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成果及论文

1. Yang Liu, Lulu Wang, Qianqian Song, Muhammad Ali, William N. Crowe, Gregory L. Kucera, Gregory A. Hawkins, Shay Soker, Karl W. Thomas, Lance D. Miller, Yong Lu, Christina R. Bellinger, Wei Zhang, Amyn A. Habib, W. Jeffrey Petty, Dawen Zhao*, Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion, Nature Nanotechnology, 2022, 17, 206–216

2. Yang Liu, Dawen Zhao*, A novel nanoimmunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through singlecell RNAsequencing, Clinical and Translational Medicine, 2022, 12, e774

3. Yang Liu, William N. Crowe, Lulu Wang, W.Jeffrey Petty, Amyn A. Habib, Dawen Zhao*, Aerosolized immunotherapeutic nanoparticle inhalation potentiates PD-L1 blockade for locally advanced lung cancer, Nano Research, 2022 https://www.sciopen.com/article/10.1007/s12274-022-5205-6%20.

4. Yang Liu, William N. Crowe, Lulu Wang, Yong Lu, W.Jeffrey Petty, Amyn A. Habib, Dawen Zhao*, An Inhalable Nanoparticulate STING Agonist Synergizes with Radiotherapy to Confer Long-Term Control of Lung Metastases, Nature Communications, 2019, 10, 5108

5. Yang Liu, Zhi-Ting Cao, Cong-Fei Xu*, Zi-Dong Lu, Ying-Li Luo, Jun Wang*, Optimization of Lipid-assisted Nanoparticle for Disturbing Neutrophils-related Inflammation, Biomaterials, 2018, 172, 92-104

6. Yang Liu, Gui Zhao, Cong-Fei Xu*, Ying-Li Luo, Zi-Dong Lu*, Jun Wang, Systemic Delivery of CRISPR/Cas9 with PEG-PLGA Nanoparticles for Chronic Myeloid Leukemia targeted therapy, Biomaterials Science, 2018,6, 1592-1603

7. Yang Liu, Cong-Fei Xu, Shoaib Iqbal, Xian-Zhu Yang*, Jun Wang*, Responsive Nanocarriers as an Emerging Platform for Cascaded Delivery of Nucleic Acids to Cancer, Advanced Drug Delivery Reviews, 2017, 115, 98-114

8. Yang Liu, Xin Wang, Chun-Yang Sun, Jun Wang*, Delivery of Mitogen-Activated Protein Kinase Inhibitor for Hepatocellular Carcinoma Stem Cell Therapy, ACS Applied Materials & Interfaces, 2015, 7, 1012-1020

9. Yang Liu, Yan-Hua Zhu, Cheng-Qiong Mao, Shuang Dou, Song Shen, Zi-Bin Tan, Jun Wang*, Triple Negative Breast Cancer Therapy with CDK1 siRNA Delivered by Cationic Lipid Assisted PEG-PLA Nanoparticles, Journal of Controlled Release, 2014, 192, 114-121 (22)

10. Rong Sun, Yang Liu (co-first author), Shi-Yong Li, Song Shen, Xiao-Jiao Du, Cong-Fei Xu, Zhi-Ting Cao, Yan Bao, Yan-Hua Zhu, Ya-Ping Li, Xian-Zhu Yang, Jun Wang*, Co-delivery of All-Trans-Retinoic Acid and Doxorubicin for Cancer Therapy with Synergistic Inhibition of Cancer Stem Cell, Biomaterials, 2015, 37, 405-414 (20)

11. Chun Yang Sun, Yang Liu (co-first author), Jin-Zhi Du, Zhi-Ting Cao, Cong-Fei Xu, Jun Wang*. Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery, Angewandte Chemie-International Edition, 2016, 55, 1010-1014 (20)

12. Shi-Yong Li, Yang Liu (co-first author), Cong-Fei Xu, Song Shen, Rong Sun, Xiao-Jiao Du, Jin-Xing Xia, Yan-Hua Zhu, Jun Wang*, Restoring Anti-Tumor Functions of T Cells via Nanoparticle-mediated Immune Checkpoint Modulation, Journal of Controlled Release, 2016, 231,17-28 (3)

13. Jun-Xia Wang, Yang Liu (co-first author), Yin-Chu Ma, Chun-Yang Sun, Wei Tao, Yu-Cai Wang, Xian-Zhu Yang*, Jun Wang, NIR-Activated Super-Sensitive Drug Release using Nanoparticles with A Flow Core, Advanced Functional Materials,2016, 41, 7516-7524 (2)

14. Chad A. Arledge, Deeksha M. Sankepalle, William N. Crowe, Yang Liu, Lulu Wang, Dawen Zhao1* Deep learning quantification of vascular pharmacokinetic parameters in mouse brain tumor models, Front. Biosci. (Landmark Ed) 2022 , 27(3), 099; https://doi.org/10.31083/j.fbl2703099

15. Cong-Fei Xu, Zi-Dong Lu, Ying-Li Luo, Yang Liu, Zhi-Ting Cao, Song Shen, Hong-Jun Li, Jing Liu, Kai-Ge Chen, Zhi-Yao Chen, Xian-Zhu Yang, Zhen Gu, Jun Wang*, Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases, Nature Communications, 2018, 9, 4092.

