代表性工作：   

Xinya Hemu#; Ning-Yu Chan#; Heng Tai Liew; Side Hu; Xiaohong Zhang; Aida Serra; Julien Lescar; Chuan-Fa Liu; James P Tam*; Substrate-binding glycine residues are major determinants for hydrolase and ligase activity of plant legumains, New Phytologist, 2023, 238(4): 1534-1545.

Xinya Hemu; Xiaohong Zhang; Hong Yi Chang; Poh Jin En; James P. Tam*; Consensus design and engineering of an efficient and high-yield peptide asparaginyl ligase for protein cyclization and ligation, Journal of Biological Chemistry, 2023, 299(3): 102997.

Xinya Hemu; Xiaohong Zhang; Giang K. T. Nguyen; Janet To; Aida Serra; Shining Loo; Siu Kwan Sze; Chuan-Fa Liu; James P. Tam*; Characterization and application of natural and recombinant butelase-1 to improve industrial enzymes by end-to-end circularization, RSC Advances, 2021, 11(37): 23105-23112.

Xinya Hemu#; Abbas El Sahili#; Side Hu; Xiaohong Zhang; Aida Serra; Boon Chong Goh; Dina A.Darwis; Ming Wei Chen; Siu Kwan Sze; Chuan-Fa Liu; Julien Lescar*; James P. Tam*; Turning anasparaginyl endopeptidase into a peptide ligase, ACS Catalysis, 2020, 10(15): 8825-8834.

Xinya Hemu; Janet To; Xiaohong Zhang; James P. Tam*; Immobilized peptide asparaginyl ligases enhance stability and facilitate macrocyclization and site-specific ligation, Journal of Organic Chemistry, 2020, 85(3): 1504-1512.

Xinya Hemu#; Abbas El Sahili#; Side Hu; Kaho Wong; Yu Chen; Yee Hwa Wong; Xiaohong Zhang; Aida Serra; Boon Chong Goh; Dina A. Darwis; Ming Wei Chen; Siu Kwan Sze; Chuan-Fa Liu; JulienLescar*; James P. Tam*; Structural determinants for peptide-bond formation by asparaginyl ligases,Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(24):11737-11746.

Xinya Hemu; Xiaohong Zhang; Xiaobao Bi; Chuan-Fa Liu; and James P. Tam*. Butelase 1-mediated ligation of peptides and proteins. in Timo Nuijens and Marcel Schmidt (eds.), Enzyme-Mediated Ligation Methods, 2019, 83-110.

Xinya Hemu; Xiaohong Zhang; James P. Tam*; Ligase-controlled cyclo-oligomerization of peptides, Organic letters, 2019, 21(7): 2029-2032.

Xinya Hemu; Aida Serra; Dina A. Darwis; Tobias Cornvik; Siu Kwan Sze*; James P. Tam*; Peptidomic identification of cysteine-rich peptides from plants, Methods in Molecular Biology, 2018, 1719: 379-393.

Xinya Hemu; James P. Tam*; Macrocyclic antimicrobial peptides engineered from omega-conotoxin, Current Pharmacological Design, 2017, 23(14): 2131-2138.

Xinya Hemu; Yibo Qiu; Giang K. T. Nguyen; James P. Tam*; Total synthesis of circular bacteriocins by butelase 1, Journal of the American Chemical Society, 2016, 138(22): 6968-6971.

Aida Serra#; Xinya Hemu#; Giang K. T. Nguyen; Ngan T. K. Nguyen; Siu Kwan Sze*; James P. Tam*; A high-throughput peptidomic strategy to decipher the molecular diversity of cyclic cysteine-richpeptides, Scientific Reports, 2016, 6: 23005.

Xinya Hemu; Yibo Qiu; James P. Tam*; Peptide macrocyclization through amide-to-amide transpeptidation, Tetrahedron, 2014, 70(42): 7707-7713.

Xinya Hemu; Misako Taichi; Yibo Qiu; Ding-Xiang Liu; James P. Tam*; Biomimetic synthesis of cyclic peptides using novel thioester surrogates, Peptide Science, 2013, 100(5): 492-501.