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成果及论文

1. Mingda Zhou, Tong Wang, Ke Xu, Han Wang, Zibin Li, Wei-xian Zhang, Yayi Wang. (2024) Broadening environmental research in the era of accurate protein structure determination and predictions.Front. Environ. Sci. Eng. 18(7): 91

2. Jian Zhang, Ji Huang, Ke Xu, Peiqi Xing, Yue Huang, Zhaoqi Liu, Liang Tong, and James L. Manley.(2022)DHX15 is involved in SUGP1-mediated RNA missplicing by  mutant SF3B1 in cancer. Proc. Natl. Acad. Sci. USA.119 (49) e2216712119

3.Yi Sun*, Lijuan Xu*, Hongming Shao, Danni Quan, Zixin Mo, Jue Wang, Wannian Zhang, Jianqiang Yu, Chunlin Zhuang#,and Ke Xu#. (2022) Discovery of a Triuoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease. J. Med. Chem. 65(21):14957−14969 (Cover Story)

4. Guodong Liu*,Ruilin Hou* Lijuan Xu*,Xinqi Zhang, Jianyu Yan, Chengguo Xing, Ke Xu#, and Chunlin Zhuang#.(2022) Crystallography-Guided Optimizations of the Keap1–Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides. J. Med. Chem. 65(12):8289-8302 (Cover Story)

5. Chushu Li*, Hao Chi, Shouyan Deng, Ke Xu, Huanbin Wang, Han Yao, Yungang Wang, Dawei Chen, Xun Guo, Jing-Yuan Fang, Fang He,  Jie Xu#.(2021) THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy. J Immunother Cancer.9:e002443.

6. Shukun Luo*, Ke Xu, Shaoyun Xiang, Jie Chen, Chunyun Chen, Chuangxin Guo, Youzhi Tong and Liang Tong#. (2018) High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr. F. 74 (11).

7. Zhihao Bao*, Xiaofeng Qi*, Sen Hong, Ke Xu, Fangyuan He, Minhua Zhang, Jiugeng Chen, Daiyin Chao, Wei Zhao, Dianfan Li, Jiawei Wang#, Peng Zhang#. (2017) Structure and mechanism of a group-I cobalt energy coupling factor transporter. Cell Res. 27:675–687.

8. Chun-Min Shan*, Jiyong Wang*, Ke Xu*, Huijie Chen, Jia-Xing Yue, Stuart Andrews, James J Moresco, John R Yates III, Peter L Nagy, Liang Tong#, Songtao Jia#.(2016) A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. eLife. 5:e17903.
9. Minhua Zhang*, Zhihao Bao*, Qin Zhao, Hui Guo, Ke Xu, Chengcheng Wang, Peng Zhang#. (2014) Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters. Proc. Natl. Acad. Sci. USA.111(52):18560-565.

10. Ke Xu*, Minhua Zhang*, Qin Zhao*, Fang Yu*, Hui Guo, Chengyuan Wang, Fangyuan He, Jianping Ding, Peng Zhang#. (2013) Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature. 497(7448):268-271.


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