, 1268-1272.   


3. "Organocatalytic Asymmetric Synthesis of Chiral Dioxazinanes and Dioxazepanes with In Situ generated Nitrones via Tandem Reaction Pathway using a Cooperative Cation Binding Catalyst,"  Y. Liu; J. Ao; S. Paladhi; C. E. Song* and H. Yan  J. Am. Chem. Soc. 2016138, 16486-16492.   


2.  "Efficient Enrichment of Chiral β-Sulfonyl Ketones through Asymmetric β-Elimination,"  Y. Liu; W. Qin and H. Yan*  Synlett 201627, 2756-2760


1.  "Kinetic Resolution of β-Sulfonyl Ketones through Enantioselective β-Elimination using a Cation-Binding Polyether Catalyst," L. Li; Y. Liu; Y. Peng; L. Yu; X. Wu and H. Yan*  Angew. Chem. Int. Ed. 2016128, 339–343.