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成果及论文
  1. Mingxing Hu, Yujue Li, Jiaxuan Li, et al. Discovery of potent and selective HER2 PROTAC degrader based Tucatinib with improved efficacy against HER2 positive cancers.  European Journal of Medicinal Chemistry, 2022 Dec 15;244:114775. doi: 10.1016/j.ejmech.2022.114775.SCIIF7.088

  2. Liu Z, Hu M, Yang Y, et al.An overview of PROTACs: a promising drug discovery paradigm. Molecular Biomedicine, 2022 Dec 20;3(1):46. doi: 10.1186/s43556-022-00112-0.

  3. Yang C, Xia AJ, Du CH, et al. Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents.  Frontiers in Pharmacology, 2022 Nov 23;13:1014854. doi: 10.3389/fphar.2022.1014854. SCIIF5.988

  4. Mingxing Hu, Weilin Zhou, Yijie Wang, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2, 3-dioxygenase 1. Acta Pharmaceutica Sinica B, 2020, 10(10):1943-1953.SCIIF14.903

  5. Shuping Yang, Xiang Gao, Yihong He, et al. Applying an innovative biodegradable self-assembly nanomicelles to deliver α-mangostin for improving anti-melanoma activity. Cell Death & Disease, 2019, 10, 146. SCIIF9.685

  6. Mingxing Hu, Chao Yang, Yi Luo, et al. A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells. Journal of Materials Chemistry B, 2018,6, 2413-2416SCIIF7.571

  7. Shuping Yang, Yange Zhang, Yi Luo, et al. Hinokiflavone induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion. Biomedicine & Pharmacotherapy, 2018, 103:101-110 SCIIF7.419

  8. Xiuli Chen, Hao Chen, Chunyan Lu, et al. Novel mitochondria-targeted, nitrogen mustard-based DNA alkylation agents with near infrared fluorescence emission. Talanta, 2016, 161: 888-893 SCIIF6.556

  9. Yuqin Yao, Lin Yu, Xiaolan Su, et al. Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates. Journal of Controlled Release, 2015, 220(Pt A): 5-17SCIIF11.457

  10. Fangfang Yang, Mingxing Hu, Qing Lei, et al. Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model. Cell Death & Disease, 2015, 6:e1701SCIIF9.685

  11. Fangfang Yang, Yang Yu, Qian Lei, et al. Lobaplatin arrests cell cycle progression, induces apoptosis and impairs migration and invasion in B16-F10 melanoma cell line in vitro. Biomedicine & Pharmacotherapy, 2015, 69:402–408SCIIF7.419)

  12. Yu LiuKun LiMing-Yu Wuet al. A mitochondria-targeted colorimetric and ratiometric fluorescent probe for biological SO2 derivatives in living cells. Chemical Communications, 2015, 51(50): 10236-10239SCIIF6.065