16. Cong-Fei Xu, Hou-Bing Zhang, Chun-Yang Sun, Yang Liu, Song Shen, Xian-Zhu Yang, Yan-Hua Zhu, Jun Wang*, Tumor Acidity-Sensitive Linkage-Bridged Block Copolymer for Therapeutic siRNA Delivery, Biomaterials, 2016, 88, 48-59 (9)

17. Chun-Yang Sun, Song Shen, Cong-Fei Xu, Hong-Jun Li, Yang Liu, Zhi-Ting Cao, Xian-Zhu Yang, Jin-Xing Xia, Jun Wang*, Tumor acidity-sensitive polymeric vector for active targeted siRNA delivery, Journal of the American Chemical Society, 2015, 137, 15217–15224 (43)

18. Song Shen, Chun-Yang Sun, Xiao-Jiao Du, Hong-Jun Li, Yang Liu, Jin-Xing Xia*, Yan-Hua Zhu, Jun Wang*, Co-delivery of platinum drug and siNotch1 with micelleplex for enhanced hepatocellular carcinoma therapy, Biomaterials, 2015, 70, 81-83 (8)

19. Rong Sun, Xiao-Jiao Du, Chun-Yang Sun, Song Shen, Yang Liu, Xian-Zhu Yang*, Yan Bao, Yan-Hua Zhu, Jun Wang*, A Block Copolymer of Zwitterionic Polyphosphoester and Polylactic acid for Drug Delivery, Biomaterials Science, 2015,3, 1105-1113 (6)

20. Cong-Fei Xu, Yang Liu, Song Shen, Yan-Hua Zhu, Jun Wang*, Targeting Glucose Uptake with siRNA-Based Nanomedicine for Cancer Therapy, Biomaterials, 2015, 51, 1-11 (13)

21. Shi-Yong Li, Rong Sun, Hong-Xia Wang, Song Shen, Yang Liu, Xiao-Jiao Du, Yan-Hua Zhu, Jun Wang*, Combination Therapy with Epigenetic-Targeted and Chemotherapeutic Drugs Delivered by Nanoparticles to Enhance the Chemotherapy Response and Overcome Resistance by Breast Cancer Stem Cells, Journal of Controlled Release, 2015,10, 7-14 (24)

22. Song Shen, Chong-Qiong Mao, Xian-Zhu Yang*, Xiao-Jiao Du, Yang Liu, Yan-Hua Zhu, Jun Wang*, Cationic Lipid-Assisted Polymeric Nanoparticles Mediated GATA2 siRNA Delivery for Synthetic Lethal Therapy of KRAS Mutant Non-Small-Cell Lung Carcinoma, Molecular Pharmaceutics, 2014, 11, 2612-2622 (12)

23. Cheng-Qiong Mao, Meng-Hua Xiong, Yang Liu, Song Shen, Xiao-Jiao Du, Xian-Zhu Yang, Shuan Dou, Pei-Zhuo Zhang, Jun Wang*, Synthetic Lethal Therapy for KRAS Mutant Non-Small-Cell Lung Carcinoma with Nanoparticle-Mediated CDK4 siRNA Delivery, Molecular Therapy, 2014, 22, 964-973 (19)

24. Xian-Zhu Yang, Xiao-Jiao Du, Yang Liu, Yan-Hua Zhu, Yang-Zhong Liu, Ya-Ping Li, Jun Wang*, Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy, Advanced Materials, 2014, 26, 931-936 (52)

25. Tian-Meng Sun, Yu-Cai Wang, Feng Wang, Jin-Zhi Du, Cheng-Qiong Mao, Chun-Yang Sun, Rui-Zhi Tang, Yang Liu, Jing Zhu, Yan-Hua Zhu, Xian-Zhu Yang, Jun Wang*, Cancer Stem Cell Therapy Using Doxorubicin Conjugated to Gold Nanoparticles via Hydrazone Bonds, Biomaterials, 2014, 35, 836-845 (42)